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Pascale Chavatte-Palmer
Pascale Chavatte-Palmer, INRAE
Director of the BREED Research unit, University Paris-Saclay, INRAE, University Versailles Saint-Quentin, Ecole nationale Vétérinaire d'Alfort
France
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Libre accès
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Documents
Affiliations actuelles
- 1003282
Identifiants chercheurs
- pascale-chavatte-palmer
- ResearcherId : K-7349-2012
- 0000-0002-4581-6092
- IdRef : 153497998
- ResearcherId : http://www.researcherid.com/rid/K-7349-2012
Présentation
**Directrice de l'unité Mixte de Recherches Biologie de la Reproduction, Environnement, Epigénétique et Développement**
Université Paris-Saclay, UVSQ, INRAE, BREED, 78350, Jouy-en-Josas, France
Ecole Nationale Vétérinaire d’Alfort, BREED, 94700, Maisons-Alfort, France
Initially trained as a veterinarian, I specialized in animal, and particularly equine reproduction with a focus on pregnancy and neonatology through my internship, residency and PhD, post-doctoral fellowship and initial position. After my recruitment at AgroParisTech and subsequently INRAE in France, I have been more widely focusing on feto-placental development and the developmental origins of health and disease (DOHaD), with a dual purpose in agriculture and as biomedical models. The aim of my research is to understand the role of the placenta in the programming of long term post-natal health, in the context of the developmental origins of health and diseases. First as a veterinarian and subsequently to be able to perform longitudinal studies in research animals, I have also been developing in vivo imaging technologies such as ultrasound and Doppler to assess placental feto-placental development and placental perfusion. After having led a research group at the National Institute of Agronomical Research (now INRAE), with a mean of 12 permanent staff for the past 14 years, I have recently taken the lead of the new Biology of Reproduction, Environment, Epigenetics and Development (BREED) research unit (90 permanent staff), focusing on the development of the mammalian embryo from the formation of the egg cell to birth and development to adulthood. Projects range from fundamental studies on the functioning of the genome during embryo and fetal growth to applied research on the effects of the environment at large on development in the agronomic, veterinary and biomedical fields. The scientific objective is to understand and control the mechanisms of epigenetic programming during prenatal life, leading to the birth of a healthy, fertile and robust individual, able to adapt to changes in his environment. Meanwhile, I pursue my own research programs on effects of maternal and post-natal breeding conditions, including nutrition, on metabolic and osteoarticular outcomes in the foal. I have served as PI or co-PIU to several national and European research projects (see section D).
Publications
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Effect of sex on gene expression in equine blastocysts.10th International Symposium on Equine Embryo Transfer and technology, University of Pisa, Jun 2022, Pise, Italy
Communication dans un congrès
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Effets d’un régime maternel hypergras sur le transcriptome ovocytaire et embryonnaireSociété Francophone du Diabète, May 2022, Nice, France
Communication dans un congrès
hal-03808248v1
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Nursing in the periconceptional period alters placental gene expression and subsequent foal growth18th European Placenta Group IFPA meeting, European Placenta Group, Nov 2022, Jouy en Josas, France
Communication dans un congrès
hal-03903205v1
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Effects of F0 maternal diesel engine exhaust exposure during gestation on F1 and F2 offspring phenotypeESRI, Mar 2022, Paris, France. ⟨10.1016/j.jri.2022.103562⟩
Communication dans un congrès
hal-03643599v1
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Impact d’un environnement (pré)-diabétique sur le développement embryonnaire précoceSF-DOHAD, Nov 2021, Jouy-en-Josas, France
Communication dans un congrès
hal-03808220v1
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Exposition maternelle aux nanoparticules métalliques (Au-pvp, Ag, CeO2) par instillation: effets sur la fonction placentaire et le phénotype fœtal.SF-DOHaD, Nov 2021, Jouy-en-Josas, France
Communication dans un congrès
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Effets de l'exposition aux nanoparticules d'or par inhalation sur la fonction placentaire et le phénotype de la descendanceGFP-Groupe de la Francophonie Placentaire, Sep 2021, Nantes, France
Communication dans un congrès
hal-03341279v1
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142 Nulliparity alters gene expression in inner cell mass and trophoblast of equine blastocysts in old mares47TH ANNUAL CONFERENCE OF THE IETS, Jan 2021, online, United States. pp.179, ⟨10.1071/RDv33n2Ab142⟩
Communication dans un congrès
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Proteomic, metabolomic and fatty acid composition in lactating and non-lactating mares’ uterine fluids46th IETS conference, Jan 2020, New York, United States. ⟨10.1071/RDv32n2abs⟩
Communication dans un congrès
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Mares’ age affects embryo ICM and trophoblast RNA-seq transcriptome at about D8International Symposium on Equine Embryo Transfer, Jul 2020, Pisa, Italy. pp.103031, ⟨10.1016/j.jevs.2020.103031⟩
Communication dans un congrès
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Effects of maternal au-np exposure by inhalation on foeto-placental development and placental function, in a rabbit modelIPTC, Sep 2019, Salzburg, Austria
Communication dans un congrès
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Effets de l’exposition maternelle aux nanoparticules d’or par ingestion, pendant la gestation, sur le développement foeto-placentaire et la fonction placentaire, dans un modèle lapin.7. Rencontre du Groupe de la Francophonie Placentaire 2019, Groupe de la francophonie Placentaire (GfP). FRA., Mar 2019, Paris, France. 36 p
Communication dans un congrès
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Effets de l’exposition maternelle aux nanoparticules d’or par ingestion pendant la gestation, sur le développement foeto-placentaire et la fonction placentaire, dans un modèle lapin4. Congrès de la SF-Dohad, Société Francophone-DOHaD. FRA., Nov 2018, Grenoble, France. pp.120
Communication dans un congrès
hal-02734001v1
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Placental function at term is altered in broodmares fed with cereals from mid gestationIETS, International Embryo Transfer Society (IETS). USA., Jan 2018, Bangkok, Thailand. pp.250, ⟨10.1071/RDv30n1Ab65⟩
Communication dans un congrès
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Maternal exposure to diluted diesel engine exhaust alters placental function of the first and second generation in rabbit model35. Congrès de la Société Française de Toxicologie Génétique "Conséquences pour l'homme et l'environnement des effets génotoxiques et épigénétiques transgénérationnels", Société Française de Toxicologie Génétique. FRA., Oct 2017, Marseille, France
Communication dans un congrès
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Reproductive effects of gestational exposure to diesel exhaust in a rabbit model3. congrès de la SF-DOHaD, Société Francophone pour la Recherche et l'Education sur les Origines Développementales, Environnementales et Epigénétiques de la Santé et des Maladies (SF-DOHAD). FRA., Dec 2016, Paris, France. 84 p
Communication dans un congrès
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Reproductive effects of gestational exposure to diesel exhaust in a rabbit model18. International Congress on Animal Reproduction (ICAR), International Organisation on Animal Reproduction. FRA., Jun 2016, Tours, France. 676 p
Communication dans un congrès
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An aberrant age of liver DNA methylation is associated with cloning-induced pathologiesConférence Jacques Monod, DNA methylation and demethylation, Centre National de la Recherche Scientifique (CNRS). FRA., Nov 2015, Roscoff, France
Communication dans un congrès
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Conséquences tardives de perturbations épigénétiques précoces : exemple des clones bovins1. Journée de Séminaires du Département Phase sur l'Epigénétique EpiPhase, Institut National de Recherche Agronomique (INRA). UAR Département Physiologie Animale et Systèmes d'Elevage (0558)., Jun 2015, Paris, France
Communication dans un congrès
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Investigation of inter-individual epigenetic variability in bovine clones: a high throughput study64. Annual Meeting of the European Federation of Animal Science (EAAP), European Association of Animal Production (EAAP). FRA., Aug 2013, Nantes, France. pp.542
Communication dans un congrès
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Cloning disrupts the methylation signatures associated to age in cattleConférence Jacques Monod Méthylation et déméthylation de l'ADN, Centre National de la Recherche Scientifique (CNRS). FRA., Sep 2013, Roscoff, France
Communication dans un congrès
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Investigation of inter-individual epigenetic variability in bovine clones: A high throughput studyAnnual Conference of the International Embryo Transfer Society, Jan 2013, Hanovre, Germany. pp.173, ⟨10.1071/RDv25n1Ab51⟩
Communication dans un congrès
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Genomic instability following somatic cell nuclear transfer in cattle60. Annual Meeting of the European Association for Animal Production (EAAP), Aug 2009, Barcelona, Spain
Communication dans un congrès
hal-02752742v1
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Placental gene expression reveals reduced angiogenesis in primiparous maresXIIth International Symposium on Equine Reproduction (ISER), Jul 2023, Fos do Iguaçu, Brazil. Journal of equine veterinary science, 125, pp.104763, 2023, ⟨10.1016/j.jevs.2023.104763⟩
Poster de conférence
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NURSING IN THE PERICONCEPTIONAL PERIOD ALTERS PLACENTAL GENE EXPRESSION AND SUBSEQUENT FOAL GROWTHPoster de conférence hal-03793660v1 |
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Equine embryo size does matter!48th Annual Conference of the International Society of Embryo Technology, Jan 2022, Savannah, GA, United States. , Reproduction, Fertility and Development, 34 (1-2), pp.261, 2022, Proceedings of the Annual Conference of the International Embryo Technology Society, Savannah, Georgia, 10–13 January 2022. ⟨10.1071/RDv34n2Ab52⟩
Poster de conférence
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Mare aging as young as 10 years old alters gene expression and structure of term placenta without affecting foal growth19th International Congress on Animal Reproduction, Jun 2022, Bologna, Italy. , p. 192, 2022, Abstract book ICAR 2020+2
Poster de conférence
hal-03716763v1
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Dimorphisme sexuel chez les blastocystes équinsPoster de conférence hal-03469695v1 |
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Maternal age alters gene expression in blastocyst trophoblast and term placenta as well as term placental structurePoster de conférence hal-03348714v1 |
L'âge maternel modifie l'expression des gènes de l'embryonJournées sciences et innovations équines, Nov 2020, Jouy-en-Josas, France. 2020
Poster de conférence
hal-03290867v1
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Effects of maternal au-np exposure by inhalation on feto-placental development and placental function, in a rabbit modelIFPA 2019, Sep 2019, Buenos Aires, Argentina. , 135 p., 2019, IFPA 2019- VIII SLIMP Full Program Book
Poster de conférence
hal-02733979v1
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Maternal exposure to diluted diesel engine exhaust alters placental function of the first and second generation in rabbit model8. International Symposium on Nanotechnology, Occupational and Environmental Health, May 2017, Elsinore, Denmark. , 147 p., 2017, 8th International Symposium on Nanotechnology, Occupational and Environmental Health
Poster de conférence
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La supplémentation en céréales en fin de gestation perturbe la fonction placentaire chez la jument6. Colloque International du Groupe de la Francophonie Placentaire, Sep 2017, Grenoble, France. , 47 p., 2017, Sixième Colloque International du Groupe de la Francophonie Placentaire "De l'implantation à la parturition: Bases fondamentales et cliniques"
Poster de conférence
hal-01607380v1
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High fat maternal diet impacts the nutrient sensing signaling network in rabbit blastocystPoster de conférence hal-02741274v1 |
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The mare’s placenta is able to adapt to moderate maternal undernutrition during late gestation to sustain fetal growth18. International Congress on Animal Reproduction (ICAR), Jun 2016, Tours, France. , 676 p., 2016, 18th International Congress on Animal Reproduction (ICAR)
Poster de conférence
hal-02742103v1
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In utero exposure to diluted diesel engine exhaust alters placental function, fatty acids profiles and fetal metabolism of the second generation in rabbitsPoster de conférence hal-02741181v1 |
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Reproductive effects of gestational exposure to diesel exhaust in a rabbit modelXIV. International Congress of Toxicology, Oct 2016, Merida, Mexico. Elsevier Ireland Ltd, Toxicology Letters, 259, pp.269, 2016, Toxicology Letters. ⟨10.1016/j.toxlet.2016.07.100⟩
Poster de conférence
hal-01533918v1
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High fat maternal diet impacts the nutrient sensing signaling network in rabbit blastocystEpiconcept Conference 2016, Sep 2016, Giardini Naxos, Italy. COST Office, 84 p., 2016, Epigenetics and Periconception Environment
Poster de conférence
hal-02741142v1
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Studying the placental rabbit methylome and its alteration in intrauterine growth restriction (IUGR) cases during gestationConférence Jacques Monod, DNA methylation and demethylation, Nov 2015, Roscoff, France. , 2015, Conférence Jacques Monod, DNA methylation and demethylation
Poster de conférence
hal-02741269v1
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Developing a toolbox to study the rabbit methylome and its alteration in IUGR cases during gestationConference 2014 Epiconcept "Epigenetics and Periconception Environment", Oct 2014, Vilamoura, Portugal. COST Office European Cooperation in Science and Technology, 72 p., 2014, Epigenetics and Periconception Environment
Poster de conférence
hal-02741118v1
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Maternal parity affects Day 8 embryo gene expression in old mares2024
Pré-publication, Document de travail
hal-04446577v1
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Nulliparity affects the expression of a limited number of genes and pathways in Day 8 equine embryos2024
Pré-publication, Document de travail
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230 Slight alterations of trophoblast gene expression are related to the term placenta morphology and gene expression in horsesInternational Embryo Technology Society (IETS), Reproduction, Fertility and Development, 35 (2), pp. 244-244, 2022, ⟨10.1071/RDv35n2Ab230⟩
Proceedings/Recueil des communications
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