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Pascale Chavatte-Palmer

Pascale Chavatte-Palmer, INRAE Director of the BREED Research unit, University Paris-Saclay, INRAE, University Versailles Saint-Quentin, Ecole nationale Vétérinaire d'Alfort France
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**Directrice de l'unité Mixte de Recherches Biologie de la Reproduction, Environnement, Epigénétique et Développement** Université Paris-Saclay, UVSQ, INRAE, BREED, 78350, Jouy-en-Josas, France Ecole Nationale Vétérinaire d’Alfort, BREED, 94700, Maisons-Alfort, France Initially trained as a veterinarian, I specialized in animal, and particularly equine reproduction with a focus on pregnancy and neonatology through my internship, residency and PhD, post-doctoral fellowship and initial position. After my recruitment at AgroParisTech and subsequently INRAE in France, I have been more widely focusing on feto-placental development and the developmental origins of health and disease (DOHaD), with a dual purpose in agriculture and as biomedical models. The aim of my research is to understand the role of the placenta in the programming of long term post-natal health, in the context of the developmental origins of health and diseases. First as a veterinarian and subsequently to be able to perform longitudinal studies in research animals, I have also been developing in vivo imaging technologies such as ultrasound and Doppler to assess placental feto-placental development and placental perfusion. After having led a research group at the National Institute of Agronomical Research (now INRAE), with a mean of 12 permanent staff for the past 14 years, I have recently taken the lead of the new Biology of Reproduction, Environment, Epigenetics and Development (BREED) research unit (90 permanent staff), focusing on the development of the mammalian embryo from the formation of the egg cell to birth and development to adulthood. Projects range from fundamental studies on the functioning of the genome during embryo and fetal growth to applied research on the effects of the environment at large on development in the agronomic, veterinary and biomedical fields. The scientific objective is to understand and control the mechanisms of epigenetic programming during prenatal life, leading to the birth of a healthy, fertile and robust individual, able to adapt to changes in his environment. Meanwhile, I pursue my own research programs on effects of maternal and post-natal breeding conditions, including nutrition, on metabolic and osteoarticular outcomes in the foal. I have served as PI or co-PIU to several national and European research projects (see section D).

Publications

luc-jouneau

Alteration of the embryonic microenvironment and sex-specific responses of the preimplantation embryo related to a maternal high-fat diet in the rabbit model

Sophie Calderari , Catherine Archilla , Luc Jouneau , Nathalie Daniel , Nathalie N. Peynot
Journal of Developmental Origins of Health and Disease, In press, pp.1-12. ⟨10.1017/S2040174423000260⟩
Article dans une revue hal-04249255v1

Equine blastocyst size affects gene expression

Emilie Derisoud , Luc Jouneau , A Margat , C Gourtay , C Dubois
Journal of Equine Veterinary Science, 2022, 113 (27), pp.103982. ⟨10.1016/j.jevs.2022.103982⟩
Article dans une revue hal-03703215v1

Effect of sex on gene expression in equine blastocysts

Pascale Chavatte-Palmer , Emilie Derisoud , Luc Jouneau , A Margat , C Gourtay
Journal of Equine Veterinary Science, 2022, 113 (25), pp.103980. ⟨10.1016/j.jevs.2022.103980⟩
Article dans une revue hal-03703063v1
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Maternal age affects equine day 8 embryo gene expression both in trophoblast and inner cell mass

Emilie Derisoud , Luc Jouneau , Cédric Dubois , Catherine Archilla , Yan Jaszczyszyn
BMC Genomics, 2022, 23 (1), pp.443. ⟨10.1186/s12864-022-08593-7⟩
Article dans une revue hal-03695686v2
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105 Sexual dimorphism in equine D8 blastocysts (abstract)

Emilie Derisoud , Luc Jouneau , C. Dubois , A. Margat , C. Gourtay
Journal of Equine Veterinary Science, 2021, 100, pp.103568. ⟨10.1016/j.jevs.2021.103568⟩
Article dans une revue hal-03288513v1
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Effects of first-generation in utero exposure to diesel engine exhaust on second-generation placental function, fatty acid profiles and foetal metabolism in rabbits: preliminary results

Delphine Rousseau-Ralliard , Sarah A. Valentino , Marie-Christine Aubrière , Michèle Dahirel , Marie Sylvie Lallemand
Scientific Reports, 2019, 9 (1), pp.9710. ⟨10.1038/s41598-019-46130-x⟩
Article dans une revue hal-02185870v1
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Differentiation of derived rabbit trophoblast stem cells under fluid shear stress to mimic the trophoblastic barrier

Guenhaël Sanz , Nathalie Daniel , Catherine Archilla , Luc Jouneau , Yan Jaszczyszyn
Biochimica et Biophysica Acta (BBA) - General Subjects, 2019, 1863 (10), pp.1608-1618. ⟨10.1016/j.bbagen.2019.07.003⟩
Article dans une revue hal-02183790v1

Placental function and structure at term is altered in broodmares fed with cereals from mid-gestation

Morgane Robles , Pauline P. Peugnet , C Dubois , François Piumi , Luc Jouneau
Placenta, 2018, 64, pp.44-52. ⟨10.1016/j.placenta.2018.02.003⟩
Article dans une revue hal-02621731v1
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Altered DNA methylation associated with an abnormal liver phenotype in a cattle model with a high incidence of perinatal pathologies

Hélène Kiefer , Luc Jouneau , Evelyne E. Campion , Delphine Rousseau-Ralliard , Thibaut Larcher
Scientific Reports, 2016, 6, pp.38869. ⟨10.1038/srep38869⟩
Article dans une revue hal-02633915v1
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Enhanced or reduced fetal growth induced by embryo transfer into smaller or larger breeds alters post-natal growth and metabolism in pre-weaning horses

Pauline Peugnet , Laurence Wimel , Guy Duchamp , Charlotte Sandersen , Sylvaine Camous
PLoS ONE, 2014, 9 (7), pp.1-13. ⟨10.1371/journal.pone.0102044⟩
Article dans une revue hal-01129848v1

Effect of sex on gene expression in equine blastocysts.

Pascale Chavatte-Palmer , Emilie Derisoud , Luc Jouneau , Anne Margat , Clothilde Gourtay
10th International Symposium on Equine Embryo Transfer and technology, University of Pisa, Jun 2022, Pise, Italy
Communication dans un congrès hal-03716812v1

Effets d’un régime maternel hypergras sur le transcriptome ovocytaire et embryonnaire

Sophie Calderari , Catherine Archilla , Luc Jouneau , Nathalie Daniel , Nathalie N. Peynot
Société Francophone du Diabète, May 2022, Nice, France
Communication dans un congrès hal-03808248v1
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Nursing in the periconceptional period alters placental gene expression and subsequent foal growth

Emilie Derisoud , Orianne Valais , Luc Jouneau , Alexia Durand , Michèle Dahirel
18th European Placenta Group IFPA meeting, European Placenta Group, Nov 2022, Jouy en Josas, France
Communication dans un congrès hal-03903205v1

Effects of F0 maternal diesel engine exhaust exposure during gestation on F1 and F2 offspring phenotype

Anne Couturier-Tarrade , Delphine Rousseau-Ralliard , Sarah A. Valentino , Christophe Richard , Pauline Hoarau
ESRI, Mar 2022, Paris, France. ⟨10.1016/j.jri.2022.103562⟩
Communication dans un congrès hal-03643599v1

Impact d’un environnement (pré)-diabétique sur le développement embryonnaire précoce

Sophie Calderari , Catherine Archilla , Luc Jouneau , Nathalie Daniel , Nathalie N. Peynot
SF-DOHAD, Nov 2021, Jouy-en-Josas, France
Communication dans un congrès hal-03808220v1

Exposition maternelle aux nanoparticules métalliques (Au-pvp, Ag, CeO2) par instillation: effets sur la fonction placentaire et le phénotype fœtal.

Anne Couturier-Tarrade , Delphine Rousseau-Ralliard , Audrey Geeverding , Luc Jouneau , Valerie Gelin
SF-DOHaD, Nov 2021, Jouy-en-Josas, France
Communication dans un congrès hal-03483311v1

Effets de l'exposition aux nanoparticules d'or par inhalation sur la fonction placentaire et le phénotype de la descendance

Delphine Rousseau-Ralliard , Valérie Fessard , Michèle Dahirel , John Boere , Christophe Richard
GFP-Groupe de la Francophonie Placentaire, Sep 2021, Nantes, France
Communication dans un congrès hal-03341279v1

142 Nulliparity alters gene expression in inner cell mass and trophoblast of equine blastocysts in old mares

Emilie Derisoud , Luc Jouneau , Catherine Archilla , N. Daniel , Y. Jaszczyszyn
47TH ANNUAL CONFERENCE OF THE IETS, Jan 2021, online, United States. pp.179, ⟨10.1071/RDv33n2Ab142⟩
Communication dans un congrès hal-03153864v1

Proteomic, metabolomic and fatty acid composition in lactating and non-lactating mares’ uterine fluids

Emilie Derisoud , Anna Hankele , Luc Jouneau , Cédric Dubois , Delphine Rousseau-Ralliard
46th IETS conference, Jan 2020, New York, United States. ⟨10.1071/RDv32n2abs⟩
Communication dans un congrès hal-02454910v1

Mares’ age affects embryo ICM and trophoblast RNA-seq transcriptome at about D8

Emilie Derisoud , Luc Jouneau , C. Dubois , Catherine Archilla , N. Daniel
International Symposium on Equine Embryo Transfer, Jul 2020, Pisa, Italy. pp.103031, ⟨10.1016/j.jevs.2020.103031⟩
Communication dans un congrès hal-03029288v1
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Effects of maternal au-np exposure by inhalation on foeto-placental development and placental function, in a rabbit model

Delphine Rousseau-Ralliard , Valérie Fessard , John A. Boere , Paul Fokkens , Michèle Dahirel
IPTC, Sep 2019, Salzburg, Austria
Communication dans un congrès hal-02733978v1
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Effets de l’exposition maternelle aux nanoparticules d’or par ingestion, pendant la gestation, sur le développement foeto-placentaire et la fonction placentaire, dans un modèle lapin.

Camille Rousseau , Delphine Rousseau-Ralliard , Michèle Dahirel , Luc Jouneau , Josiane Aioun
7. Rencontre du Groupe de la Francophonie Placentaire 2019, Groupe de la francophonie Placentaire (GfP). FRA., Mar 2019, Paris, France. 36 p
Communication dans un congrès hal-02734084v1
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Effets de l’exposition maternelle aux nanoparticules d’or par ingestion pendant la gestation, sur le développement foeto-placentaire et la fonction placentaire, dans un modèle lapin

Camille Rousseau , Delphine Rousseau-Ralliard , Michèle Dahirel , Christophe Richard , Luc Jouneau
4. Congrès de la SF-Dohad, Société Francophone-DOHaD. FRA., Nov 2018, Grenoble, France. pp.120
Communication dans un congrès hal-02734001v1

Placental function at term is altered in broodmares fed with cereals from mid gestation

Morgane Robles , Pauline P. Peugnet , C. Dubois , François Piumi , Luc Jouneau
IETS, International Embryo Transfer Society (IETS). USA., Jan 2018, Bangkok, Thailand. pp.250, ⟨10.1071/RDv30n1Ab65⟩
Communication dans un congrès hal-02734074v1

Maternal exposure to diluted diesel engine exhaust alters placental function of the first and second generation in rabbit model

Anne Couturier-Tarrade , Sarah Valentino , Delphine Rousseau-Ralliard , Marie-Christine Aubrière , Michèle Dahirel
35. Congrès de la Société Française de Toxicologie Génétique "Conséquences pour l'homme et l'environnement des effets génotoxiques et épigénétiques transgénérationnels", Société Française de Toxicologie Génétique. FRA., Oct 2017, Marseille, France
Communication dans un congrès hal-02735196v1

Reproductive effects of gestational exposure to diesel exhaust in a rabbit model

Sarah Valentino , Anne Couturier-Tarrade , Delphine Rousseau-Ralliard , Eve Mourier , Christophe Richard
3. congrès de la SF-DOHaD, Société Francophone pour la Recherche et l'Education sur les Origines Développementales, Environnementales et Epigénétiques de la Santé et des Maladies (SF-DOHAD). FRA., Dec 2016, Paris, France. 84 p
Communication dans un congrès hal-02743432v1

Reproductive effects of gestational exposure to diesel exhaust in a rabbit model

Sarah Valentino , Véronique Duranthon , Anne Couturier-Tarrade , Delphine Rousseau-Ralliard , Eve Mourier Mourier
18. International Congress on Animal Reproduction (ICAR), International Organisation on Animal Reproduction. FRA., Jun 2016, Tours, France. 676 p
Communication dans un congrès hal-02740895v1

An aberrant age of liver DNA methylation is associated with cloning-induced pathologies

Hélène Kiefer , Luc Jouneau , Evelyne E. Campion , Delphine Rousseau-Ralliard , Thibaut T. Larcher
Conférence Jacques Monod, DNA methylation and demethylation, Centre National de la Recherche Scientifique (CNRS). FRA., Nov 2015, Roscoff, France
Communication dans un congrès hal-02797595v1

Conséquences tardives de perturbations épigénétiques précoces : exemple des clones bovins

Hélène Kiefer , Luc Jouneau , Evelyne Campion , Delphine Rousseau-Ralliard , Thibaut Larcher
1. Journée de Séminaires du Département Phase sur l'Epigénétique EpiPhase, Institut National de Recherche Agronomique (INRA). UAR Département Physiologie Animale et Systèmes d'Elevage (0558)., Jun 2015, Paris, France
Communication dans un congrès hal-01197642v1

Investigation of inter-individual epigenetic variability in bovine clones: a high throughput study

Hélène Kiefer , Luc Jouneau , Evelyne E. Campion , Marie-Laure Magniette Martin-Magniette , Sandrine Balzergue
64. Annual Meeting of the European Federation of Animal Science (EAAP), European Association of Animal Production (EAAP). FRA., Aug 2013, Nantes, France. pp.542
Communication dans un congrès hal-01004784v1

Cloning disrupts the methylation signatures associated to age in cattle

Hélène Kiefer , Luc Jouneau , Evelyne Campion , Marie-Laure Martin-Magniette , Sandrine Balzergue
Conférence Jacques Monod Méthylation et déméthylation de l'ADN, Centre National de la Recherche Scientifique (CNRS). FRA., Sep 2013, Roscoff, France
Communication dans un congrès hal-01019185v1
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Investigation of inter-individual epigenetic variability in bovine clones: A high throughput study

Hélène Kiefer , Luc Jouneau , Marie-Laure Magniette Martin-Magniette , Sandrine Balzergue , Evelyne E. Campion
Annual Conference of the International Embryo Transfer Society, Jan 2013, Hanovre, Germany. pp.173, ⟨10.1071/RDv25n1Ab51⟩
Communication dans un congrès hal-01004742v1

Genomic instability following somatic cell nuclear transfer in cattle

Beatrice de Montera , Jean-Francois Oudin , Luc Jouneau , Guy Noé , Pascale Chavatte-Palmer
60. Annual Meeting of the European Association for Animal Production (EAAP), Aug 2009, Barcelona, Spain
Communication dans un congrès hal-02752742v1

Placental gene expression reveals reduced angiogenesis in primiparous mares

Emilie Derisoud , Orianne Valais , Luc Jouneau , Alexia Durand , Audrey Prézelin
XIIth International Symposium on Equine Reproduction (ISER), Jul 2023, Fos do Iguaçu, Brazil. Journal of equine veterinary science, 125, pp.104763, 2023, ⟨10.1016/j.jevs.2023.104763⟩
Poster de conférence hal-04147559v1
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NURSING IN THE PERICONCEPTIONAL PERIOD ALTERS PLACENTAL GENE EXPRESSION AND SUBSEQUENT FOAL GROWTH

Emilie Derisoud , Juliette Auclair-Ronzaud , Orianne Valais , Luc Jouneau , Alexia Durand
DOHAD World Congress 2022, Aug 2022, Vancouver, Canada.
Poster de conférence hal-03793660v1
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Equine embryo size does matter!

Emilie Derisoud , Luc Jouneau , A. Margat , C. Gourtay , C. Dubois
48th Annual Conference of the International Society of Embryo Technology, Jan 2022, Savannah, GA, United States. , Reproduction, Fertility and Development, 34 (1-2), pp.261, 2022, Proceedings of the Annual Conference of the International Embryo Technology Society, Savannah, Georgia, 10–13 January 2022. ⟨10.1071/RDv34n2Ab52⟩
Poster de conférence hal-03538184v1
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Mare aging as young as 10 years old alters gene expression and structure of term placenta without affecting foal growth

E Derisoud , S Gastaldo , O Valais , Luc Jouneau , Van Cauter
19th International Congress on Animal Reproduction, Jun 2022, Bologna, Italy. , p. 192, 2022, Abstract book ICAR 2020+2
Poster de conférence hal-03716763v1
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Dimorphisme sexuel chez les blastocystes équins

Emilie Derisoud , Luc Jouneau , C Dubois , A Margat , C Gourtay
5ème congrès de la SF-DOHAD, Nov 2021, Jouy-en-Josas, France.
Poster de conférence hal-03469695v1
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Maternal age alters gene expression in blastocyst trophoblast and term placenta as well as term placental structure

Emilie Derisoud , Sarah Gastaldo , Orianne Valais , Luc Jouneau , Cedric Dubois
IFPA meeting 2021, Aug 2021, online, Netherlands.
Poster de conférence hal-03348714v1

L'âge maternel modifie l'expression des gènes de l'embryon

Emilie Derisoud , Luc Jouneau , Catherine Archilla , Nathalie Daniel , Nathalie N. Peynot
Journées sciences et innovations équines, Nov 2020, Jouy-en-Josas, France. 2020
Poster de conférence hal-03290867v1
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Effects of maternal au-np exposure by inhalation on feto-placental development and placental function, in a rabbit model

Delphine Rousseau-Ralliard , Valérie Fessard , John Boere , Paul Fokkens , Michèle Dahirel
IFPA 2019, Sep 2019, Buenos Aires, Argentina. , 135 p., 2019, IFPA 2019- VIII SLIMP Full Program Book
Poster de conférence hal-02733979v1

Maternal exposure to diluted diesel engine exhaust alters placental function of the first and second generation in rabbit model

Anne Couturier-Tarrade , Sarah Valentino , Delphine Rousseau-Ralliard , Marie-Christine Aubrière , Michèle Dahirel
8. International Symposium on Nanotechnology, Occupational and Environmental Health, May 2017, Elsinore, Denmark. , 147 p., 2017, 8th International Symposium on Nanotechnology, Occupational and Environmental Health
Poster de conférence hal-01605995v1
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La supplémentation en céréales en fin de gestation perturbe la fonction placentaire chez la jument

Morgane Robles , Pauline Peugnet , C. Dubois , François Piumi , Luc Jouneau
6. Colloque International du Groupe de la Francophonie Placentaire, Sep 2017, Grenoble, France. , 47 p., 2017, Sixième Colloque International du Groupe de la Francophonie Placentaire "De l'implantation à la parturition: Bases fondamentales et cliniques"
Poster de conférence hal-01607380v1

High fat maternal diet impacts the nutrient sensing signaling network in rabbit blastocyst

Sophie Calderari , Catherine Archilla , Luc Jouneau , Nathalie Peynot , Nathalie Daniel
3. congrès de la SF-DOHaD, Dec 2016, Paris, France. , 84 p., 2016, 3ème congrès de la SF-DOHaD
Poster de conférence hal-02741274v1

The mare’s placenta is able to adapt to moderate maternal undernutrition during late gestation to sustain fetal growth

Morgane Robles , Pauline P. Peugnet , Cédric Dubois , François Piumi , Luc Jouneau
18. International Congress on Animal Reproduction (ICAR), Jun 2016, Tours, France. , 676 p., 2016, 18th International Congress on Animal Reproduction (ICAR)
Poster de conférence hal-02742103v1

In utero exposure to diluted diesel engine exhaust alters placental function, fatty acids profiles and fetal metabolism of the second generation in rabbits

Sarah Valentino , Delphine Rousseau-Ralliard , Marie-Christine Aubrière , Michèle Dahirel , Marie-Sylvie Lallemand
3. congrès de la SF-DOHaD, Dec 2016, Paris, France. , 84 p., 2016, 3ème congrès de la SF-DOHaD
Poster de conférence hal-02741181v1

Reproductive effects of gestational exposure to diesel exhaust in a rabbit model

Sarah Valentino , Véronique Duranthon , Anne Couturier-Tarrade , Delphine Rousseau-Ralliard , Eve Mourier
XIV. International Congress of Toxicology, Oct 2016, Merida, Mexico. Elsevier Ireland Ltd, Toxicology Letters, 259, pp.269, 2016, Toxicology Letters. ⟨10.1016/j.toxlet.2016.07.100⟩
Poster de conférence hal-01533918v1

High fat maternal diet impacts the nutrient sensing signaling network in rabbit blastocyst

Sophie Calderari , Catherine Archilla , Luc Jouneau , Nathalie N. Peynot , Nathalie N. Daniel
Epiconcept Conference 2016, Sep 2016, Giardini Naxos, Italy. COST Office, 84 p., 2016, Epigenetics and Periconception Environment
Poster de conférence hal-02741142v1

Studying the placental rabbit methylome and its alteration in intrauterine growth restriction (IUGR) cases during gestation

Hala Al Adhami , Hélène Kiefer , Luc Jouneau , François Piumi , Sarah Valentino
Conférence Jacques Monod, DNA methylation and demethylation, Nov 2015, Roscoff, France. , 2015, Conférence Jacques Monod, DNA methylation and demethylation
Poster de conférence hal-02741269v1

Developing a toolbox to study the rabbit methylome and its alteration in IUGR cases during gestation

Hala Al-Adhami , Anne Couturier-Tarrade , Sarah Valentino , Eve Mourier Mourier , Christophe Richard
Conference 2014 Epiconcept "Epigenetics and Periconception Environment", Oct 2014, Vilamoura, Portugal. COST Office European Cooperation in Science and Technology, 72 p., 2014, Epigenetics and Periconception Environment
Poster de conférence hal-02741118v1

230 Slight alterations of trophoblast gene expression are related to the term placenta morphology and gene expression in horses

Emilie Derisoud , O. Valais , Luc Jouneau , C. Dubois , A. Durand
International Embryo Technology Society (IETS), Reproduction, Fertility and Development, 35 (2), pp. 244-244, 2022, ⟨10.1071/RDv35n2Ab230⟩
Proceedings/Recueil des communications hal-04444899v1