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66

Main research area


Osteoarthritis is the most common disease in the elderly. Indeed, 65% of people over 60 years of age have osteoarthritis. Despite the high prevalence of osteoarthritis, its pathophysiology is not clearly established, especially since osteoarthritis is a multifactorial disease. The initial definition of osteoarthritis as the degeneration of cartilage with cyclic inflammatory phases under the dependence of the synovial membrane (the membrane surrounding the joint) is somewhat simplistic. Indeed, it is now accepted that bone and in particular subchondral bone (bone under the cartilage) plays a role in the arthritic process.

One of the characteristics of osteoarthritis is an attempt to repair cartilage by chondrocytes (cartilage cells), but this repair fails, particularly under the influence of factors secreted by the synovial membrane and subchondral bone. These factors can concurrently increase cartilage degradation and decrease repair, but also cause chondrocytes to dedifferentiate and return to expressing genes normally found in growth plates (conjugation cartilage) or during bone repair (endochondral ossification). Among the different re-expressed genes are those of collagenase-3 (MMP-13) and galectin-3.

            One of the growth factors found in greater quantity in osteoarthritic cartilage is hepatocyte growth factor (HGF). However, its synthesis is restricted to osteoblasts (bone cells), which suggests a paracrine role of this factor. In addition, in human chondrocytes, this HGF stimulates the production of collagenase-3, which is involved in cartilage remodeling and destruction, via the mitogen-activated protein kinases (MAPK) pathway.

During their de-differentiation, osteoarthritic chondrocytes also express and produce larger quantities of galectin-3, which is a lectin with different functions depending on its intra- or extracellular distribution. Although osteoarthritic chondrocytes produce more galectin-3, they secrete only small amounts. However, its intracellular presence is beneficial for chondrocytes since animals deficient in galectin-3 develop more osteoarthritis than non-mutated animals. In addition, using in vitro experiments, galectin-3 has a protective role against chondrocyte death. These results highlight the role of galectin-3 in cartilage homeostasis. However, animals deficient in galectin-3 do not have subchondral bone abnormalities except in the induction of osteoarthritis by intra-articular injection of mono-iodoacetate. These results show that galectin-3 does not appear to be essential for bone homeostasis, but when bone is subjected to metabolic stress, the absence of intracellular galectin-3 is harmful.

In contrast, galectin-3 can be secreted by the synovial membrane during inflammatory phases. During the latter, the synovial membrane generates a specific structure called pannus that envelops the cartilage and bone. Galectin-3 secretion can therefore directly reach chondrocytes and osteoblasts. Using chondrocytes, galectin-3 induces the expression of two major enzymes involved in the degradation of proteoglycans, one of the major components of the cartilage matrix. Galectin-3 also stimulates the expression of type X collagen, another cartilage compound normally expressed in the growth plate. Incubation of arthrosic osteoblasts in the presence of galectin-3 decreases the expression of osteocalcin, which is a marker of terminal osteoblast differentiation. According to literature,a truncated form of galectin-3, capable of binding to galectin-3 ligands but without activating a cellular signal, does not have this effect. Several strategies in order to produce a Trc-gal-3, devoid of biological activities was developed in the lab. Unfortunately, all of them presented biological effects on osteoarthritic chondrocytes. Among the Trc-gal-3 forms developed, one was selected because it had enough affinity for lactose and a great solubility. Thanks to theses properties, this form is used to generate a new method of purification of recombinant proteins.


Journal articles56 documents

  • Julie Hablot, Maroua Ferhat, Aonghus Lavelle, Fatouma Salem, Mahdia Taieb, et al.. Tofacitinib treatment alters mucosal immunity and gut microbiota during experimental arthritis. Clinical and Translational Medicine, Heidelberg : Springer-Verlag, 2020, 10 (5), pp.e163. ⟨10.1002/ctm2.163⟩. ⟨hal-03005532⟩
  • Marie Maumus, Danièle Noël, Hang Korng Ea, David Moulin, Maxime Ruiz, et al.. Identification of TGFβ signatures in six murine models mimicking different osteoarthritis clinical phenotypes. Osteoarthritis and Cartilage, Elsevier, 2020, 28 (10), pp.1373-1384. ⟨10.1016/j.joca.2020.06.008⟩. ⟨hal-02899374⟩
  • Martine Paindorge, Virginie Lang, Virginie Libante, Pascal Reboul, Bertrand Aigle. Accompagnement dans l’apprentissage de l’argumentation par une équipe pluridisciplinaire : quels effets sur les acteurs?. Revue internationale de pédagogie de l’enseignement supérieur, Association internationale de pédagogie universitaire, 2020, 36 (2), ⟨10.4000/ripes.2717⟩. ⟨hal-03041936⟩
  • Narjès Hafsia, Marine Forien, Félix Renaudin, Delphine Delacour, Pascal Reboul, et al.. Galectin 3 Deficiency Alters Chondrocyte Primary Cilium Formation and Exacerbates Cartilage Destruction via Mitochondrial Apoptosis. International Journal of Molecular Sciences, MDPI, 2020, 21 (4), pp.1486. ⟨10.3390/ijms21041486⟩. ⟨hal-02935722⟩
  • Alexandre Kriznik, Melissa Yelehe-Okouma, Christophe Lec, Guillaume Groshenry, Hélène Le Cordier, et al.. CRD SAT generated by pCARGHO: A new efficient lectin-based affinity tag method for safe, simple and low-cost protein purification. Biotechnology Journal, Wiley-VCH Verlag, 2019, 14 (4), pp.e1800214. ⟨10.1002/biot.201800214⟩. ⟨hal-01892441⟩
  • G Vargas, M Bouchet, L Bouazza, P Reboul, C Boyault, et al.. ERRα promotes breast cancer cell dissemination to bone by increasing RANK expression in primary breast tumors. Oncogene, Nature Publishing Group, 2019, 38 (7), pp.950-964. ⟨10.1038/s41388-018-0579-3⟩. ⟨hal-02353108⟩
  • Yong Hu, Mélissa Yéléhé-Okouma, Hang-Korng Ea, Jean-Yves Jouzeau, Pascal Reboul. Galectin-3: A key player in arthritis. Joint Bone Spine, Elsevier Masson, 2017, 84 (1), pp.15-20. ⟨10.1016/j.jbspin.2016.02.029⟩. ⟨hal-01704704⟩
  • Jean-Baptiste Gross, Cecile Guillaume, Pascal Gegout-Pottie, Pascal Reboul, Jean-Yves Jouzeau, et al.. The infrapatellar fat pad induces inflammatory and degradative effects in articular cells but not through leptin or adiponectin. Clinical and experimental rheumatology, Clinical and Experimental Rheumatology Sas, 2017, 35 (1), pp.53-60. ⟨hal-01532184⟩
  • Magali Cucchiarini, Laura de Girolamo, Giuseppe Filardo, J. Miguel Miguel Oliveira, Patrick Orth, et al.. Basic science of osteoarthritis. Journal of Experimental Orthopaedics, Springer Verlag, 2016, 3 (1), pp.22. ⟨10.1186/s40634-016-0060-6⟩. ⟨hal-01705047⟩
  • A. Bianchi, M. Guibert, F. Cailotto, Alain Gasser, N. Presle, et al.. Fibroblast Growth Factor 23 drives MMP13 expression in human osteoarthritic chondrocytes in a Klotho-independent manner. Osteoarthritis and Cartilage, Elsevier, 2016, 24 (11), pp.1961-1969. ⟨10.1016/j.joca.2016.06.003⟩. ⟨hal-01452316⟩
  • E. Abed, B. Bouvard, X. Martineau, J.-Y. Jouzeau, P. Reboul, et al.. Elevated hepatocyte growth factor levels in osteoarthritis osteoblasts contribute to their altered response to bone morphogenetic protein-2 and reduced mineralization capacity. BONE, Elsevier, 2015, 75, pp.111-119. ⟨10.1016/j.bone.2015.02.001⟩. ⟨hal-02921974⟩
  • Yong Hu, Yang Liu, Daniel Lajeunesse, Didier Mainard, Jean-Yves Jouzeau, et al.. Identification of two populations of osteoarthritic osteoblasts according to the 1,25[OH](2) vitamin D-3 potency to stimulate osteocalcin. Bio-Medical Materials and Engineering, IOS Press, 2015, 25 (1), pp.S103-S110. ⟨10.3233/BME-141230⟩. ⟨hal-01452238⟩
  • Béatrice Bouvard, Elie Abed, Mélissa Yéléhé-Okouma, Arnaud Bianchi, Didier Mainard, et al.. Hypoxia and vitamin D differently contribute to leptin and dickkopf-related protein 2 production in human osteoarthritic subchondral bone osteoblasts. Arthritis Research and Therapy, BioMed Central, 2014, 16 (5), pp.459. ⟨10.1186/s13075-014-0459-3⟩. ⟨hal-01471845⟩
  • Arnaud Bianchi, D. Moulin, S. Hupont, M. Koufany, P. Netter, et al.. Oxidative stress-induced expression of HSP70 contributes to the inhibitory effect of 15d-PGJ(2) on inducible prostaglandin pathway in chondrocytes. Free Radical Biology and Medicine, Elsevier, 2014, 76, pp.114-126. ⟨10.1016/j.freeradbiomed.2014.07.028⟩. ⟨hal-01453217⟩
  • Pascal Reboul, Jean-Yves Jouzeau, Daniel Lajeunesse. Osteoarthritis: rationale for a new paradigm shift involving transforming growth factor-β1. OA Arthritis, OA Publishing London, 2013, 1 (1), pp.10. ⟨10.13172/2052-9554--1-702⟩. ⟨hal-01473925⟩
  • Laurent Calvier, Maria Miana, Pascal Reboul, Victoria Cachofeiro, Ernesto Martinez-Martinez, et al.. Galectin-3 mediates aldosterone-induced vascular fibrosis.. Arteriosclerosis, Thrombosis, and Vascular Biology, American Heart Association, 2013, 33 (1), pp.67-75. ⟨10.1161/ATVBAHA.112.300569⟩. ⟨hal-00812594⟩
  • Edith E Bonnelye, Pascal Reboul, Nicolas Duval, Marco Cardelli, Jane Aubin. Estrogen receptor-related receptor α regulation by interleukin-1β in prostaglandin E2- and cAMP-dependent pathways in osteoarthritic chondrocytes. Arthritis and Rheumatism, Wiley, 2011, 63 (8), pp.2374-2384. ⟨10.1002/art.30398⟩. ⟨hal-01705064⟩
  • Frederic Cailotto, Pascal Reboul, Sylvie Sébillaud, Patrick Netter, Jean-Yves Jouzeau, et al.. Calcium Input Potentiates the Transforming Growth Factor (TGF)-β1-dependent Signaling to Promote the Export of Inorganic Pyrophosphate by Articular Chondrocyte. Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2011, 286 (22), pp.19215-19228. ⟨10.1074/jbc.M110.175448⟩. ⟨hal-01704454⟩
  • Hang-Korng Ea, Christelle Nguyen, Dominique Bazin, Arnaud Bianchi, Jérome Guicheux, et al.. Articular cartilage calcification in osteoarthritis: Insights into crystal-induced stress. Arthritis & rheumatology, Wiley, 2011, 63 (1), pp.10 - 18. ⟨10.1002/art.27761⟩. ⟨hal-01705871⟩
  • C. Boileau, P. Poirier, P Pelletier, M Guévremont, N Duval, et al.. Intracellular localisation of galectin-3 has a protective role in chondrocyte survival. Annals of the Rheumatic Diseases, BMJ Publishing Group, 2008, 67 (2), pp.175 - 181. ⟨10.1136/ard.2006.066514⟩. ⟨hal-01704462⟩
  • J. Monfort, G. Tardif, P. Roughley, P. Reboul, C. Boileau, et al.. Identification of opticin, a member of the small leucine-rich repeat proteoglycan family, in human articular tissues: a novel target for MMP-13 in osteoarthritis. Osteoarthritis and Cartilage, Elsevier, 2008, 16 (7), pp.749 - 755. ⟨10.1016/j.joca.2007.11.007⟩. ⟨hal-01705873⟩
  • Audrée Janelle-Montcalm, Christelle Boileau, Françoise Poirier, Jean-Pierre Pelletier, Mélanie Guévremont, et al.. Extracellular localization of galectin-3 has a deleterious role in joint tissues. Arthritis Research and Therapy, BioMed Central, 2007, 9 (1), pp.R20. ⟨10.1186/ar2130⟩. ⟨hal-01704438⟩
  • Jordi Monfort, Ginette Tardif, Pascal Reboul, François Mineau, Peter Roughley, et al.. Degradation of small leucine-rich repeat proteoglycans by matrix metalloprotease-13: identification of a new biglycan cleavage site. Arthritis Research and Therapy, BioMed Central, 2006, 8 (1), pp.R26. ⟨10.1186/ar1873⟩. ⟨hal-01705700⟩
  • Jean-Pierre Pelletier, Christelle Boileau, Martin Boily, Julie Brunet, François Mineau, et al.. The protective effect of licofelone on experimental osteoarthritis is correlated with the downregulation of gene expression and protein synthesis of several major cartilage catabolic factors: MMP-13, cathepsin K and aggrecanases. Arthritis Research and Therapy, BioMed Central, 2005, 7 (5), pp.R1091. ⟨10.1186/ar1788⟩. ⟨hal-01705710⟩
  • Patrick Marcouiller, Pierre Pelletier, Mélanie Guévremont, Johanne Martel-Pelletier, Pierre Ranger, et al.. Leukotriene and prostaglandin synthesis pathways in osteoarthritic synovial membranes: regulating factors for interleukin 1beta synthesis.. Journal of Rheumatology, Journal of Rheumatology Publishing Company Limited, 2005, pp.704-12. ⟨hal-01705121⟩
  • P. Lavigne, M. Benderdour, D. Lajeunesse, P. Reboul, Q. Shi, et al.. Subchondral and trabecular bone metabolism regulation in canine experimental knee osteoarthritis. Osteoarthritis and Cartilage, Elsevier, 2005, 13 (4), pp.310 - 317. ⟨10.1016/j.joca.2004.12.015⟩. ⟨hal-01705735⟩
  • Ginette Tardif, Pascal Reboul, Jean-Pierre Pelletier, Johanne Martel-Pelletier. Ten years in the life of an enzyme: the story of the human MMP-13 (collagenase-3). Modern Rheumatology, Springer Verlag, 2004, 14 (3), pp.197-204. ⟨10.1007/s10165-004-0292-7⟩. ⟨hal-01705132⟩
  • Jean-Pierre Pelletier, Christelle Boileau, Julie Brunet, Martin Boily, Daniel Lajeunesse, et al.. The inhibition of subchondral bone resorption in the early phase of experimental dog osteoarthritis by licofelone is associated with a reduction in the synthesis of MMP-13 and cathepsin K. BONE, Elsevier, 2004, 34 (3), pp.527 - 538. ⟨10.1016/j.bone.2003.11.021⟩. ⟨hal-01705856⟩
  • Johanne Pelletier, François Mineau, Hassan Fahmi, Stefan Laufer, Pascal Reboul, et al.. Regulation of the expression of 5-lipoxygenase-activating protein/5-lipoxygenase and the synthesis of leukotriene B4 in osteoarthritic chondrocytes: Role of transforming growth factor ? and eicosanoids. Arthritis and Rheumatism, Wiley, 2004, 50 (12), pp.3925 - 3933. ⟨10.1002/art.20632⟩. ⟨hal-01705750⟩
  • Mélanie Guevremont, Johanne Martel-Pelletier, Christelle Boileau, Ft Liu, Michel Richard, et al.. Galectin-3 surface expression on human adult chondrocytes: a potential substrate for collagenase-3. Annals of the Rheumatic Diseases, BMJ Publishing Group, 2004, 63 (6), pp.636 - 643. ⟨10.1136/ard.2003.007229⟩. ⟨hal-01704652⟩
  • Daniel Lajeunesse, Pascal Reboul. Subchondral bone in osteoarthritis: a biologic link with articular cartilage leading to abnormal remodeling.. Current Opinion in Rheumatology, Lippincott, Williams & Wilkins, 2003, pp.628-33. ⟨hal-01705858⟩
  • Mohammad Amraei, Zongjian Jia, Pascal Reboul, Ivan R Nabi. Acid-induced Conformational Changes in Phosphoglucose Isomerase Result in Its Increased Cell Surface Association and Deposition on Fibronectin Fibrils. Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2003, 278 (40), pp.38935 - 38941. ⟨10.1074/jbc.M304778200⟩. ⟨hal-01705860⟩
  • G. Tardif, M. Dupuis, P. Reboul, C.S Geng, Jean Pelletier, et al.. Identification and differential expression of human collagenase-3 mRNA species derived from internal deletion, alternative splicing, and different polyadenylation and transcription initiation sites. Osteoarthritis and Cartilage, Elsevier, 2003, 11 (7), pp.524 - 537. ⟨10.1016/S1063-4584(03)00079-7⟩. ⟨hal-01705862⟩
  • Mélanie Guévremont, Johanne Pelletier, Frédéric Massicotte, Ginette Tardif, Pierre Pelletier, et al.. Human Adult Chondrocytes Express Hepatocyte Growth Factor (HGF) Isoforms but Not HGF: Potential Implication of Osteoblasts on the Presence of HGF in Cartilage. Journal of Bone and Mineral Research, American Society for Bone and Mineral Research, 2003, 18 (6), pp.1073 - 1081. ⟨10.1359/jbmr.2003.18.6.1073⟩. ⟨hal-01704559⟩
  • Johanne Martel-Pelletier, Daniel Lajeunesse, Pascal Reboul, Jean-Pierre Pelletier. Therapeutic role of dual inhibitors of 5-LOX and COX, selective and non-selective non-steroidal anti-inflammatory drugs. Annals of the Rheumatic Diseases, BMJ Publishing Group, 2003, 62 (6), pp.501 - 509. ⟨10.1136/ard.62.6.501⟩. ⟨hal-01705863⟩
  • Mohamed Benderdour, Ginette Tardif, Pierre Pelletier, John Di Battista, Pascal Reboul, et al.. Interleukin 17 (IL-17) induces collagenase-3 production in human osteoarthritic chondrocytes via AP-1 dependent activation: differential activation of AP-1 members by IL-17 and IL-1beta.. Journal of Rheumatology, Journal of Rheumatology Publishing Company Limited, 2002, pp.1262-72. ⟨hal-01705867⟩
  • Dragan Jovanovic, François Mineau, Kohei Notoya, Pascal Reboul, Johanne Pelletier, et al.. Nitric oxide induced cell death in human osteoarthritic synoviocytes is mediated by tyrosine kinase activation and hydrogen peroxide and/or superoxide formation.. Journal of Rheumatology, Journal of Rheumatology Publishing Company Limited, 2002, pp.2165-75. ⟨hal-01705864⟩
  • Qin Shi, Daniel Lajeunesse, Pascal Reboul, Johanne Pelletier, Jean-Pierre Pelletier, et al.. Metabolic activity of osteoblasts from periprosthetic trabecular bone in failed total hip arthroplasties and osteoarthritis as markers of osteolysis and loosening.. Journal of Rheumatology, Journal of Rheumatology Publishing Company Limited, 2002, pp.1437-45. ⟨hal-01705866⟩
  • Pascal Reboul, Jean-Pierre Pelletier, Ginette Tardif, Mohamed Benderdour, Pierre Ranger, et al.. Hepatocyte growth factor induction of collagenase 3 production in human osteoarthritic cartilage: Involvement of the stress-activated protein kinase/c-Jun N-terminal kinase pathway and a sensitive p38 mitogen-activated protein kinase inhibitor cascade. Arthritis and Rheumatism, Wiley, 2001, 44 (1), pp.73 - 84. ⟨10.1002/1529-0131(200101)44:1<73::AID-ANR11>3.0.CO;2-E⟩. ⟨hal-01705308⟩
  • Dragan Jovanovic, Julio C. Fernandes, Johanne Pelletier, François-Cyril Jolicoeur, Pascal Reboul, et al.. In vivo dual inhibition of cyclooxygenase and lipoxygenase by ML-3000 reduces the progression of experimental osteoarthritis: Suppression of collagenase 1 and interleukin-1β synthesis. Arthritis and Rheumatism, Wiley, 2001, 44 (10), pp.2320-2330. ⟨10.1002/1529-0131(200110)44:10<2320::AID-ART394>3.0.CO;2-P⟩. ⟨hal-01705269⟩
  • D Jovanovic, J Di Battista, J. Martel-Pelletier, P. Reboul, Y. He, et al.. Modulation of TIMP-1 synthesis by antiinflammatory cytokines and prostaglandin E2 in interleukin 17 stimulated human monocytes/macrophages.. Journal of Rheumatology, Journal of Rheumatology Publishing Company Limited, 2001, pp.712-8. ⟨hal-01705579⟩
  • Jean Pelletier, D Lajeunesse, P. Reboul, F Mineau, J. Fernandes, et al.. Diacerein reduces the excess synthesis of bone remodeling factors by human osteoblast cells from osteoarthritic subchondral bone.. Journal of Rheumatology, Journal of Rheumatology Publishing Company Limited, 2001, pp.814-24. ⟨hal-01705289⟩
  • Jean Pelletier, J. Fernandes, J Jovanovic, P. Reboul, J. Martel-Pelletier. Chondrocyte death in experimental osteoarthritis is mediated by MEK 1/2 and p38 pathways: role of cyclooxygenase-2 and inducible nitric oxide synthase.. Journal of Rheumatology, Journal of Rheumatology Publishing Company Limited, 2001, pp.2509-19. ⟨hal-01705868⟩
  • G Tardif, P. Reboul, M. Dupuis, C. Geng, N Duval, et al.. Transforming growth factor-beta induced collagenase-3 production in human osteoarthritic chondrocytes is triggered by Smad proteins: cooperation between activator protein-1 and PEA-3 binding sites.. Journal of Rheumatology, Journal of Rheumatology Publishing Company Limited, 2001, pp.1631-9. ⟨hal-01705281⟩
  • M. Piperno, P. Reboul, M Hellio Le Graverand, M J Peschard, M Annefeld, et al.. Glucosamine sulfate modulates dysregulated activities of human osteoarthritic chondrocytes in vitro. Osteoarthritis and Cartilage, Elsevier, 2000, 8 (3), pp.207 - 212. ⟨10.1053/joca.1999.0291⟩. ⟨hal-01705629⟩
  • Kohei Notoya, Dragan Jovanovic, P. Reboul, Johanne Martel-Pelletier, François Mineau, et al.. The Induction of Cell Death in Human Osteoarthritis Chondrocytes by Nitric Oxide Is Related to the Production of Prostaglandin E 2 Via the Induction of Cyclooxygenase-2. Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2000, 165 (6), pp.3402-3410. ⟨10.4049/jimmunol.165.6.3402⟩. ⟨hal-01705606⟩
  • Muriel Piperno, P. Reboul, Marie-Pierre Hellio Le Graverand, Mj Peschard, Marliese Annefeld, et al.. Osteoarthritic cartilage fibrillation is associated with a decrease in chondrocyte adhesion to fibronectin.. Osteoarthritis and Cartilage, Elsevier, 1998, 6 (6), pp.393-399. ⟨10.1053/joca.1998.0138⟩. ⟨hal-01705650⟩
  • M. Piperno, M Hellio Le Graverand, P. Reboul, M. Mathieu, M Tron, et al.. Phospholipase A2 activity in herniated lumbar discs. Clinical correlations and inhibition by piroxicam.. Spine, Lippincott, Williams & Wilkins, 1997, pp.2061-5. ⟨hal-01705664⟩
  • Pascal Reboul, Pascal George, Delphine Miquel, Pierre Louisot, Pierre Broquet. Study ofO-sialylation of glycoproteins in C6 glioma cells treated with retinoic acid. Glycoconjugate Journal, Springer Verlag, 1996, 13 (1), pp.69 - 79. ⟨10.1007/BF01049682⟩. ⟨hal-01705189⟩
  • S Tavera, T Abribat, P. Reboul, S Doré, P Brazeau, et al.. IGF and IGF-binding protein system in the synovial fluid of osteoarthritic and rheumatoid arthritic patients.. Osteoarthritis and Cartilage, Elsevier, 1996, pp.263-74. ⟨hal-01705669⟩
  • Ginette Tardif, Pascal Reboul, Jean-Pierre Pelletier, Changshan Geng, Jean-Marie Cloutier, et al.. Normal expression of type 1 insulin-like growth factor receptor by human osteoarthritic chondrocytes with increased expression and synthesis of insulin-like growth factor binding proteins.. Arthritis and Rheumatism, Wiley, 1996, 39 (6), pp.968-978. ⟨10.1002/art.1780390614⟩. ⟨hal-01705166⟩
  • P. Reboul, Jean-Pierre Pelletier, Ginette Tardif, Jean-Marie Cloutier, Johanne Martel-Pelletier. The New Collagenase, Collagenase-3, Is Expressed and Synthesized by Human Chondrocytes but not by Synoviocytes A Role in Osteoarthritis. Journal of Clinical Investigation, American Society for Clinical Investigation, 1996, 97 (9), pp.2011-2019. ⟨10.1172/JCI118636⟩. ⟨hal-01705146⟩
  • P. Reboul, P George, P. Louisot, P. Broquet. Study of retinoic acid effect upon retinoic acid receptors beta (RAR-beta) in C6 cultured glioma cells.. Biochemistry and molecular biology international, 1995, pp.1097-105. ⟨hal-01705678⟩
  • Pascal Reboul, Pascal George, Jocelyne Geoffroy, Pierre Louisot, Pierre Broquet. Study of o-glycan sialylation in c6 cultured glioma cells: Regulation of a β-galactoside α2,3 sialyltransferase activity by ca2+/calmodulin antagonists and phosphatase inhibitors. Biochemical and Biophysical Research Communications, Elsevier, 1992, 186 (3), pp.1575 - 1581. ⟨10.1016/S0006-291X(05)81587-6⟩. ⟨hal-01705216⟩
  • Pierre Broquet, Pascal George, Jocelyne Geoffroy, Pascal Reboul, Pierre Louisot. Study of O-glycan sialylation in C6 cultured glioma cells: Evidence for post-translational regulation of Aβ-galactoside α2,3 sialyltransferase activity by N-glycosylation. Biochemical and Biophysical Research Communications, Elsevier, 1991, 178 (3), pp.1437 - 1443. ⟨10.1016/0006-291X(91)91054-G⟩. ⟨hal-01705236⟩
  • Pascal Reboul, Pierre Broquet, Pascal George, Pierre Louisot. Effect of retinoic acid on two glycosyltransferase activities in c6 cultured glioma cells. The International journal of biochemistry, Elsevier, 1990, 22 (8), pp.889 - 893. ⟨10.1016/0020-711X(90)90293-C⟩. ⟨hal-01705242⟩

Conference papers5 documents

  • Alexandre Kriznik, Melissa Yelehe-Okouma, Christophe Charron, Hortense Mazon, Hélène Le Cordier, et al.. Efficient new lectin-based affinity tag allowing simple, safe and low-cost recombinant protein purification. The 14th International Symposium on BioChromatography and Nanoseparations, May 2018, Bordeaux, France. ⟨hal-01719814⟩
  • Akim Chayem, Guillaume Toussaint, Marion Claudel, Pascal Reboul, Jean-Yves Jouzeau, et al.. Le domaine «Netrin-Like» de la protéine sFRP3 module les effets Wnts-dépendants dans les cellules et tissus articulaires. 30ème Congrès Français de Rhumatologie (SFR), Dec 2017, Paris, France. pp.A263 (PE.Ma-004). ⟨hal-01775284⟩
  • J. Hablot, M. Koufany, P. Reboul, J.-Y. Jouzeau, D. Moulin. FRI0017 Pharmacological Blockade of CCR3 Reduces Collagen-Induced Arthritis Severity. Annual European Congress of Rheumatology (EULAR), 2016, Londres, United Kingdom. pp.431.3 - 432, ⟨10.1136/annrheumdis-2016-eular.4069⟩. ⟨hal-01706984⟩
  • Béatrice Bouvard, Elie Abed, Melissa Yelehe-Okouma, Arnaud Bianchi, Didier Mainard, et al.. Hypoxia and vitamin D contribute to leptin and DKK2 production in human osteoarthritic subchondral bone osteoblasts. 2014 Annual Meeting of the American Society for Bone and Mineral Research, Sep 2014, Houston, United States. pp.S161. ⟨hal-01511623⟩
  • N. Hafsia, F. Poirier, D. Delacour, Pascal Reboul, D. Côme, et al.. Galectin 3 exerts a protective role in a murine model of osteoarthritis. EULAR 2014, Jun 2014, Paris, France. pp.796. ⟨hal-01511612⟩

Poster communications1 document

  • Arnaud Bianchi, David Moulin, Sebastien Hupont, Meriem Koufany, Patrick Netter, et al.. Expression of HSP70 by oxidative stress contributes to the inhibitory effect of 15d-PGJ2 on inducible prostaglandin pathway in chondrocyte. 10ème Congrès de la Société Française de Pharmacologie & Thérapeutique (SFP&T), Apr 2015, Caen, France. Fundamental and Clinical Pharmacology, 29 (Suppl 1), pp.31, 2015. ⟨hal-01775312⟩

Book sections3 documents

  • Elie Abed, Pascal Reboul, Daniel Lajeunesse. Sirtuins as markers of bone disease: a focus on osteoarthritis and osteoporosis. Vinood B. Patel, Victor R. Preedy. Biomarkers in Bone Disease. Biomarkers in Disease: Methods, Discoveries and Applications, Springer publisher, pp.157-175, 2017, 978-94-007-7745-3 (online) - 978-94-007-7692-0 (print). ⟨10.1007/978-94-007-7693-7_41⟩. ⟨hal-01709897⟩
  • Daniel Lajeunesse, P. Reboul. The role of bone in the development of osteoarthritis.. F Bronner and MC Farach-Carson. Bone and Osteoarthritis, 4, pp.19-39, 2007, Topics in Bone Biology. ⟨hal-01710478⟩
  • Johanne Martel-Pelletier, Daniel Lajeunesse, Pascal Reboul, Jean-Pierre Pelletier. The role of subchondral bone in osteoarthritis. Leena Sharma & Francis Berenbaum. Osteoarthritis, first edition, Mosby Elsevier publisher, pp.15-32, 2007. ⟨hal-01709917⟩

Patents1 document

  • Alexandre Kriznik, Pascal Reboul, Melissa Yelehe-Okouma. Method for the affinity purification of recombinant proteins based on the lectin affinity of the CRD of a Galectin. France, N° de brevet: WO2017194888. 2017. ⟨hal-01872013⟩