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Pascale Chavatte-Palmer

Pascale Chavatte-Palmer, INRAE Director of the BREED Research unit, University Paris-Saclay, INRAE, University Versailles Saint-Quentin, Ecole nationale Vétérinaire d'Alfort France
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Présentation

**Directrice de l'unité Mixte de Recherches Biologie de la Reproduction, Environnement, Epigénétique et Développement** Université Paris-Saclay, UVSQ, INRAE, BREED, 78350, Jouy-en-Josas, France Ecole Nationale Vétérinaire d’Alfort, BREED, 94700, Maisons-Alfort, France Initially trained as a veterinarian, I specialized in animal, and particularly equine reproduction with a focus on pregnancy and neonatology through my internship, residency and PhD, post-doctoral fellowship and initial position. After my recruitment at AgroParisTech and subsequently INRAE in France, I have been more widely focusing on feto-placental development and the developmental origins of health and disease (DOHaD), with a dual purpose in agriculture and as biomedical models. The aim of my research is to understand the role of the placenta in the programming of long term post-natal health, in the context of the developmental origins of health and diseases. First as a veterinarian and subsequently to be able to perform longitudinal studies in research animals, I have also been developing in vivo imaging technologies such as ultrasound and Doppler to assess placental feto-placental development and placental perfusion. After having led a research group at the National Institute of Agronomical Research (now INRAE), with a mean of 12 permanent staff for the past 14 years, I have recently taken the lead of the new Biology of Reproduction, Environment, Epigenetics and Development (BREED) research unit (90 permanent staff), focusing on the development of the mammalian embryo from the formation of the egg cell to birth and development to adulthood. Projects range from fundamental studies on the functioning of the genome during embryo and fetal growth to applied research on the effects of the environment at large on development in the agronomic, veterinary and biomedical fields. The scientific objective is to understand and control the mechanisms of epigenetic programming during prenatal life, leading to the birth of a healthy, fertile and robust individual, able to adapt to changes in his environment. Meanwhile, I pursue my own research programs on effects of maternal and post-natal breeding conditions, including nutrition, on metabolic and osteoarticular outcomes in the foal. I have served as PI or co-PIU to several national and European research projects (see section D).

Publications

francois-piumi

Placental function at term is altered in broodmares fed with cereals from mid gestation

Morgane Robles , Pauline P. Peugnet , C. Dubois , François Piumi , Luc Jouneau
IETS, International Embryo Transfer Society (IETS). USA., Jan 2018, Bangkok, Thailand. pp.250, ⟨10.1071/RDv30n1Ab65⟩
Communication dans un congrès hal-02734074v1
Image document

La supplémentation en céréales en fin de gestation perturbe la fonction placentaire chez la jument

Morgane Robles , Pauline Peugnet , C. Dubois , François Piumi , Luc Jouneau
6. Colloque International du Groupe de la Francophonie Placentaire, Sep 2017, Grenoble, France. , 47 p., 2017, Sixième Colloque International du Groupe de la Francophonie Placentaire "De l'implantation à la parturition: Bases fondamentales et cliniques"
Poster de conférence hal-01607380v1

The mare’s placenta is able to adapt to moderate maternal undernutrition during late gestation to sustain fetal growth

Morgane Robles , Pauline P. Peugnet , Cédric Dubois , François Piumi , Luc Jouneau
18. International Congress on Animal Reproduction (ICAR), Jun 2016, Tours, France. , 676 p., 2016, 18th International Congress on Animal Reproduction (ICAR)
Poster de conférence hal-02742103v1

Studying the placental rabbit methylome and its alteration in intrauterine growth restriction (IUGR) cases during gestation

Hala Al Adhami , Hélène Kiefer , Luc Jouneau , François Piumi , Sarah Valentino
Conférence Jacques Monod, DNA methylation and demethylation, Nov 2015, Roscoff, France. , 2015, Conférence Jacques Monod, DNA methylation and demethylation
Poster de conférence hal-02741269v1