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Pascale Chavatte-Palmer
Pascale Chavatte-Palmer, INRAE
Director of the BREED Research unit, University Paris-Saclay, INRAE, University Versailles Saint-Quentin, Ecole nationale Vétérinaire d'Alfort
France
40%
Libre accès
10
Documents
Affiliations actuelles
- 1003282
Identifiants chercheurs
- pascale-chavatte-palmer
- ResearcherId : K-7349-2012
- 0000-0002-4581-6092
- IdRef : 153497998
- ResearcherId : http://www.researcherid.com/rid/K-7349-2012
Présentation
**Directrice de l'unité Mixte de Recherches Biologie de la Reproduction, Environnement, Epigénétique et Développement**
Université Paris-Saclay, UVSQ, INRAE, BREED, 78350, Jouy-en-Josas, France
Ecole Nationale Vétérinaire d’Alfort, BREED, 94700, Maisons-Alfort, France
Initially trained as a veterinarian, I specialized in animal, and particularly equine reproduction with a focus on pregnancy and neonatology through my internship, residency and PhD, post-doctoral fellowship and initial position. After my recruitment at AgroParisTech and subsequently INRAE in France, I have been more widely focusing on feto-placental development and the developmental origins of health and disease (DOHaD), with a dual purpose in agriculture and as biomedical models. The aim of my research is to understand the role of the placenta in the programming of long term post-natal health, in the context of the developmental origins of health and diseases. First as a veterinarian and subsequently to be able to perform longitudinal studies in research animals, I have also been developing in vivo imaging technologies such as ultrasound and Doppler to assess placental feto-placental development and placental perfusion. After having led a research group at the National Institute of Agronomical Research (now INRAE), with a mean of 12 permanent staff for the past 14 years, I have recently taken the lead of the new Biology of Reproduction, Environment, Epigenetics and Development (BREED) research unit (90 permanent staff), focusing on the development of the mammalian embryo from the formation of the egg cell to birth and development to adulthood. Projects range from fundamental studies on the functioning of the genome during embryo and fetal growth to applied research on the effects of the environment at large on development in the agronomic, veterinary and biomedical fields. The scientific objective is to understand and control the mechanisms of epigenetic programming during prenatal life, leading to the birth of a healthy, fertile and robust individual, able to adapt to changes in his environment. Meanwhile, I pursue my own research programs on effects of maternal and post-natal breeding conditions, including nutrition, on metabolic and osteoarticular outcomes in the foal. I have served as PI or co-PIU to several national and European research projects (see section D).
Publications
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Dopaminergic and serotonergic changes in rabbit fetal brain upon repeated gestational exposure to diesel engine exhaustArchives of Toxicology, 2021, ⟨10.1007/s00204-021-03110-3⟩
Article dans une revue
hal-03275790v1
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Repeated gestational exposure to diesel engine exhaust affects the fetal olfactory system and alters olfactory-based behavior in rabbit offspringParticle and Fibre Toxicology, 2019, 16 (1), pp.1-17. ⟨10.1186/s12989-018-0288-7⟩
Article dans une revue
hal-02110667v1
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Exposure to airborne nanoparticles during pregnancy: lessons from rabbit modelsPoster de conférence hal-02296173v1 |
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Brain and olfactory dopaminergic pathways are impaired in rabbit pups daily exposed to diesel exhaust nanoparticules during gestation2. International Meeting for Environment & Health, Nov 2017, Strasbourg, France. 52 p., 2017, 2èmes Rencontres Internationales & Citoyennes Santé et Environnement/2nd International Meeting for Environment & Health
Poster de conférence
hal-02737280v1
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Effets à court terme d’une exposition quotidienne aux particules de fumées de diesel pendant la gestation sur le développement du système olfactif chez le lapinJournées de restitution du programme national de recherches Environnement-Santé-Travail, Nov 2016, Paris, France. 2016
Poster de conférence
hal-02795555v1
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Short-term effects of daily exposure to diesel exhaust during gestation on the olfactory system development in rabbits pupsJournées Promotion Procédés Produits (J3P) – Nanoparticules : quels risques, quelles protections ?, Oct 2016, Nancy, France. 2016
Poster de conférence
hal-02799883v1
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