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Norbert GARNIER

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Thiopurine Derivative-Induced Fpg/Nei DNA Glycosylase Inhibition: Structural, Dynamic and Functional Insights

Charlotte Rieux , Stéphane Goffinont , Franck Coste , Zahira Tber , Julien Cros
International Journal of Molecular Sciences, 2020, 21 (6), pp.2058. ⟨10.3390/ijms21062058⟩
Article dans une revue hal-03082414v1
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Residence Time Prediction of Type 1 and 2 Kinase Inhibitors from Unbinding Simulations

Abdennour Braka , Norbert Garnier , Pascal Bonnet , Samia Aci-Seche
Journal of Chemical Information and Modeling, 2019, 60 (1), pp.342-348. ⟨10.1021/acs.jcim.9b00497⟩
Article dans une revue hal-02494409v1

Inhibition of PlexA1-mediated brain tumor growth and tumor-associated angiogenesis using a transmembrane domain targeting peptide

Laurent Jacob , Paul Sawma , Norbert Garnier , Lionel A.T. Meyer , Justine Fritz
Article dans une revue hal-01407022v1
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Transmembrane Domain Targeting Peptide Antagonizing ErbB2/Neu Inhibits Breast Tumor Growth and Metastasis.

Alexia Arpel , Paul Sawma , Caroline Spenlé , Justine Fritz , Lionel Meyer
Cell Reports, 2014, 8 (6), pp.1714-1721. ⟨10.1016/j.celrep.2014.07.044⟩
Article dans une revue hal-01071710v1
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Transmembrane Recognition of the Semaphorin Co-Receptors Neuropilin 1 and Plexin A1 : Coarse-Grained Simulations

Samia Aci-Sèche , Paul Sawma , Pierre Hubert , James N. Sturgis , Dominique Bagnard
PLoS ONE, 2014, 9 (5), pp.e97779. ⟨10.1371/journal.pone.0097779⟩
Article dans une revue hal-01175479v1

The X-ray structure of NccX from Cupriavidus metallidurans 31A illustrates potential dangers of detergent solubilization when generating and interpreting crystal structures of membrane proteins.

Widade Ziani , Antoine P. Maillard , Isabelle Petit-Härtlein , Norbert Garnier , Serge Crouzy
Journal of Biological Chemistry, 2014, 289 (45), pp.31160-31172. ⟨10.1074/jbc.M114.586537⟩
Article dans une revue hal-01109416v1

The addressing fragment of mitogaligin: first insights into functional and structural properties.

Violette Senille , Dominique Lelievre , Françoise Paquet , Norbert Garnier , Ned Lamb
ChemBioChem, 2013, 14 (6), pp.711-20. ⟨10.1002/cbic.201200715⟩
Article dans une revue hal-00817503v1

Ligand entry pathways in the ligand binding domain of PPAR gamma receptor

Samia Aci-Seche , Monique Genest , Norbert Garnier
FEBS Letters, 2011, 585 (16), pp.2599-2603. ⟨10.1016/j.febslet.2011.07.014⟩
Article dans une revue hal-00624897v1

An alternative flexible conformation of the E. coli HU beta(2) protein: structural, dynamics, and functional aspects

Norbert Garnier , Karine Loth , Franck Coste , Rafal Augustyniak , Virginie Nadan
European Biophysics Journal, 2011, 40 (2), pp.117-129. ⟨10.1007/s00249-010-0630-y⟩
Article dans une revue hal-00602370v1

Comparing native and irradiated E. coli lactose repressor-operator complex by molecular dynamics simulation

Samia Aci-Sèche , Norbert Garnier , Stéphane Goffinont , Daniel Genest , Spotheim-Maurizot Mélanie
European Biophysics Journal, 2010, 39 (10), pp.1375-1384. ⟨10.1007/s00249-010-0591-1⟩
Article dans une revue hal-00529210v1

Molecular Dynamics Empirical Approach for Generating a Small Set of Structures Representative of the Internal Flexibility of a Receptor

Samia Aci-Seche , Norbert Garnier , Daniel Genest , Stéphane Bourg , Christophe Marot
QSAR & Combinatorial Science, 2009, 28 (9), pp.959-968
Article dans une revue hal-00521647v1

A Restrained Molecular Dynamics Empirical Approach for Generating a Small Set of Structures Representative of the Internal Flexibility of a Receptor

Samia Aci-Seche , Norbert Garnier , Daniel Genest , Stéphane Bourg , Christophe Marot
QSAR & Combinatorial Science, 2009, 28 (9), pp.959-968. ⟨10.1002/qsar.200910031⟩
Article dans une revue hal-02904717v1

Ligand-escape pathways from the ligand-binding domain of PPAR gamma receptor as probed by molecular dynamics simulations

Daniel Genest , Norbert Garnier , Alban Arrault , Christophe Marot , Luc Morin-Allory
European Biophysics Journal, 2008, 37, pp.369-379. ⟨10.1007/s00249-007-0220-9⟩
Article dans une revue hal-00512476v1

Insight into the recognition patterns of the ErbB receptor family transmembrane domains: heterodimerization models through MD search

Oumarou Samna Soumana , Norbert Garnier , Monique Genest
European Biophysics Journal, 2008, 37 (6), pp.851-864. ⟨10.1007/s00249-008-0293-0⟩
Article dans une revue hal-00284330v1

Molecular dynamics simulation approach for the prediction of transmembrane helix–helix heterodimers assembly

Oumarou Samna Soumana , Norbert Garnier , Monique Genest
European Biophysics Journal, 2007, 36 (8), pp.1071-1082. ⟨10.1021/jm0702175S0022-2623(07)00217-8⟩
Article dans une revue hal-00166544v1

Transmembrane Helix Packing of ErbB/Neu Receptor in Membrane Environment: A Molecular Dynamics Study

Pierre Aller , Norbert Garnier , Monique Genest
Journal of Biomolecular Structure and Dynamics, 2006, 24 (3), pp.209-228
Article dans une revue hal-00111939v1

Transmembrane peptides from tyrosine kinase receptor. Mutation-related behavior in a lipid bilayer investigated by molecular dynamics simulations

O. Samna Soumana , P. Aller , Norbert Garnier , M. Genest
Journal of Biomolecular Structure and Dynamics, 2005, 23, pp.91-100
Article dans une revue hal-00088672v1

Molecular dynamics (MD) investigations of preformed structures of the transmembrane domain of the oncogenic Neu receptor dimer in a DMPC bilayer

P. Aller , L. Voiry , Norbert Garnier , M. Genest
Biopolymers, 2005, 77, pp.184-197
Article dans une revue hal-00088475v1

Molecular Dynamics Simulations of the Transmembrane Domain of the Oncogenic ErbB2 Receptor Dimer in a DMPC Bilayer

Norbert Garnier , Serge Crouzy , Monique Genest
Journal of Biomolecular Structure and Dynamics, 2003, 21 (2), pp.179-200. ⟨10.1080/07391102.2003.10506916⟩
Article dans une revue hal-02123803v1
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Effects of curvature on hydrothermal waves instability of radial thermocapillary flows

N. Garnier , C. Normand
Comptes Rendus. Physique, 2001, 2, pp.1227-1233
Article dans une revue hal-00132425v1

Dimer models for ErbB-2/neu transmembrane domains from molecular dynamics simulations

Nicolas Sajot , Norbert Garnier , Monique Genest
Theoretical Chemistry Accounts: Theory, Computation, and Modeling, 1999, 101 (1-3), pp.67-72. ⟨10.1007/s002140050408⟩
Article dans une revue hal-02123800v1

Molecular dynamics simulations of the ErbB-2 transmembrane domain within an explicit membrane environment: comparison with vacuum simulations.

J-P Duneau , S. Crouzy , Norbert Garnier , Y. Chapron , M Genest
Biophysical Chemistry, 1999, 76 (1), pp.35-53
Article dans une revue hal-02123801v1

Time resolved fluorescence properties of phenylalanine in different environments. Comparison with molecular dynamics simulation.

J-P Duneau , Norbert Garnier , G Cremel , G Nullans , P. Hubert
Biophysical Chemistry, 1998, 73 (1-2), pp.109-19
Article dans une revue hal-02123796v1

Molecular modeling of c-erbB2 receptor dimerization: Coiled-coil structure of wild and oncogenic transmembrane domains—Stabilization by interhelical hydrogen bonds in the oncogenic form

Norbert Garnier , Daniel Genest , Jean Pierre Duneau , Monique Genest
Article dans une revue hal-02123792v1

Insight into Signal Transduction: Structural Alterations in Transmembrane Helices Probed by Multi-1 ns Molecular Dynamics Simulations

Jean-Pierre Duneau , Norbert Garnier , Monique Genest
Journal of Biomolecular Structure and Dynamics, 1997, 15 (3), pp.555-572. ⟨10.1080/07391102.1997.10508966⟩
Article dans une revue hal-02123789v1

Correlated motions and propagation of the effect of a local conformational change in the transmembrane helix of the c-erb B2 encoded protein and its V659E mutant, studied by molecular dynamics simulations.

Norbert Garnier , D. Genest , M Genest
Biophysical Chemistry, 1996, 58 (3), pp.225-37
Article dans une revue hal-02123788v1

Influence of a Mutation in the Transmembrane Domain of the pl85 c- erb B2 Oncogene-Encoded Protein Studied by Molecular Dynamics Simulations

Norbert Garnier , Daniel Genest , Eric Hebert , Monique Genest
Journal of Biomolecular Structure and Dynamics, 1994, 11 (5), pp.983-1002. ⟨10.1080/07391102.1994.10508047⟩
Article dans une revue hal-02123785v1

Quasi-elastic light scattering from an evanescent wave to probe particle/wall interactions.

N Ostrowsky , Norbert Garnier
Biochemical Society Transactions, 1991, 19 (2), pp.500-1
Article dans une revue hal-02123775v1
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Brownian dynamics in a confined geometry. Experiments and numerical simulations

Norbert Garnier , N. Ostrowsky
Journal de Physique II, 1991, 1 (10), pp.1221-1232. ⟨10.1051/jp2:1991129⟩
Article dans une revue jpa-00247585v1

THE USE OF DYNAMIC LIGHT SCATTERING IN STUDIES OF VESICLES INTERACTIONS

Nicole Ostrowsky , Norbert Garnier , Didier Sornette
Journal of Dispersion Science and Technology, 1989, 10 (3), pp.277-284. ⟨10.1080/01932698908943176⟩
Article dans une revue hal-02123769v1

Architecture et dynamique de protéines histone-like de bactérie et d’archées

Justine Largillière , Rémy Le Meur , David Ginguené , Norbert Garnier , Celine Landon
Journée BioRMN IdF, Sep 2020, Gif-sur-Yvette, France
Communication dans un congrès hal-03053296v1

Vers une description cinétique et structurale complète du mécanisme d'échange de chaînes de la protéine HU d'Escherichia coli.

Justine Largillière , Rémy Le Meur , David Ginguené , Norbert Garnier , Celine Landon
XXXIe congrès du GERM (Groupement d'Etudes de Résonance Magnétique), May 2019, Oléron, France
Communication dans un congrès hal-02361645v1

Discovery and characterization of inhibitors of the DNA repair enzymes hNEIL1 and hOGG1, pertinent therapeutic targets for cancer therapy

J. Cros , F. Coste , S. Goffinont , Virginie Nadan , V. Roy
Laboratoire International Associé, Jun 2019, Varsovie, Poland
Communication dans un congrès hal-02903108v1

Interaction de la protéine NS1 avec l’ARN : mécanismes impliqués dans la reconnaissance spécifique

A. Wacquiez , F. Coste , V. Nadan , E. Kut , Norbert Garnier
Colloque annuel de ResaFlu, Réseau français sur les virus Influenza, Mar 2019, Lyon, France
Communication dans un congrès hal-02903093v1

Impact and prediction of binding kinetics on in vivo drug efficacy

A. Braka , S. Aci-Sèche , Bourg Stéphane , Norbert Garnier , P. Bonnet
5th EFMC Young Medical Chemist Symposium, Sep 2018, Ljubljana, Slovenia
Communication dans un congrès hal-02903060v1

Développement de modulateurs des LIM kinases

Béatrice Vallée , S. Routier , A. Cosson , M. Doudeau , F. Godin
Cancéropôle Grand Ouest - 14e colloque du Réseau Produits de la mer en cancérologie - 5e colloque du Réseau Canaux ioniques et cancer, May 2018, Mansigné, France
Communication dans un congrès hal-02928559v1

Développement de petites molécules inhibitrices des LIM kinases, nouvelles cibles thérapeutiques pour lutter contre le cancer, les maladies neurologiques et la neurofibromatose

Béatrice Vallée , Karen Plé , A. Cosson , M. Doudeau , F. Godin
Journée Fédération CBM-ICOA, Jan 2018, Orléans, France
Communication dans un congrès hal-02928530v1

Sur la nature de la transition convectif/absolu de l'instabilité d'Eckhaus d'une onde non-linéaire

N. Garnier , A. Casner
2001, pp.18-20
Communication dans un congrès hal-00124009v1

To a complete kinetics and structural description of the EcHU chain exchange system

Justine Largillière , Rémy Le Meur , David Ginguené , Norbert Garnier , Celine Landon
NMR : a tool for biology XITh, Jan 2019, Paris, France
Poster de conférence hal-02362588v1

Screening, characterization and structural studies of small molecules inhibitors of the DNA glycosylase hNEIL1 and hOGG1, potential therapeutic targets in cancer and neurodegenerative disease

Julien Cros , Franck Coste , Stéphane Goffinont , Virginie Nadan , Norbert Garnier
1st French congress on Integrative Structural Biology (BSI-2019), Oct 2019, Toulouse, France
Poster de conférence hal-03385201v1

Search for small molecule inhibitors of the DNA repair enzymes hNEIL1 and hOGG1, potential therapeutic targets in cancer

J. Cros , F. Coste , S. Goffinont , V. Gaudon , V. Roy
Journée Fédération de recherche “Physique et Chimie du Vivant” FR2708 (CBM/ICOA), Apr 2019, Orléans, France
Poster de conférence hal-02903223v1

Search for small molecule inhibitors of the DNA repair enzymes hNEIL1 and hOGG1, potential therapeutic targets in cancer

J. Cros , F. Coste , S. Goffinont , V. Gaudon , V. Roy
13th French 3R meeting, May 2019, Presqu’île de Giens, France
Poster de conférence hal-02903219v1

To a complete kinetics and structural description of the EcHU chain exchange system.

Justine Largillière , Rémy Le Meur , David Ginguené , Norbert Garnier , Celine Landon
Journée Fédération de recherche “Physique et Chimie du Vivant”, Apr 2019, Orléans, France
Poster de conférence hal-02362578v1

LIM kinases, new therapeutic targets to treat cancers, neurological disorders and Neurofibromatosis: development of small molecule inhibitors

Béatrice Vallée , A. Cosson , M. Doudeau , F. Godin , A. Champiré
FEBS Meeting 2019, Jul 2019, Cracovie, Poland
Poster de conférence hal-02924140v1

LIM kinase inhibitors discovery by flexible protein high-throughput virtual screening. Structure-based design of LIM kinase inhibitors

A. Braka , S. Aci-Sèche , S. Bourg , Norbert Garnier , P. Bonnet
Journée Fédération de recherche “Physique et Chimie du Vivant” FR2708 (CBM/ICOA), Jan 2018, Orléans, France
Poster de conférence hal-02904708v1

To a complete kinetics and structural description of the EcHU chain exchange system.

Justine Largillière , Rémy Le Meur , David Ginguené , Norbert Garnier , Celine Landon
31e colloque Biotechnocentre, Oct 2018, Seillac, France
Poster de conférence hal-02362818v1

Development of small molecule inhibitors of LIM kinases, new therapeutic targets to treat Neurofibromatosis type I

Béatrice Vallée , A. Cosson , M. Doudeau , F. Godin , A. Champiré
Joint Global Neurofibromatosis Conference 2018, Nov 2018, Paris, France
Poster de conférence hal-02924077v1

Native and Intermediate conformations of the three HU dimers of E.coli.

Justine Largillière , Rémy Le Meur , Norbert Garnier , Celine Landon , A.F. Delmas
28th ICMRBS - International Council on Magnetic Resonance in Biological Systems, Aug 2018, Dublin, Ireland
Poster de conférence hal-02362585v1

Design, synthesis and biological evaluation of LIMK inhibitors

A. Champiré , A. Braka , Béatrice Vallée , M. Doudeau , F. Godin
XXIVe Journées Jeunes Chercheurs (SCT), Feb 2017, Châtenay-Malabry, France
Poster de conférence hal-02904837v1

Simulation of the protein-ligand association process for kinetics prediction

A. Braka , S. Aci-Sèche , S. Bourg , Norbert Garnier , P. Bonnet
20e congrès du Groupe de Graphisme et Modélisation Moléculaire (GGMM), May 2017, Reims, France
Poster de conférence hal-02904825v1

LIM kinases as new therapeutic targets for the treatment of neurofibromatosis type 1

A. Champiré , A. Braka , B. Vallée , M. Doudeau , F. Godin
VII International Symposium on Advances in Synthetic and Medicinal Chemistry (EFMC) –, Aug 2017, Vienne, Austria
Poster de conférence hal-02904794v1

Path-based simulation of ligand-receptor binding process for binding kinetics prediction

A. Braka , S. Aci-Sèche , S. Bourg , Norbert Garnier , P. Bonnet
XXIVe Journées Jeunes Chercheurs (SCT), Feb 2017, Châtenay-Malabry, France
Poster de conférence hal-02904830v1

Kinetic rates prediction of protein kinase inhibitors by enhanced molecular dynamics

A. Braka , S. Aci-Sèche , Norbert Garnier , S. Bourg , P. Bonnet
K4 DD Meeting - Binding kinetics: Time is of the essence, Nov 2017, Berlin, Germany
Poster de conférence hal-02904780v1

Computational study of ligand-receptor binding process using enhanced molecular dynamics simulations

A. Braka , Samia Aci-Seche , S. Bourg , Norbert Garnier , Pascal Bonnet
21st European Symposium on Quantitative Structure-Activity Relationship, Sep 2016, Vérone, Italy
Poster de conférence hal-02919149v1

Small-molecule inhibitors of Fpg/Nei DNA glycosylases, enzymes initiating the base excision repair pathway, new targets for cancer therapy

C. Rieux , F. Coste , F. Culard , S. Goffinont , S. Bourg
XXII International Roundtable on Nucleosides, Nucleotides and Nucleic Acids, Jul 2016, Paris, France
Poster de conférence hal-02919151v1

Conception, synthèse et évaluation biologique d’inhibiteurs de LIM kinases

A. Champiré , A. Braka , Béatrice Vallée , M. Doudeau , F. Godin
29e colloque de Biotechnocentre, Oct 2016, Seillac, France
Poster de conférence hal-02904847v1

Etude par simulations de dynamique moléculaire de la cinétique du processus d’association récepteur-ligand

A. Braka , S. Aci-Sèche , S. Bourg , Norbert Garnier , P. Bonnet
29e colloque de Biotechnocentre, Oct 2016, Seillac, France
Poster de conférence hal-02904842v1

Motions and correlations of the transmembrane domain of a protein receptor studied by molecular dynamics simulation

Norbert Garnier , D. Genest , M. Genest
Nonlinear excitations in biomolecules, Springer Berlin Heidelberg, pp.241-246, 1994
Chapitre d'ouvrage hal-02123780v1

Brownian dynamics close to a wall, measured by quasi-elastic light scattering from an evanescent wave

N. Ostrowsky , Norbert Garnier
Progress in colloid and polymer science, 84, Steinkopff, Heildberg, pp.371-376, 1991, Progress in Colloid & Polymer Science
Chapitre d'ouvrage hal-02123777v1