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Preliminary Studies on the Activity of Mixed Polyphenol-Heterocyclic Systems Against B16-F10 Melanoma Cancer Cells

 Duc Duy Vo , Isabelle Rouaud , Françoise Lohézic-Le Dévéhat , Fabien Gautier , Sophie Barillé-Nion , et al.
Medicinal Chemistry, 2016
Article dans une revue inserm-01406309v1
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Survivin contributes to DNA repair by homologous recombination in breast cancer cells

 Eloise Véquaud , Grégoire Desplanques , Pascal Jézéquel , Philippe Juin , Sophie Barillé-Nion
Breast Cancer Research and Treatment, 2016, 155, pp.53-63. ⟨10.1007/s10549-015-3657-z⟩
Article dans une revue inserm-01273318v1

The small organic compound HA14-1 sensitizes human glioblastoma cells to induction of cell death through inhibition of Bcl-2.

 F. Manero , F. Gautier , T. Gallenne , N. Cauquil , D. Grée , et al.
Cancer Research, 2006, 66, pp.2757-2764
Article dans une revue hal-00322859v1
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bc-GenExMiner 4.5: new mining module computes breast cancer differential gene expression analyses

 Pascal Jézéquel , Wilfried Gouraud , Fadoua Ben Azzouz , Catherine Guérin-Charbonnel , Philippe Juin , et al.
Database - The journal of Biological Databases and Curation, 2021, 2021, pp.baab007. ⟨10.1093/database/baab007⟩
Article dans une revue inserm-03349355v1

Dysidamide : a cell death inducing drug bypassing Bcl-2 protective activity

 F. Manero , P. Sauleau , P. Juin , F. Vallette , M.L. Bourguet-Kondracki
IVth European Conference on Marine Natural Products, 2005, Paris, France
Communication dans un congrès hal-00013843v1
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TCTP contains a BH3-like domain, which instead of inhibiting, activates Bcl-xL.

 Stéphanie Thébault , Morgane Agez , Xiaoke Chi , Johann Stojko , Vincent Cura , et al.
Scientific Reports, 2015, 6 (1), pp.19725. ⟨10.1038/srep19725⟩
Article dans une revue inserm-01334033v1
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Random forest of perfect trees: concept, performance, applications and perspectives

 Jean-Michel Nguyen , Pascal Jézéquel , Pierre Gillois , Luisa Silva , Faouda Ben Azzouz , et al.
Bioinformatics, 2021, 37 (15), pp.2165-2174. ⟨10.1093/bioinformatics/btab074⟩
Article dans une revue inserm-03546813v1

Corrigendum to “Synthesis of new mixed phenol/heterocyclic derivatives and studies of their activity as inhibitors of Bax/Bcl-xL interaction” [Tetrahedron 70 (2014) 301–311]

 Duc Duy Vo , Fabien Gautier , Sophie Barillé-Nion , Philippe Juin , Nicolas Levoin , et al.
Tetrahedron, 2014, 70 (33), pp.4977. ⟨10.1016/j.tet.2014.05.062⟩
Article dans une revue hal-01153823v1
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A combination of in-silico and SAR studies to identify binding hot spots of Bcl-xL inhibitors

 Nicolas Levoin , Duc Duy Vo , Fabien Gautier , Sophie Barillé-Nion , Philippe Juin , et al.
Bioorganic and Medicinal Chemistry, 2015, 23 (8), pp.1747-1757. ⟨10.1016/j.bmc.2015.02.060⟩
Article dans une revue hal-01133213v1

First Evidence That Oligopyridines, α-Helix Foldamers, Inhibit Mcl-1 and Sensitize Ovarian Carcinoma Cells to Bcl-x L -Targeting Strategies

 Céline Gloaguen , Anne-Sophie Voisin-Chiret , Jana Sopkova-de Oliveira Santos , Jade Fogha , Fabien Gautier , et al.
Journal of Medicinal Chemistry, 2015, 58 (4), pp.1644-1668. ⟨10.1021/jm500672y⟩
Article dans une revue hal-02043913v1
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Targeting of BCL-2 Family Members during Anticancer Treatment: A Necessary Compromise between Individual Cell and Ecosystemic Responses?

 Sophie C Barillé-Nion , Steven Lohard , Philippe Juin
Biomolecules, 2020, 10 (8), pp.1109. ⟨10.3390/biom10081109⟩
Article dans une revue inserm-03319435v1
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Targeting PUMA/Bcl-xL interaction by new specific compounds to unleash apoptotic process in cancer cells

 Appala Venkata Ramana Murthy , Vennu Narendar , Nangunoori Sampath Kumar , Pasula Aparna , Anagani Kanaka Durga Bhavani , et al.
European Journal of Medicinal Chemistry, 2019, 162, pp.334-347. ⟨10.1016/j.ejmech.2018.10.069⟩
Article dans une revue hal-01937242v1

HA 14-1, a small molecule inhibitor of Bcl-2, bypasses chemo-resistance in leukaemia cells.

 L. Oliver , B. Mahé , R. Grée , F.M. Vallette , P. Juin
Leukemia Research, 2007, 31, pp.859-863
Article dans une revue hal-00323090v1

TOM22, a core component of the mitochondria outer membrane protein translocation pore, is a mitochondrial receptor for the proapoptotic protein Bax.

 G. Bellot , P.F. Cartron , E. Er , L. Oliver , P. Juin , et al.
Cell Death and Differentiation, 2007, 14 ((4)), pp.785-94
Article dans une revue hal-00113567v1

Synthesis of new mixed phenol/heterocyclic derivatives and studies of their activity as inhibitors of Bax/Bcl-xL interaction

 Duc Duy Vo , Fabien Gautier , Sophie Barillé-Nion , Philippe Juin , Nicolas Levoin , et al.
Tetrahedron, 2014, 70 (2), pp.301-311. ⟨10.1016/j.tet.2013.11.060⟩
Article dans une revue hal-01114411v1
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E2F1 interacts with BCL‐xL and regulates its subcellular localization dynamics to trigger cell death

 Céline Vuillier , Steven Lohard , Aurélie Fétiveau , Jennifer Allègre , Cémile Kayaci , et al.
EMBO Reports, 2018, 19 (2), pp.234-243. ⟨10.15252/embr.201744046⟩
Article dans une revue inserm-01669957v1
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Mitochondria at Center of Exchanges between Cancer Cells and Cancer-Associated Fibroblasts during Tumor Progression

 Lisa Nocquet , Philippe Juin , Frédérique Souazé
Cancers, 2020, 12 (10), pp.3017. ⟨10.3390/cancers12103017⟩
Article dans une revue inserm-02978374v1
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BCL-XL directly modulates RAS signalling to favour cancer cell stemness.

 Sophie de Carné Trécesson , Frédérique Souazé , Agnes Basseville , Anne-Charlotte Bernard , Jessie Pécot , et al.
Nature Communications, 2017, 8 (1), pp.1123. ⟨10.1038/s41467-017-01079-1⟩
Article dans une revue inserm-01628330v1
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STING-dependent paracriny shapes apoptotic priming of breast tumors in response to anti-mitotic treatment

 Steven Lohard , Nathalie Bourgeois , Laurent A Maillet , Fabien P Gautier , Aurélie Fétiveau , et al.
Nature Communications, 2020, 11 (1), pp.259. ⟨10.1038/s41467-019-13689-y⟩
Article dans une revue inserm-02448103v1

Mitotic stress-induced secretome primes cancer cells to apoptosis and maximizes paclitaxel response in breast tumors when combined with BCL-xL-targeting BH3 mimetics

 Steven Lohard , Philippe Juin , Sophie C Barillé-Nion
Molecular & Cellular Oncology, 2020, 7 (3), pp.1735912. ⟨10.1080/23723556.2020.1735912⟩
Article dans une revue inserm-03319352v1
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Tight Sequestration of BH3 Proteins by BCL-xL at Subcellular Membranes Contributes to Apoptotic Resistance

 Jessie Pécot , Laurent A Maillet , Janic P Le Pen , Céline Vuillier , Sophie de Carné Trécesson , et al.
Cell Reports, 2016, ⟨10.1016/j.celrep.2016.11.064⟩
Article dans une revue inserm-01416194v1

miR-491-5p-induced apoptosis in ovarian carcinoma depends on the direct inhibition of both BCL-XL and EGFR leading to BIM activation

 Christophe Denoyelle , Bernard Lambert , M Meryet-Figuière , N Vigneron , E Brotin , et al.
Cell Death and Disease, 2014, 5 (10), pp.e1445-e1445. ⟨10.1038/cddis.2014.389⟩
Article dans une revue hal-02403183v1
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Decoding and unlocking the BCL‐2 dependency of cancer cells

 Philippe Juin , Olivier Geneste , Fabien Gautier , Stéphane Depil , Mario Campone
Nature Reviews Cancer, 2013, 13 (7), pp.455-465. ⟨10.1038/nrc3538⟩
Article dans une revue inserm-02481124v1

The oncogenic tyrosine kinase Lyn impairs the pro-apoptotic function of Bim.

 Lazaro E Aira , Elodie Villa , Pascal Colosetti , Parvati Gamas , Laurie Signetti , et al.
Oncogene, 2018, 37 (16), pp.2122 - 2136. ⟨10.1038/s41388-017-0112-0⟩
Article dans une revue inserm-01814383v1
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Structure-guided design of pyridoclax derivatives based on Noxa / Mcl-1 interaction mode

 Siham Hedir , Marcella de Giorgi , Jade Fogha , Martina de Pascale , Louis-Bastien Weiswald , et al.
European Journal of Medicinal Chemistry, 2018, 159, pp.357-380. ⟨10.1016/j.ejmech.2018.10.003⟩
Article dans une revue inserm-01980723v1

Synthesis of new selected analogues of the proapoptotic and anticancer molecule HA 14-1.

 D. Grée , S. Vorin , V.L. Manthati , F. Caijo , G. Viault , et al.
Tetrahedron Letters, 2008, 49, pp.3276-3278
Article dans une revue hal-00323433v1

Design, synthesis and biological evaluation of new inhibitors of Bax/Bcl-xL interaction in cancer cells.

 Duc Duy Vo , Fabien Gautier , Sophie Barillé-Nion , Philippe Juin , Nicolas Levoin , et al.
Bioorganic and Medicinal Chemistry Letters, 2014, 24 (7), pp.1758-61. ⟨10.1016/j.bmcl.2014.02.035⟩
Article dans une revue hal-01116303v1

Hemisynthesis of selected embelin analogs and investigation of their proapoptotic activity against cancer cells

 Guillaume Viault , Katragadda Suresh Babu , Fabien Gautier , Sophie Barillé-Nion , Philippe Juin , et al.
Medicinal Chemistry (Shāriqah (United Arab Emirates)), 2013, 9 (8), pp.1028--1034. ⟨10.2174/1573406411309080003⟩
Article dans une revue hal-01147397v1

Mitochondria as the target of the pro-apoptotic protein Bax.

 E. Er , L. Oliver , P.F. Cartron , P. Juin , S. Manon , et al.
BBA - Biochimica et Biophysica Acta, 2006, 1757 (9-10), pp.1301-1311
Article dans une revue hal-00107269v1
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Bcl-xL controls a switch between cell death modes during mitotic arrest

 N Bah , Laurent A Maillet , J. Ryan , S Dubreil , Fabien P Gautier , et al.
Cell Death and Disease, 2014, 5, pp.e1291. ⟨10.1038/cddis.2014.251⟩
Article dans une revue inserm-02446956v1
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