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Multiplexed Droplet Digital PCR Assays for the Simultaneous Screening of Major Genetic Alterations in Tumors of the Central Nervous System

Romain Appay , Frederic Fina , Doriane Barets , Catherine Gallardo , Isabelle Nanni-Metellus , et al.
Frontiers in Oncology, 2020, 10, ⟨10.3389/fonc.2020.579762⟩
Article dans une revue hal-03038656v1

Targeting the genetic alterations of the PI3K–AKT–mTOR pathway: Its potential use in the treatment of bladder cancers

Nadine Houédé , Philippe Pourquier
Alimentary Pharmacology & Therapeutics (Suppl), 2015, 145, pp.1-18. ⟨10.1016/j.pharmthera.2014.06.004⟩
Article dans une revue inserm-02438837v1

Genetic polymorphisms of the XPG and XPD nucleotide excision repair genes in sarcoma patients

Valérie Le Morvan , Michel Longy , Catherine C. Bonaiti-Pellie , Binh Bui , Nadine Houédé , et al.
International Journal of Cancer, 2006, 119 (7), pp.1732-1735. ⟨10.1002/ijc.22009⟩
Article dans une revue inserm-02438664v1

Elongation of oligonucleotide primers forming a triple helix on double-stranded DNA templates by purified DNA polymerases

Patrick Lestienne , Philippe Pourquier , Jacques Bonnet
Biochemical and Biophysical Research Communications, 2003, 311 (2), pp.380-385. ⟨10.1016/j.bbrc.2003.10.014⟩
Article dans une revue istex inserm-02438635v1

General overview on DNA repair

Philippe Pourquier , Jacques Robert
Bulletin du Cancer, 2011, 98 (3), pp.229-237. ⟨10.1684/bdc.2011.1323⟩
Article dans une revue inserm-02438820v1
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Early objective response may not be a prognostic factor of survival for patients with metastatic urothelial carcinoma: from a retrospective analysis of a cohort of 113 patients

Guilhem Roubaud , Véronique Brouste , Phillipe Beuzeboc , Aude Fléchon , Diego Tosi , et al.
Journal of Negative Results in BioMedicine, 2015, 14 (1), pp.18. ⟨10.1186/s12952-015-0037-5⟩
Article dans une revue inserm-01264496v1
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Multiplexed-Based Assessment of DNA Damage Response to Chemotherapies Using Cell Imaging Cytometry

Nadia Vezzio-Vié , Marie-Alice Kong-Hap , Eve Combès , Augusto Faria Andrade , Maguy del Rio , et al.
International Journal of Molecular Sciences, 2022, 23 (10), pp.5701. ⟨10.3390/ijms23105701⟩
Article dans une revue hal-04246934v1

Molecular determinants of response to topoisomerase I inhibitors

Philippe Pourquier , Amélie Lansiaux
Bulletin du Cancer, 2011, 98 (11), pp.1287-1298. ⟨10.1684/bdc.2011.1474⟩
Article dans une revue inserm-02438828v1

Mechanism of action of eukaryotic DNA topoisomerase I and drugs targeted to the enzyme

Yves Pommier , Philippe Pourquier , Yi Fan , Dirk Strumberg
BBA - Gene Structure and Expression, 1998, 1400 (1-3), pp.83-106. ⟨10.1016/s0167-4781(98)00129-8⟩
Article dans une revue istex inserm-02438240v1

Polymorphisms in SLCO1B3 and NR1I2 as genetic determinants of hematotoxicity of carboplatin and paclitaxel combination

Litaty Céphanoée Mbatchi , Antonin Schmitt , Fabienne Thomas , Yoann Cazaubon , Jacques Robert , et al.
Pharmacogenomics, 2015, 16 (13), pp.1439 - 1450. ⟨10.2217/pgs.15.84⟩
Article dans une revue hal-01913499v1
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Targeting the genetic alterations of the PI3K-AKT-mTOR pathway: Its potential use in the treatment of bladder cancers.

Nadine Houédé , Philippe Pourquier
Pharmacology and Therapeutics, 2014, epub ahead of print. ⟨10.1016/j.pharmthera.2014.06.004⟩
Article dans une revue inserm-01015885v1
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High Content Screening Using New U2OS Reporter Cell Models Identifies Harmol Hydrochloride as a Selective and Competitive Antagonist of the Androgen Receptor

Hadjer Dellal , Abdelhay Boulahtouf , Elina Alaterre , Alice Cuenant , Marina Grimaldi , et al.
Cells, 2020, 9 (6), pp.1469. ⟨10.3390/cells9061469⟩
Article dans une revue hal-03003926v1
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Redox mechanism of levobupivacaine cytostatic effect on human prostate cancer cells

Caroline Jose , Etienne Hebert-Chatelain , Nivea Dias Amoedo , Emmanuel Roche , Emilie Obre , et al.
Redox Biology, 2018, 18, pp.33-42. ⟨10.1016/j.redox.2018.05.014⟩
Article dans une revue hal-01830852v1
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New Topoisomerase I mutations are associated with resistance to camptothecin.

Céline Gongora , Nadia Vezzio-Vie , Sandie Tuduri , Vincent Denis , Annick Causse , et al.
Molecular Cancer, 2011, 10 (1), pp.64. ⟨10.1186/1476-4598-10-64⟩
Article dans une revue inserm-00602236v1
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Internalization of Foldamer-Based DNA Mimics through a Site-Specific Antibody Conjugate to Target HER2-Positive Cancer Cells

Valentina Corvaglia , Imène Ait Mohamed Amar , Véronique Garambois , Stéphanie Letast , Aurélie Garcin , et al.
Pharmaceuticals, 2021, 14 (7), pp.624. ⟨10.3390/ph14070624⟩
Article dans une revue hal-03456576v1
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Validation of a commercially available indirect ELISA using a nucleocapside recombinant protein for detection of Schmallenberg virus antibodies

Emmanuel Breard , Estelle Lara , Loic Comtet , Cyril Viarouge , Virginie Doceul , et al.
PLoS ONE, 2013, 8 (1), pp.e53446. ⟨10.1371/journal.pone.0053446⟩
Article dans une revue hal-02646280v1

Structural Basis for Topoisomerase I Inhibition by Nucleoside Analogs

William Gmeiner , Shuyuan Yu , Richard Pon , Philippe Pourquier , Yves Pommier
Nucleosides, Nucleotides and Nucleic Acids, 2003, 22 (5-8), pp.653-658. ⟨10.1081/NCN-120022604⟩
Article dans une revue inserm-02438628v1

DNA Protein Cross-Links Produced by NSC 652287, a Novel Thiophene Derivative Active Against Human Renal Cancer Cells

Wilberto Nieves-Neira , Maria Rivera , Glenda Kohlhagen , Miriam Hursey , Philippe Pourquier , et al.
Molecular Pharmacology, 1999, 56 (3), pp.478-484. ⟨10.1124/mol.56.3.478⟩
Article dans une revue inserm-02438279v1
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Ovarian carcinoma patient derived xenografts reproduce their tumor of origin and preserve an oligoclonal structure

Pierre-Emmanuel Colombo , Stanislas Du Manoir , Beatrice Orsetti , Rui Bras-Goncalves , Mario Lambros , et al.
Oncotarget, 2015, 6 (29), pp.28327-28340. ⟨10.18632/oncotarget.5069⟩
Article dans une revue hal-02317488v1
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Doxorubicin-induced lipid peroxidation and glutathione peroxidase activity in tumor cell lines selected for resistance to doxorubicin

M. Nabil Benchekroun , Philippe Pourquier , Brigitte Schott , Jacques Robert
European Journal of Biochemistry, 1993, 211 (1-2), pp.141-146. ⟨10.1111/j.1432-1033.1993.tb19880.x⟩
Article dans une revue inserm-02438185v1

LINE-1 as a therapeutic target for castration-resistant prostate cancer

Nadine Houédé , Pier Vincenzo Piazza , Philippe Pourquier
Frontiers in Bioscience, 2018, 23 (4), pp.1292-1309. ⟨10.2741/4644⟩
Article dans une revue inserm-02438852v1

Effects of modulators of multidrug resistance on the expression of the MDR1 gene in human KB cells in culture

Yan-Ping Hu , Philippe Pourquier , François Doignon , Marc Crouzet , Jacques Robert
Anti-Cancer Drugs, 1996, 7 (7), pp.738-744. ⟨10.1097/00001813-199609000-00004⟩
Article dans une revue inserm-02438213v1

Inhibition of Topoisomerase I Cleavage Activity by Thiol-reactive Compounds

Danièle Montaudon , Komaraiah Palle , Laurent Rivory , Jacques Robert , Celine Douat-Casassus , et al.
Journal of Biological Chemistry, 2007, 282 (19), pp.14403-14412. ⟨10.1074/jbc.M611673200⟩
Article dans une revue inserm-02438667v1
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Induction of Reversible Complexes between Eukaryotic DNA Topoisomerase I and DNA-containing Oxidative Base Damages

Philippe Pourquier , Li-Ming Ueng , Jolanta Fertala , David Wang , Hyun-Ju Park , et al.
Journal of Biological Chemistry, 1999, 274 (13), pp.8516-8523. ⟨10.1074/jbc.274.13.8516⟩
Article dans une revue inserm-02438264v1

Gemcitabine (2',2'-difluoro-2'-deoxycytidine), an antimetabolite that poisons topoisomerase I.

Philippe Pourquier , Christopher Gioffre , Glenda Kohlhagen , Yoshimasa Urasaki , François Goldwasser , et al.
Clinical Cancer Research, 2002, 8 (8), pp.2499-504
Article dans une revue inserm-02438313v1
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Trapping of Mammalian Topoisomerase I and Recombinations Induced by Damaged DNA Containing Nicks or Gaps

Philippe Pourquier , André Pilon , Glenda Kohlhagen , Abhijit Mazumder , Aditi Sharma , et al.
Journal of Biological Chemistry, 1997, 272 (42), pp.26441-26447. ⟨10.1074/jbc.272.42.26441⟩
Article dans une revue inserm-02438225v1

Transcriptional down-regulation of c-myc expression in an erythroleukemic cell line, K562, and its doxorubicin-resistant variant by two topoisomerase II inhibitors, doxorubicin and amsacrine

Audrey Clary , Annick Larrue , Philippe Pourquier , Jacques Robert
Anti-Cancer Drugs, 1998, 9 (3), pp.245-254. ⟨10.1097/00001813-199803000-00007⟩
Article dans une revue inserm-02438227v1

Molecular determinants of response to topoisomerase II inhibitors

Amélie Lansiaux , Philippe Pourquier
Bulletin du Cancer, 2011, 98 (11), pp.1299-1310. ⟨10.1684/bdc.2011.1475⟩
Article dans une revue inserm-02438827v1

From old alkylating agents to new minor groove binders

Stéphane Puyo , Danièle Montaudon , Philippe Pourquier
Critical Reviews in Oncology/Hematology, 2014, 89 (1), pp.43-61. ⟨10.1016/j.critrevonc.2013.07.006⟩
Article dans une revue inserm-02438836v1

Signatures moléculaires dans les cancers de la prostate résistants à la castration : état des lieux

Nadine Houédé , Philippe Pourquier
Bulletin du Cancer, 2022, 109 (9), pp.881-883. ⟨10.1016/j.bulcan.2022.06.007⟩
Article dans une revue hal-04065732v1