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Pascale Chavatte-Palmer

Pascale Chavatte-Palmer, INRAE Director of the BREED Research unit, University Paris-Saclay, INRAE, University Versailles Saint-Quentin, Ecole nationale Vétérinaire d'Alfort France
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**Directrice de l'unité Mixte de Recherches Biologie de la Reproduction, Environnement, Epigénétique et Développement** Université Paris-Saclay, UVSQ, INRAE, BREED, 78350, Jouy-en-Josas, France Ecole Nationale Vétérinaire d’Alfort, BREED, 94700, Maisons-Alfort, France Initially trained as a veterinarian, I specialized in animal, and particularly equine reproduction with a focus on pregnancy and neonatology through my internship, residency and PhD, post-doctoral fellowship and initial position. After my recruitment at AgroParisTech and subsequently INRAE in France, I have been more widely focusing on feto-placental development and the developmental origins of health and disease (DOHaD), with a dual purpose in agriculture and as biomedical models. The aim of my research is to understand the role of the placenta in the programming of long term post-natal health, in the context of the developmental origins of health and diseases. First as a veterinarian and subsequently to be able to perform longitudinal studies in research animals, I have also been developing in vivo imaging technologies such as ultrasound and Doppler to assess placental feto-placental development and placental perfusion. After having led a research group at the National Institute of Agronomical Research (now INRAE), with a mean of 12 permanent staff for the past 14 years, I have recently taken the lead of the new Biology of Reproduction, Environment, Epigenetics and Development (BREED) research unit (90 permanent staff), focusing on the development of the mammalian embryo from the formation of the egg cell to birth and development to adulthood. Projects range from fundamental studies on the functioning of the genome during embryo and fetal growth to applied research on the effects of the environment at large on development in the agronomic, veterinary and biomedical fields. The scientific objective is to understand and control the mechanisms of epigenetic programming during prenatal life, leading to the birth of a healthy, fertile and robust individual, able to adapt to changes in his environment. Meanwhile, I pursue my own research programs on effects of maternal and post-natal breeding conditions, including nutrition, on metabolic and osteoarticular outcomes in the foal. I have served as PI or co-PIU to several national and European research projects (see section D).

Publications

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An aberrant age of liver DNA methylation is associated with cloning-induced pathologies

Hélène Kiefer , Luc Jouneau , Evelyne E. Campion , Delphine Rousseau-Ralliard , Thibaut T. Larcher
Conférence Jacques Monod, DNA methylation and demethylation, Centre National de la Recherche Scientifique (CNRS). FRA., Nov 2015, Roscoff, France
Communication dans un congrès hal-02797595v1

Conséquences tardives de perturbations épigénétiques précoces : exemple des clones bovins

Hélène Kiefer , Luc Jouneau , Evelyne Campion , Delphine Rousseau-Ralliard , Thibaut Larcher
1. Journée de Séminaires du Département Phase sur l'Epigénétique EpiPhase, Institut National de Recherche Agronomique (INRA). UAR Département Physiologie Animale et Systèmes d'Elevage (0558)., Jun 2015, Paris, France
Communication dans un congrès hal-01197642v1

Effects of a preconceptional and gestational mutli-vitamin-mineral-omega3 supplementation on fetoplacental development in a rabbit model

Eve Mourier , Anne Couturier-Tarrade , Delphine Rousseau-Ralliard , Thibaut Larcher , Jean-Pierre Albert
40th Annual Conference of the IETS, International Embryo Transfer Society (IETS). USA., Jan 2014, Reno, Nevada, United States. pp.150, ⟨10.1071/RDv26n1Ab72⟩
Communication dans un congrès hal-01019240v1

Effets d’une supplémentation multi-vitamines-minéraux-oméga3 préconceptionnelle et gestationnelle sur le développement fœtoplacentaire dans un modèle lapin

Eve Mourier , Anne Couturier-Tarrade , Delphine Rousseau-Ralliard , Thibaut Larcher , Jean-Pierre Albert
Journées nationales de la société française de médecine périnatale, Nov 2013, Monaco, R.A.S. chinoise de Macao
Communication dans un congrès hal-01189852v1

Influence of a hyperlidic hypercholesterolemic diet on folliculogenesis and adipophlin expression in the preimplantation embryo in rabbits

Olivier Picone , Anne Gaël Cordier , Nathalie N. Peynot , Patrice Laigre , Michèle Dahirel
Proceeding of the 2nd General Meeting GEMINI: Maternal Communication with Gametes and Embryos, Oct 2009, Sardinia, Italy
Communication dans un congrès hal-02756721v1

Effect of a hyperlipidic and hypercholesterolemic diet on maternal hormonal secretion and ovarian function in rabbits

Ag Cordier , Olivier Picone , Thibaut T. Larcher , Patrice Laigre , Mc Maurel
IntraUterine Growth Restriction and Metabolic programming, Mar 2009, Beauvais, France. pp.Inconnu
Communication dans un congrès hal-02815082v1

UCP 1 is present in porcine adipose tissue and is responsive to postnatal leptin

Alison Mostyn , Samir Dou , Linda Attig , Thibaut T. Larcher , Pascale Chavatte-Palmer
2. Colloque de la SF-DOHaD, Origine Développementale de la santé et des maladies et épigénétique, Nov 2014, Nantes, France. , 57 p., 2014, Second Colloque SF-DOHaD 2014
Poster de conférence hal-02741081v1

Effets d’une supplémentation multi-vitamines, minéraux, Oméga 3, préconceptionelle et gestationnelle sur le développement foetoplacentaire dans un modèle lapin

Eve Mourier Mourier , Anne Couturier-Tarrade , Delphine Rousseau-Ralliard , Thibaut T. Larcher , Jean-Pierre Albert
43. Journées Nationales de la Société Française de Médecine Périnatale, Nov 2013, Monaco, France. Editions Springer, Revue de Médecine Périnatale, 5 (Supplément 1), 164 p., 2013, 43es Journées Nationales de la Société Française de Médecine Périnatale
Poster de conférence hal-02747523v1