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Development of Pleiotropic TrkB and 5-HT4 Receptor Ligands as Neuroprotective Agents
Mirjana Antonijevic
,
Despoina Charou
,
Audrey Davis
,
Thomas Curel
,
Maria Valcarcel
Article dans une revue
hal-04414817v1
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Conceptual Framework of the Design of Pleiotropic Drugs against Alzheimer’s Disease
Thomas Guiselin
,
Cédric Lecoutey
,
Christophe Rochais
,
Patrick Dallemagne
Article dans une revue
hal-04414828v1
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Biginelli Reaction Synthesis of Novel Multitarget-Directed Ligands with Ca2+ Channel Blocking Ability, Cholinesterase Inhibition, Antioxidant Capacity, and Nrf2 Activation
Rim Malek
,
Alexey Simakov
,
Audrey Davis
,
Maciej Maj
,
Paul Bernard
Article dans une revue
hal-03969932v1
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C3-Symmetric Ligands in Drug Design: When the Target Controls the Aesthetics of the Drug
Mirjana Antonijevic
,
Christophe Rochais
,
Patrick Dallemagne
Article dans une revue
hal-03969919v1
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Advances in prodrug design for Alzheimer’s disease: the state of the art
Valentin Travers--Lesage
,
Serge Mignani
,
Patrick Dallemagne
,
Christophe Rochais
Article dans une revue
hal-03969939v1
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Aminothiaindanone as an Accessible Scaffold for a Three-Point Chemical Diversity
Pauline Zipfel
,
Julien Lalut
,
Jana Sopková-de Oliveira Santos
,
Christophe Rochais
,
Patrick Dallemagne
Article dans une revue
hal-03969969v1
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Pleiotropic prodrugs: Design of a dual butyrylcholinesterase inhibitor and 5-HT6 receptor antagonist with therapeutic interest in Alzheimer’s disease
François-Xavier Toublet
,
Julien Lalut
,
Bérénice Hatat
,
Cédric Lecoutey
,
Audrey Davis
Article dans une revue
hal-03082877v1
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Desirable drug–drug interactions or when a matter of concern becomes a renewed therapeutic strategy
Benjamin Guieu
,
Jean-Pierre Jourdan
,
Aurore Dreneau
,
Nicolas Willand
,
Christophe Rochais
Article dans une revue
hal-03969988v1
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Development of Novel Potential Pleiotropic Compounds of Interest in Alzheimer’s Disease Treatment through Rigidification Strategy
Cédric Lecoutey
,
Rémi Legay
,
Audrey Davis
,
Jana Sopková-de Oliveira Santos
,
Patrick Dallemagne
Article dans une revue
hal-03969972v1
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First Synthesis of Racemic Trans Propargylamino-Donepezil, a Pleiotrope Agent Able to Both Inhibit AChE and MAO-B, with Potential Interest against Alzheimer’s Disease
Benjamin Guieu
,
Cedric Lecoutey
,
Rémi Legay
,
Audrey Davis
,
Jana Sopkova de Oliveira Santos
Article dans une revue
hal-03969980v1
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5-HT4R modulators: a patent landscape
Patrick Dallemagne
,
Christophe Rochais
Article dans une revue
hal-03969965v1
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Therapeutic modulators of the serotonin 5-HT4 receptor: a patent review (2014-present)
Caroline Lanthier
,
Patrick Dallemagne
,
Cédric Lecoutey
,
Sylvie Claeysen
,
Cédric Lecoutey
Article dans une revue
hal-02863879v1
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Replication of Equine arteritis virus is efficiently suppressed by purine and pyrimidine biosynthesis inhibitors
José-Carlos Valle-Casuso
,
Delphine Gaudaire
,
Lydie Martin-Faivre
,
Anthony Madeline
,
Patrick Dallemagne
Article dans une revue
inserm-02888514v1
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Drug repositioning: a brief overview
Jean-Pierre Jourdan
,
Ronan Bureau
,
Christophe Rochais
,
Patrick Dallemagne
Article dans une revue
hal-03961788v1
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Phenanthrolinic analogs of quinolones show antibacterial activity against M. tuberculosis
Songuigama Coulibaly
,
Mena Cimino
,
Mahama Ouattara
,
Cédric Lecoutey
,
Maria V Buchieri
Article dans une revue
pasteur-03261309v1
|
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Rational design of novel benzisoxazole derivatives with acetylcholinesterase inhibitory and serotoninergic 5-HT4 receptors activities for the treatment of Alzheimer’s disease
Julien Lalut
,
Hugo Payan
,
Audrey Davis
,
Cédric Lecoutey
,
Rémi Legay
Article dans une revue
hal-02485740v1
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Screening of potential antiviral molecules against equid herpesvirus-1 using cellular impedance measurement: dataset of 2,891 compounds
Côme Thieulent
,
Christine Fortier
,
Hélène Munier-Lehmann
,
Peggy Suzanne
,
Patrick Dallemagne
Article dans une revue
hal-03022297v1
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Pharmacotechnical Development of a Nasal Drug Delivery Composite Nanosystem Intended for Alzheimer’s Disease Treatment
Thomas Adnet
,
Anne-Claire Groo
,
Céline Picard
,
Audrey Davis
,
Sophie Corvaisier
Article dans une revue
hal-03969997v1
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Two Antagonistic Microtubule Targeting Drugs Act Synergistically to Kill Cancer Cells
Lauralie Peronne
,
Eric Denarier
,
Ankit Rai
,
Renaud Prudent
,
Audrey Vernet
Article dans une revue
hal-03034449v1
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Donecopride, a Swiss army knife with potential interest against Alzheimer's disease
Christophe Rochais
,
Cédric Lecoutey
,
Katia Hamidouche
,
Patrizia Giannoni
,
Florence Gaven
Article dans une revue
hal-02428730v1
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Novel multi target-directed ligands targeting 5-HT4 receptors with in cellulo antioxidant properties as promising leads in Alzheimer's disease
Caroline Lanthier
,
Hugo Payan
,
Irene Liparulo
,
Bérénice Hatat
,
Cédric Lecoutey
Article dans une revue
hal-02399942v1
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Inhibiting Acetylcholinesterase to Activate Pleiotropic Prodrugs with Therapeutic Interest in Alzheimer’s Disease
François-Xavier Toublet
,
Cédric Lecoutey
,
Julien Lalut
,
Bérénice Hatat
,
Audrey Davis
Article dans une revue
hal-02399906v1
|
|
Screening and evaluation of antiviral compounds against Equid alpha-herpesviruses using an impedance-based cellular assay
Côme Thieulent
,
Erika Hue
,
Christine Fortier
,
Patrick Dallemagne
,
Stéphan Zientara
Article dans une revue
hal-01968305v1
|
|
26th Annual GP2A Medicinal Chemistry Conference & 32nd Journées Franco-Belges de Pharmacochimie
Patrick Dallemagne
,
Christophe Rochais
,
Pascal Marchand
,
Thierry Besson
Article dans une revue
hal-02330438v1
|
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Novel multitarget-directed ligands targeting acetylcholinesterase and σ1 receptors as lead compounds for treatment of Alzheimer's disease: Synthesis, evaluation, and structural characterization of their complexes with acetylcholinesterase
Julien Lalut
,
Gianluca Santoni
,
Delphine Karila
,
Cédric Lecoutey
,
Audrey Davis
Article dans une revue
hal-01994096v1
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New piperazine multi-effect drugs prevent neurofibrillary degeneration and amyloid deposition, and preserve memory in animal models of Alzheimer's disease
Nicolas Sergeant
,
Valérie Vingtdeux
,
Sabiha Eddarkaoui
,
Marion Gay
,
Caroline Evrard
Article dans une revue
inserm-02350071v1
|
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A chemical screen identifies two novel small compounds that alter Arabidopsis thaliana pollen tube growth
Ferdousse Laggoun
,
Flavien Dardelle
,
Jérémy Dehors
,
Denis Falconet
,
Azeddine Driouich
Article dans une revue
hal-02106475v1
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A Novel in vivo Anti-amnesic Agent, Specially Designed to Express Both Acetylcholinesterase (AChE) Inhibitory, Serotonergic Subtype 4 Receptor (5-HT4R) Agonist and Serotonergic Subtype 6 Receptor (5-HT6R) Inverse Agonist Activities, With a Potential Interest Against Alzheimer’s Disease
Bérénice Hatat
,
Samir Yahiaoui
,
Cédric Lecoutey
,
Audrey Davis
,
Thomas Freret
Article dans une revue
hal-02399864v1
|
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Multifaceted properties of 1,4-dimethylcarbazoles: Focus on trimethoxybenzamide and trimethoxyphenylurea derivatives as novel human topoisomerase II inhibitors
Domenico Iacopetta
,
Camillo Rosano
,
Francesco Puoci
,
Ortensia Ilaria Parisi
,
Carmela Saturnino
Article dans une revue
hal-02043748v1
|
|
The 52 nd International Conference on Medicinal Chemistry (RICT 2016) of the French Medicinal Chemistry Society (SCT) Held in Caen (Normandy)
Janos Sapi
,
Luc Van hijfte
,
Patrick Dallemagne
Article dans une revue
hal-02043722v1
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|
Benzylphenylpyrrolizinones with Anti-amyloid and Radical Scavenging Effects, Potentially Useful in Alzheimer's Disease Treatment
Jean-Pierre Jourdan
,
Marc Since
,
Laïla El kihel
,
Cédric Lecoutey
,
Sophie Corvaisier
Article dans une revue
hal-02043731v1
|
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Modulating 5-HT 4 and 5-HT 6 receptors in Alzheimer’s disease treatment
Julien Lalut
,
Delphine Karila
,
Patrick Dallemagne
,
Christophe Rochais
Article dans une revue
hal-02043735v1
|
|
Synthesis and evaluation of novel serotonin 4 receptor radiotracers for single photon emission computed tomography
Julien Lalut
,
Benjamin B. Tournier
,
Thomas Cailly
,
Cédric Lecoutey
,
Sophie Corvaisier
Article dans une revue
hal-02011098v1
|
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3-(Dipropylamino)-5-hydroxybenzofuro[2,3-f]quinazolin-1(2H)-one (DPA-HBFQ-1) plays an inhibitory role on breast cancer cell growth and progression
Pietro Rizza
,
Michele Pellegrino
,
Anna Caruso
,
Domenico Iacopetta
,
Maria Stefania Sinicropi
Article dans une revue
hal-02043777v1
|
|
Design, synthesis, and pharmacological evaluation of multitarget-directed ligands with both serotonergic subtype 4 receptor (5-HT 4 R) partial agonist and 5-HT 6 R antagonist activities, as potential treatment of Alzheimer’s disease
Samir Yahiaoui
,
Katia Hamidouche
,
Céline Ballandonne
,
Audrey Davis
,
Jana Sopkova-de Oliveira Santos
Article dans une revue
hal-02043759v1
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|
Novel benzylidenephenylpyrrolizinones with pleiotropic activities potentially useful in Alzheimer's disease treatment
Jean-Pierre Jourdan
,
Marc Since
,
Laïla El Kihel
,
Cédric Lecoutey
,
Sophie Corvaisier
Article dans une revue
hal-02043765v1
|
|
Therapeutic Potential of 5-HT 6 Receptor Agonists
Delphine Karila
,
Thomas Freret
,
Valentine Bouet
,
Michel Boulouard
,
Patrick Dallemagne
Article dans une revue
hal-02043781v1
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6-Sulfonylbenzothiazolones as potential scaffolds for the design of 5-HT6 ligands
Paul-Emmanuel Larchanche
,
Vincent Ultré
,
Delphine Le Broc
,
Céline Ballandonne
,
Christophe Furman
Article dans une revue
hal-01116521v1
|
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Discovery of new thienopyrimidinone derivatives displaying antimalarial properties toward both erythrocytic and hepatic stages of Plasmodium
Anita Cohen
,
Peggy Suzanne
,
Jean-Charles Lancelot
,
Pierre Verhaeghe
,
Aurélien Lesnard
Article dans une revue
hal-01460555v1
|
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Indenopyrazole oxime ethers: Synthesis and β1-adrenergic blocking activity
Tomaso Angelone
,
Anna Caruso
,
Christophe Rochais
,
Angela Caputa
,
Maria Cerra
Article dans une revue
hal-01116512v1
|
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Novel Multitarget-Directed Ligands (MTDLs) with Acetylcholinesterase (AChE) Inhibitory and Serotonergic Subtype 4 Receptor (5-HT 4 R) Agonist Activities As Potential Agents against Alzheimer’s Disease: The Design of Donecopride
Cédric Lecoutey
,
Cédric Lecoutey
,
Florence Gaven
,
Patrizia Giannoni
,
Katia Hamidouche
Article dans une revue
hal-02043873v1
|
|
Recent Advances in Phenanthroindolizidine and Phenanthroquinolizidine Derivatives with Anticancer Activities
Maria Fatima Pereira
,
Christophe Rochais
,
Patrick Dallemagne
Article dans une revue
hal-02043788v1
|
|
Chronic activation of 5-HT4 receptors or blockade of 5-HT6 receptors improve memory performances
Anne Quiedeville
,
Michel Boulouard
,
Katia Hamidouche
,
Virginie da Silva Costa-Aze
,
Gerald Nee
Article dans une revue
hal-02043824v1
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Synthesis and in vitro evaluation of 4-trichloromethylpyrrolo[1,2-a]quinoxalines as new antiplasmodial agents
Nicolas Primas
,
Peggy Suzanne
,
Pierre Verhaeghe
,
Sébastien Hutter
,
Charline Kieffer
Article dans une revue
hal-01417058v1
|
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Design of donecopride, a dual serotonin subtype 4 receptor agonist/acetylcholinesterase inhibitor with potential interest for Alzheimer's disease treatment
Cédric Lecoutey
,
Damien Hedou
,
Thomas Freret
,
Patrizia Giannoni
,
Florence Gaven
Proceedings of the National Academy of Sciences of the United States of America, 2014, 111 (36), pp.E3825--30. ⟨10.1073/pnas.1410315111⟩
Article dans une revue
hal-01800439v2
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Synthesis and evaluation of cytotoxic activities of new guanidines derived from carbazoles.
Anna Caruso
,
Maria Stefania Sinicropi
,
Jean-Charles Lancelot
,
Hussein El-Kashef
,
Carmela Saturnino
Article dans une revue
hal-00945836v1
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Design, synthesis and biological evaluation of novel indano- and thiaindano-pyrazoles with potential interest for Alzheimer's disease.
David Genest
,
Christophe Rochais
,
Cédric Lecoutey
,
Jana Sopkova-de Oliveira Santos
,
Céline Ballandonne
MedChemComm, 2013, 4, pp.925-931
Article dans une revue
hal-00840942v1
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N-substituted piperazinopyridylsteroid derivatives as abiraterone analogues inhibit growth and induce pro-apoptosis in human hormone-independent prostate cancer cell lines.
Dominique Brossard
,
Ying Zhang
,
Shozeb Haider
,
Miriam Sgobba
,
Mohamed Khalid
Article dans une revue
hal-00918445v1
|
|
Tripentones: A Promising Series of Potent Anti-Cancer Agents.
Christophe Rochais
,
Sylvain Rault
,
Patrick Dallemagne
Anti-Cancer Agents in Medicinal Chemistry, 2013, 2, pp.313-343
Article dans une revue
hal-00840950v1
|
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An unusual boron tribromide-mediated, one-pot bromination/cyclization reaction. Application to the synthesis of a highly strained cyclopenta[1,3]cyclopropa[1,2-b]pyrrolizin-8-one.
Jean-Pierre Jourdan
,
Christophe Rochais
,
Rémi Legay
,
Jana Sopkova-de Oliveira Santos
,
Patrick Dallemagne
Tetrahedron Letters, 2013, 54 (9), pp.1133-1136
Article dans une revue
hal-00821455v1
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MR22388, a novel anti-cancer agent with a strong FLT-3 ITD kinase affinity.
Christophe Rochais
,
Thierry Cresteil
,
Vittoria Perri
,
Marie Jouanne
,
Aurélien Lesnard
Article dans une revue
hal-00807871v1
|
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2,5-Dimethoxytetrahydrofuran, first update.
Christophe Rochais
,
Patrick Dallemagne
Encyclopedia of Reagents for Organic Synthesis, 2012, pp.2012
Article dans une revue
hal-00821463v1
|
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Synergistic effect of acetylcholinesterase inhibition (donepezil) and 5-HT(4) receptor activation (RS67333) on object recognition in mice.
Thomas Freret
,
Valentine Bouet
,
Anne Quiedeville
,
Gérald Nee
,
Patrick Dallemagne
Article dans une revue
hal-00862757v1
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|
Synthesis of dual AChE/5-HT4 receptor multi-target directed ligands.
Cédric Lecoutey
,
Christophe Rochais
,
David Genest
,
Sabrina Butt-Gueulle
,
Céline Ballandonne
MedChemComm, 2012, 3, pp.627-634
Article dans une revue
hal-00764795v1
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Synergistic effect of acetylcholinesterase inhibition (donepezil) and 5-HT4 receptor activation (RS67333) on object recognition in mice.
Thomas Freret
,
Valentine Bouet
,
Anne Quiedeville
,
Gerald Nee
,
Patrick Dallemagne
Behavioural Brain Research, 2012, 230, pp.304-308
Article dans une revue
hal-00821461v1
|
|
Synthesis of novel 7-oxo and 7-hydroxy trifluoroallocolchicinoids with cytotoxic effect
Elizabeth Chosson
,
Francesca Santoro
,
Christophe Rochais
,
Jana Sopkova-de Oliveira Santos
,
Rémi Legay
Article dans une revue
hal-02357753v1
|
|
One-pot synthesis of new aza- and diaza-aminopenanthrenes
Christophe Rochais
,
Rodrigue Yougnia
,
Thomas Cailly
,
Jana Sopkova-de Oliveira Santos
,
Sylvain Rault
Article dans une revue
hal-01061754v1
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First and mild synthesis of fluorene-9-malonic acid and some substituted derivatives via the intramolecular hydroarylation of 2-phenylbenzylidenemalonic acids
Elizabeth Chosson
,
Christophe Rochais
,
Rémi Legay
,
Jana Sopkova-de Oliveira Santos
,
Sylvain Rault
Article dans une revue
hal-01018072v1
|
|
Intramolecular Cyclisation of β-Aryl-β-Amino Acids in the Design of Novel Heterocyclic Systems with Therapeutic Interest: An Unfailing Source of Diversity
Christophe Rochais
,
Sylvain Rault
,
Patrick Dallemagne
Current Medicinal Chemistry, 2010, 17 (35), pp.4342-4369
Article dans une revue
hal-02045949v1
|
|
Hydrogenative desulphurization of thienopyrrolizinones: An easy and selective access to (Z)-phenethylidenepyrrolizinones with in vitro cytotoxic activity
Vittoria Perri
,
Christophe Rochais
,
Jana Sopkova-de Oliveira Santos
,
Rémi Legay
,
Thierry Cresteil
Article dans une revue
hal-02045946v1
|
|
Virtual Screening Discovery of New Acetylcholinesterase Inhibitors Issued from CERMN Chemical Library
Jana Sopkova-de Oliveira Santos
,
Aurélien Lesnard
,
Jean-Hugues Agondanou
,
Nathalie Dupont
,
Anne-Marie Godard
Article dans une revue
hal-00705935v1
|
|
One-pot synthesis of novel poly-substituted phenanthrenes
Rodrigue Yougnia
,
Christophe Rochais
,
Jana Sopkova-de Oliveira Santos
,
Patrick Dallemagne
,
Sylvain Rault
Article dans une revue
hal-02045958v1
|
|
Synthesis, reactivity and biological evaluation of novel halogenated tripentones.
Vittoria Perri
,
Christophe Rochais
,
Thierry Cresteil
,
Patrick Dallemagne
,
Sylvain Rault
Article dans une revue
hal-00433244v1
|
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Synthesis of new dipyrrolo- and furopyrrolopyrazinones related to tripentones and their biological evaluation as potential kinases (CDKs1-5, GSK-3) inhibitors.
Christophe Rochais
,
Nghia Vu Duc
,
Elodie Lescot
,
Jana Sopkova-de Oliveira Santos
,
Ronan Bureau
Article dans une revue
hal-00319802v1
|
|
Synthesis of new 4-[2-(alkylamino) ethylthio]pyrrolo[1,2-a]quinoxaline and 5-[2-(alkylamino) ethylthio]pyrrolo[1,2-a]thieno[3,2-e]pyrazine derivatives, as potential bacterial multidrug resistance pump inhibitors.
Céline Vidaillac
,
Jean Guillon
,
Stéphane Moreau
,
Corinne Arpin
,
Annie Lagardère
Journal of Enzyme Inhibition and Medicinal Chemistry, 2007, 22 (5), pp.620-31
Article dans une revue
hal-00319134v1
|
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Synthesis, Antimalarial Activity, and Molecular Modeling of New Pyrrolo[1,2- a ]quinoxalines, Bispyrrolo[1,2- a ]quinoxalines, Bispyrido[3,2- e ]pyrrolo[1,2- a ]pyrazines, and Bispyrrolo[1,2- a ]thieno[3,2- e ]pyrazines
Jean Guillon
,
Philippe Grellier
,
Mehdi Labaied
,
Pascal Sonnet
,
Jean-Michel Léger
Article dans une revue
mnhn-02867477v1
|
|
Pyrrolothieno[1,4]diazepines. Part V. Study of their chemical reactivity and first synthesis of oxazino[4,3- c ]pyrrolo[1,2- a ]thieno[2,3- f ] [1,4]diazepines
Michel Boulouard
,
Patrick Dallemagne
,
Sylvain Rault
Article dans une revue
hal-03970074v1
|