Nicolas Jonckheere

57%

Libre accès

103

Documents

Affiliations actuelles

1004619

Identifiants chercheurs

nicolasjonckheere
0000-0002-0496-0661
IdRef : 094282153

Contact

Publications

	A novel anti-galectin-9 immunotherapy limits the early progression of pancreatic neoplastic lesions in transgenic mice Alexandre Quilbe , Rami Mustapha , Belinda Duchêne , Abhishek Kumar , Elisabeth Werkmeister Frontiers in Immunology, 2023, 14, pp.1267279. ⟨10.3389/fimmu.2023.1267279⟩ Article dans une revue hal-04469183v1
	Metabolism of pancreatic neuroendocrine tumors: what can omics tell us? Arnaud Jannin , Anne-Frédérique Dessein , Christine Do Cao , Marie-Christine Vantyghem , Benjamin Chevalier Frontiers in Endocrinology, 2023, 14, ⟨10.3389/fendo.2023.1248575⟩ Article dans une revue hal-04273585v1
	Inositol (1,4,5)-Trisphosphate Receptors in Invasive Breast Cancer: A New Prognostic Tool? Arthur Foulon , Pierre Rybarczyk , Nicolas Jonckheere , Eva Brabencova , Henri Sevestre International Journal of Molecular Sciences, 2022, 23 (6), pp.2962. ⟨10.3390/ijms23062962⟩ Article dans une revue hal-04326232v1
	TRPM7 Modulates Human Pancreatic Stellate Cell Activation. Julie Auwercx , Philippe Kischel , Thibaut Lefebvre , Nicolas Jonckheere , Alison Vanlaeys Cells, 2022, 11 (14), pp.2255. ⟨10.3390/cells11142255⟩ Article dans une revue hal-03740502v1
	Evaluation of the expression of fatty acid synthase and O ‑GlcNAc transferase in patients with liver cancer by exploration of transcriptome databases and experimental approaches Sadia Raab , Ninon Very , Belinda Duchêne , Pierre Rybarczyk , Nicolas Jonckheere Oncology Letters, 2022, 23 (4), pp.105. ⟨10.3892/ol.2022.13225⟩ Article dans une revue hal-03608015v2
	Antagonistic Roles of the Tumor Suppressor miR-210-3p and Oncomucin MUC4 Forming a Negative Feedback Loop in Pancreatic Adenocarcinoma Nihad Boukrout , Mouloud Souidi , Fatima Lahdaoui , Belinda Duchêne , Bernadette Neve Cancers, 2021, 13 (24), pp.6197. ⟨10.3390/cancers13246197⟩ Article dans une revue hal-03777017v1
	The EGF Domains of MUC4 Oncomucin Mediate HER2 Binding Affinity and Promote Pancreatic Cancer Cell Tumorigenesis Nicolas Stoup , Maxime Liberelle , Céline Schulz , Sumeyye Cavdarli , Romain Vasseur Cancers, 2021, 13 (22), pp.5746. ⟨10.3390/cancers13225746⟩ Article dans une revue hal-03641795v1
	A new pancreatic adenocarcinoma‐derived organoid model of acquired chemoresistance to FOLFIRINOX: first insight of the underlying mechanisms Elsa Hadj Bachir , Charles Poiraud , Sonia Paget , Nicolas Stoup , Soumaya El Moghrabi Biology of the Cell, 2021, 114 (1), pp.32-55. ⟨10.1111/boc.202100003⟩ Article dans une revue hal-03369738v1
	Mg2+ Transporters in Digestive Cancers Julie Auwercx , Pierre Rybarczyk , Philippe Kischel , Isabelle Dhennin-Duthille , Denis Chatelain Nutrients, 2021, 13 (1), pp.210. ⟨10.3390/nu13010210⟩ Article dans une revue hal-03195960v1
	Mucin expression, epigenetic regulation and patient survival: A toolkit of prognostic biomarkers in epithelial cancers Nicolas Jonckheere , Audrey Vincent , Bernadette Neve , Isabelle van Seuningen Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2021, 1876 (1), pp.188538. ⟨10.1016/j.bbcan.2021.188538⟩ Article dans une revue hal-03294583v1
	EGF-Containing Membrane-Bound Mucins: A Hidden ErbB2 Targeting Pathway? Maxime Liberelle , Nicolas Jonckheere , Patricia Melnyk , Isabelle van Seuningen , Nicolas Lebègue Journal of Medicinal Chemistry, 2020, 63 (10), pp.5074-5088. ⟨10.1021/acs.jmedchem.9b02001⟩ Article dans une revue hal-02955348v1
	Unsupervised Hierarchical Clustering of Pancreatic Adenocarcinoma Dataset from TCGA Defines a Mucin Expression Profile that Impacts Overall Survival Nicolas Jonckheere , Julie Auwercx , Elsa Hadj Bachir , Lucie Coppin , Nihad Boukrout Cancers, 2020, 12 (11), pp.3309. ⟨10.3390/cancers12113309⟩ Article dans une revue hal-03003452v2
	Long non-coding RNAs: the tentacles of chromatin remodeler complexes Bernadette Neve , Nicolas Jonckheere , Audrey Vincent , Isabelle van Seuningen Cellular and Molecular Life Sciences, 2020, 78 (4), pp.1139-1161. ⟨10.1007/s00018-020-03646-0⟩ Article dans une revue hal-03195963v1
	Long-term consequences of one anastomosis gastric bypass on esogastric mucosa in a preclinical rat model Matthieu Siebert , Lara Ribeiro-Parenti , Nicholas Nguyen , Muriel Hourseau , Belinda Duchêne Scientific Reports, 2020, 10 (1), ⟨10.1038/s41598-020-64425-2⟩ Article dans une revue hal-02617527v1
	Fine-tuning autophagy in pancreatic adenocarcinoma: full blockage is required Nicolas Jonckheere , Isabelle van Seuningen Annals of translational medicine, 2019, 7 (S1), pp.S43-S43. ⟨10.21037/atm.2019.03.01⟩ Article dans une revue inserm-02341315v1
	TGF-βRII Knock-down in Pancreatic Cancer Cells Promotes Tumor Growth and Gemcitabine Resistance. Importance of STAT3 Phosphorylation on S727 Vincent Drubay , Nicolas Skrypek , Lucie Cordiez , Romain Vasseur , Céline Schulz Cancers, 2018, 10 (8), pii: E254. ⟨10.3390/cancers10080254⟩ Article dans une revue inserm-02341320v1
	Epigenetic Regulation by lncRNAs: An Overview Focused on UCA1 in Colorectal Cancer Bernadette Neve , Nicolas Jonckheere , Audrey Vincent , Isabelle van Seuningen Cancers, 2018, 10 (11), pp.440. ⟨10.3390/cancers10110440⟩ Article dans une revue inserm-02341333v1
	Integrative analysis of the cancer genome atlas and cancer cell lines encyclopedia large-scale genomic databases: MUC4/MUC16/MUC20 signature is associated with poor survival in human carcinomas. Nicolas Jonckheere , Isabelle van Seuningen Journal of Translational Medicine, 2018, 16 (1), pp.259. ⟨10.1186/s12967-018-1632-2⟩ Article dans une revue hal-02341297v1
	Depletion of MUC5B mucin in gastrointestinal cancer cells alters their tumorigenic properties: implication of the Wnt/β-catenin pathway Fatima Lahdaoui , Mathieu Messager , Audrey Vincent , Flora Hec , Anne Gandon Biochemical Journal, 2017, 474 (22), pp.3733-3746. ⟨10.1042/BCJ20170348⟩ Article dans une revue inserm-02341337v1
	The cornerstone K-RAS mutation in pancreatic adenocarcinoma: From cell signaling network, target genes, biological processes to therapeutic targeting Nicolas Jonckheere , Romain Vasseur , Isabelle Van Seuningen Critical Reviews in Oncology/Hematology, 2017, 111, pp.7-19. ⟨10.1016/j.critrevonc.2017.01.002⟩ Article dans une revue inserm-02341607v1
	Flagellin-Mediated Protection against Intestinal Yersinia pseudotuberculosis Infection Does Not Require Interleukin-22. Rémi Porte , Laurye van Maele , Natalia Muñoz-Wolf , Benoit Foligné , Laure Dumoutier Infection and Immunity, 2017, 85 (2), pp.e00806-16. ⟨10.1128/IAI.00806-16⟩ Article dans une revue inserm-01529315v1
	Overexpression of chemokine receptor CXCR2 and ligand CXCL7 in liver metastases from colon cancer is correlated to shorter disease-free and overall survival Thibault Desurmont , Nicolas Skrypek , Alain Duhamel , Nicolas Jonckheere , Guillaume Millet Cancer Science, 2015, 106 (3), pp.262-269. ⟨10.1111/cas.12603⟩ Article dans une revue hal-02954490v1
	Micro-RNAs miR-29a and miR-330-5p function as tumor suppressors by targeting the MUC1 mucin in pancreatic cancer cells Solange Tréhoux , Fatima Lahdaoui , Yannick Delpu , Florence Renaud , Emmanuelle Leteurtre Biochimica et Biophysica Acta - Molecular Cell Research, 2015, ⟨10.1016/j.bbamcr.2015.05.033⟩ Article dans une revue hal-02905657v1
	Cryosectioning the intestinal crypt-villus axis: An ex vivo method to study the dynamics of epigenetic modifications from stem cells to differentiated cells Audrey Vincent , Catherine Kazmierczak , Belinda Duchêne , Nicolas Jonckheere , Emmanuelle Leteurtre Stem Cell Research, 2015, 14, ⟨10.1016/j.scr.2014.12.002⟩ Article dans une revue hal-02905864v1
	The mucin MUC4 is a transcriptional and post-transcriptional target of K-ras oncogene in pancreatic cancer. Implication of MAPK/AP-1, NF-κB and RalB signaling pathways Romain Vasseur , Nicolas Skrypek , Belinda Duchêne , Florence Renaud , Daniel Martínez-Maqueda Biochimica et Biophysica Acta - Gene Regulatory Mechanisms , 2015, 1849 (12), pp.1375-1384. ⟨10.1016/j.bbagrm.2015.10.014⟩ Article dans une revue hal-02906327v1
	miR-219-1-3p is a negative regulator of the mucin MUC4 expression and is a tumor suppressor in pancreatic cancer F Lahdaoui , Y Delpu , A. Vincent , F. Renaud , M Messager Oncogene, 2015, 34, pp.780 - 788. ⟨10.1038/onc.2014.11⟩ Article dans une revue hal-02905857v1
	Targeting MUC4 in pancreatic cancer: miRNAs Nicolas Jonckheere , Fatima Lahdaoui , Isabelle van Seuningen Oncoscience, 2015, 2 (10), pp.799-800. ⟨10.18632/oncoscience.249⟩ Article dans une revue hal-02905858v1
	The oncogenic receptor ErbB2 modulates gemcitabine and irinotecan/SN-38 chemoresistance of human pancreatic cancer cells via hCNT1 transporter and multidrug-resistance associated protein MRP-2 Nicolas Skrypek , Romain Vasseur , Audrey Vincent , Bélinda Duchêne , Isabelle van Seuningen Oncotarget, 2015, 6 (13), pp.10853-1067. ⟨10.18632/oncotarget.3414⟩ Article dans une revue inserm-02341515v1
	The MUC1 mucin regulates the tumorigenic properties of human esophageal adenocarcinomatous cells Caroline Gronnier , Emilie Bruyère , Fatima Lahdaoui , Nicolas Jonckheere , Michael Perrais Biochimica et Biophysica Acta - Molecular Cell Research, 2014, ⟨10.1016/j.bbamcr.2014.06.021⟩ Article dans une revue hal-02905652v1
	Comment on: Functional MUC4 suppress epithelial-mesenchymal transition in lung adenocarcinoma metastasis. Gao L, Liu J, Zhang B, Zhang H, Wang D, Zhang T, Liu Y, Wang C. Tumour Biol. 2013, in press Nicolas Jonckheere , Isabelle van Seuningen Tumor Biology, 2014, 35 (4), pp.3941-3942. ⟨10.1007/s13277-013-1390-y⟩ Article dans une revue inserm-02371186v1
	Of autophagy and in vivo pancreatic carcinogenesis: The p53 status matters! Nicolas Jonckheere , Audrey Vincent , Isabelle Van Seuningen Clinics and Research in Hepatology and Gastroenterology, 2014, 38 (4), pp.423-425. ⟨10.1016/j.clinre.2014.04.009⟩ Article dans une revue inserm-02341594v1
	Mucins and tumor resistance to chemotherapeutic drugs Nicolas Jonckheere , Nicolas Skrypek , Isabelle Van Seuningen Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2014, 1846 (1), pp.142-151. ⟨10.1016/j.bbcan.2014.04.008⟩ Article dans une revue inserm-02341531v1
	The MUC1 oncomucin regulates pancreatic cancer cell biological properties and chemoresistance. Implication of p42-44 MAPK, Akt, Bcl-2 and MMP13 pathways Solange Tréhoux , Bélinda Duchêne , Nicolas Jonckheere , Isabelle van Seuningen Biochemical and Biophysical Research Communications, 2014, ⟨10.1016/j.bbrc.2014.12.025⟩ Article dans une revue hal-02905690v1
	Helicobacter pylori urease and flagellin alter mucin gene expression in human gastric cancer cells Michael Perrais , Christel Rousseaux , Marie-Paule Ducourouble , René Courcol , Pascal Vincent Gastric Cancer, 2014, 17, pp.235-246. ⟨10.1007/s10120-013-0267-5⟩ Article dans une revue hal-02905802v1
	Membrane-bound mucin modular domains: from structure to function. Nicolas Jonckheere , Nicolas Skrypek , Frédéric Frénois , Isabelle van Seuningen Biochimie, 2013, 95 (6), pp.1077-86. ⟨10.1016/j.biochi.2012.11.005⟩ Article dans une revue inserm-00807818v1
	The MUC4 mucin mediates gemcitabine resistance of human pancreatic cancer cells via the Concentrative Nucleoside Transporter family. Nicolas Skrypek , Bélinda Duchêne , Mohamed Hebbar , Emmanuelle Leteurtre , Isabelle van Seuningen Oncogene, 2013, 32 (13), pp.1714-23. ⟨10.1038/onc.2012.179⟩ Article dans une revue inserm-00807837v1
	Membrane-bound mucin modular domains: From structure to function Nicolas Jonckheere , Frédéric Frénois , Isabelle van Seuningen , Nicolas Q1 , Nicolas Skrypek Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2012, ⟨10.1016/j.biochi.2012.11.005⟩ Article dans une revue hal-02905700v1
	Tif1γ Suppresses Murine Pancreatic Tumoral Transformation by a Smad4-Independent Pathway David Vincent , Johann Gout , Nicolas Chuvin , Vanessa Arfi , Roxane M. Pommier American Journal of Pathology, 2012, 180 (6), pp.2214-2221. ⟨10.1016/j.ajpath.2012.02.006⟩ Article dans une revue hal-02954464v1
	GATA-4/-6 and HNF-1/-4 families of transcription factors control the transcriptional regulation of the murine Muc5ac mucin during stomach development and in epithelial cancer cells. Nicolas Jonckheere , Audrey Vincent , Hélène Franquet-Ansart , Janneke Witte-Bouma , Anita Korteland-van Male BBA - Biochimica et Biophysica Acta, 2012, 1819 (8), pp.869-76. ⟨10.1016/j.bbagrm.2012.04.003⟩ Article dans une revue inserm-00807845v1
	The mucin MUC4 and its membrane partner ErbB2 regulate biological properties of human CAPAN-2 pancreatic cancer cells via different signalling pathways. Nicolas Jonckheere , Nicolas Skrypek , Johann Merlin , Anne Frédérique Dessein , Patrick Dumont PLoS ONE, 2012, 7 (2), pp.e32232. ⟨10.1371/journal.pone.0032232⟩ Article dans une revue inserm-00807830v1
	The mouse Muc5b mucin gene is transcriptionally regulated by thyroid transcription factor-1 (TTF-1) and GATA-6 transcription factors. Nicolas Jonckheere , Amélie Velghe , Marie-Paule Ducourouble , Marie-Christine Copin , Ingrid B. Renes FEBS Journal, 2011, 278 (2), pp.282-94. ⟨10.1111/j.1742-4658.2010.07945.x⟩ Article dans une revue inserm-00807850v1
	The MUC4 membrane-bound mucin regulates esophageal cancer cell proliferation and migration properties: Implication for S100A4 protein Emilie Bruyère , Nicolas Jonckheere , Frédéric Frénois , Christophe Mariette , Isabelle van Seuningen Biochemical and Biophysical Research Communications, 2011, pp.325-329. ⟨10.1016/j.bbrc.2011.08.095⟩ Article dans une revue hal-02905689v1
	Mucins and Pancreatic Cancer Nicolas Jonckheere , Nicolas Skrypek , Isabelle van Seuningen Cancers, 2010, 2, pp.1794-1812. ⟨10.3390/cancers2041794⟩ Article dans une revue inserm-00807873v1
	Autocrine Induction of Invasive and Metastatic Phenotypes by the MIF-CXCR4 Axis in Drug-Resistant Human Colon Cancer Cells Anne-Frédérique Dessein , Laurence Stechly , Nicolas Jonckheere , Patrick Dumont , Didier Monté Cancer Research, 2010, 70 (11), pp.4644-4654. ⟨10.1158/0008-5472.CAN-09-3828⟩ Article dans une revue hal-02106460v1
	The membrane-bound mucins: From cell signalling to transcriptional regulation and expression in epithelial cancers Nicolas Jonckheere , Isabelle van Seuningen Biochimie, 2009, ⟨10.1016/j.biochi.2009.09.018⟩ Article dans une revue hal-02905696v1
	Tumour growth and resistance to gemcitabine of pancreatic cancer cells are decreased by AP-2alpha overexpression. Nicolas Jonckheere , Valérie Fauquette , Laurence Stechly , Nathalie Saint-Laurent , Sébastien Aubert British Journal of Cancer, 2009, 101 (4), pp.637-44. ⟨10.1038/sj.bjc.6605190⟩ Article dans une revue inserm-00410436v1
	The Membrane-Bound Mucins: How Large O-Glycoproteins Play Key Roles in Epithelial Cancers and Hold Promise as Biological Tools for Gene-Based and Immunotherapies Nicolas Jonckheere , Isabelle Van Seuningen Critical Review in Oncogenesis, 2008, 14 (2-3), pp.177-196. ⟨10.1615/CritRevOncog.v14.i2-3.30⟩ Article dans une revue hal-02905788v1
	Analysis of mPygo2 mutant mice suggests a requirement for mesenchymal Wnt signaling in pancreatic growth and differentiation Nicolas Jonckheere , Erin Mayes , Hung-Ping Shih , Boan Li , Oleg Lioubinski Developmental Biology, 2008, 318 (2), pp.224-235. ⟨10.1016/j.ydbio.2008.03.014⟩ Article dans une revue hal-02954468v1
	The Human Mucin MUC4 Is Transcriptionally Regulated by Caudal-related Homeobox, Hepatocyte Nuclear Factors, Forkhead Box A, and GATA Endodermal Transcription Factors in Epithelial Cancer Cells Nicolas Jonckheere , Audrey Vincent , Michaël Perrais , Marie-Paule Ducourouble , Anita Korteland-van Male Journal of Biological Chemistry, 2007, ⟨10.1074/jbc.M700905200⟩ Article dans une revue hal-02905844v1
	Regulation of the human mucin MUC4 by taurodeoxycholic and taurochenodeoxycholic bile acids in oesophageal cancer cells is mediated by hepatocyte nuclear factor 1α Guillaume Piessen , Nicolas Jonckheere , Audrey Vincent , Brigitte Hemon , Marie-Paule Ducourouble Biochemical Journal, 2007, 402, pp.81 - 91. ⟨10.1042/BJ20061461⟩ Article dans une revue hal-02905759v1
	Evidence for a functional genetic polymorphism of the human retinoic acid–metabolizing enzyme CYP26A1, an enzyme that may be involved in spina bifida Emmanuel Rat , Ingrid Billaut-Laden , Delphine Allorge , Jean-Marc Lo-Guidice , Marie Tellier Birth Defects Research Part A: Clinical and Molecular Teratology, 2006, 76 (6), pp.491-498. ⟨10.1002/bdra.20275⟩ Article dans une revue hal-02954484v1
	Regulation of the human mucin MUC4 by taurodeoxycholic and taurochenodeoxycholic bile acids in oesophageal cancer cells is mediated by hepatocyte nuclear factor 1{alpha} Guillaume Piessen , Nicolas Jonckheere , Audrey Vincent , Brigitte Hémon , Marie-Paule Ducourouble Biochemical Journal, 2006, 402 (1), pp.81-91. ⟨10.1042/BJ20061461⟩ Article dans une revue hal-00478670v1
	The antagonistic regulation of human MUC4 and ErbB-2 genes by the Ets protein PEA3 in pancreatic cancer cells: implications for the proliferation/differentiation balance in the cells Valérie Fauquette , Michael Perrais , Sylvain Cerulis , Nicolas Jonckheere , Marie-Paule Ducourouble Biochemical Journal, 2005, 386, pp.35 - 45 Article dans une revue hal-02905757v1
	The antagonistic regulation of human MUC4 and ErbB-2 genes by the Ets protein PEA3 in pancreatic cancer cells: implications for the proliferation/differentiation balance in the cells Valérie Fauquette , Michael Perrais , Sylvain Cerulis , Nicolas Jonckheere , Marie-Paule Ducourouble Biochemical Journal, 2005, 386 (1), pp.35-45. ⟨10.1042/BJ20040706⟩ Article dans une revue hal-02954487v1
	The murine Muc2 mucin gene is transcriptionally regulated by the zinc-finger GATA-4 transcription factor in intestinal cells Maria van Der Sluis , Monique H M Melis , Nicolas Jonckheere , Marie-Paule Ducourouble , Hans A Bü Ller A Biochemical and Biophysical Research Communications, 2004, 325, pp.952 - 960. ⟨10.1016/j.bbrc.2004.10.108⟩ Article dans une revue hal-02905675v1
	Transcriptional activation of the murine Muc5ac mucin gene in epithelial cancer cells by TGF-β/Smad4 signalling pathway is potentiated by Sp1 Nicolas Jonckheere , Maria van Der Sluis , Amélie Velghe , Marie-Pierre Buisine , Marjolein Sutmuller Biochemical Journal, 2004, 377, pp.797 - 808 Article dans une revue hal-02905715v1
	Transcriptional regulation of human mucin MUC4 by bile acids in oesophageal cancer cells is promoter-dependent and involves activation of the phosphatidylinositol 3-kinase signalling pathway Michael Perrais , Brigitte Hemon , Isabelle van Seuningen , Christophe Mariette , Michaël Perrais Biochemical Journal, 2004, 377, pp.701 - 708 Article dans une revue hal-02905748v1
	Transcriptional activation of the murine Muc5ac mucin gene in epithelial cancer cells by TGF-β/Smad4 signalling pathway is potentiated by Sp1 Nicolas Jonckheere , Maria van Der Sluis , Amélie Velghe , Marie-Pierre Buisine , Marjolein Sutmuller Biochemical Journal, 2004, 377, pp.797 - 808. ⟨10.1042/BJ20030948⟩ Article dans une revue hal-02905751v1
	A role for human MUC4 mucin gene, the ErbB2 ligand, as a target of TGF-b in pancreatic carcinogenesis Nicolas Jonckheere , Michael Perrais , Christophe Mariette , Surinder K Batra , Jean-Pierre Aubert Oncogene, 2004, 23, pp.5729 - 5738. ⟨10.1038/sj.onc.1207769⟩ Article dans une revue hal-02905851v1
	Transcriptional regulation of human mucin MUC4 by bile acids in oesophageal cancer cells is promoter-dependent and involves activation of the phosphatidylinositol 3-kinase signalling pathway Christophe Mariette , Michael Perrais , Emmanuelle Leteurtre , Nicolas Jonckheere , Brigitte Hemon Biochemical Journal, 2004, 377, pp.701 - 708 Article dans une revue hal-02905712v1
	Transcriptional regulation of human mucin MUC4 by bile acids in oesophageal cancer cells is promoter-dependent and involves activation of the phosphatidylinositol 3-kinase signalling pathway Christophe Mariette , Michaël Perrais , Emmanuelle Leteurtre , Nicolas Jonckheere , Brigitte Hémon Biochemical Journal, 2004, 377 (3), pp.701-708. ⟨10.1042/bj20031132⟩ Article dans une revue hal-03314562v1
	Human MUC2 Mucin Gene Is Transcriptionally Regulated by Cdx Homeodomain Proteins in Gastrointestinal Carcinoma Cell Lines Patrícia Mesquita , Nicolas Jonckheere , Raquel Almeida , Marie-Paule Ducourouble , Jacinta Serpa Journal of Biological Chemistry, 2003, ⟨10.1074/jbc.M309019200⟩ Article dans une revue hal-02905842v1

	Deciphering and targeting GD2 ganglioside O-Acetylation pathways in neuroectoderm-derived cancers Angélina Kasprowicz , Sumeyye Cavdarli , Christine Bal , Tiziano Ingegnere , Silvia Gaggero 15èmes Journées scientifiques du Cancéropôle Nord-Ouest (CNO) 2023., 2023, Deauville, France Poster de conférence hal-04466124v1
	Acquisition d’un phénotype myofibroblastique par les cellules stellaires pancréatiques exposées au cadmium. Mathilde Fourgeaud , Sara Agrane , Océane Dusailly , Sylvie Brassart-Pasco , Julie Auwercx Club Français du Pancréas, 2023, Lille, France Poster de conférence hal-04466501v1
	Bioinformatics identification of key regulators associated with MUC4 expression in pancreatic adenocarcinoma. Nicolas Jonckheere , Julie Auwercx , Elsa Hadj Bachir , Lucie Coppin , Audrey Vincent Mucins in health and Disease, Jul 2022, Utrecht (Netherland), Netherlands Poster de conférence hal-04465160v1
	Deciphering and targeting GD2 ganglioside O-Acetylation pathways in neuroectoderm-derived cancers Angélina Kasprowicz , Sumeyye Cavdarli , Christine Bal , Tiziano Ingegnere , Silvia Gaggero 1 st ONCOLille days, Oct 2022, Deauville, France Poster de conférence hal-04466201v1
	L’alpha-kinase de TRPM7: comprendre son rôle dans les propriétés invasives de l’adénocarcinome canalaire pancréatique Julie Auwercx , Alison Vanlaeys , Isabelle Dhennin-Duthille , Philippe Kischel , Frédéric Hague Journées scientifiques du Cancéropôle Nord-Ouest (CNO) 2022, 2022, Deauville, France Poster de conférence hal-04465802v1
	MUC4 interactants: to infinity and beyond. Nicolas Stoup , Tristan Girgin , Maxime Liberelle , Leila Moum , Nicolas Jonckheere Mucins in health and Disease, Jul 2022, Utrecht (Netherland), Netherlands Poster de conférence hal-04465179v1
	Établissement d’une signature prédictive de la survie globale des patients atteints de cancer colique basée sur le profil d’expression d’enzymes responsables de modifications épigénétiques. Elsa Hadj Bachir , Bernadette Neve , Guillaum Piessen , Emmanuelle Leteurtre , Florence Renaud Journées scientifiques du Cancéropôle Nord-Ouest (CNO) 2022, 2022, Deauville, France Poster de conférence hal-04465808v1
	Abstract 2965: Epigenetic mechanisms involved in acquired resistance to combined chemotherapies in digestive cancer cells Elsa Hadj Bachir , Charles Poiraud , Hugo Claux , Soumaya El Moghrabi , Sonia Paget AACR Annual Meeting 2022, 2022, New Orleans (Louisiana), United States. 82 (12_Supplement), pp.2965-2965, 2022, ⟨10.1158/1538-7445.AM2022-2965⟩ Poster de conférence hal-04465616v1
	Le rôle du domaine kinase de TRPM7 : A la recherche de nouveaux partenaires d’interaction dans l’adénocarcinome canalaire pancréatique. Julie Auwercx , Alison Vanlaeys , Frédéric Hague , Philippe Kischel , Bernadette Neve Club Français du Pancréas, 2021, Bron, France Poster de conférence hal-04465863v1
	MAGNESIUM TRANSPORTERS EXPRESSION AND PROGNOSTIC IMPACT IN DIGESTIVE CANCERS Julie Auwercx , Pierre Rybarczyk , Philippe Kischel , Isabelle Dhennin-Duthille , Denis Chatelain Future Physiology 2021, Apr 2021, On line conference, United Kingdom Poster de conférence hal-04465644v1
	Abstract LB106: The EGF domains of MUC4 oncomucin interact with ErbB2 and mediate tumorigenic activity of cancer cells represent new potential therapeutic targets Nicolas Stoup , Maxime Liberelle , Céline Schulz , Romain Vasseur , Romain Magnez AACR Annual Meeting 2021, 2021, Philadelphia, United States. 81 (13_Supplement), pp.LB106-LB106, 2021, ⟨10.1158/1538-7445.AM2021-LB106⟩ Poster de conférence hal-04465601v1
	Expression des transporteurs au magnésium et impact pronostic dans les cancers digestifs. Julie Auwercx , Pierre Rybarczyk , Philippe Kischel , Isabelle Dhennin-Duthille , Denis Chatelain Journées scientifiques du Cancéropôle Nord-Ouest (CNO) 2021, 2021, Deauville, France Poster de conférence hal-04465849v1
	Evaluation in vitro et in vivo d'une Nouvelle Stratégie d’Immunothérapie ciblant la Galectine-9 dans un modèle de cancer pancréatique. Alexandre Quilbe , Rami Mustapha , S Renaud , Belinda Duchêne , Clémentine de Schutter 12èmes journées scientifiques du Cancéropôle Nord-Ouest, 2019, Deauville, France Poster de conférence hal-04466053v1
	Roles of the MUC4-miRNA loop in pancreatic carcinogenesis and chemoresistance. Nihad Boukrout , Fatima Lahdaoui , Céline Schulz , Romain Vasseur , Belinda Duchêne 12èmes journées scientifiques du Cancéropôle Nord-Ouest, 2019, Deauville, France Poster de conférence hal-04466063v1
	Roles of the MUC4-miRNA loop in pancreatic carcinogenesis and chemoresistance. Nihad Boukrout , Fatima Lahdaoui , Céline Schulz , Romain Vasseur , Belinda Duchêne 11èmes journées scientifiques du Cancéropôle Nord-Ouest, 2018, Deauville, France Poster de conférence hal-04466077v1
	Evaluation of a New Anti-Galectin 9 Immunotherapy Strategy in Pancreatic Cancers. Alexandre Quilbe , Rami Mustapha , S Renaud , Belinda Duchêne , Clémentine de Schutter 11èmes journées scientifiques du Cancéropôle Nord-Ouest, 2018, Deauville, France Poster de conférence hal-04466070v1

	L’alpha-kinase de TRPM7 : un acteur impliqué dans la migration, l’invasion et la TEM des cellules cancéreuses pancréatiques humaines. Julie Auwercx , Bernadette Neve , Alison Vanlaeys , Sylvie Brassart-Pasco , Mathilde Fourgeaud 15èmes journées scientifiques du Cancéropôle Nord-Ouest, Deauville, 2023., 2023, Deauville, France Communication dans un congrès hal-04466150v1
	In Vitro Study of the Role of TRPM7 Kinase in Metastatic Mechanisms of Pancreatic Cancer Cells. Julie Auwercx , Alison Vanlaeys , Frédéric Hague , Isabelle Dhennin-Duthille , Philippe Kischel 1 st ONCOLille days, Oct 2022, Lille, France Communication dans un congrès hal-04466179v1
	TRPM7 Modulates Human Pancreatic Stellate Cell Activation. Julie Auwercx , Philippe Kischel , Thibault Lefebvre , Nicolas Jonckheere , Alison Vanlaeys XVI International Magnesium Symposium (SDRM)., Jun 2022, Glasgow, United Kingdom Communication dans un congrès hal-04465334v1
	MUC4 oncomucin and pancreatic carcinogenesis: The NeverEnding Story Nicolas Jonckheere Seminar CANTHER, Nov 2021, Lille (France), France Communication dans un congrès inserm-04541455v1
	Magnesium transporters: discovering new potential biomarkers in digestive cancers. Julie Auwercx , Pierre Rybarczyk , Philippe Kischel , Isabelle Dhennin-Duthille , Denis Chatelain XV International Magnesium Symposium (SDRM)., Jun 2021, online virtual meeting, United Kingdom Communication dans un congrès hal-04465355v1
	Pnliprp1 hypermethylation in human exocrine pancreas reveals a link between diabetes and pancreatic cancer Amna Khamis , Mickael Canouil , Lorella Marselli , Raphaël Boutry , Mara Suleiman 56th Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD)., 2020, virtual meeting, United Kingdom Communication dans un congrès hal-04465919v1
	Evaluation of a New Anti-Galectin 9 Immunotherapy Strategy in Pancreatic Cancers. Alexandre Quilbe , Rami Mustapha , Belinda Duchêne , S Renaud , Clémentine de Schutter Club Français du Pancréas, 2019, Bron, France Communication dans un congrès hal-04465692v1
	Roles of MUC4-miR-210 in pancreatic carcinogenesis and Chemotherapy resistance. Nihad Boukrout , Fatima Lahdaoui , Céline Schulz , Romain Vasseur , Belinda Duchêne Mucins in health and disease (15th International Workshop on Carcinoma-associated Mucins), 2019, Cambridge, United Kingdom Communication dans un congrès hal-04465368v1
	Roles of MUC4 mucin and ErbB2 receptor in pancreatic carcinogenesis and chemoresistance. Nicolas Jonckheere Seminar NAmur Research Institute for LIfe Sciences (NARILIS), Apr 2019, Namur, Belgium Communication dans un congrès inserm-04541450v1
	MUC4 dans la résistance aux traitements chimiothérapeutiques et voies de signalisations associées Nicolas Jonckheere 1ère journée de recherche : signalisation oncogénique et canaux ioniques du cancéropole Nord Ouest, 2018, Amiens (Somme), France Communication dans un congrès inserm-04541452v1
	Strategy of inhibition of TRPM7 channel in pancreatic cancer cells by CRISPR/Cas9. Alison Vanlaeys , Bernadette Neve , Mouloud Souidi , Isabelle van Seuningen , Halima Ouadid-Ahidouch 4ème Journée Scientifique de l’Association pour la Recherche sur le Cancer du pancréas (AFRCP), 2018, Clichy, France Communication dans un congrès hal-04465699v1
	Evaluation of a New Anti-Galectin 9 Immunotherapy Strategy in Pancreatic Cancers Alexandre Quilbe , Rami Mustapha , S Renaud , Belinda Duchêne , Clémentine de Schutter 4ème Journée Scientifique de l’Association pour la Recherche sur le Cancer du pancréas (AFRCP), 2018, Clichy, France Communication dans un congrès hal-04465715v1
	Evaluation of a New Anti-Galectin 9 Immunotherapy Strategy in Pancreatic Cancers Alexandre Quilbe , Rami Mustapha , S Renaud , Belinda Duchêne , Clémentine de Schutter 5th European Congress of Immunology, 2018, Amsterdam, Netherlands Communication dans un congrès hal-04465749v1
	Evaluation of a New Anti-Galectin 9 Immunotherapy Strategy in Pancreatic Cancers Alexandre Quilbe , Rami Mustapha , S Renaud , Belinda Duchêne , Clémentine de Schutter 11èmes journées scientifiques du Cancéropole Nord Ouest, 2018, Deauville, France Communication dans un congrès hal-04465768v1
	MUC4, chimioresistance et cancérogenèse pancréatique Nicolas Jonckheere Séminaire JPARC., Apr 2016, Lille, France Communication dans un congrès hal-04543891v1
	MUC4, Cancérogenèse pancréatique et chimiorésistance Nicolas Jonckheere Séminaire Unité de Glycobiologie Structurale et Fonctionnelle (UGSF)., Oct 2016, Villeneuve d'Ascq, France Communication dans un congrès hal-04543882v1
	MUC4, Cancérogenèse pancréatique et chimiorésistance. Nicolas Jonckheere Journées scientifiques SFR Cancer 2016., LPCM, Sep 2016, Amiens (Université Picardie Jules Verne), France Communication dans un congrès hal-04543885v1
	The MUC4 membrane-bound mucin mediates FOLFIRINOX drugs resistance of human pancreatic cancer cells. Nicolas Skrypek , Luc Kotzmann , Romain Vasseur , Fatima Lahdaoui , Belinda Duchêne Mucins in health and disease (13th International Workshop on Carcinoma-associated Mucins), 2015, Cambridge, United Kingdom Communication dans un congrès hal-04465781v1
	Rôle du complexe MUC4-ErbB2 dans la cancérogenèse pancréatique Nicolas Jonckheere SFR Cap-Santé, Jan 2015, Amiens (Université Picardie Jules Verne), France Communication dans un congrès hal-04543908v1
	Rôle et ciblage du complexe MUC4-ErbB2. Nicolas Jonckheere Journée scientifique « Résistance » SIRIC ONCOLille., SIRIC ONCOLille, Jun 2015, Lille (FR), France Communication dans un congrès hal-04543904v1
	The MUC4-ErbB2 complex and its role in pancreatic carcinogenesis Nicolas Jonckheere Séminaire, Institut de Recherche sur le Cancer de Montpellier, Nov 2014, Montpellier (34000), France Communication dans un congrès hal-04543929v1

	The EGF domains of MUC4 oncomucin interact with ErbB2 and mediate tumorigenic activity of cancer cells represent new potential therapeutic targets Nicolas Stoup , Maxime Liberelle , Céline Schulz , Romain Vasseur , Romain Magnez 2023 Pré-publication, Document de travail hal-04338884v1
	TGF-βRII knock-down promotes tumor growth and chemoresistance to gemcitabine of pancreatic cancer cells via phosphorylation of STAT3 Vincent Drubay , Nicolas Skrypek , Lucie Cordiez , Romain Vasseur , Céline Schulz 2020 Pré-publication, Document de travail hal-02954689v1

	Single-Cell Analysis May Shed New Lights on the Role of LncRNAs in Chemoresistance in Gastrointestinal Cancers Bernadette Neve , Nicolas Jonckheere , Audrey Vincent , Isabelle van Seuningen The Chemical Biology of Long Noncoding RNAs, 11, Springer International Publishing, pp.229-253, 2020, RNA Technologies, ⟨10.1007/978-3-030-44743-4_9⟩ Chapitre d'ouvrage inserm-04541444v1
	Reporter, Inducible And Synthetic Promoters: Engineering Tools To Study Gene Regulation And Biological Systems Nicolas Jonckheere , Isabelle Van Seuningen The Analysis of Regulatory DNA: Current Developments, Knowledge and Applications Uncovering Gene Regulation, BENTHAM SCIENCE PUBLISHERS, pp.149-161, 2013, ⟨10.2174/9781608054923113010010⟩ Chapitre d'ouvrage hal-04541719v1

Nicolas Jonckheere

Publications

A novel anti-galectin-9 immunotherapy limits the early progression of pancreatic neoplastic lesions in transgenic mice

Metabolism of pancreatic neuroendocrine tumors: what can omics tell us?

Inositol (1,4,5)-Trisphosphate Receptors in Invasive Breast Cancer: A New Prognostic Tool?

TRPM7 Modulates Human Pancreatic Stellate Cell Activation.

Evaluation of the expression of fatty acid synthase and O ‑GlcNAc transferase in patients with liver cancer by exploration of transcriptome databases and experimental approaches

Antagonistic Roles of the Tumor Suppressor miR-210-3p and Oncomucin MUC4 Forming a Negative Feedback Loop in Pancreatic Adenocarcinoma

The EGF Domains of MUC4 Oncomucin Mediate HER2 Binding Affinity and Promote Pancreatic Cancer Cell Tumorigenesis

A new pancreatic adenocarcinoma‐derived organoid model of acquired chemoresistance to FOLFIRINOX: first insight of the underlying mechanisms

Mg2+ Transporters in Digestive Cancers

Mucin expression, epigenetic regulation and patient survival: A toolkit of prognostic biomarkers in epithelial cancers

EGF-Containing Membrane-Bound Mucins: A Hidden ErbB2 Targeting Pathway?

Unsupervised Hierarchical Clustering of Pancreatic Adenocarcinoma Dataset from TCGA Defines a Mucin Expression Profile that Impacts Overall Survival

Long non-coding RNAs: the tentacles of chromatin remodeler complexes

Long-term consequences of one anastomosis gastric bypass on esogastric mucosa in a preclinical rat model

Fine-tuning autophagy in pancreatic adenocarcinoma: full blockage is required

TGF-βRII Knock-down in Pancreatic Cancer Cells Promotes Tumor Growth and Gemcitabine Resistance. Importance of STAT3 Phosphorylation on S727

Epigenetic Regulation by lncRNAs: An Overview Focused on UCA1 in Colorectal Cancer

Integrative analysis of the cancer genome atlas and cancer cell lines encyclopedia large-scale genomic databases: MUC4/MUC16/MUC20 signature is associated with poor survival in human carcinomas.

Depletion of MUC5B mucin in gastrointestinal cancer cells alters their tumorigenic properties: implication of the Wnt/β-catenin pathway

The cornerstone K-RAS mutation in pancreatic adenocarcinoma: From cell signaling network, target genes, biological processes to therapeutic targeting

Flagellin-Mediated Protection against Intestinal Yersinia pseudotuberculosis Infection Does Not Require Interleukin-22.

Overexpression of chemokine receptor CXCR2 and ligand CXCL7 in liver metastases from colon cancer is correlated to shorter disease-free and overall survival

Micro-RNAs miR-29a and miR-330-5p function as tumor suppressors by targeting the MUC1 mucin in pancreatic cancer cells

Cryosectioning the intestinal crypt-villus axis: An ex vivo method to study the dynamics of epigenetic modifications from stem cells to differentiated cells

The mucin MUC4 is a transcriptional and post-transcriptional target of K-ras oncogene in pancreatic cancer. Implication of MAPK/AP-1, NF-κB and RalB signaling pathways

miR-219-1-3p is a negative regulator of the mucin MUC4 expression and is a tumor suppressor in pancreatic cancer

Targeting MUC4 in pancreatic cancer: miRNAs

The oncogenic receptor ErbB2 modulates gemcitabine and irinotecan/SN-38 chemoresistance of human pancreatic cancer cells via hCNT1 transporter and multidrug-resistance associated protein MRP-2

The MUC1 mucin regulates the tumorigenic properties of human esophageal adenocarcinomatous cells

Comment on: Functional MUC4 suppress epithelial-mesenchymal transition in lung adenocarcinoma metastasis. Gao L, Liu J, Zhang B, Zhang H, Wang D, Zhang T, Liu Y, Wang C. Tumour Biol. 2013, in press

Of autophagy and in vivo pancreatic carcinogenesis: The p53 status matters!

Mucins and tumor resistance to chemotherapeutic drugs

The MUC1 oncomucin regulates pancreatic cancer cell biological properties and chemoresistance. Implication of p42-44 MAPK, Akt, Bcl-2 and MMP13 pathways

Helicobacter pylori urease and flagellin alter mucin gene expression in human gastric cancer cells

Membrane-bound mucin modular domains: from structure to function.

The MUC4 mucin mediates gemcitabine resistance of human pancreatic cancer cells via the Concentrative Nucleoside Transporter family.

Membrane-bound mucin modular domains: From structure to function

Tif1γ Suppresses Murine Pancreatic Tumoral Transformation by a Smad4-Independent Pathway

GATA-4/-6 and HNF-1/-4 families of transcription factors control the transcriptional regulation of the murine Muc5ac mucin during stomach development and in epithelial cancer cells.

The mucin MUC4 and its membrane partner ErbB2 regulate biological properties of human CAPAN-2 pancreatic cancer cells via different signalling pathways.

The mouse Muc5b mucin gene is transcriptionally regulated by thyroid transcription factor-1 (TTF-1) and GATA-6 transcription factors.

The MUC4 membrane-bound mucin regulates esophageal cancer cell proliferation and migration properties: Implication for S100A4 protein

Mucins and Pancreatic Cancer

Autocrine Induction of Invasive and Metastatic Phenotypes by the MIF-CXCR4 Axis in Drug-Resistant Human Colon Cancer Cells

The membrane-bound mucins: From cell signalling to transcriptional regulation and expression in epithelial cancers

Tumour growth and resistance to gemcitabine of pancreatic cancer cells are decreased by AP-2alpha overexpression.

The Membrane-Bound Mucins: How Large O-Glycoproteins Play Key Roles in Epithelial Cancers and Hold Promise as Biological Tools for Gene-Based and Immunotherapies

Analysis of mPygo2 mutant mice suggests a requirement for mesenchymal Wnt signaling in pancreatic growth and differentiation

The Human Mucin MUC4 Is Transcriptionally Regulated by Caudal-related Homeobox, Hepatocyte Nuclear Factors, Forkhead Box A, and GATA Endodermal Transcription Factors in Epithelial Cancer Cells

Regulation of the human mucin MUC4 by taurodeoxycholic and taurochenodeoxycholic bile acids in oesophageal cancer cells is mediated by hepatocyte nuclear factor 1α

Evidence for a functional genetic polymorphism of the human retinoic acid–metabolizing enzyme CYP26A1, an enzyme that may be involved in spina bifida

Regulation of the human mucin MUC4 by taurodeoxycholic and taurochenodeoxycholic bile acids in oesophageal cancer cells is mediated by hepatocyte nuclear factor 1{alpha}

The antagonistic regulation of human MUC4 and ErbB-2 genes by the Ets protein PEA3 in pancreatic cancer cells: implications for the proliferation/differentiation balance in the cells

The antagonistic regulation of human MUC4 and ErbB-2 genes by the Ets protein PEA3 in pancreatic cancer cells: implications for the proliferation/differentiation balance in the cells

The murine Muc2 mucin gene is transcriptionally regulated by the zinc-finger GATA-4 transcription factor in intestinal cells

Transcriptional activation of the murine Muc5ac mucin gene in epithelial cancer cells by TGF-β/Smad4 signalling pathway is potentiated by Sp1

Transcriptional regulation of human mucin MUC4 by bile acids in oesophageal cancer cells is promoter-dependent and involves activation of the phosphatidylinositol 3-kinase signalling pathway

Transcriptional activation of the murine Muc5ac mucin gene in epithelial cancer cells by TGF-β/Smad4 signalling pathway is potentiated by Sp1

A role for human MUC4 mucin gene, the ErbB2 ligand, as a target of TGF-b in pancreatic carcinogenesis

Transcriptional regulation of human mucin MUC4 by bile acids in oesophageal cancer cells is promoter-dependent and involves activation of the phosphatidylinositol 3-kinase signalling pathway

Transcriptional regulation of human mucin MUC4 by bile acids in oesophageal cancer cells is promoter-dependent and involves activation of the phosphatidylinositol 3-kinase signalling pathway

Human MUC2 Mucin Gene Is Transcriptionally Regulated by Cdx Homeodomain Proteins in Gastrointestinal Carcinoma Cell Lines

Deciphering and targeting GD2 ganglioside O-Acetylation pathways in neuroectoderm-derived cancers

Acquisition d’un phénotype myofibroblastique par les cellules stellaires pancréatiques exposées au cadmium.

Bioinformatics identification of key regulators associated with MUC4 expression in pancreatic adenocarcinoma.

Deciphering and targeting GD2 ganglioside O-Acetylation pathways in neuroectoderm-derived cancers

L’alpha-kinase de TRPM7: comprendre son rôle dans les propriétés invasives de l’adénocarcinome canalaire pancréatique

MUC4 interactants: to infinity and beyond.

Établissement d’une signature prédictive de la survie globale des patients atteints de cancer colique basée sur le profil d’expression d’enzymes responsables de modifications épigénétiques.

Abstract 2965: Epigenetic mechanisms involved in acquired resistance to combined chemotherapies in digestive cancer cells

Le rôle du domaine kinase de TRPM7 : A la recherche de nouveaux partenaires d’interaction dans l’adénocarcinome canalaire pancréatique.

MAGNESIUM TRANSPORTERS EXPRESSION AND PROGNOSTIC IMPACT IN DIGESTIVE CANCERS

Abstract LB106: The EGF domains of MUC4 oncomucin interact with ErbB2 and mediate tumorigenic activity of cancer cells represent new potential therapeutic targets

Expression des transporteurs au magnésium et impact pronostic dans les cancers digestifs.

Evaluation in vitro et in vivo d'une Nouvelle Stratégie d’Immunothérapie ciblant la Galectine-9 dans un modèle de cancer pancréatique.

Roles of the MUC4-miRNA loop in pancreatic carcinogenesis and chemoresistance.

Roles of the MUC4-miRNA loop in pancreatic carcinogenesis and chemoresistance.

Evaluation of a New Anti-Galectin 9 Immunotherapy Strategy in Pancreatic Cancers.