Researcher identifiers

Number of documents


Dr. Philippe Lesot (Director of research / Senior scientist)

CNRS Director of research (INC, S-12)
(Research PI) "NMR methodologies and anisotropic deuterium NMR applications"

ORCID ID: 0000-0002-5811-7530
Researcher ID: M-3390-2017
Publons ID: Philippe Lesot

RMN en Milieu Orienté, ICMMO, UMR-CNRS 8182, Bât. 410
Université de Paris-Sud / Paris-Saclay 91405 Orsay cedex, Fra


Tél  : ++ 33 (0)1 69 15 47 59 / 70 17 // Fax. : ++ 33 (0)1 69 15 81 05



Dr. Philippe Lesot, born in October 1967, has been Research Director since 2007 at Institut de Chimie Moléculaire et des Materiaux d’Orsay (ICMMO) (France) located at Orsay (University of Paris-Sud/Paris-Saclay).  He is affiliated to the french National Center for Scientific Research (CNRS since 1997.  

He received his Ph.D degree (cum laudae) at University of Paris-Sud (Orsay) in 1995 (supervisor: Prof. J. Courtieu), and then pursued his NMR research activities at University of Southampton (UK) with Prof. J.W. Emsley, awarded by both a grant from the Royal Society of London and the French Foreign Ministry (Lavoisier).  

After holding a temporary assistant professor position at Orsay for one year, he joined the CNRS in 1997.  He was a recipient of the 2001 Bronze Medal from CNRS for young scientists for his pioneering work on the Natural abundance 2D-NMR spectroscopy in chiral liquid crystals.

He has published over 110 publications in international, peer-review journals, 10 bbok chapters inclused two encyclopedian and given approx. 55 invited talks on the analytical and methodological developments in anisotropic NMR in collaboration with numerous (bio)chemists.  His current research interests focus on the natural isotope fractionation of bioproducts by anisotropic NAD NMR and the fight against counterfeiting.



* Scientific board of the INC (CNRS)(2019-2024)  

* Member of S-12 du CoNRS (2008-2016)

* Board of the Academic Council of the COMUE Paris-Saclay (2015-2019)



* Associated Editors of Magnetic Resonance (MR)

* Academic Editors of Concept in Magnetic Resonance A


* Member of editorial borad of "Spectra Analyse" PCI presse, (2014-2018)


* Board of the "Société Française des IsotopeS" (SFIS)

* Member of  the India National Magnetic Resonance Society (NMRS) 


* Expert for the French MESRI (BAP B) 

* Expert for the «DFG» (Deutsche ForschungsGemeinschaft /Allemagne)
* Expert for the «Volskwagen Freigeist fellowships» (
* Expert «European Science Fundation »  (

* Expert «HCERES / AERES»
* Expert «ANR»
* Expert «Agences régionales»   

Chairman and expert of selection committees (ITRF, ITA, Assistant reader,  


- DR2 at CNRS (2007-2019)
- CR1 at CNRS (1997 -2007)
- CR2 at CNRS (1997 -2000)
- Assistant lecturer (Univ Paris-Sud) (1996 -1997)
- Post-Doctoral researcher (University of Southamptopn, UK) (1995-1996)
- Thesis (1992-1995)


* Bronze medal of CNRS (2001)
* Royal Society of London fellowship (1995-1996)
* Lavoisier Grant (1995-1996)


* Scientific book chapters : 9
* Other book chapters : 2
* Communications : 19
* Full articles : 80
* Review/feature articles : 9
* Miscellaneous : 12

* Invited talks:  : 33
* Seminars : 22
* Oral communications : 67
* Posters : 56


* "Thematic GBP NMR network" conference, France, Paris (2020)
* "GBP NMR network" Workshop, France, Orsay (2020)
* "7th Congress of SFIS, France (2019)
* "1st JFPSA", Marocco, Marrakesh, (2017)
* "Thematic GBP NMR network" conference ,France, Paris (2014)
* "GBP NMR network" Workshop, France, Orsay (2014)



"Olivier Lafon"   

Journal articles23 documents

  • Philippe Lesot, Christie Aroulanda, Philippe Berdagué, Abdelkrim Meddour, Denis Merlet, et al.. Multinuclear NMR in Polypeptide Liquid Crystals: Three Fertile Decades of Methodological Developments and Analytical Challenges. Progress in Nuclear Magnetic Resonance Spectroscopy, Elsevier, 2019, ⟨10.1016/j.pnmrs.2019.10.001⟩. ⟨hal-02351278⟩
  • Philippe Lesot, Krzysztof Kazimierczuk, Julien Trébosc, Jean-Paul Amoureux, Olivier Lafon. Fast acquisition of multidimensional NMR spectra of solids and mesophases using alternative sampling methods. Magnetic Resonance in Chemistry, Wiley, 2015, 53 (11), pp.927-939. ⟨10.1002/mrc.4290⟩. ⟨hal-02314353⟩
  • Krzysztof Kazimierczuk, Olivier Lafon, Philippe Lesot. Criteria for sensitivity enhancement by compressed sensing: practical application to anisotropic NAD 2D-NMR spectroscopy. Analyst, Royal Society of Chemistry, 2014, 139 (11), pp.2702. ⟨10.1039/c4an00381k⟩. ⟨hal-02314349⟩
  • Philippe Lesot, Olivier Lafon, Philippe Berdagué. Correlation 2D-NMR experiments involving both $^{13}$C and $^{2}$H isotopes in oriented media: methodological developments and analytical applications. Magnetic Resonance in Chemistry, Wiley, 2014, 52 (10), pp.595-613. ⟨10.1002/mrc.4118⟩. ⟨hal-02314351⟩
  • Philippe Lesot, Olivier Lafon. Experimental Detection of Achiral and Chiral Naturally Abundant 13 C– 2 H Isotopomers by 2D-NMR in Liquids and Chiral Oriented Solvents. Analytical Chemistry, American Chemical Society, 2012, 84 (10), pp.4569-4573. ⟨10.1021/ac300667n⟩. ⟨hal-02311506⟩
  • Philippe Lesot, Olivier Lafon. Détection d’Isotopomères 2H-13C en Abondance Naturelle par RMN 2D Isotrope et Anisotrope, ou Comment Distinguer Expérimentalement une Molécule parmi 600 000?. Spectra Analyse, Paris : PCI, 2012, 287, pp.24-30. ⟨hal-02317494⟩
  • Jacques Courtieu, Nicolas Giraud, Olivier Lafon, Philippe Lesot, Jean-Marc Nuzillard, et al.. La RMN en chimie organique. L'Actualité Chimique, Société chimique de France, 2012, pp.30-41. ⟨hal-02317465⟩
  • Olivier Lafon, Bingwen Hu, Jean-Paul Amoureux, Philippe Lesot. Fast and High-Resolution Stereochemical Analysis by Nonuniform Sampling and Covariance Processing of Anisotropic Natural Abundance 2D 2H NMR Datasets. Chemistry - A European Journal, Wiley-VCH Verlag, 2011, 17 (24), pp.6716-6724. ⟨10.1002/chem.201100461⟩. ⟨hal-02311041⟩
  • Christie Aroulanda, Olivier Lafon, Philippe Lesot. Enantiodiscrimination of Flexible Cyclic Solutes Using NMR Spectroscopy in Polypeptide Chiral Mesophases: Investigation of cis -Decalin and THF. Journal of Physical Chemistry B, American Chemical Society, 2009, 113 (31), pp.10628-10640. ⟨10.1021/jp902233m⟩. ⟨hal-02310982⟩
  • Philippe Lesot, Olivier Lafon, Herbert Zimmermann, Zeev Luz. Enantiodiscrimination in Deuterium NMR Spectra of Flexible Chiral Molecules with Average Axial Symmetry Dissolved in Chiral Liquid Crystals: The Case of Tridioxyethylenetriphenylene. Journal of the American Chemical Society, American Chemical Society, 2008, 130 (27), pp.8754-8761. ⟨10.1021/ja800957a⟩. ⟨hal-02310973⟩
  • Philippe Lesot, Olivier Lafon. Enantiomeric analysis using natural abundance deuterium 3D NMR spectroscopy in polypeptide chiral oriented media. Chemical Physics Letters, Elsevier, 2008, 458 (1-3), pp.219-222. ⟨10.1016/j.cplett.2008.04.065⟩. ⟨hal-02310970⟩
  • Chun-An Fan, Benoit Ferber, Henri Kagan, Olivier Lafon, Philippe Lesot. Two aspects of the desymmetrization of selected prochiral aromatic or vinylic dihalides: enantioselective halogen–lithium exchange and prochiral recognition in chiral liquid crystals. Tetrahedron: Asymmetry, Elsevier, 2008, 19 (23), pp.2666-2677. ⟨10.1016/j.tetasy.2008.12.003⟩. ⟨hal-02310976⟩
  • Philippe Lesot, Olivier Lafon, Christie Aroulanda, Ronald Dong. 2H NMR Studies on Two-Homopolypeptide Lyotropic Enantiodiscriminating Mesophases: Experimental Quantification of Solute-Fiber Affinities. Chemistry - A European Journal, Wiley-VCH Verlag, 2008, 14 (13), pp.4082-4092. ⟨10.1002/chem.200701543⟩. ⟨hal-00298353⟩
  • Karim Ben Ali, Olivier Lafon, Herbert Zimmermann, Eric Guittet, Philippe Lesot. Homo- and heteronuclear 2D NMR approaches to analyse a mixture of deuterated unlike/like stereoisomers using weakly ordering chiral liquid crystals. Journal of Magnetic Resonance, Elsevier, 2007, 187 (2), pp.205-215. ⟨10.1016/j.jmr.2007.04.007⟩. ⟨hal-02310947⟩
  • Olivier Lafon, Philippe Lesot, Chun-An Fan, Henri b. Kagan. Analysis of Intramolecular Dynamic Processes in Enantiomeric Diaryl Atropisomers and Related Derivatives by 2H NMR Spectroscopy in Polypeptide Liquid Crystals. Chemistry - A European Journal, Wiley-VCH Verlag, 2007, 13 (13), pp.3772-3786. ⟨10.1002/chem.200601284⟩. ⟨hal-02310936⟩
  • Olivier Lafon, Philippe Lesot, Herbert Zimmermann, Raphy Poupko, Zeev Luz. Chiral Discrimination in the 13 C and 2 H NMR of the Crown and Saddle Isomers of Nonamethoxy-Cyclotriveratrylene in Chiral Liquid-Crystalline Solutions. Journal of Physical Chemistry B, American Chemical Society, 2007, 111 (32), pp.9453-9467. ⟨10.1021/jp070564q⟩. ⟨hal-02310954⟩
  • Philippe Lesot, Olivier Lafon, Henri Kagan, Chun-An Fan. Study of molecular rotational isomerism using deuterium NMR in chiral oriented solvents. Chemical Communications, Royal Society of Chemistry, 2006, pp.389-391. ⟨10.1039/b514694a⟩. ⟨hal-02310907⟩
  • Olivier Lafon, Philippe Lesot. Theoretical and experimental investigation of 13C relayed 2H–2H-COSY 2D experiments: Application to the analysis of weakly aligned solutes. Journal of Magnetic Resonance, Elsevier, 2005, 174 (2), pp.254-264. ⟨10.1016/j.jmr.2005.02.011⟩. ⟨hal-02310894⟩
  • Olivier Lafon, Philippe Lesot. Deuterium 3D NMR experiments for analysing weakly aligned, isotopically enriched solutes. Chemical Physics Letters, Elsevier, 2005, 404 (1-3), pp.90-94. ⟨10.1016/j.cplett.2005.01.040⟩. ⟨hal-02310889⟩
  • Olivier Lafon, Philippe Lesot, Françoise Rose-Munch, Eric Rose. Enantiomeric Analysis of Planar Chiral (η 6 -Arene)chromium Tricarbonyl Complexes using NMR in Oriented Solvents. Organometallics, American Chemical Society, 2005, 24 (16), pp.4021-4028. ⟨10.1021/om050239u⟩. ⟨hal-02310905⟩
  • Olivier Lafon, Denis Merlet, Jacques Courtieu, Philippe Lesot. Modified z-gradient filtering as a mean to obtain phased deuterium autocorrelation 2D NMR spectra in oriented solvents. Journal of Magnetic Resonance, Elsevier, 2004, 171 (1), pp.135-142. ⟨10.1016/j.jmr.2004.08.010⟩. ⟨hal-02310847⟩
  • Olivier Lafon, Philippe Berdagué, Philippe Lesot. Use of two-dimensional correlation between 2H quadrupolar splittings and 13 C CSA's for assignment of NMR spectra in chiral nematics. Physical Chemistry Chemical Physics, Royal Society of Chemistry, 2004, 6 (6), pp.1080-1084. ⟨10.1039/b316488h⟩. ⟨hal-02310797⟩
  • Philippe Lesot, Olivier Lafon, Jacques Courtieu, Philippe Berdagué. Analysis of the13C NMR Spectra of Molecules, Chiral by Isotopic Substitution, Dissolved in a Chiral Oriented Environment: Towards the Absolute Assignment of the pro-R/pro-S Character of Enantiotopic Ligands in Prochiral Molecules. Chemistry - A European Journal, Wiley-VCH Verlag, 2004, 10 (15), pp.3741-3746. ⟨10.1002/chem.200400065⟩. ⟨hal-02310803⟩

Conference papers1 document

  • Lucie Vandromme, Li Chen, Lai Wei, Franck Le Bideau, André Loupy, et al.. Chiral imines on the wave: reactivity of tert-butyl acrylate and stereoselectivity determination using NMR in liquid crystals. MOL2NET, International Conference on Multidisciplinary Sciences, 2015, SCIForum, France. pp.1-18, ⟨10.3390/MOL2NET-1-a003⟩. ⟨hal-02314359⟩

Book sections1 document