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Pascale Chavatte-Palmer
Pascale Chavatte-Palmer, INRAE
Director of the BREED Research unit, University Paris-Saclay, INRAE, University Versailles Saint-Quentin, Ecole nationale Vétérinaire d'Alfort
France
22%
Libre accès
9
Documents
Affiliations actuelles
- 1003282
Identifiants chercheurs
- pascale-chavatte-palmer
- ResearcherId : K-7349-2012
- 0000-0002-4581-6092
- IdRef : 153497998
- ResearcherId : http://www.researcherid.com/rid/K-7349-2012
Présentation
**Directrice de l'unité Mixte de Recherches Biologie de la Reproduction, Environnement, Epigénétique et Développement**
Université Paris-Saclay, UVSQ, INRAE, BREED, 78350, Jouy-en-Josas, France
Ecole Nationale Vétérinaire d’Alfort, BREED, 94700, Maisons-Alfort, France
Initially trained as a veterinarian, I specialized in animal, and particularly equine reproduction with a focus on pregnancy and neonatology through my internship, residency and PhD, post-doctoral fellowship and initial position. After my recruitment at AgroParisTech and subsequently INRAE in France, I have been more widely focusing on feto-placental development and the developmental origins of health and disease (DOHaD), with a dual purpose in agriculture and as biomedical models. The aim of my research is to understand the role of the placenta in the programming of long term post-natal health, in the context of the developmental origins of health and diseases. First as a veterinarian and subsequently to be able to perform longitudinal studies in research animals, I have also been developing in vivo imaging technologies such as ultrasound and Doppler to assess placental feto-placental development and placental perfusion. After having led a research group at the National Institute of Agronomical Research (now INRAE), with a mean of 12 permanent staff for the past 14 years, I have recently taken the lead of the new Biology of Reproduction, Environment, Epigenetics and Development (BREED) research unit (90 permanent staff), focusing on the development of the mammalian embryo from the formation of the egg cell to birth and development to adulthood. Projects range from fundamental studies on the functioning of the genome during embryo and fetal growth to applied research on the effects of the environment at large on development in the agronomic, veterinary and biomedical fields. The scientific objective is to understand and control the mechanisms of epigenetic programming during prenatal life, leading to the birth of a healthy, fertile and robust individual, able to adapt to changes in his environment. Meanwhile, I pursue my own research programs on effects of maternal and post-natal breeding conditions, including nutrition, on metabolic and osteoarticular outcomes in the foal. I have served as PI or co-PIU to several national and European research projects (see section D).
Publications
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Alteration of the embryonic microenvironment and sex-specific responses of the preimplantation embryo related to a maternal high-fat diet in the rabbit modelJournal of Developmental Origins of Health and Disease, 2023, 14 (5), pp.602-613. ⟨10.1017/S2040174423000260⟩
Article dans une revue
hal-04249255v1
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Sexual dimorphism of the feto-placental phenotype in response to a high fat and control maternal diets in a rabbit modelPLoS ONE, 2013, 8 (12), pp.1-13. ⟨10.1371/journal.pone.0083458⟩
Article dans une revue
hal-01019142v1
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Effets d’un régime maternel hypergras sur le transcriptome ovocytaire et embryonnaireSociété Francophone du Diabète, May 2022, Nice, France
Communication dans un congrès
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Impact d’un environnement (pré)-diabétique sur le développement embryonnaire précoceSF-DOHAD, Nov 2021, Jouy-en-Josas, France
Communication dans un congrès
hal-03808220v1
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Reproductive effects of gestational exposure to diesel exhaust in a rabbit model18. International Congress on Animal Reproduction (ICAR), International Organisation on Animal Reproduction. FRA., Jun 2016, Tours, France. 676 p
Communication dans un congrès
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Reproductive effects of gestational exposure to diesel exhaust in a rabbit model3. congrès de la SF-DOHaD, Société Francophone pour la Recherche et l'Education sur les Origines Développementales, Environnementales et Epigénétiques de la Santé et des Maladies (SF-DOHAD). FRA., Dec 2016, Paris, France. 84 p
Communication dans un congrès
hal-02743432v1
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Maternal exposure to diesel engine exhaust during pregnancy affects early embryo development in a rabbit model41. Annual Conference of IETS, International Embryo Transfer Society (IETS). USA., Jan 2015, Versailles, France. ⟨10.1071/RDv27n1Ab120⟩
Communication dans un congrès
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Sexual dimorphism starting from the blastocyst stage in response to an imbalanced maternal diet in a rabbit modelMeeting of the International Federation of Placenta Associations (IFPA), Sep 2013, Whistler, British Columbia, Canada. ⟨10.1016/j.placenta.2013.06.054⟩
Communication dans un congrès
hal-01190599v1
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Hyperlipidic hypercholesterolemic maternal died affects early embryonic gene expression and trophoblast functionColloque SF-DOHaD, Société Francophone pour la Recherche et l'Education sur les Origines Développementales, Environnementales et Epigénétiques de la Santé et des Maladies (SF-DOHAD). FRA., Nov 2012, Paris, France
Communication dans un congrès
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