Keywords

Researcher identifiers

Number of documents

29

Dr. Philippe Lesot (Director of research / Senior scientist)


CNRS Director of research (INC, S-12)
(Research PI) "NMR methodologies and anisotropic deuterium NMR applications"

ORCID ID: 0000-0002-5811-7530
Researcher ID: M-3390-2017
Publons ID: Philippe Lesot

RMN en Milieu Orienté, ICMMO, UMR-CNRS 8182, Bât. 410
Université de Paris-Sud / Paris-Saclay 91405 Orsay cedex, Fra
nce

CONTACT & WEBSITES :

Tél  : ++ 33 (0)1 69 15 47 59 / 70 17 // Fax. : ++ 33 (0)1 69 15 81 05
E-mail: philippe.lesot@u-psud.fr

https://www.icmmo.u-psud.fr/fr/perso/philippe-lesot/
https://www.researchgate.net/profile/Philippe_Lesot
https://twitter.com/LesotPhilippe

 

SHORT CV :

Dr. Philippe Lesot, born in October 1967, has been Research Director since 2007 at Institut de Chimie Moléculaire et des Materiaux d’Orsay (ICMMO) (France) located at Orsay (University of Paris-Sud/Paris-Saclay).  He is affiliated to the french National Center for Scientific Research (CNRS since 1997.  

He received his Ph.D degree (cum laudae) at University of Paris-Sud (Orsay) in 1995 (supervisor: Prof. J. Courtieu), and then pursued his NMR research activities at University of Southampton (UK) with Prof. J.W. Emsley, awarded by both a grant from the Royal Society of London and the French Foreign Ministry (Lavoisier).  

After holding a temporary assistant professor position at Orsay for one year, he joined the CNRS in 1997.  He was a recipient of the 2001 Bronze Medal from CNRS for young scientists for his pioneering work on the Natural abundance 2D-NMR spectroscopy in chiral liquid crystals.

He has published over 110 publications in international, peer-review journals, 10 bbok chapters inclused two encyclopedian and given approx. 55 invited talks on the analytical and methodological developments in anisotropic NMR in collaboration with numerous (bio)chemists.  His current research interests focus on the natural isotope fractionation of bioproducts by anisotropic NAD NMR and the fight against counterfeiting.

 

SCIENTIFIC MANAGEMENT ACTIVITY :

* Scientific board of the INC (CNRS)(2019-2024)

http://www.cnrs.fr/comitenational/csi/csi_acc.htm  

* Member of S-12 du CoNRS (2008-2016)

* Board of the Academic Council of the COMUE Paris-Saclay (2015-2019)

 

SCIENTIFIC EDITORIAL ACTIVITY :

* Associated Editors of Magnetic Resonance (MR)

https://www.magnetic-resonance-ampere.net/editorial_board.html

* Academic Editors of Concept in Magnetic Resonance A

* https://www.hindawi.com/journals/cmra/editors/

* Member of editorial borad of "Spectra Analyse" PCI presse, (2014-2018)

 

* Board of the "Société Française des IsotopeS" (SFIS)

https://www.sfis.eu

* Member of  the India National Magnetic Resonance Society (NMRS)  

http://nmrs.iisc.ernet.in 

EXPERTISE COMMITMENT :

* Expert for the French MESRI (BAP B) 

* Expert for the «DFG» (Deutsche ForschungsGemeinschaft /Allemagne)
* Expert for the «Volskwagen Freigeist fellowships» (http://www.volkswagenstiftung.de)
* Expert «European Science Fundation »  (http://www..esf.org)

* Expert «HCERES / AERES»
* Expert «ANR»
* Expert «Agences régionales»   

Chairman and expert of selection committees (ITRF, ITA, Assistant reader,  

PREVIOUSLY :

- DR2 at CNRS (2007-2019)
- CR1 at CNRS (1997 -2007)
- CR2 at CNRS (1997 -2000)
- Assistant lecturer (Univ Paris-Sud) (1996 -1997)
- Post-Doctoral researcher (University of Southamptopn, UK) (1995-1996)
- Thesis (1992-1995)

DISTINCTION :

* Bronze medal of CNRS (2001)
* Royal Society of London fellowship (1995-1996)
* Lavoisier Grant (1995-1996)

SCIENTIFIC PRODUCTION : 

* Scientific book chapters : 9
* Other book chapters : 2
* Communications : 19
* Full articles : 80
* Review/feature articles : 9
* Miscellaneous : 12

* Invited talks:  : 33
* Seminars : 22
* Oral communications : 67
* Posters : 56


CONFERENCE ORGANISATION :

* "Thematic GBP NMR network" conference, France, Paris (2020)
* "GBP NMR network" Workshop, France, Orsay (2020)
* "7th Congress of SFIS, France (2019)
* "1st JFPSA", Marocco, Marrakesh, (2017)
* "Thematic GBP NMR network" conference ,France, Paris (2014)
* "GBP NMR network" Workshop, France, Orsay (2014)

 

 


"Jacques Courtieu"   

Journal articles28 documents

  • Robert Berger, Jacques Courtieu, Roberto Gil, Christian Griesinger, Matthias Köck, et al.. Is Enantiomer Assignment Possible by NMR Spectroscopy Using Residual Dipolar Couplings from Chiral Nonracemic Alignment Media?-A Critical Assessment. Angewandte Chemie International Edition, Wiley-VCH Verlag, 2012, 51 (33), pp.8388-8391. ⟨10.1002/anie.201107626⟩. ⟨hal-02311507⟩
  • Jacques Courtieu, Nicolas Giraud, Olivier Lafon, Philippe Lesot, Jean-Marc Nuzillard, et al.. La RMN en chimie organique. L'Actualité Chimique, Société chimique de France, 2012, pp.30-41. ⟨hal-02317465⟩
  • Philippe Lesot, Jacques Courtieu. Natural abundance deuterium NMR spectroscopy: Developments and analytical applications in liquids, liquid crystals and solid phases. Progress in Nuclear Magnetic Resonance Spectroscopy, Elsevier, 2009, 55 (2), pp.128-159. ⟨10.1016/j.pnmrs.2009.01.001⟩. ⟨hal-02310981⟩
  • Latifa Ziani, Philippe Lesot, Abdelkhrim Meddour, Jacques Courtieu. Empirical determination of the absolute configuration of small chiral molecules using natural abundance 2H NMR in chiral liquid crystals. Chemical Communications, Royal Society of Chemistry, 2007, pp.4737. ⟨10.1039/b711493a⟩. ⟨hal-02310959⟩
  • Olivier Lafon, Denis Merlet, Jacques Courtieu, Philippe Lesot. Modified z-gradient filtering as a mean to obtain phased deuterium autocorrelation 2D NMR spectra in oriented solvents. Journal of Magnetic Resonance, Elsevier, 2004, 171 (1), pp.135-142. ⟨10.1016/j.jmr.2004.08.010⟩. ⟨hal-02310847⟩
  • Philippe Lesot, Olivier Lafon, Jacques Courtieu, Philippe Berdagué. Analysis of the13C NMR Spectra of Molecules, Chiral by Isotopic Substitution, Dissolved in a Chiral Oriented Environment: Towards the Absolute Assignment of the pro-R/pro-S Character of Enantiotopic Ligands in Prochiral Molecules. Chemistry - A European Journal, Wiley-VCH Verlag, 2004, 10 (15), pp.3741-3746. ⟨10.1002/chem.200400065⟩. ⟨hal-02310803⟩
  • James W. Emsley, Philippe Lesot, Jacques Courtieu, Denis Merlet. The effect of a chiral nematic solvent on the orientational order and conformational distribution of a flexible prochiral solute. Physical Chemistry Chemical Physics, Royal Society of Chemistry, 2004, 6 (23), pp.5331. ⟨10.1039/b411203b⟩. ⟨hal-02310857⟩
  • Christie Aroulanda, Denis Merlet, Jacques Courtieu, Philippe Lesot. Structural Ambiguities Revisited in Two Bridged Ring Systems Exhibiting Enantiotopic Elements, Using Natural Abundance Deuterium NMR in Chiral Liquid Crystals. Journal of Physical Chemistry A, American Chemical Society, 2003, 107 (50), pp.10911-10918. ⟨10.1021/jp030137m⟩. ⟨hal-02310640⟩
  • Jonathan Farjon, Denis Merlet, Philippe Lesot, Jacques Courtieu. Enantiomeric excess measurements in weakly oriented chiral liquid crystal solvents through 2D 1H selective refocusing experiments. Journal of Magnetic Resonance, Elsevier, 2002, 158 (1-2), pp.169-172. ⟨10.1016/S1090-7807(02)00070-8⟩. ⟨hal-02310612⟩
  • Philippe Lesot, Denis Merlet, Muriel Sarfati, Jacques Courtieu, Herbert Zimmermann, et al.. Enantiomeric and Enantiotopic Analysis of Cone-Shaped Compounds with C 3 and C 3 v Symmetry Using NMR Spectroscopy in Chiral Anisotropic Solvents. Journal of the American Chemical Society, American Chemical Society, 2002, 124 (34), pp.10071-10082. ⟨10.1021/ja020269d⟩. ⟨hal-02310599⟩
  • Christie Aroulanda, Denis Merlet, Jacques Courtieu, Philippe Lesot. NMR Experimental Evidence of the Differentiation of Enantiotopic Directions in Cs and C2v Molecules Using Partially Oriented, Chiral Media. Journal of the American Chemical Society, American Chemical Society, 2001, 123 (48), pp.12059-12066. ⟨10.1021/ja011685l⟩. ⟨hal-02309135⟩
  • Philippe Lesot, Muriel Sarfati, Denis Merlet, Jacques Courtieu, Bernard Ancian, et al.. Determining Enantiomeric Purity by NMR: Deuterium 2D NMR at Natural Abundance in Weakly Oriented Chiral Liquid Crystals. Bruker Report, 2001, 149, pp.29-33. ⟨hal-02321012⟩
  • Muriel Sarfati, Jacques Courtieu, Philippe Lesot. First successful enantiomeric discrimination of chiral alkanes using NMR spectroscopy. Chemical Communications, Royal Society of Chemistry, 2001, pp.1113-1114. ⟨10.1039/b002806l⟩. ⟨hal-02309085⟩
  • Muriel Sarfati, Christie Aroulanda, Jacques Courtieu, Philippe Lesot. Enantiomeric recognition of chiral invertomers through NMR in chiral oriented phases: a study of cis-decalin. Tetrahedron: Asymmetry, Elsevier, 2001, 12 (5), pp.737-744. ⟨10.1016/S0957-4166(01)00103-3⟩. ⟨hal-02338088⟩
  • Muriel Sarfati, Christie Aroulanda, Jacques Courtieu, Philippe Lesot. Enantiomeric recognition of chiral invertomers through NMR in chiral oriented phases: a study of cis-decalin. Tetrahedron: Asymmetry, Elsevier, 2001, 12 (5), pp.737-744. ⟨10.1016/S0957-4166(01)00103-3⟩. ⟨hal-02309129⟩
  • Muriel Sarfati, Philippe Lesot, Denis Merlet, Jacques Courtieu. Theoretical and experimental aspects of enantiomeric differentiation using natural abundance multinuclear nmr spectroscopy in chiral polypeptide liquid crystals. Chemical Communications, Royal Society of Chemistry, 2000, pp.2069-2081. ⟨10.1039/B006244H⟩. ⟨hal-02309126⟩
  • Valérie Madiot, Philippe Lesot, Danielle Gree, Jacques Courtieu, René Grée. Highly enantioselective propargylic monofluorination established by carbon-13 and fluorine-19 NMR in chiral liquid crystals. Chemical Communications, Royal Society of Chemistry, 2000, pp.169-170. ⟨10.1039/A909012F⟩. ⟨hal-02309109⟩
  • Denis Merlet, Muriel Sarfati, Bernard Ancian, Jacques Courtieu, Philippe Lesot. Description of natural abundance deuterium 2D-NMR experiments in weakly ordered liquid-crystalline solvents using a tailored cartesian spin-operator formalism. Physical Chemistry Chemical Physics, Royal Society of Chemistry, 2000, 2 (10), pp.2283-2290. ⟨10.1039/b000834f⟩. ⟨hal-02309116⟩
  • Cécile Canlet, Denis Merlet, Philippe Lesot, Abdelkrim Meddour, Jacques Courtieu. Deuterium NMR stereochemical analysis of threo–erythro isomers bearing remote stereogenic centres in racemic and non-racemic liquid crystalline solvents. Tetrahedron: Asymmetry, Elsevier, 2000, 11 (9), pp.1911-1918. ⟨10.1016/S0957-4166(00)00125-7⟩. ⟨hal-02309123⟩
  • Denis Merlet, Bernard Ancian, Jacques Courtieu, Philippe Lesot. Two-Dimensional Deuterium NMR Spectroscopy of Chiral Molecules Oriented in a Polypeptide Liquid Crystal: Applications for the Enantiomeric Analysis through Natural Abundance Deuterium NMR. Journal of the American Chemical Society, American Chemical Society, 1999, 121 (22), pp.5249-5258. ⟨10.1021/ja9837699⟩. ⟨hal-02309106⟩
  • Denis Merlet, James Emsley, Philippe Lesot, Jacques Courtieu. The relationship between molecular symmetry and second-rank orientational order parameters for molecules in chiral liquid crystalline solvents. Journal of Chemical Physics, American Institute of Physics, 1999, 111 (15), pp.6890-6896. ⟨10.1063/1.479982⟩. ⟨hal-02309108⟩
  • Olivier Dirat, Cyrille Kouklovsky, Yves Langlois, Philippe Lesot, Jacques Courtieu. Double diastereoselection in asymmetric [2+3] cycloaddition of chiral oxazoline N-oxides: application to the kinetic resolution of a racemic α,β-unsaturated δ-lactone. Tetrahedron: Asymmetry, Elsevier, 1999, 10 (16), pp.3197-3207. ⟨10.1016/S0957-4166(99)00317-1⟩. ⟨hal-02309107⟩
  • Denis Merlet, Bernard Ancian, William Smadja, Jacques Courtieu, Philippe Lesot. Analysis of natural abundance deuterium NMR spectra of enantiomers in chiral liquid crystals via 2D auto-correlation experiments. Chemical Communications, Royal Society of Chemistry, 1998, pp.2301-2302. ⟨10.1039/A805020A⟩. ⟨hal-02309103⟩
  • Philippe Lesot, Denis Merlet, Aharon Loewenstein, Jacques Courtieu. Enantiomeric visualization using proton-decoupled natural abundance deuterium NMR in poly(γ-benzyl-l-glutamate) liquid crystalline solutions. Tetrahedron: Asymmetry, Elsevier, 1998, 9 (11), pp.1871-1881. ⟨10.1016/S0957-4166(98)00179-7⟩. ⟨hal-02309102⟩
  • Philippe Lesot, Denis Merlet, Jacques Courtieu, James Emsley, Tapio Rantala, et al.. Calculation of the Molecular Ordering Parameters of (±)-3-Butyn-2-ol Dissolved in an Organic Solution of Poly(γ-benzyl- l -glutamate). Journal of Physical Chemistry A, American Chemical Society, 1997, 101 (31), pp.5719-5724. ⟨10.1021/jp9709262⟩. ⟨hal-02309087⟩
  • Philippe Lesot, Denis Merlet, Jacques Courtieu, J. Emsley. Discrimination and analysis of the NMR spectra of enantiomers dissolved in chiral liquid crystal solvents through 2D correlation experiments. Liquid Crystals, Taylor & Francis, 1996, 21 (3), pp.427-435. ⟨10.1080/02678299608032851⟩. ⟨hal-02308703⟩
  • Philippe Lesot, Yves Gounelle, Denis Merlet, Aharon Loewenstein, Jacques Courtieu. Measurement and Analysis of the Molecular Ordering Tensors of Two Enantiomers Oriented in a Polypeptide Liquid Crystalline System. The Journal of physical chemistry, American Chemical Society (ACS), 1995, 99 (40), pp.14871-14875. ⟨10.1021/j100040a042⟩. ⟨hal-02309083⟩
  • Philippe Lesot, Denis Merlet, Abdelkrim Meddour, Jacques Courtieu, Aharon Loewenstein. Visualization of enantiomers in a polypeptide liquid-crystal solvent through carbon-13 NMR spectroscopy. Journal of the Chemical Society, Faraday Transactions, Royal Society of Chemistry, 1995, 91 (9), pp.1371. ⟨10.1039/ft9959101371⟩. ⟨hal-02309082⟩

Book sections1 document

  • Jacques Courtieu, Philippe Lesot, Denis Merlet, Abdelkrim Meddour, Christie Aroulanda. Chiral Liquid Crystal NMR: a Tool for Enantiomeric Analysis. Eds. D.M. Grant & R.K. Harris, J. Wiley & Sons. Encyclopedia of NMR: Advances in NMR", 1st print edition, 9, pp.497-505, 2002. ⟨hal-02321152⟩