Philippe Lesnik

Documents

Affiliations actuelles

542105
93591
250071
2910
81447

Identifiants chercheurs

philippe-lesnik
0000-0002-6909-7715
IdRef : 131219391
Google Scholar : _a_-HkMAAAAJ
ResearcherId : F-7803-2011

Publications

	Profound systemic alteration of the immune phenotype and an immunoglobulin switch in Erdheim–Chester disease in a single-center of 78 patients Fleur Cohen Aubart , Lucie Poupel , Flora Saint-Charles , Frederic Charlotte , Youssef Arsafi Haematologica, 2022, 107 (6), pp.1347-1357. ⟨10.3324/haematol.2021.279118⟩ Article dans une revue hal-03388029v2
	Tolerogenic Dendritic Cells Shape a Transmissible Gut Microbiota that Protects from Metabolic Diseases Emelyne Lécuyer , Tiphaine Le Roy , Aurélie Gestin , Amélie Lacombe , Catherine Philippe Diabetes, 2021, 70 (9), p. 2067-2080. ⟨10.2337/db20-1177⟩ Article dans une revue hal-03252103v1
	Phospholipid transfer to high-density lipoprotein (HDL) upon triglyceride lipolysis is directly correlated with HDL-cholesterol levels and is not associated with cardiovascular risk Feng Ma , Maryam Darabi , Marie Lhomme , Emilie Tubeuf , Aurélie Canicio Atherosclerosis, 2021, 324, pp.1-8. ⟨10.1016/j.atherosclerosis.2021.03.002⟩ Article dans une revue hal-03280868v1
	Ex-Vivo Pharmacological Defatting of the Liver: A Review Claire Goumard , Célia Turco , Mehdi Sakka , Lynda Aoudjehane , Philippe Lesnik Journal of Clinical Medicine, 2021, 10 (6), pp.1253. ⟨10.3390/jcm10061253⟩ Article dans une revue hal-03177239v1
	Gut Microbiome and Space Travelers’ Health: State of the Art and Possible Pro/Prebiotic Strategies for Long-Term Space Missions Silvia Turroni , Marciane Magnani , Pukar Kc , Philippe Lesnik , Hubert Vidal Frontiers in Physiology, 2020, 11, pp.553929. ⟨10.3389/fphys.2020.553929⟩ Article dans une revue hal-03105593v1
	Targeted invalidation of SR-B1 in macrophages reduces macrophage apoptosis and accelerates atherosclerosis Lauriane Galle-Treger , Martine Moreau , Raphaëlle Ballaire , Lucie Poupel , Thomas Huby Cardiovascular Research, 2020, 116 (3), pp.554-565. ⟨10.1093/cvr/cvz138⟩ Article dans une revue hal-02967904v1
	Novel defatting strategies reduce lipid accumulation in primary human culture models of liver steatosis Lynda Aoudjehane , Jérémie Gautheron , Wilfried Le Goff , Claire Goumard , Julia Gilaizeau Disease Models & Mechanisms, 2020, 13 (4), pp.dmm042663. ⟨10.1242/dmm.042663⟩ Article dans une revue hal-02735664v1
	Distinct Postprandial Bile Acids Responses to a High-Calorie Diet in Men Volunteers Underscore Metabolically Healthy and Unhealthy Phenotypes Antonin Lamazière , Dominique Rainteau , K.C. Pukar , Lydie Humbert , Emilie Gauliard Nutrients, 2020, Diet and Post-prandial Metabolism, 12 (11), pp.3545. ⟨10.3390/nu12113545⟩ Article dans une revue hal-03028253v1
	Unraveling Host-Gut Microbiota Dialogue and Its Impact on Cholesterol Levels Remy Villette , Pukar Kc , Sophie Beliard , Maria Fernanda Salas Tapia , Dominique Rainteau Frontiers in Pharmacology, 2020, 11, pp.278. ⟨10.3389/fphar.2020.00278⟩ Article dans une revue hal-02569834v1
	Interleukin-1β and Risk of Premature Death in Patients With Myocardial Infarction Johanne Silvain , Mathieu Kerneis , Michel Zeitouni , Benoit Lattuca , Sophie Galier Journal of the American College of Cardiology, 2020, 76 (15), pp.1763-1773. ⟨10.1016/j.jacc.2020.08.026⟩ Article dans une revue hal-02964413v1
	Mucosal-associated invariant T cells promote inflammation and intestinal dysbiosis leading to metabolic dysfunction during obesity Amine Toubal , Badr Kiaf , Lucie Beaudoin , Lucie Cagninacci , Moez Rhimi Nature Communications, 2020, 11 (1), pp.3755. ⟨10.1038/s41467-020-17307-0⟩ Article dans une revue inserm-02948958v1
	Mucosal-associated invariant T cells promote inflammation and intestinal dysbiosis leading to metabolic dysfunction during obesity Amine Toubal , Badr Kiaf , Lucie Beaudoin , Lucie Cagninacci , Moez Rhimi Nature Communications, 2020, 11 (1), pp.3755. ⟨10.1038/s41467-020-17307-0⟩ Article dans une revue hal-04395377v1
	Free cholesterol transfer to high-density lipoprotein (HDL) upon triglyceride lipolysis underlies the U-shape relationship between HDL-cholesterol and cardiovascular disease Ma Feng , Maryam Darabi , Emilie Tubeuf , Aurélie Canicio , Marie Lhomme European Journal of Preventive Cardiology, In press, pp.204748731989411. ⟨10.1177/2047487319894114⟩ Article dans une revue hal-02433564v1
	Exploring the Bacterial Impact on Cholesterol Cycle: A Numerical Study Mélanie Bourgin , Simon Labarthe , Aicha Kriaa , Marie Lhomme , Philippe Gérard Frontiers in Microbiology, 2020, 11, pp.1121. ⟨10.3389/fmicb.2020.01121⟩ Article dans une revue hal-02863236v1
	Antiatherogenic properties of high-density lipoproteins from arterial plasma are attenuated as compared to their counterparts of venous origin Dominique Bonnefont-Rousselot , Leila Benouda , Randa Bittar , Maryam Darabi-Amin , Pierre Demondion Nutrition, Metabolism and Cardiovascular Diseases, 2020, 30 (1), pp.33-39. ⟨10.1016/j.numecd.2019.07.022⟩ Article dans une revue hal-02965526v1
	Impaired Kupffer Cell Self-Renewal Alters the Liver Response to Lipid Overload during Non-alcoholic Steatohepatitis Sophie Tran , Ines Baba , Lucie Poupel , Sébastien Dussaud , Martine Moreau Immunity, 2020, 53 (3), pp.627-640.e5. ⟨10.1016/j.immuni.2020.06.003⟩ Article dans une revue hal-02967896v1
	Inclusion of endophenotypes in a standard GWAS facilitate a detailed mechanistic understanding of genetic elements that control blood lipid levels. Qianqian Zhang , Zexi Cai , Marie Lhomme , Goutam Sahana , Philippe Lesnik Scientific Reports, 2020, 10 (1), pp.18434. ⟨10.1038/s41598-020-75612-6⟩ Article dans une revue hal-03023064v1
	The intestinal microbiota regulates host cholesterol homeostasis Tiphaine Le Roy , Emelyne Lécuyer , Benoit Chassaing , Moez Rhimi , Marie Lhomme BMC Biology, 2019, 17 (1), pp.94. ⟨10.1186/s12915-019-0715-8⟩ Article dans une revue hal-04395140v1
	The intestinal microbiota regulates host cholesterol homeostasis Tiphaine Le Roy , Emelyne Lécuyer , Benoit Chassaing , Moez Rhimi , Marie Lhomme BMC Biology, 2019, 17 (1), pp.94. ⟨10.1186/s12915-019-0715-8⟩ Article dans une revue hal-02404677v1
	Association of Serum Cholesterol Efflux~Capacity With Mortality in Patients~With ST-Segment~Elevation Myocardial Infarction Gilles Montalescot , Maryse Guerin , Johanne Silvain , Julie Gall , Maryam Darabi Journal of the American College of Cardiology, 2018, 72 (25), pp.3259--3269. ⟨10.1016/j.jacc.2018.09.080⟩ Article dans une revue hal-02359955v1
	Small dense HDLs display potent vasorelaxing activity, reflecting their elevated content of sphingosine-1-phosphate Laurence Persègol , Maryam Darabi , Carolane Dauteuille , Marie Lhomme , Sandrine Chantepie Journal of Lipid Research, 2018, 59 (1), pp.25 - 34. ⟨10.1194/jlr.M076927⟩ Article dans une revue hal-01707695v1
	Modulation of Gr1low monocyte subset impacts insulin sensitivity and weight gain upon high-fat diet in female mice Sophie Béliard , L Le Goff , F Saint-Charles , P Poupel , V Deswaerte International Journal of Obesity, 2017, ⟨10.1038/ijo.2017.179⟩ Article dans une revue hal-01580410v1
	Extended-Release Niacin/Laropiprant Improves Overall Efficacy of Postprandial Reverse Cholesterol Transport Petra El Khoury , Elisa Waldmann , Thierry Huby , Julie Gall , Philippe Couvert Arteriosclerosis, Thrombosis, and Vascular Biology, 2016, 36 (2), pp.285-294. ⟨10.1161/ATVBAHA.115.306834⟩ Article dans une revue hal-03624977v1
	Association of Cholesterol Efflux Capacity With Clinical Features of Metabolic Syndrome: Relevance to Atherosclerosis Julie Gall , Eric Frisdal , Randa Bittar , Wilfried Le Goff , Eric Bruckert Journal of the American Heart Association, 2016, 5 (12), ⟨10.1161/JAHA.116.004808⟩ Article dans une revue hal-01406011v1
	αVβ3 integrin-targeted microSPECT/CT imaging of inflamed atherosclerotic plaques in mice David Vancraeynest , Véronique Roelants , Caroline Bouzin , François-Xavier Hanin , Stephan Walrand EJNMMI Research, 2016, 6, pp.29. ⟨10.1186/s13550-016-0184-9⟩ Article dans une revue hal-01298089v1
	Promoting macrophage survival delays progression of pre-existing atherosclerotic lesions through macrophage-derived apoE Laura Bouchareychas , John Pirault , Flora Saint-Charles , Virginie Deswaerte , Tiphaine Le Roy Cardiovascular Research, 2015, 108 (1), pp.111-123. ⟨10.1093/cvr/cvv177⟩ Article dans une revue hal-03624947v1
	Adipocyte ATP-Binding Cassette G1 Promotes Triglyceride Storage, Fat Mass Growth, and Human Obesity E. Frisdal , Soazig Le Lay , Henri Hooton , Lucie Poupel , Maryline Olivier Diabetes, 2015, ⟨10.2337/db14-0245⟩ Article dans une revue hal-02545916v1
	The spectrum of neutrophilic dermatoses associated with monoclonal gammopathy: Association with IgA isotype and inflammatory profile Raphael Szalat , Gentiane Monsel , Wilfried Le Goff , Maxime Battistella , Djaouida Bengouffa Journal of The American Academy of Dermatology, 2015, 73 (5), pp.809-820. ⟨10.1016/j.jaad.2015.07.031⟩ Article dans une revue hal-03624957v1
	Recent patents on hypocholesterolemic therapeutic strategies: an update Aline Potiron , Philippe Gerard , Tiphaine Le Roy , Philippe Lesnik , Emmanuelle Maguin Recent Advances in DNA and Gene Sequences, 2015, 9 (1), pp.36-44. ⟨10.2174/2352092210666151216143459⟩ Article dans une revue hal-01536579v1
	Circulating phospholipid profiling identifies portal contribution to NASH signature in obesity Kavya Anjani , Marie Lhomme , Nataliya Sokolovska , Christine Poitou , Judith Aron-Wisnewsky Journal of Hepatology, 2014, 62 (4), pp.905-912. ⟨10.1016/j.jhep.2014.11.002⟩ Article dans une revue hal-01090208v1
	Cholesteryl Ester Transfer Protein Expression Partially Attenuates the Adverse Effects of SR-BI Receptor Deficiency on Cholesterol Metabolism and Atherosclerosis Majda El Bouhassani , Sophie Gilibert , Martine Moreau , Flora Saint-Charles , Morgan Tréguier Journal of Biological Chemistry, 2011, 286 (19), pp.17227-17238. ⟨10.1074/jbc.M111.220483⟩ Article dans une revue hal-03624849v1
	Triglyceride-rich lipoproteins and high-density lipoprotein cholesterol in patients at high risk of cardiovascular disease: evidence and guidance for management M. John Chapman , Henry N Ginsberg , Pierre Amarenco , Felicita Andreotti , Jan Borén European Heart Journal, 2011, 32 (11), pp.1345 - 1361. ⟨10.1093/eurheartj/ehr112⟩ Article dans une revue hal-03330019v1
	Interleukin-6 Protects Human Macrophages from Cellular Cholesterol Accumulation and Attenuates the Proinflammatory Response Eric Frisdal , Philippe Lesnik , Maryline Olivier , Paul Robillard , M. John Chapman Journal of Biological Chemistry, 2011, 286 (35), pp.30926-30936. ⟨10.1074/jbc.M111.264325⟩ Article dans une revue hal-03624859v1
	Atheroprotective Reverse Cholesterol Transport Pathway Is Defective in Familial Hypercholesterolemia Natacha Bellanger , Alexina Orsoni , Zélie Julia , Natalie Fournier , Eric Frisdal Arteriosclerosis, Thrombosis, and Vascular Biology, 2011, 31 (7), pp.1675-1681. ⟨10.1161/ATVBAHA.111.227181⟩ Article dans une revue hal-03624854v1
	Lipoprotein(a) as a cardiovascular risk factor: current status. Børge G. Nordestgaard , M John Chapman , Kausik Ray , Jan Borén , Felicita Andreotti European Heart Journal, 2010, 31 (23), pp.2844-53. ⟨10.1093/eurheartj/ehq386⟩ Article dans une revue inserm-00578888v1

	Genetic testign of familial hypercholesterolemia : monogenic form and polygenic contribution to cardiovascular risk Philippe Couvert , Philippe Giral , Pierre-Yves Boëlle , Valérie Carreau , Sophie Béliard 85. Congress of the European-Atherosclerosis-Society (EAS), Apr 2017, Prague, Czech Republic. Elsevier Ireland Ltd, Atherosclerosis, 263, pp.1, 2017 Poster de conférence hal-02735087v1
	Distinct proteomic and lipidomic composition and atheroprotective functionof human plasma pre-b high-density lipoprotein (HDL) Isabelle Guillas , Marie Lhomme , Marie Delbos , Emilie Tubeuf , Lucrèce Matheron 12ième congrès de la Société Francophone d’Athérosclérose NSFA, Jun 2016, Biarritz, France Poster de conférence inserm-04048146v1

	Purification and multi-omics characterization of human pre-beta-HDL reveals specific proteomic and lipidomic signature relevant to biological activities Isabelle Guillas , Marie Lhomme , Lucrèce Mathéron , Sandrine Lebreton , Maharajah Ponnaiah european lipoprotein club, EAS, Sep 2018, Tutzing, Germany Communication dans un congrès inserm-04046669v1

Philippe Lesnik

Publications

Profound systemic alteration of the immune phenotype and an immunoglobulin switch in Erdheim–Chester disease in a single-center of 78 patients

Tolerogenic Dendritic Cells Shape a Transmissible Gut Microbiota that Protects from Metabolic Diseases

Phospholipid transfer to high-density lipoprotein (HDL) upon triglyceride lipolysis is directly correlated with HDL-cholesterol levels and is not associated with cardiovascular risk

Ex-Vivo Pharmacological Defatting of the Liver: A Review

Gut Microbiome and Space Travelers’ Health: State of the Art and Possible Pro/Prebiotic Strategies for Long-Term Space Missions

Targeted invalidation of SR-B1 in macrophages reduces macrophage apoptosis and accelerates atherosclerosis

Novel defatting strategies reduce lipid accumulation in primary human culture models of liver steatosis

Distinct Postprandial Bile Acids Responses to a High-Calorie Diet in Men Volunteers Underscore Metabolically Healthy and Unhealthy Phenotypes

Unraveling Host-Gut Microbiota Dialogue and Its Impact on Cholesterol Levels

Interleukin-1β and Risk of Premature Death in Patients With Myocardial Infarction

Mucosal-associated invariant T cells promote inflammation and intestinal dysbiosis leading to metabolic dysfunction during obesity

Mucosal-associated invariant T cells promote inflammation and intestinal dysbiosis leading to metabolic dysfunction during obesity

Free cholesterol transfer to high-density lipoprotein (HDL) upon triglyceride lipolysis underlies the U-shape relationship between HDL-cholesterol and cardiovascular disease

Exploring the Bacterial Impact on Cholesterol Cycle: A Numerical Study

Antiatherogenic properties of high-density lipoproteins from arterial plasma are attenuated as compared to their counterparts of venous origin

Impaired Kupffer Cell Self-Renewal Alters the Liver Response to Lipid Overload during Non-alcoholic Steatohepatitis

Inclusion of endophenotypes in a standard GWAS facilitate a detailed mechanistic understanding of genetic elements that control blood lipid levels.

The intestinal microbiota regulates host cholesterol homeostasis

The intestinal microbiota regulates host cholesterol homeostasis

Association of Serum Cholesterol Efflux~Capacity With Mortality in Patients~With ST-Segment~Elevation Myocardial Infarction

Small dense HDLs display potent vasorelaxing activity, reflecting their elevated content of sphingosine-1-phosphate

Modulation of Gr1low monocyte subset impacts insulin sensitivity and weight gain upon high-fat diet in female mice

Extended-Release Niacin/Laropiprant Improves Overall Efficacy of Postprandial Reverse Cholesterol Transport

Association of Cholesterol Efflux Capacity With Clinical Features of Metabolic Syndrome: Relevance to Atherosclerosis

αVβ3 integrin-targeted microSPECT/CT imaging of inflamed atherosclerotic plaques in mice

Promoting macrophage survival delays progression of pre-existing atherosclerotic lesions through macrophage-derived apoE

Adipocyte ATP-Binding Cassette G1 Promotes Triglyceride Storage, Fat Mass Growth, and Human Obesity

The spectrum of neutrophilic dermatoses associated with monoclonal gammopathy: Association with IgA isotype and inflammatory profile

Recent patents on hypocholesterolemic therapeutic strategies: an update

Circulating phospholipid profiling identifies portal contribution to NASH signature in obesity

Cholesteryl Ester Transfer Protein Expression Partially Attenuates the Adverse Effects of SR-BI Receptor Deficiency on Cholesterol Metabolism and Atherosclerosis

Triglyceride-rich lipoproteins and high-density lipoprotein cholesterol in patients at high risk of cardiovascular disease: evidence and guidance for management

Interleukin-6 Protects Human Macrophages from Cellular Cholesterol Accumulation and Attenuates the Proinflammatory Response

Atheroprotective Reverse Cholesterol Transport Pathway Is Defective in Familial Hypercholesterolemia

Lipoprotein(a) as a cardiovascular risk factor: current status.

Genetic testign of familial hypercholesterolemia : monogenic form and polygenic contribution to cardiovascular risk

Distinct proteomic and lipidomic composition and atheroprotective function of human plasma pre-b high-density lipoprotein (HDL)

Purification and multi-omics characterization of human pre-beta-HDL reveals specific proteomic and lipidomic signature relevant to biological activities

Distinct proteomic and lipidomic composition and atheroprotective functionof human plasma pre-b high-density lipoprotein (HDL)