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Pascale Chavatte-Palmer
Pascale Chavatte-Palmer, INRAE
Director of the BREED Research unit, University Paris-Saclay, INRAE, University Versailles Saint-Quentin, Ecole nationale Vétérinaire d'Alfort
France
33%
Libre accès
12
Documents
Affiliations actuelles
- 1003282
Identifiants chercheurs
- pascale-chavatte-palmer
- ResearcherId : K-7349-2012
- 0000-0002-4581-6092
- IdRef : 153497998
- ResearcherId : http://www.researcherid.com/rid/K-7349-2012
Présentation
**Directrice de l'unité Mixte de Recherches Biologie de la Reproduction, Environnement, Epigénétique et Développement**
Université Paris-Saclay, UVSQ, INRAE, BREED, 78350, Jouy-en-Josas, France
Ecole Nationale Vétérinaire d’Alfort, BREED, 94700, Maisons-Alfort, France
Initially trained as a veterinarian, I specialized in animal, and particularly equine reproduction with a focus on pregnancy and neonatology through my internship, residency and PhD, post-doctoral fellowship and initial position. After my recruitment at AgroParisTech and subsequently INRAE in France, I have been more widely focusing on feto-placental development and the developmental origins of health and disease (DOHaD), with a dual purpose in agriculture and as biomedical models. The aim of my research is to understand the role of the placenta in the programming of long term post-natal health, in the context of the developmental origins of health and diseases. First as a veterinarian and subsequently to be able to perform longitudinal studies in research animals, I have also been developing in vivo imaging technologies such as ultrasound and Doppler to assess placental feto-placental development and placental perfusion. After having led a research group at the National Institute of Agronomical Research (now INRAE), with a mean of 12 permanent staff for the past 14 years, I have recently taken the lead of the new Biology of Reproduction, Environment, Epigenetics and Development (BREED) research unit (90 permanent staff), focusing on the development of the mammalian embryo from the formation of the egg cell to birth and development to adulthood. Projects range from fundamental studies on the functioning of the genome during embryo and fetal growth to applied research on the effects of the environment at large on development in the agronomic, veterinary and biomedical fields. The scientific objective is to understand and control the mechanisms of epigenetic programming during prenatal life, leading to the birth of a healthy, fertile and robust individual, able to adapt to changes in his environment. Meanwhile, I pursue my own research programs on effects of maternal and post-natal breeding conditions, including nutrition, on metabolic and osteoarticular outcomes in the foal. I have served as PI or co-PIU to several national and European research projects (see section D).
Publications
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Alteration of the embryonic microenvironment and sex-specific responses of the preimplantation embryo related to a maternal high-fat diet in the rabbit modelJournal of Developmental Origins of Health and Disease, 2023, 14 (5), pp.602-613. ⟨10.1017/S2040174423000260⟩
Article dans une revue
hal-04249255v1
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Effects of first-generation in utero exposure to diesel engine exhaust on second-generation placental function, fatty acid profiles and foetal metabolism in rabbits: preliminary resultsScientific Reports, 2019, 9 (1), pp.9710. ⟨10.1038/s41598-019-46130-x⟩
Article dans une revue
hal-02185870v1
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Effects of F0 maternal diesel engine exhaust exposure during gestation on F1 and F2 offspring phenotypeESRI, Mar 2022, Paris, France. ⟨10.1016/j.jri.2022.103562⟩
Communication dans un congrès
hal-03643599v1
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Effets de l'exposition aux nanoparticules d'or par inhalation sur la fonction placentaire et le phénotype de la descendanceGFP-Groupe de la Francophonie Placentaire, Sep 2021, Nantes, France
Communication dans un congrès
hal-03341279v1
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Effects of maternal au-np exposure by inhalation on foeto-placental development and placental function, in a rabbit modelIPTC, Sep 2019, Salzburg, Austria
Communication dans un congrès
hal-02733978v1
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Effets de l’exposition maternelle aux nanoparticules d’or par ingestion pendant la gestation, sur le développement foeto-placentaire et la fonction placentaire, dans un modèle lapin4. Congrès de la SF-Dohad, Société Francophone-DOHaD. FRA., Nov 2018, Grenoble, France. pp.120
Communication dans un congrès
hal-02734001v1
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Maternal exposure to diluted diesel engine exhaust alters placental function of the first and second generation in rabbit model35. Congrès de la Société Française de Toxicologie Génétique "Conséquences pour l'homme et l'environnement des effets génotoxiques et épigénétiques transgénérationnels", Société Française de Toxicologie Génétique. FRA., Oct 2017, Marseille, France
Communication dans un congrès
hal-02735196v1
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Reproductive effects of gestational exposure to diesel exhaust in a rabbit model18. International Congress on Animal Reproduction (ICAR), International Organisation on Animal Reproduction. FRA., Jun 2016, Tours, France. 676 p
Communication dans un congrès
hal-02740895v1
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Reproductive effects of gestational exposure to diesel exhaust in a rabbit model3. congrès de la SF-DOHaD, Société Francophone pour la Recherche et l'Education sur les Origines Développementales, Environnementales et Epigénétiques de la Santé et des Maladies (SF-DOHAD). FRA., Dec 2016, Paris, France. 84 p
Communication dans un congrès
hal-02743432v1
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Effects of maternal au-np exposure by inhalation on feto-placental development and placental function, in a rabbit modelIFPA 2019, Sep 2019, Buenos Aires, Argentina. , 135 p., 2019, IFPA 2019- VIII SLIMP Full Program Book
Poster de conférence
hal-02733979v1
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Maternal exposure to diluted diesel engine exhaust alters placental function of the first and second generation in rabbit model8. International Symposium on Nanotechnology, Occupational and Environmental Health, May 2017, Elsinore, Denmark. , 147 p., 2017, 8th International Symposium on Nanotechnology, Occupational and Environmental Health
Poster de conférence
hal-01605995v1
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In utero exposure to diluted diesel engine exhaust alters placental function, fatty acids profiles and fetal metabolism of the second generation in rabbitsPoster de conférence hal-02741181v1 |