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Researcher identifiers

Keywords

Chiral HPLC Ethynylglycine synthon Antibiotic Unsaturated amino acid Thiophene derivatives Amino acids Antibacterial Biological activity Bestmann-Ohira Tillandsia xiphioides Synthesis Apparent 3H/3He age Chemical ecology Absolute configuration Betti reaction Allamanda cathartica Bacterial histidine kinase HK 1 2 3-triazole Antibacterial agents Absolute configuration determination
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Number of documents

63

CV-Patrick-Meffre

 

Patrick Meffre was born in Marseille, France, in 1964. After engineering studies at the Ecole Nationale Supérieure de Chimie de Paris (ENSCP, Chimie ParisTech, a member of Université Paris-Sciences et Lettres, PSL, France) he receives his Ph.D. at the Pierre and Marie Curie University (Paris) in 1991. After post-doctoral training with Prof S. Hanessian (Montreal University, Québec, Canada) he was appointed Assistant Professor at the Ecole Nationale Supérieure de Chimie de Paris in 1993. Since 2004 he moved to university of Nîmes (France) where he was appointed as Professor.

His current interests concern :

-The extractions and identification of natural products from plants and their biological activity

-The synthesis of chiral or non-chiral biologically active compounds, of unusual amino acids, chiral synthons derived from natural amino acids and their biological activity.

-The use of epiphytic plants (Tillandsia) as natural source of biologically active compounds or as biomonitors of air pollution

Patrick Meffre is Consulting Editor, Amino Acids journal (Springer)
https://www.springer.com/journal/726

Journal articles32 documents

  • Mame-Marietou Lo, Zohra Benfodda, David Bénimélis, Jean-Xavier Fontaine, Roland Molinié, et al.. Development of a HS-SPME/GC-MS Method for the Extraction and Identification of the Volatile Compounds Emitted by Flowers of Tillandsia xiphioides. ACS Omega, ACS Publications, 2021, 6 (19), pp.12691-12698. ⟨10.1021/acsomega.1c00917⟩. ⟨hal-03243914⟩
  • Mame-Marietou Lo, Zohra Benfodda, David Bénimélis, Jean-Xavier Fontaine, Roland Molinié, et al.. Extraction and Identification of Volatile Organic Compounds Emitted by Fragrant Flowers of Three Tillandsia Species by HS-SPME/GC-MS. Metabolites, MDPI, 2021, 11 (9), pp.594. ⟨10.3390/metabo11090594⟩. ⟨hal-03334373⟩
  • Valentin Duvauchelle, Elsa Causse, Julien Michon, Patrick Rateau, Karine Weiss, et al.. Evaluation of Knowledge and Risk Perception about Antibiotic Resistance in Biology and Mathematics Young Students in Nîmes University in France. International Journal of Environmental Research and Public Health, MDPI, 2021, 18 (18), pp.9692. ⟨10.3390/ijerph18189692⟩. ⟨hal-03344418⟩
  • Valentin Duvauchelle, Chaimae Majdi, David Bénimélis, Catherine Dunyach-Remy, Patrick Meffre, et al.. Synthesis, Structure Elucidation, Antibacterial Activities, and Synergistic Effects of Novel Juglone and Naphthazarin Derivatives Against Clinical Methicillin-Resistant Staphylococcus aureus Strains. Frontiers in Chemistry, Frontiers Media, 2021, 9, ⟨10.3389/fchem.2021.773981⟩. ⟨hal-03446358⟩
  • Miyanou Rosales-Hurtado, Patrick Meffre, Hendrik Szurmant, Zohra Benfodda. Synthesis of histidine kinase inhibitors and their biological properties. Medicinal Research Reviews, Wiley, 2019, ⟨10.1002/med.21651⟩. ⟨hal-02400521⟩
  • Miyanou Rosales-Hurtado, Alexandre Lebeau, Cyril Bourouh, Gerardo Cebrian-Torrejon, Muriel Albalat, et al.. Improved synthesis, resolution, absolute configuration determination and biological evaluation of HLM006474 enantiomers. Bioorganic and Medicinal Chemistry Letters, Elsevier, 2019, 29, pp.380-382. ⟨10.1016/j.bmcl.2018.12.037⟩. ⟨hal-01968387⟩
  • Zohra Benfodda, David Bénimélis, Gianna Reginato, Patrick Meffre. Ethynylglycine synthon, a useful precursor for the synthesis of biologically active compounds: an update. Part II: synthetic uses of ethynylglycine synthon. Amino Acids, Springer Verlag, 2018, 50 (10), pp.1307-1328. ⟨10.1007/s00726-018-2628-1⟩. ⟨hal-01859944⟩
  • Lara Sassine, Corinne Le Gal La Salle, Mahmoud Khaska, Patrick Verdoux, Patrick Meffre, et al.. Spatial distribution of triazine residues in a shallow alluvial aquifer linked to groundwater residence time. Environmental Science and Pollution Research, Springer Verlag, 2017, 24 (8), pp.6878-6888. ⟨10.1007/s11356-016-7224-x⟩. ⟨hal-01544262⟩
  • Alexandre Lebeau, Cyril Abrioux, David Bénimèlis, Zohra Benfodda, Patrick Meffre. Synthesis of 1,4-disubstituted 1,2,3-triazole Derivatives Using Click Chemistry and their Src Kinase Activities. Medicinal Chemistry, Bentham Science Publishers, 2017, Medicinal Chemistry, 13, pp.40-48. ⟨10.2174/1573406412666160404125718⟩. ⟨hal-01495029⟩
  • Thibaut Boibessot, David Bénimélis, Patrick Meffre, Zohra Benfodda. Advances in the synthesis of α‑quaternary α‑ethynyl α‑amino acids. Amino Acids, Springer Verlag, 2016, 48 (9), pp.2081-2101. ⟨10.1007/s00726-016-2276-2⟩. ⟨hal-01540958⟩
  • Thibaut Boibessot, Christopher Zschiedrich, Alexandre Lebeau, David Bénimélis, Catherine Dunyach-Remy, et al.. The Rational Design, Synthesis, and Antimicrobial Properties of Thiophene Derivatives That Inhibit Bacterial Histidine Kinases. Journal of Medicinal Chemistry, American Chemical Society, 2016, pp.8830-8847. ⟨10.1021/acs.jmedchem.6b00580⟩. ⟨hal-01543599⟩
  • Thibaut Boibessot, David Bénimélis, Marion Jean, Zohra Benfodda, Patrick Meffre. Synthesis of a Novel Rhizobitoxine-Like Triazole-Containing Amino Acid. SYNLETT, Georg Thieme Verlag, 2016, 27 (19), pp.2685-2688. ⟨10.1055/s-0036-1588300⟩. ⟨hal-01404310⟩
  • Zohra Benfodda, David Bénimélis, Gianna Reginato, Patrick Meffre. Ethynylglycine synthon, a useful precursor for the synthesis of biologically active compounds: an update: Part I: preparations of ethynylglycine synthon. Amino Acids, Springer Verlag, 2015, 47 (2), pp.271-279. ⟨10.1007/s00726-014-1902-0⟩. ⟨hal-01676812⟩
  • Z Benfodda, David Bénimèlis, Marion Jean, Jean-Valère Naubron, Valerie Rolland, et al.. Synthesis, resolution, and determination of absolute configuration of protected α-ethynylphenylalanine enantiomers. Amino Acids, Springer Verlag, 2015, 47 (5), pp.899-907. ⟨10.1007/s00726-015-1917-1⟩. ⟨hal-02002634⟩
  • Zohra Benfodda, David Bénimélis, Marion Jean, Jean-Valère Naubron, Valérie Rolland, et al.. Synthesis, resolution, and determination of absolute configuration of protected α- [alpha]-ethynylphenylalanine enantiomers. Amino Acids, Springer Verlag, 2015, ⟨10.10007/s00726-015-1917-1⟩. ⟨hal-01274000⟩
  • Stéphanie Ortial, Rajesh Dave, Zohra Benfodda, David Bénimélis, Patrick Meffre. Synthesis of cis-5-Trifluoromethylproline from L-Glutamic Acid. SYNLETT, Georg Thieme Verlag, 2013, 2014 (25), pp.0569-0573. ⟨10.1055/s-0033-1340553⟩. ⟨hal-00969187⟩
  • Amer Moussa, Patrick Meffre, Valérie Rolland, Jean Martinez. Chemoenzymatic routes to enantiomerically pure 2-azatyrosine and 2-, 3- and 4-pyridylalanine derivatives. Amino Acids, Springer Verlag, 2012, 42, pp.1339-1348. ⟨10.1007/s00726-010-0829-3⟩. ⟨hal-00616942⟩
  • Gianna Reginato, Alessandro Mordini, Patrick Meffre, Alice Tenti, Michela Valacchi, et al.. New unsaturated amino acids containing an allylsilane moiety on the lateral chain. Tetrahedron: Asymmetry, Elsevier, 2006, 17 (6), pp.922-926. ⟨10.1016/j.tetasy.2006.02.017⟩. ⟨hal-02002619⟩
  • Patrick Meffre, Patrick Mcffrc, Philippe Durand. NEW ROUTES TO a-AMINO ACID b,g-THIOENOL ETHER DERIVATIVES. Synthetic Communications, Taylor & Francis: STM, Behavioural Science and Public Health Titles, 2006, 32 (2), pp.287-296. ⟨hal-02002695⟩
  • Patrick Meffre, Sébastien Hermann, Philippe Durand, Gianna Reginato, Antonella Riu. Practical one-step synthesis of ethynylglycine synthon from Garner's aldehyde. Tetrahedron, Elsevier, 2002, 58 (25), pp.5159-5162. ⟨10.1016/S0040-4020(02)00438-6⟩. ⟨hal-02002686⟩
  • Patrick Meffre, Sébastien Hermann, Philippe Durand, Gianna Reginato, Antonella Riu. Practical one-step synthesis of ethynylglycine synthon from Garner's aldehyde. Tetrahedron, Elsevier, 2002, 58 (25), pp.5159-5162. ⟨10.1016/S0040-4020(02)00438-6⟩. ⟨hal-02010614⟩
  • Patrick Meffre, Rajesh Dave, Jacques Leroy, Bernard Badet. A concise synthesis of l-4,4-difluoroglutamine. Tetrahedron Letters, Elsevier, 2001, 42 (49), pp.8625-8627. ⟨hal-02002782⟩
  • Lars Veum, Hélène Brouard, Patrick Meffre, Marc Larchevêque, Didier Buisson*, et al.. Chemoenzymatic synthesis of enantiopure 1,1′-disubstituted ferrocenyl aminoalcohols. Tetrahedron: Asymmetry, Elsevier, 2000, 11 (20), pp.4055-4059. ⟨hal-02002779⟩
  • Patrick Meffre, Philippe Durand, François Le Goffic. METHYL (S)-2-PHTHALIMIDO-4-OXOBUTANOATE. Organic Syntheses : An annual publication of satisfactory methods for the preparation of organic chemicals, J. Wiley & Sons, 1999, 76, pp.123. ⟨hal-02002772⟩
  • Patrick Meffre. Syntheses of optically active 2-amino-4-oxobutyric acid and N,O-protected derivatives. Amino Acids, Springer Verlag, 1999, 16 (3-4), pp.251-272. ⟨hal-02002777⟩
  • Eric Branquet, Patrick Meffre, Philippe Durand, François Le Goffic. Synthesis of New Chiral Vinyl Halides from L-Serinal. Synthetic Communications, Taylor & Francis: STM, Behavioural Science and Public Health Titles, 1998, 28 (4), pp.613-622. ⟨hal-02002767⟩
  • Patrick Meffre, Laurence Gauzy, Eric Branquet, Philippe Durand, François Le Goffic. Synthesis of optically active β,γ-alkynylglycine derivatives. Tetrahedron, Elsevier, 1996, 52 (34), pp.11215-11238. ⟨hal-02002738⟩
  • Patrick Meffre, Laurence Gauzy, Chantal Perdigues, Florence Desanges-Levecque, Eric Branquet, et al.. En route to optically active ethynylglycine derivatives. Tetrahedron Letters, Elsevier, 1995, 36 (6), pp.877-880. ⟨hal-02010594⟩
  • Patrick Meffre, Philippe Durand, François Le Goffic. Straightforward Synthesis of Optically Pure Methyl (S)-2-Phthalimido-4-oxobutanoate and Some of Its Acetal and Thioacetal Derivatives. SYNTHESIS, Georg Thieme Verlag, 1995, 1995 (09), pp.1111-1114. ⟨hal-02002741⟩
  • Patrick Meffre, Philippe Durand, Eric Branquet, Fran°cois Le Goffic. A Straightforward Synthesis of N-Boc-L-serinal and N-Boc-L-threoninal Acetonides. Synthetic Communications, Taylor & Francis: STM, Behavioural Science and Public Health Titles, 1994, 24 (15), pp.2147-2152. ⟨hal-02002737⟩
  • Stephen Hanessian, Patrick Meffre, Mario Girard, Serge Beaudoin, Jean Yves Sanceau, et al.. Asymmetric dihydroxylation of olefins with a simple chiral ligand. Journal of Organic Chemistry, American Chemical Society, 1993, 58 (8), pp.1991-1993. ⟨hal-02002729⟩
  • Patrick Meffre, Liliane Vo-Quang, Yen Vo-Quang, François Le Goffic. N-(Benzyloxycarbonyl)-L-vinylglycike Methyl Ester from L-Methionine Methyl Ester Hydrochloride. Synthetic Communications, Taylor & Francis: STM, Behavioural Science and Public Health Titles, 1989, 19 (20), pp.3457-3468. ⟨hal-02002719⟩

Conference papers16 documents

  • Zohra Benfodda, Miyanou Rosales-Hurtado, Thibaut Boibessot, Christopher Zschiedrich, Alexandre Lebeau, et al.. Rational design, synthesis and antimicrobial properties of thiophene derivatives that inhibit bacterial histidine kinases. 2nd international conference Antimicrobial and antibacterial Istanbul Turkey, Nov 2019, Istanbul, Turkey. ⟨hal-02400581⟩
  • Zohra Benfodda, Thibaut Boibessot, Christopher Zschiedrich, Alexandre Lebeau, David Bénimèlis, et al.. Rational design, synthesis and antimicrobial properties of thiophene derivatives that inhibit bacterial histidine kinases. 24th ISCB international conference-Frontier research in chemistry&biology interface, Jan 2018, JAIPUR, India. ⟨hal-01998540⟩
  • Patrick Meffre, Zohra Benfodda, David Bénimèlis, Stéphanie Ortial, Valerie Rolland, et al.. Addendum to Abstracts presented at the 14th International Congress on Amino Acids, Peptides and Proteins. 14th International Congress on Amino Acids, Peptides and Proteins, Aug 2015, Vienna, Austria. pp.615-636. ⟨hal-02002708⟩
  • Stéphanie Ortial, Rajesh Dave, Zohra Benfodda, David Bénimèlis, Patrick Meffre. Synthesis of 5-trifluoromethylproline from L-glutamic acid. 14th International Congress on Amino Acids, Peptides and Proteins, Aug 2015, Wien, Austria. pp.615-636, ⟨10.1007/s00726-015-2160-5⟩. ⟨hal-02010135⟩
  • Patrick Meffre, Stéphanie Ortial, David Bénimèlis, Valerie Rolland, Zohra Benfodda. Synthesis of acetylenic analogue of phenylalanine. 13th International Congress on Amino acids, peptides and proteins, Oct 2013, Galveston, United States. pp.563-612, ⟨10.1007/s00726-013-1540-y⟩. ⟨hal-02010130⟩
  • Zohra Benfodda, Stéphanie Ortial, David Bénimélis, Valerie Rolland, Patrick Meffre. Synthesis of acetylenic analogue of phenylalanine.. 13th International Congress on Amino acids, peptides and proteins, Oct 2013, Galvestion (Texas), United States. pp.611, ⟨10.1007/s00726-013-1540-y⟩. ⟨hal-00993416⟩
  • Patrick Meffre, Zohra Benfodda, David Bénimélis, Valérie Rolland, Francine Acher. New developments in the synthesis of acetylenic analogues of glutamate. 12 th International Congress on Amino Acids, Peptides and Proteins, Aug 2011, Beijing, China. pp.S79. ⟨hal-00621161⟩
  • Patrick Meffre, Zohra Benfodda, David Bénimèlis, Valerie Rolland, Francine C. Acher. New developements in the synthesis of acetylenic analogues of glutamate. 12th International Congress on Amino Acids, Peptides and Proteins, Aug 2011, Beijing, China. pp.1-86, ⟨10.1007/s00726-011-0955-6⟩. ⟨hal-02010128⟩
  • Patrick Meffre, Zohra Benfodda, David Bénimèlis, Guillaume Vierling, Francine C. Acher. Synthesis of acetylenic analogues of glutamate. 10th International Congress on Amino Acids and Proteins (ICAAP), Aug 2007, Kalithea, Chalkidiki, Greece. pp.I-LXX, ⟨10.1007/s00726-007-0578-0⟩. ⟨hal-02010124⟩
  • Zohra Benfodda, David Bénimèlis, Patrick Meffre, Francine Acher. Synthesis of acetylenic analogues of glutamate. 10th International Congress on amino acids and proteins, Aug 2007, Kallithea, Greece. ⟨hal-01998510⟩
  • Patrick Meffre, Rajesh Dave, Bernard Badet. New developments in the synthesis of fluorinated analogues of glutamic acid and glutamine. 8th International Congress on Aminoacids, Sep 2003, Roma, Italy. pp.111-204, ⟨10.1007/s00726-003-0037-5⟩. ⟨hal-02010117⟩
  • Patrick Meffre, Rajesh Dave, Bernard Badet. Synthesis and biological evaluation of optically active fluorinated analogues of glutamine. 7th International Congress on Amino Acids and Proteins, Aug 2001, Wien, Austria. pp.1-90, ⟨10.1007/s007260170030⟩. ⟨hal-02010112⟩
  • Patrick Meffre, Jacques Leroy, Bernard Badet. Synthesis of optically active fluorinated analogues of glutamic acid and glutamine with potential biological activity. 6th International Congress on Amino Acids, Aug 1999, Bonn, Germany. pp.1-129, ⟨10.1007/BF01362415⟩. ⟨hal-02010105⟩
  • Patrick Meffre. Synthesis and uses of aspartaldehyde derivatives. 5th International Congress on Aminoacids, Aug 1997, Kalithea, Chalkidiki, Greece. pp.25-89, ⟨10.1007/BF01373046⟩. ⟨hal-02010098⟩
  • Patrick Meffre. New developments in the synthesis of optically active ethynylglycine derivatives. 4th International Congress on Aminoacids, Aug 1995, Wien, Austria. ⟨10.1007/BF00811751⟩. ⟨hal-02010089⟩
  • Patrick Meffre, François Le Goffic. Different aspects of synthetic approaches including enzymatic enantioselective synthesis of aminoacids. 3rd International Congress on Aminoacids, Aug 1993, Wien, Austria. ⟨10.1007/BF00806197⟩. ⟨hal-02010087⟩

Poster communications12 documents

  • Valentin Duvauchelle, Miyanou Rosales-Hurtado, Thibaut Boibessot, David Bénimèlis, Catherine Dunyach-Remy, et al.. Synthesis and biological evaluations of new families of histidine kinases inhibitors. GSO-JMJC-JED2019, Oct 2019, Montpellier, France. ⟨hal-02333120⟩
  • Linda Matignon, Mame Marietou Lo, Antonio Doménech-Carbó, Muriel Sylvestre, Patrick Meffre, et al.. Trophic interactions between Pseudosphinx tetrio larvae and Allamanda cathartica. Caribbean Science and Innovation Meeting 2019, Oct 2019, Pointe-à-Pitre (Guadeloupe), France. ⟨hal-02893707⟩
  • Zohra Benfodda, Gerardo Cebrian-Torrejon, Bourguet Romane, Sciortino Giuseppe, Jean-Didier Maréchal, et al.. Design and synthesis of novel HLM 006474 derivatives.. 24th ISCB international conference-Frontier research in chemistry&biology interface., Jan 2018, JAIPUR, India. ⟨hal-01998366⟩
  • Miyanou Rosales-Hurtado, Thibaut Boibessot, Christopher Zschiedrich, Alexandre Lebeau, David Bénimélis, et al.. Synthesis of thiophene derivatives: Potential new inhibitors of histidine kinases. Rencontres en Chimie Organique Biologique (Recob 17), Mar 2018, Aussois, France. ⟨hal-01997587⟩
  • Patrick Meffre, Miyanou Rosales-Hurtado, Alexandre Lebeau, Gerardo Cebrian-Torrejon, Muriel Albalat, et al.. Improved synthesis, resolution, absolute configuration determination of HLM006474 enantiomer. XXII International conférence on Organic synthesis (22-ICOS), Sep 2018, Florence, Italy. ⟨hal-02011288⟩
  • Patrick Meffre, Thibaut Boibessot, David Bénimèlis, Zohra Benfodda. Synthesis of Novel Triazole Amino Acids Analogues of Natural Amino Acids. 20th European symposium on Organic Chemistry (ESOC), Jul 2017, Cologne, Germany. ⟨hal-02011261⟩
  • Zohra Benfodda, Christopher Zschiedrich, Alexandre Lebeau, Thibaut Boibessot, Marta Maria Perego, et al.. Rational design of potent histidine kinase inhibitors with antimicrobial activities.. Experimental Biology meeting in San Diego, Apr 2016, San Diego, United States. ⟨hal-01998350⟩
  • Zohra Benfodda, Alexandre Lebeau, David Bénimèlis, Hendrik Szurmant, Patrick Meffre. Design and synthesis of 1,4-disubstituted 1,2,3-triazole derivatives as Histidine Kinase inhibitor.. 77th Harden Conference: Two Component Signalling in Bacteria: Integrating Approaches and Science, Aug 2015, Warwickshire, United Kingdom. ⟨hal-01998338⟩
  • Zohra Benfodda, Thibaut Boibessot, Alexandre Lebeau, David Bénimèlis, Patrick Meffre. Synthesis of triazole amino acids. 14th International Congress on Amino Acids, Peptides and Proteins, Aug 2015, Vienne, Austria. ⟨hal-01998273⟩
  • Zohra Benfodda, Christopher Zschiedrich, Alexandre Lebeau, Thibaut Boibessot, Patrick Meffre, et al.. Rational design of potent histidine kinase inhibitors with antimicrobial activities. 8ème congrès international sur les microorganismes gram-positive, Jun 2015, Montecatini, Italy. ⟨hal-01998292⟩
  • Zohra Benfodda, David Bénimèlis, Valérie Rolland, Patrick Meffre. Synthesis of ethynyl phenylalanine. The 5th European Chemistry Congress, Aug 2014, Istanbul, Turkey. ⟨hal-01998193⟩
  • Zohra Benfodda, David Benimelis, Valerie Rolland, Thibaut Boibessot, Patrick Meffre. Synthesis of ethynyl phenylalanine. 21ème journée de l’Institut de Recherche Pierre Fabre (IRPF) de chimie. Chambre de commerce et d’industrie de Castres, Sep 2014, Castres, France. ⟨hal-01998205⟩

Book sections2 documents

  • Patrick Meffre, Liliane Vo-Quang, Yen Vo-Quang, François Le Goffic. Synthetic uses of methionine. Amino Acid Derivatives : A Practical Approach, Ed. G. C. Barrett, The Practical Approach in Chemistry Series (Series Editors : L. M. Harwood, C. J. Moody), Oxford University Press, Dec. 1999, ISBN0198558538., 1999. ⟨hal-02010083⟩
  • Patrick Meffre, Liliane Vo-Quang, Yen Vo-Quang, François Le Goffic. Synthetic uses of serine, threonine and cysteine. Amino Acid Derivatives : A Practical Approach, Ed. G. C. Barrett, The Practical Approach in Chemistry Series (Series Editors : L. M. Harwood, C. J. Moody), Oxford University Press, Dec. 1999, ISBN0198558538, 1999. ⟨hal-02010084⟩

Directions of work or proceedings1 document