Pierre LEBLOND
Pierre Leblond
137
Documents
Affiliations actuelles
Identifiants chercheurs
- pierre-leblond
- 0000-0002-8703-454X
- IdRef : 074217127
Présentation
**Bio**
I received my PhD in molecular genetics in 1990 under the supervision of Prof. Bernard Decaris at Université Henri Poincaré in Nancy. Then, I did my military service (1 yr) as a scientist in the lab of Profs. I. Gresser and M. Tovey at Hôpital Paul Brousse (CNRS, Villejuif). Afterwards, I joined for 2 years Pr. J. Cullum at Kaiserslautern (Germany) thanks to EMBO and European Community fellowships. I was appointed to the position of Maître de Conférences at Université Henri Poincaré and was granted a professorship in 1995. Since then, I lead a research team; today named *Streptomyces Adaptation*, StrAda.
In the past, I was director of the research unit from 2007 to 2018 (co-director from 2001 to 2007). At the national level, I sat at the National University Committee (CNU 65, cellular biology, 3 terms between 2004 and 2018). I sat in several instances of the Université de Lorraine (executive board, cluster council, faculty council). I was vice-president UL in charge of technology transfer in 2017-18, and currently project manager for the construction of a research building at the Faculty of Sciences.
**Research**
The guiding thread of all my research is to better understand the molecular mechanisms of bacterial genome evolution. Early in my career, I met *Streptomyces* and it became my pet bacteria. I developed methods (pulsed-field gel electrophoresis) and applied approaches (genome mapping, comparative genomics, genome mining) to study genome structure, organization and dynamics. Notably, I focused on recombination mechanisms shaping the genome (homologous and illegitimate recombination). Hence, these soil bacteria have to face variable environmental (biotic and abiotic parameters) conditions. They show an extraordinary capacity to adapt and to evolve through horizontal gene transfer. We currently study this dynamic in natural populations of *Streptomyces* (isolated from grains of forest soil) in terms of acquisition and diversification of new genes (secondary metabolite gene clusters, nutriment utilization, mobile genetic elements).
**Teaching**
I am teaching since 1989 in the field of genetics and microbiology in undergraduate and graduate courses. I continuously managed University programs; from 1995 to 2018 Licence de Biologie, Maîtrise de Génétique Moléculaire et Cellulaire, DESS Ressources Génomiques et Traitements Informatiques, Master de Microbiologie, Master Biotechnologies, Microbiologie, Aliment, Nutrition ; and founded several of them: DESS RGTI (2001), Master de Microbiologie (2008). I also contributed to the creation of the Cursus Master of Engineering (CMI ‘Biologie Santé Environnement’) in 2010 and supervised the cursus at its opening in 2012. Since 2018, I supervise the RIM (Research in Microbiology) orientation of the Master Microbiology (M2), a project-driven course in the omics field with full immersion in research laboratories.
**Contact**
E-mail : <pierre.leblond@univ-lorraine.fr>
Téléphone : +33 (0)3 72 74 51 43
IdeHAL **pierre-leblond**
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Nonhomologous End-Joining in BacteriaJoseph Jez. Encyclopedia of Biological Chemistry 3rd Edition,, 4, Elsevier, 2021, 9780128194607
Chapitre d'ouvrage
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Evolution Underway in ProkaryotesSébastien Wielgoss; Pierre Leblond; Catherine Masson-Boivin; Philippe Normand. Prokaryotes and Evolution, Springer International Publishing, pp.339-391, 2019, 978-3-319-99784-1. ⟨10.1007/978-3-319-99784-1_6⟩
Chapitre d'ouvrage
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Subtelomere Plasticity in the Bacterium StreptomycesEdward J Louis, Marion M Becker. Subtelomeres, Springer Berlin Heidelberg, pp.243-258, 2013, 978-3-642-41565-4. ⟨10.1007/978-3-642-41566-1_14⟩
Chapitre d'ouvrage
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Genome-guided Exploration of Streptomyces ambofaciens Secondary MetabolismPaul J Dyson Institute of Life Sciences, School of Medicine, Swansea, UK. Streptomyces: Molecular Biology and Biotechnology, Caister Academic Press, Chapter 10 pp. 179-194, 2011, 978-1-904455-77-6
Chapitre d'ouvrage
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Using Markov Models to Mine Temporal and Spatial DataKimito Funatsu and Kiyoshi Hasegawa. New Fundamental Technologies in Data Mining, Intech, pp.561--584, 2011, 978-953-307-547-1
Chapitre d'ouvrage
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Fouille de données du génome à l'aide de modèles de Markov cachésExtraction et gestion des connaissances. EGC 2005, Cépaduès, 2005, Revue des Nouvelles Technologies de l'Information, 2-85428-677-4 2-85428-682-0 (vol. 1) 2-85428-683-9 (vol. 2)
Chapitre d'ouvrage
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PFGE: électrophorèse en champs pulsés (pulse field electrophoresis)INRA. Principes des techniques de biologie moléculaire, INRA Editions, pp.152-153, 2004, 9782738010674
Chapitre d'ouvrage
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Unstable Linear Chromosomes: the Case of StreptomycesRobert L Charlebois. Organization of the prokaryotic genome, ASM Press, pp.235-262, 1999, 1-55581-151-5
Chapitre d'ouvrage
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Biosenseur bactérien de la dégradation du boisFrance, N° de brevet: WO2016131665. 2016
Brevet
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Stambomycin and derivatives: their production and their use as drugsFrance, Patent n° : WO2011009938. 2011
Brevet
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La folle course aux armements des bactéries contre les antibiotiques2018
Autre publication scientifique
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Ne me cassez pas les chromosomes !2018
Autre publication scientifique
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Gene flux and chromosomal recombination as key drivers of adaptability and population functioning of StreptomycesActino 2020 Journées des actinobactéries (en ligne), Dec 2020, Paris, France
Communication dans un congrès
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Genome dynamics of the Streptomyces genusACTINO 2020 - Journées des actinobactéries, Dec 2020, Gif-sur-Yvette, France
Communication dans un congrès
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Diversity and mobility of conjugative elements in a population of Streptomyces isolated from a rhizospheric micro-habitat.Journées des Actinobactéries 2020 - ACTINO 2020, Dec 2020, Conférence virtuelle Gif Sur Yvette, France
Communication dans un congrès
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Suivi sur une année de la biodiversité microbienne dans les bioaerosols émis dans un centre de tri des déchetsCongrès français sur les aérosols 2018 (CFA), Jan 2018, Paris, France
Communication dans un congrès
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Massive gene fluxes in bacterial population fuels adaptation to soil forest ecosystemFunctional Ecology Conference Nancy 2018, Dec 2018, Nancy, France
Communication dans un congrès
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Decipher and exploit interactions between bacteria and fungi to identify new bioactive metabolitesSéminaire LUE Impact/Biomolécules du futur : de la découverte aux applications, May 2018, Nancy, France
Communication dans un congrès
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Double strand break repair triggers genome plasticity in StreptomycesActino2017 Journées des Actinobactéries, Oct 2017, Lyon, France
Communication dans un congrès
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Evolution génomique au sein d'une population naturelle de StreptomycesActino2017 Journées des Actinobactéries, Oct 2017, Lyon, France
Communication dans un congrès
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Generation of a fungal consortium: impact of analytic tools on biodiversity analysisEuropean Aerosol Conference EAC 2017, Aug 2017, Zurich, Switzerland
Communication dans un congrès
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Micro-time scale genome evolution among natural populations of StreptomycesInternational Symposium of the Biology of Actinomycetes, May 2017, Jeju, South Korea
Communication dans un congrès
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One year follow up of microbial biodiversity in French waste sorting plant 9th International Symposium on Modern Principles of Air Monitoring and Biomonitoring (AIRMON 2017), Jun 2017, Dresden, Germany
Communication dans un congrès
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Searching For Specialized Metabolites Gene Clusters By Mining Genomic Islands: A New Comparative Genomics-Based ApproachInternational Symposium on the Biology of Actinomycetes, May 2017, Jeju, South Korea
Communication dans un congrès
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Double strand break repair triggers genome plasticity in StreptomycesProkagenomics 2017 7th European Conference on Prokaryotic and Fungal Genomics, Sep 2017, Göttingen, Germany
Communication dans un congrès
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Double strand break repair triggers genome plasticity in StreptomycesInternational Symposium on the Biology of Actinomycetes, May 2017, Jeju, South Korea
Communication dans un congrès
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Mining genomic islands with Synteruptor, a new strategy for identifying secondary metabolism gene clustersThe 13th International Symposium on the Genetics of Industrial Microorganisms, Oct 2016, Wuhan, China
Communication dans un congrès
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Impact of nutrient availability on the diversity, function and functioning of the forest soil bacterial communities: insights from the soil succession of the forest experimental site of Montiers.Labex ARBRE conference, Oct 2016, Champenoux, France
Communication dans un congrès
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Bioaerosol biodiversity in waste sorting plant: feasibility and uncertainty measurementEuropean Aerosol Conference EAC 2016, Sep 2016, Tours, France
Communication dans un congrès
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Taxonomic and functional diversity of Streptomyces in a forest soilJournées Actinomycètes, 2012, Nancy, France
Communication dans un congrès
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Regulation of Streptococcus thermophilus genomic islandsFEMS 2011, Jun 2011, Geneva, Switzerland
Communication dans un congrès
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Etude de la régulation d'ICESt1 et ICESt3, deux éléments intégratifs conjugatifs de Streptococcus thermophilusGDR 2157 - Evolution des éléments transposables : des génomes aux populations, Dec 2010, Paris, France
Communication dans un congrès
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Etude de la régulation d'ICESt1 et ICESt3, deux éléments intégratifs conjugatifs de Streptococcus thermophilus17éme colloque du Club des Bactéries Lactiques, Oct 2010, Nancy, France
Communication dans un congrès
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Data Mining Using Hidden Markov Models (HMM2) to Detect Heterogeneities into Bacteria GenomesJournées Ouvertes Biologie, Informatique et Mathématiques - JOBIM 2005, JOBIM, Jul 2005, Lyon/France, France
Communication dans un congrès
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SIGffRid : Programme de recherche des sites de fixation des facteurs de transcription par approche comparativeJournées Ouvertes Biologie Informatique Mathématiques - JOBIM'05, Guy Perrière, Alain Guénoche et Christophe Geourjon, Jul 2005, Lyon, France. pp.417-425
Communication dans un congrès
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Fouille de données du génome à l'aide de modèles de Markov cachésExtraction et Gestion de Connaissances - EGC 2005, Jan 2005, Paris/France, France. pp.141 -- 148
Communication dans un congrès
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Classification non supervisée par HMM de sites de fixation de facteurs de transcription chez les bactéries5èmes Journées Ouvertes : Biologie, Informatique et Mathématiques - JOBIM'04, 2004, Montréal, Canada, 1 p
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HMM, an Efficient Way to Detect Transcriptional Promoters in Bacterial Genomes?European Conference on Computational Biology - ECCB'2003, Sep 2003, Paris, France, pp.417--419
Communication dans un congrès
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Identification of Transcription Factor Binding Sites in Streptomyces coelicolor A3(2) by Phylogenetic ComparisonEuropean Conference for Computer Biology - ECCB'2003, 2003, Paris, France
Communication dans un congrès
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Identification of transcription factor binding sites in the genome of Streptomyces coelicolor A3(2)3ème Journées Post-Génomique de la DOUA 2003 - JPGD'03, 2003, Lyon, France
Communication dans un congrès
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Intragenomic reiterations detection using hidden Markov models10th International Conference on Intelligent Systems for Molecular Biology - ISMB 2002, Aug 2002, Edmonton, Canada, 1 p
Communication dans un congrès
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Fouille de données à l'aide de HMM : Application à la détection de réitérations intragénomiquesJournées Ouvertes Biologie Informatique Mathématiques - JOBIM'02, François Coste - Elisabeth Lebret, 2002, Saint Malo, France, pp.269-273
Communication dans un congrès
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Identification d’une nouvelle séquence amplifiable localisée aux extrémités du chromosome de Streptomyces ambofaciens ATCC238774ème colloque des 3R : Réplication, Recombinaison et Réparation, Jul 2001, Gif-sur-Yvette, France
Communication dans un congrès
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Identification of a new amplifiable unit of DNA located in the Terminal Inverted repeats of the chromosomal DNA of Streptomyces ambofaciens ATCC2387712th International Symposium on the Biology of Actinomycetes (ISBA), Aug 2001, Vancouver, Canada
Communication dans un congrès
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Activation of cryptic biosynthetic pathways by bacterial/fungal co-culturesBiomolecules: Research & Development, Markets and Acceptability - LUE Impact Biomolecule seminar, Oct 2019, Palma de Mallorca, Spain
Poster de conférence
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Massive gene flux in bacterial population fuels adaptation to forest soil ecosystem15ème congrès de la Société Française de Microbiologie, Sep 2019, Paris 19ème, France. 2019
Poster de conférence
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Interplay between lateral gene transfer and rhizosphere functioningFunctional ecology conference 2018, Dec 2018, Nancy, France
Poster de conférence
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Deciphering and exploiting bacteria-fungi dialogues to identify new bioactive metabolites12èmes Rencontres de Phytopathologie - Mycologie de la Société Française de Phytopathologie, Jan 2018, Aussois, France
Poster de conférence
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Bacteria/fungi Interactions (BFI): a way to awake secondary metabolite gene clustersLorraine Université d'Excellence (LUE) Séminaire Impact Biomolécules, May 2018, Nancy, France
Poster de conférence
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Searching for novel specialized metabolite gene clusters, a new comparative genomics-based approachDirecting Biosynthesis V, Mar 2017, Warwick, United Kingdom
Poster de conférence
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Dynamics and maintenance of ICEs from Streptococcus thermophilusFEMS 2011, Jun 2011, Geneva, Switzerland
Poster de conférence
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Etude de la régulation du transfert d'éléments intégratifs conjugatifs chez Streptococcus thermophilus16éme colloque du Club des Bactéries Lactiques, May 2009, Toulouse, France
Poster de conférence
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Data Mining Using Hidden Markov Models (HMM2) to Detect Heterogeneities into Bacteria Genomes6. Journées Ouvertes Biologie, Informatique et Mathématiques - JOBIM, Jul 2005, Lyon, France. , 1 p., 2005
Poster de conférence
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Evidence for a High Heterogeneity Between the Terminal Regions of the Chromosomes of Two Phylogenetically Close Species, Streptomyces ambofaciens and Streptomyces coelicolor by Genome ComparisonStreptomyces dissemination meeting, Jul 2003, Guilford, United Kingdom. 2003, Streptomyces dissemination meeting
Poster de conférence
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