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Paolo Pierobon

23
Documents

Présentation

**Working a****d****dress****:** Institut Curie - Research Institute, 26 Rue d'Ulm, 75005 Paris **Laboratory:** INSERM U932 *Immunit**y and Cancer**Unit*, Director Sebastian Amigorena Lennon-Dumenil's Team*Spatio-temporal regulation of Antigen processing* **Education** ------------- 2015: Habilitation à diriger les recherches (HDR), Université Paris Descartes, Paris 2006: Doctor Rerum Naturalium (PhD in physics), Ludwig-Maximilians Universitaet, Munich (Germany) 2002: Laurea in fisica (Master in physics), University of Padua (Italy) 1997: Diploma di maturità scientifica (high school), Liceo Primo Levi, Montebelluna (Italy) **Professional experiences** ----------------------------- Research 2013-to date: CNRS, associate researcher 1st class (CR1), Institut Curie U932 2009-2013: CNRS, associate researcher 2nd class (CR2), Institut Curie U932 2006-2009: Postdoc, Institut Curie, Paris, France, UMR168 CNRS/Institut Curie**.** Supervisor: Dr. G.Cappello 2002-2006: PhD, Ludwig-Maximilians Universitaet, Munich (Germany), Supervisor: Prof. E.Frey 2001-2002: Master, Imperial College (London) and University of Padua (Italy). Supervisor: Dr.T.Liverpool Teaching 2013-to date: Molecular motors and thermodynamics of living systems, M2, Université Paris-Sud 11 (3h) 2019-to daté: Physics of the cell, M1 Approches Interdisciplinaires du Vivant, Université Paris 5/7 (6h) 2014-to date: Dynamics of living systems, M1 Approches Interdisciplinaires du Vivant, Université Paris 5/7. (40h) 2013: Physics and biology, Ecole Doctorale Frontières du Vivant, Université Paris 5 et 7. (20h) 2005: exercises of Statistical Mechanics, Ludwig-Maximilians Universitaet, Munich, Germany (36h) <a name="_Toc366054825"></a><a name="_Toc239878085"></a> **Professional activities** ------------------------------------------------------------------------------------ Author of 16 peer reviewed papers (+5 reviews, +1 highlight), 2 book chapters Participation to 34 conferences (17 posters, 18 oral presentations, 6 invited), 19 invited seminars in research groups Supervision of 12 master students, 3 phd student (2 in progress), collaboration to 6 PhD thesis Recipient of a starting grant ANR JCJC 2010 Referee for the French Research Agency (ANR), Phys.Rev.E, Biophys.J., J.Stat.Phys., J.Cell Biol. and Lab on Chip External examiner or referee in4PhD juries Participation to the evaluation panel of the European PhD program in Institut Curie (2016-2020)

Publications

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Phenotyping polarization dynamics of immune cells using a lipid droplet-cell pairing microfluidic platform

Léa Pinon , Nicolas Ruyssen , Judith Pineau , Olivier Mesdjian , Damien Cuvelier
Cell Reports Methods, 2022, pp.100335. ⟨10.1016/j.crmeth.2022.100335⟩
Article dans une revue hal-03853948v2
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Microtubules restrict F-actin polymerization to the immune synapse via GEF-H1 to maintain polarity in lymphocytes

Judith Pineau , Léa Pinon , Olivier Mesdjian , Jacques Fattaccioli , Ana-Maria Lennon Duménil
eLife, 2022, 11, ⟨10.7554/eLife.78330⟩
Article dans une revue hal-03853910v1
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Microtubules restrict F-actin polymerization to the immune synapse via GEF-H1 to maintain polarity in lymphocytes

Judith Pineau , Léa Pinon , Olivier Mesdjian , Jacques Fattaccioli , Ana-Maria Lennon Duménil
Article dans une revue hal-03853508v1
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Traction Force Microscopy to Study B Lymphocyte Activation

Paolo Pierobon , Anita Kumari , Judith Pineau , Ana-Maria Lennon-Duménil , Martial M Balland
Journal of visualized experiments : JoVE, 2020, ⟨10.3791/60947⟩
Article dans une revue hal-02996888v1
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“If you please… draw me a cell”. Insights from immune cells

Hélène D Moreau , Ana-Maria Lennon-Duménil , Paolo Pierobon
Journal of Cell Science, 2020, 133 (5), pp.jcs244806. ⟨10.1242/jcs.244806⟩
Article dans une revue hal-02996901v1
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Diacylglycerol kinase  promotes actin cytoskeleton remodeling and mechanical forces at the B cell immune synapse

Sara V Merino-Cortés , Sofia R Gardeta , Sara Roman-Garcia , Ana Martínez-Riaño , Judith Pineau
Science Signaling, 2020, 13 (627), pp.eaaw8214. ⟨10.1126/scisignal.aaw8214⟩
Article dans une revue hal-02996885v1
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Actomyosin-driven force patterning controls endocytosis at the immune synapse

Anita Kumari , Judith Pineau , Pablo J Sáez , Mathieu Maurin , Danielle Lankar
Nature Communications, 2019, 10, pp.2870. ⟨10.1038/s41467-019-10751-7⟩
Article dans une revue hal-02284123v1

EHD2 is a mechanotransducer connecting caveolae dynamics with gene transcription

Stéphanie Torrino , Wei-Wei Shen , Cédric Blouin , Satish Kailasam Mani , Christine Viaris de Lesegno
Journal of Cell Biology, 2018, 217 (12), pp.4092-4105. ⟨10.1083/jcb.201801122⟩
Article dans une revue hal-04003221v1
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EHD2 is a mechanotransducer connecting caveolae dynamics with gene transcription

Stéphanie Torrino , Wei-Wei Shen , Cedric Blouin , Satish Kailasam Mani , Christine C. Viaris de Lesegno
Journal of Cell Biology, 2018, 217 (12), pp.4092-4105. ⟨10.1083/jcb.201801122⟩
Article dans une revue inserm-02426440v1
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To use or not to use the force: How B lymphocytes extract surface-tethered antigens

Paolo Pierobon , Ana-Maria Lennon-Duménil
Journal of Cell Biology, 2017, 216 (1), pp.17-19. ⟨10.1083/jcb.201612043⟩
Article dans une revue hal-03979098v1

Polarity protein Par3 controls B-cell receptor dynamics and antigen extraction at the immune synapse

Anne Reversat , Maria-Isabel Yuseff , Danielle Lankar , Odile Malbec , Dorian Obino
Molecular Biology of the Cell, 2015, 26 (7), pp.1273-1285. ⟨10.1091/mbc.E14-09-1373⟩
Article dans une revue hal-02391191v1
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Cdc42 controls the dilation of the exocytotic fusion pore by regulating membrane tension

Marine Bretou , Ouardane Jouannot , Isabelle Fanget , Paolo Pierobon , Nathanael Larochette
Molecular Biology of the Cell, 2014, 25 (20), pp.3195-3209. ⟨10.1091/mbc.E14-07-1229⟩
Article dans une revue hal-02391211v1
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Kinesin KIFC1 actively transports bare double-stranded DNA

Francesca Farina , Paolo Pierobon , Cédric Delevoye , Jordan Monnet , Florent Dingli
Nucleic Acids Research, 2013, 41 (9), pp.4926-4937. ⟨10.1093/nar/gkt204⟩
Article dans une revue hal-01587426v1

Quantum dots to tail single bio-molecules inside living cells

Giovanni Cappello , Paolo Pierobon
Advanced Drug Delivery Reviews, 2012, 64 (2), pp.167-78
Article dans une revue hal-01218131v1

Polarized secretion of lysosomes at the B cell synapse couples antigen extraction to processing and presentation.

Maria-Isabel Yuseff , Anne Reversat , Danielle Lankar , Jheimmy Diaz , Isabelle Fanget
Immunity, 2011, 35 (3), pp.361-374. ⟨10.1016/j.immuni.2011.07.008⟩
Article dans une revue hal-02463451v1

Separation of time scales in one-dimensional directed nucleation-growth processes.

Paolo Pierobon , Judith Miné-Hattab , Giovanni Cappello , Jean-Louis Viovy , Marco Cosentino Lagomarsino
Physical Review E : Statistical, Nonlinear, and Soft Matter Physics, 2010, 82 (6 Pt 1), pp.061904
Article dans une revue hal-01139009v1

Velocity, processivity, and individual steps of single myosin V molecules in live cells.

Paolo Pierobon , Sarra Achouri , Sébastien Courty , Alexander R Dunn , James A Spudich
Biophysical Journal, 2009, 96 (10), pp.4268-75
Article dans une revue hal-01138979v1

Myosin V stepping mechanism.

Giovanni Cappello , Paolo Pierobon , Clémentine Symonds , Lorenzo Busoni , J Christof M Gebhardt
Proceedings of the National Academy of Sciences of the United States of America, 2007, 104 (39), pp.15328-33
Article dans une revue hal-01139000v1
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Polarity in immune cells

Judith Pineau , Hélène Moreau , Ana-Maria Lennon Duménil , Paolo Pierobon
Cell Polarity in Development and Disease, 154, Elsevier, pp.197-222, 2023, Current Topics in Developmental Biology, ⟨10.1016/bs.ctdb.2023.02.011⟩
Chapitre d'ouvrage hal-04234726v1
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Functionalized Lipid Droplets and Microfluidics Approach to Study Immune Cell Polarity In Vitro

Judith Pineau , Léa Pinon , Jacques Fattaccioli , Paolo Pierobon
The Immune Synapse, 2654, Springer US, pp.345-362, 2023, Methods in Molecular Biology, ⟨10.1007/978-1-0716-3135-5_22⟩
Chapitre d'ouvrage hal-04235268v1