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Cytochrome P450 enzymes mechanism based inhibitors: Common sub-structures and reactivity
Elena Fontana
,
Patrick M. Dansette
,
Sonia Maria Poli
Article dans une revue
hal-00068554v1
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Monooxygenase- and Dioxygenase-Catalyzed Oxidative Dearomatization of Thiophenes by Sulfoxidation, cis-Dihydroxylation and Epoxidation
Derek Boyd
,
Narain Sharma
,
Paul Stevenson
,
Patrick Hoering
,
Christopher Allen
,
et al.
Article dans une revue
hal-03656571v1
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THE STRUCTURE OF A SUBSTRATE COMPLEX OF MAMMALIAN CYTOCHROME P450 2C 5 AT 2.3A RESOLUTION : EVIDENCE FOR MULTIPLE SUBSTRATE BINDING MODES
Michael R. Wester
,
Eric F. Johnson
,
Cristina Marques-Soares
,
Patrick M. Dansette
,
Daniel Mansuy
,
et al.
Biochemistry, 2003, 42, pp.6370-6379
Article dans une revue
hal-00018700v1
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Identification of liver protein targets modified by tienilic acid metabolites using a two-dimensional Western blot-mass spectrometry approach
Ruth Menque Methogo
,
Patrick M. Dansette
,
Klaus Klarskov
Article dans une revue
hal-00192244v1
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Kinetics of tienilic acid bioactivation and functional generation of drug–protein adducts in intact rat hepatocytes
Maria Pilar López-García
,
Patrick M. Dansette
,
Julio Coloma
Article dans une revue
istex
hal-00068621v1
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Mechanism of H 2 S Formation from the Metabolism of Anetholedithiolethione and Anetholedithiolone by Rat Liver Microsomes
Martin Dulac
,
Citra Nagarathinam
,
Patrick M. Dansette
,
Daniel Mansuy
,
Jean-Luc Boucher
Article dans une revue
hal-02398998v1
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STRUCTURE OF MAMMALIAN CYTOCHROME P450 2C5 COMPLEXED WITH DICLOFENAC AT 2.Å RESOLUTION : EVIDENCE FOR AN INDUCED FIT MODEL OF SUBSTRATE BINDING
Michael R. Wester
,
Eric F. Johnson
,
Cristina Marques-Soares
,
Sylvie Dijols
,
Patrick M. Dansette
,
et al.
Biochemistry, 2003, 42, pp.9335-9345
Article dans une revue
hal-00079218v1
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Sulfaphenazole Derivatives as Tools for Comparing Cytochrome P450 2C5 and Human Cytochromes P450 2Cs: Identification of a New High Affinity Substrate Common to Those Enzymes
Cristina Marques-Soares
,
Sylvie Dijols
,
Anne-Christine Macherey
,
Michael R. Wester
,
Eric F. Johnson
,
et al.
Article dans une revue
hal-00068736v1
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SULFAPHENAZOLE DERIVATIVES AS TOOLS FOR COMPARING CYTOCHROME P450 2C5 AND HUMAN CYTOCHROMES P450 2Cs : IDENTIFICATION OF A NEW HIGH AFFINITY SUBSTRATE COMMON TO THOSE ENZYMES
Cristina Marques-Soares
,
Sylvie Dijols
,
Anne-Christine Macherey
,
Michael R. Wester
,
Eric F. Johnson
,
et al.
Biochemistry, 2003, 42, pp.6363-6369
Article dans une revue
hal-00018698v1
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Substrate selectivity of human cytochrome P450 2C9: importance of residues 476, 365, and 114 in recognition of diclofenac and sulfaphenazole and in mechanism-based inactivation by tienilic acid
Armelle Melet
,
Nadine Assrir
,
Pascale Jean
,
Maria Pilar López-García
,
Cristina Marques-Soares
,
et al.
Article dans une revue
istex
hal-00069626v1
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A NEW THIOPHENE METABOLITE: NADPH, O 2 AND THIOL DEPENDENT FORMATION OF A THIOPHENE HYDRATE FROM (S)-MTPPA BY CYP2C9
Patrick M. Dansette
,
Shigeyuki Kitamura
,
Gildas Bertho
,
Daniel Mansuy
ISSX-JSSX joint symposium, Maui (Hawai) USA, novembre 2005, Nov 2005, Wailea, Maui, United States
Poster de conférence
hal-03515695v1
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Preparation of aromatic aldehydes and aromatic acids (14C) and (3H) (laboratoty note)
Patrick M. Dansette
,
Robert Azerad
Bulletin de la Societe Chimique de France, 1968, 1968 (6), pp.2492-2493
Article dans une revue
hal-04332322v1
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Selective, competitive and mechanism-based inhibitors of human cytochrome P450 2J2.
Pierre Lafite
,
Sylvie Dijols
,
Darryl C Zeldin
,
Patrick M Dansette
,
Daniel Mansuy
Article dans une revue
hal-00191990v1
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Structure of a substrate complex of mammalian cytochrome P450 2C5 at 2.3 A resolution: evidence for multiple substrate binding modes.
Michael R. Wester
,
Eric F. Johnson
,
Cristina Marques-Soares
,
Patrick M. Dansette
,
Daniel Mansuy
,
et al.
Article dans une revue
istex
hal-00068735v1
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Role of Arginine 117 in Substrate Recognition by Human Cytochrome P450 2J2
Pierre Lafite
,
François André
,
Joan P. Graves
,
Darryl C. Zeldin
,
Patrick M. Dansette
,
et al.
Article dans une revue
hal-02180797v1
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Design and synthesis of selective, high-affinity inhibitors of human cytochrome P450 2J2
Pierre Lafite
,
Sylvie Dijols
,
Didier Buisson
,
Anne-Christine Macherey
,
Darryl C. Zeldin
,
et al.
Article dans une revue
hal-00068615v1
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Drug metabolism artifacts: formation of cytochrome P450 dependent amide metabonate from thioesters and thiolactones
Patrick M. Dansette
,
Assia Hessani
,
Dan Levent
,
Daniel Mansuy
"20th International Conference on Cytochrome P450"., Aug 2017, Dusseldorf, Germany
Poster de conférence
hal-02314472v1
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Ferrocenyl Quinone Methide-Thiol Adducts as New Antiproliferative Agents: Synthesis, Metabolic Formation from Ferrociphenols, and Oxidative Transformation
Yong Wang
,
Marie-Aude Richard
,
Siden Top
,
Patrick M. Dansette
,
Pascal Pigeon
,
et al.
Article dans une revue
hal-01345781v1
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Antidepressant efficacy of a selective organic cation transporter blocker in a mouse model of depression
Alejandro Orrico-Sanchez
,
Laetitia Chausset-Boissarie
,
Rodolphe Alves de Sousa
,
Basile Coutens
,
Sara Rezai Amin
,
et al.
Article dans une revue
inserm-03943549v1
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Structure of mammalian cytochrome P450 2C5 complexed with diclofenac at 2.1 A resolution: evidence for an induced fit model of substrate binding.
Michael R. Wester
,
Eric F. Johnson
,
Cristina Marques-Soares
,
Sylvie Dijols
,
Patrick M. Dansette
,
et al.
Article dans une revue
istex
hal-00068734v1
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Analysis of human cytochrome P450 2C8 substrate specificity using a substrate pharmacophore and site-directed mutants.
Armelle Melet
,
Cristina Marques-Soares
,
Guillaume A. A. Schoch
,
Anne-Christine Macherey
,
Maryse Jaouen
,
et al.
Article dans une revue
istex
hal-00068689v1
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Oxidative Metabolism of Ferrocene Analogues of Tamoxifen: Characterization and Antiproliferative Activities of the Metabolites
Marie-Aude Richard
,
Didier Hamels
,
Pascal Pigeon
,
Siden Top
,
Patrick M. Dansette
,
et al.
Article dans une revue
hal-01230370v1
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Etude sur la biosynthèse de Naphtoquinones végétales et bactériennes
Patrick M Dansette
Biologie végétale. Université Paris Sud - Paris XI, 1972. Français. ⟨NNT : ⟩
Thèse
tel-00663831v1
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Cytochrome P450 dependent metabolism of fluindione in vitro in rat and human microsomes and in vivo in rat.
Patrick M. Dansette
,
Assia Hessani
,
Virginie Siguret
,
Catherine Boisson-Vidal
,
Jean-Luc Boucher
,
et al.
Poster de conférence
hal-02348026v1
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SYNTHESIS AND SPECTROSCOPIC, ELECTROCHEMICAL, AND CATALYTIC PROPERTIES OF A NEW MANGANESE PORPHYRIN BEARING FOUR POSITIVE CHARGES CLOSE TO THE METAL
Constance Bochot
,
Jean-François Bartoli
,
Yves Michel Frapart
,
Patrick M. Dansette
,
Daniel Mansuy
,
et al.
Journal of Molecular Catalysis A: Chemical, 2006, 263, pp.200-205
Article dans une revue
hal-00110137v1
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Mechanism of the Aromatic Hydroxylation of Thiophene by Acid-Catalyzed Peracid Oxidation.
Alexander Treiber
,
Patrick M. Dansette
,
Daniel Mansuy
Article dans une revue
hal-00069712v1
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First evidence that cytochrome P450 may catalyze both S-oxidation and epoxidation of thiophene derivatives
Patrick M. Dansette
,
Gildas Bertho
,
Daniel Mansuy
Article dans une revue
hal-00068627v1
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Diversity-oriented synthesis and bioactivity evaluation of N-substituted ferrocifen compounds as novel antiproliferative agents against TNBC cancer cells
Yong Wang
,
Pascal Pigeon
,
Wei Li
,
Jiangkun Yan
,
Patrick M Dansette
,
et al.
Article dans une revue
hal-03599161v1
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Inhibitory Effect of Trapping Agents of Reactive Intermediates of Sulfur-containing Drugs Against Major Human Cytochrome P450
Patrick M Dansette
,
Jasleen K Sodhi
,
Marie Delarosa
,
Jason S Halladay
,
James P Driscoll
,
et al.
20th International Conference on Cytochrome P450 (ICCP 20), Aug 2017, Dusseldorf, Germany.
Poster de conférence
hal-03539866v1
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MECHANISM OF THE AROMATIC HYDROXYLATION OF THIOPHENE BY ACID-CATALYZED PERACID OXIDATION
Alexander Treiber
,
Patrick M. Dansette
,
Daniel Mansuy
Journal of Organic Chemistry, 2003, 67, pp.7261-7266
Article dans une revue
hal-00018696v1
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