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A novel anti-galectin-9 immunotherapy limits the early progression of pancreatic neoplastic lesions in transgenic mice
Alexandre Quilbe
,
Rami Mustapha
,
Belinda Duchêne
,
Abhishek Kumar
,
Elisabeth Werkmeister
Article dans une revue
hal-04469183v1
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Metabolism of pancreatic neuroendocrine tumors: what can omics tell us?
Arnaud Jannin
,
Anne-Frédérique Dessein
,
Christine Do Cao
,
Marie-Christine Vantyghem
,
Benjamin Chevalier
Article dans une revue
hal-04273585v1
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Evaluation of the expression of fatty acid synthase and O ‑GlcNAc transferase in patients with liver cancer by exploration of transcriptome databases and experimental approaches
Sadia Raab
,
Ninon Very
,
Belinda Duchêne
,
Pierre Rybarczyk
,
Nicolas Jonckheere
Article dans une revue
hal-03608015v2
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TRPM7 Modulates Human Pancreatic Stellate Cell Activation.
Julie Auwercx
,
Philippe Kischel
,
Thibaut Lefebvre
,
Nicolas Jonckheere
,
Alison Vanlaeys
Article dans une revue
hal-03740502v1
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Inositol (1,4,5)-Trisphosphate Receptors in Invasive Breast Cancer: A New Prognostic Tool?
Arthur Foulon
,
Pierre Rybarczyk
,
Nicolas Jonckheere
,
Eva Brabencova
,
Henri Sevestre
Article dans une revue
hal-04326232v1
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The EGF Domains of MUC4 Oncomucin Mediate HER2 Binding Affinity and Promote Pancreatic Cancer Cell Tumorigenesis
Nicolas Stoup
,
Maxime Liberelle
,
Céline Schulz
,
Sumeyye Cavdarli
,
Romain Vasseur
Article dans une revue
hal-03641795v1
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Antagonistic Roles of the Tumor Suppressor miR-210-3p and Oncomucin MUC4 Forming a Negative Feedback Loop in Pancreatic Adenocarcinoma
Nihad Boukrout
,
Mouloud Souidi
,
Fatima Lahdaoui
,
Belinda Duchêne
,
Bernadette Neve
Article dans une revue
hal-03777017v1
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Mg2+ Transporters in Digestive Cancers
Julie Auwercx
,
Pierre Rybarczyk
,
Philippe Kischel
,
Isabelle Dhennin-Duthille
,
Denis Chatelain
Article dans une revue
hal-03195960v1
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Mucin expression, epigenetic regulation and patient survival: A toolkit of prognostic biomarkers in epithelial cancers
Nicolas Jonckheere
,
Audrey Vincent
,
Bernadette Neve
,
Isabelle van Seuningen
Article dans une revue
hal-03294583v1
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A new pancreatic adenocarcinoma‐derived organoid model of acquired chemoresistance to FOLFIRINOX: first insight of the underlying mechanisms
Elsa Hadj Bachir
,
Charles Poiraud
,
Sonia Paget
,
Nicolas Stoup
,
Soumaya El Moghrabi
Article dans une revue
hal-03369738v1
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EGF-Containing Membrane-Bound Mucins: A Hidden ErbB2 Targeting Pathway?
Maxime Liberelle
,
Nicolas Jonckheere
,
Patricia Melnyk
,
Isabelle van Seuningen
,
Nicolas Lebègue
Article dans une revue
hal-02955348v1
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Long-term consequences of one anastomosis gastric bypass on esogastric mucosa in a preclinical rat model
Matthieu Siebert
,
Lara Ribeiro-Parenti
,
Nicholas Nguyen
,
Muriel Hourseau
,
Belinda Duchêne
Article dans une revue
hal-02617527v1
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Long non-coding RNAs: the tentacles of chromatin remodeler complexes
Bernadette Neve
,
Nicolas Jonckheere
,
Audrey Vincent
,
Isabelle van Seuningen
Article dans une revue
hal-03195963v1
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Unsupervised Hierarchical Clustering of Pancreatic Adenocarcinoma Dataset from TCGA Defines a Mucin Expression Profile that Impacts Overall Survival
Nicolas Jonckheere
,
Julie Auwercx
,
Elsa Hadj Bachir
,
Lucie Coppin
,
Nihad Boukrout
Article dans une revue
hal-03003452v2
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Fine-tuning autophagy in pancreatic adenocarcinoma: full blockage is required
Nicolas Jonckheere
,
Isabelle van Seuningen
Article dans une revue
hal-02358435v1
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Fine-tuning autophagy in pancreatic adenocarcinoma: full blockage is required
Nicolas Jonckheere
,
Isabelle van Seuningen
Article dans une revue
inserm-02341315v1
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TGF-βRII Knock-down in Pancreatic Cancer Cells Promotes Tumor Growth and Gemcitabine Resistance. Importance of STAT3 Phosphorylation on S727
Vincent Drubay
,
Nicolas Skrypek
,
Lucie Cordiez
,
Romain Vasseur
,
Céline Schulz
Article dans une revue
inserm-02341320v1
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Integrative analysis of the cancer genome atlas and cancer cell lines encyclopedia large-scale genomic databases: MUC4/MUC16/MUC20 signature is associated with poor survival in human carcinomas.
Nicolas Jonckheere
,
Isabelle van Seuningen
Article dans une revue
hal-02341297v1
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Epigenetic Regulation by lncRNAs: An Overview Focused on UCA1 in Colorectal Cancer
Bernadette Neve
,
Nicolas Jonckheere
,
Audrey Vincent
,
Isabelle van Seuningen
Article dans une revue
inserm-02341333v1
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Depletion of MUC5B mucin in gastrointestinal cancer cells alters their tumorigenic properties: implication of the Wnt/β-catenin pathway
Fatima Lahdaoui
,
Mathieu Messager
,
Audrey Vincent
,
Flora Hec
,
Anne Gandon
Article dans une revue
inserm-02341337v1
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The cornerstone K-RAS mutation in pancreatic adenocarcinoma: From cell signaling network, target genes, biological processes to therapeutic targeting
Nicolas Jonckheere
,
Romain Vasseur
,
Isabelle Van Seuningen
Article dans une revue
inserm-02341607v1
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Flagellin-Mediated Protection against Intestinal Yersinia pseudotuberculosis Infection Does Not Require Interleukin-22.
Rémi Porte
,
Laurye van Maele
,
Natalia Muñoz-Wolf
,
Benoit Foligné
,
Laure Dumoutier
Article dans une revue
inserm-01529315v1
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The oncogenic receptor ErbB2 modulates gemcitabine and irinotecan/SN-38 chemoresistance of human pancreatic cancer cells via hCNT1 transporter and multidrug-resistance associated protein MRP-2
Nicolas Skrypek
,
Romain Vasseur
,
Audrey Vincent
,
Bélinda Duchêne
,
Isabelle van Seuningen
Article dans une revue
inserm-02341515v1
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Targeting MUC4 in pancreatic cancer: miRNAs
Nicolas Jonckheere
,
Fatima Lahdaoui
,
Isabelle van Seuningen
Article dans une revue
hal-02905858v1
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Micro-RNAs miR-29a and miR-330-5p function as tumor suppressors by targeting the MUC1 mucin in pancreatic cancer cells
Solange Tréhoux
,
Fatima Lahdaoui
,
Yannick Delpu
,
Florence Renaud
,
Emmanuelle Leteurtre
Article dans une revue
hal-02905657v1
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Overexpression of chemokine receptor CXCR2 and ligand CXCL7 in liver metastases from colon cancer is correlated to shorter disease-free and overall survival
Thibault Desurmont
,
Nicolas Skrypek
,
Alain Duhamel
,
Nicolas Jonckheere
,
Guillaume Millet
Article dans une revue
hal-02954490v1
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miR-219-1-3p is a negative regulator of the mucin MUC4 expression and is a tumor suppressor in pancreatic cancer
F Lahdaoui
,
Y Delpu
,
A. Vincent
,
F. Renaud
,
M Messager
Article dans une revue
hal-02905857v1
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The mucin MUC4 is a transcriptional and post-transcriptional target of K-ras oncogene in pancreatic cancer. Implication of MAPK/AP-1, NF-κB and RalB signaling pathways
Romain Vasseur
,
Nicolas Skrypek
,
Belinda Duchêne
,
Florence Renaud
,
Daniel Martínez-Maqueda
Article dans une revue
hal-02906327v1
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Cryosectioning the intestinal crypt-villus axis: An ex vivo method to study the dynamics of epigenetic modifications from stem cells to differentiated cells
Audrey Vincent
,
Catherine Kazmierczak
,
Belinda Duchêne
,
Nicolas Jonckheere
,
Emmanuelle Leteurtre
Article dans une revue
hal-02905864v1
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Of autophagy and in vivo pancreatic carcinogenesis: The p53 status matters!
Nicolas Jonckheere
,
Audrey Vincent
,
Isabelle Van Seuningen
Article dans une revue
inserm-02341594v1
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Mucins and tumor resistance to chemotherapeutic drugs
Nicolas Jonckheere
,
Nicolas Skrypek
,
Isabelle Van Seuningen
Article dans une revue
inserm-02341531v1
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The MUC1 oncomucin regulates pancreatic cancer cell biological properties and chemoresistance. Implication of p42-44 MAPK, Akt, Bcl-2 and MMP13 pathways
Solange Tréhoux
,
Bélinda Duchêne
,
Nicolas Jonckheere
,
Isabelle van Seuningen
Article dans une revue
hal-02905690v1
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Helicobacter pylori urease and flagellin alter mucin gene expression in human gastric cancer cells
Michael Perrais
,
Christel Rousseaux
,
Marie-Paule Ducourouble
,
René Courcol
,
Pascal Vincent
Article dans une revue
hal-02905802v1
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The MUC1 mucin regulates the tumorigenic properties of human esophageal adenocarcinomatous cells
Caroline Gronnier
,
Emilie Bruyère
,
Fatima Lahdaoui
,
Nicolas Jonckheere
,
Michael Perrais
Article dans une revue
hal-02905652v1
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Comment on: Functional MUC4 suppress epithelial-mesenchymal transition in lung adenocarcinoma metastasis. Gao L, Liu J, Zhang B, Zhang H, Wang D, Zhang T, Liu Y, Wang C. Tumour Biol. 2013, in press
Nicolas Jonckheere
,
Isabelle van Seuningen
Article dans une revue
inserm-02371186v1
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Membrane-bound mucin modular domains: from structure to function.
Nicolas Jonckheere
,
Nicolas Skrypek
,
Frédéric Frénois
,
Isabelle van Seuningen
Article dans une revue
inserm-00807818v1
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The MUC4 mucin mediates gemcitabine resistance of human pancreatic cancer cells via the Concentrative Nucleoside Transporter family.
Nicolas Skrypek
,
Bélinda Duchêne
,
Mohamed Hebbar
,
Emmanuelle Leteurtre
,
Isabelle van Seuningen
Article dans une revue
inserm-00807837v1
|
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Membrane-bound mucin modular domains: From structure to function
Nicolas Jonckheere
,
Frédéric Frénois
,
Isabelle van Seuningen
,
Nicolas Q1
,
Nicolas Skrypek
Article dans une revue
hal-02905700v1
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The mucin MUC4 and its membrane partner ErbB2 regulate biological properties of human CAPAN-2 pancreatic cancer cells via different signalling pathways.
Nicolas Jonckheere
,
Nicolas Skrypek
,
Johann Merlin
,
Anne Frédérique Dessein
,
Patrick Dumont
Article dans une revue
inserm-00807830v1
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GATA-4/-6 and HNF-1/-4 families of transcription factors control the transcriptional regulation of the murine Muc5ac mucin during stomach development and in epithelial cancer cells.
Nicolas Jonckheere
,
Audrey Vincent
,
Hélène Franquet-Ansart
,
Janneke Witte-Bouma
,
Anita Korteland-van Male
Article dans une revue
inserm-00807845v1
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Tif1γ Suppresses Murine Pancreatic Tumoral Transformation by a Smad4-Independent Pathway
David Vincent
,
Johann Gout
,
Nicolas Chuvin
,
Vanessa Arfi
,
Roxane M. Pommier
Article dans une revue
hal-02954464v1
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The mouse Muc5b mucin gene is transcriptionally regulated by thyroid transcription factor-1 (TTF-1) and GATA-6 transcription factors.
Nicolas Jonckheere
,
Amélie Velghe
,
Marie-Paule Ducourouble
,
Marie-Christine Copin
,
Ingrid B. Renes
Article dans une revue
inserm-00807850v1
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The MUC4 membrane-bound mucin regulates esophageal cancer cell proliferation and migration properties: Implication for S100A4 protein
Emilie Bruyère
,
Nicolas Jonckheere
,
Frédéric Frénois
,
Christophe Mariette
,
Isabelle van Seuningen
Article dans une revue
hal-02905689v1
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Autocrine Induction of Invasive and Metastatic Phenotypes by the MIF-CXCR4 Axis in Drug-Resistant Human Colon Cancer Cells
Anne-Frédérique Dessein
,
Laurence Stechly
,
Nicolas Jonckheere
,
Patrick Dumont
,
Didier Monté
Article dans une revue
hal-02106460v1
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Mucins and Pancreatic Cancer
Nicolas Jonckheere
,
Nicolas Skrypek
,
Isabelle van Seuningen
Article dans une revue
inserm-00807873v1
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|
The membrane-bound mucins: From cell signalling to transcriptional regulation and expression in epithelial cancers
Nicolas Jonckheere
,
Isabelle van Seuningen
Article dans une revue
hal-02905696v1
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Tumour growth and resistance to gemcitabine of pancreatic cancer cells are decreased by AP-2alpha overexpression.
Nicolas Jonckheere
,
Valérie Fauquette
,
Laurence Stechly
,
Nathalie Saint-Laurent
,
Sébastien Aubert
Article dans une revue
inserm-00410436v1
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|
Analysis of mPygo2 mutant mice suggests a requirement for mesenchymal Wnt signaling in pancreatic growth and differentiation
Nicolas Jonckheere
,
Erin Mayes
,
Hung-Ping Shih
,
Boan Li
,
Oleg Lioubinski
Article dans une revue
hal-02954468v1
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The Membrane-Bound Mucins: How Large O-Glycoproteins Play Key Roles in Epithelial Cancers and Hold Promise as Biological Tools for Gene-Based and Immunotherapies
Nicolas Jonckheere
,
Isabelle Van Seuningen
Article dans une revue
hal-02905788v1
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Regulation of the human mucin MUC4 by taurodeoxycholic and taurochenodeoxycholic bile acids in oesophageal cancer cells is mediated by hepatocyte nuclear factor 1α
Guillaume Piessen
,
Nicolas Jonckheere
,
Audrey Vincent
,
Brigitte Hemon
,
Marie-Paule Ducourouble
Article dans une revue
hal-02905759v1
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The Human Mucin MUC4 Is Transcriptionally Regulated by Caudal-related Homeobox, Hepatocyte Nuclear Factors, Forkhead Box A, and GATA Endodermal Transcription Factors in Epithelial Cancer Cells
Nicolas Jonckheere
,
Audrey Vincent
,
Michaël Perrais
,
Marie-Paule Ducourouble
,
Anita Korteland-van Male
Article dans une revue
hal-02905844v1
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|
Regulation of the human mucin MUC4 by taurodeoxycholic and taurochenodeoxycholic bile acids in oesophageal cancer cells is mediated by hepatocyte nuclear factor 1{alpha}
Guillaume Piessen
,
Nicolas Jonckheere
,
Audrey Vincent
,
Brigitte Hémon
,
Marie-Paule Ducourouble
Article dans une revue
hal-00478670v1
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Evidence for a functional genetic polymorphism of the human retinoic acid–metabolizing enzyme CYP26A1, an enzyme that may be involved in spina bifida
Emmanuel Rat
,
Ingrid Billaut-Laden
,
Delphine Allorge
,
Jean-Marc Lo-Guidice
,
Marie Tellier
Birth Defects Research Part A: Clinical and Molecular Teratology, 2006, 76 (6), pp.491-498. ⟨10.1002/bdra.20275⟩
Article dans une revue
hal-02954484v1
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The antagonistic regulation of human MUC4 and ErbB-2 genes by the Ets protein PEA3 in pancreatic cancer cells: implications for the proliferation/differentiation balance in the cells
Valérie Fauquette
,
Michael Perrais
,
Sylvain Cerulis
,
Nicolas Jonckheere
,
Marie-Paule Ducourouble
Article dans une revue
hal-02954487v1
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The antagonistic regulation of human MUC4 and ErbB-2 genes by the Ets protein PEA3 in pancreatic cancer cells: implications for the proliferation/differentiation balance in the cells
Valérie Fauquette
,
Michael Perrais
,
Sylvain Cerulis
,
Nicolas Jonckheere
,
Marie-Paule Ducourouble
Biochemical Journal, 2005, 386, pp.35 - 45
Article dans une revue
hal-02905757v1
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A role for human MUC4 mucin gene, the ErbB2 ligand, as a target of TGF-b in pancreatic carcinogenesis
Nicolas Jonckheere
,
Michael Perrais
,
Christophe Mariette
,
Surinder K Batra
,
Jean-Pierre Aubert
Article dans une revue
hal-02905851v1
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The murine Muc2 mucin gene is transcriptionally regulated by the zinc-finger GATA-4 transcription factor in intestinal cells
Maria van Der Sluis
,
Monique H M Melis
,
Nicolas Jonckheere
,
Marie-Paule Ducourouble
,
Hans A Bü Ller A
Article dans une revue
hal-02905675v1
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Transcriptional activation of the murine Muc5ac mucin gene in epithelial cancer cells by TGF-β/Smad4 signalling pathway is potentiated by Sp1
Nicolas Jonckheere
,
Maria van Der Sluis
,
Amélie Velghe
,
Marie-Pierre Buisine
,
Marjolein Sutmuller
Biochemical Journal, 2004, 377, pp.797 - 808
Article dans une revue
hal-02905715v1
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Transcriptional regulation of human mucin MUC4 by bile acids in oesophageal cancer cells is promoter-dependent and involves activation of the phosphatidylinositol 3-kinase signalling pathway
Michael Perrais
,
Brigitte Hemon
,
Isabelle van Seuningen
,
Christophe Mariette
,
Michaël Perrais
Biochemical Journal, 2004, 377, pp.701 - 708
Article dans une revue
hal-02905748v1
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Transcriptional regulation of human mucin MUC4 by bile acids in oesophageal cancer cells is promoter-dependent and involves activation of the phosphatidylinositol 3-kinase signalling pathway
Christophe Mariette
,
Michaël Perrais
,
Emmanuelle Leteurtre
,
Nicolas Jonckheere
,
Brigitte Hémon
Article dans une revue
hal-03314562v1
|
|
Transcriptional regulation of human mucin MUC4 by bile acids in oesophageal cancer cells is promoter-dependent and involves activation of the phosphatidylinositol 3-kinase signalling pathway
Christophe Mariette
,
Michael Perrais
,
Emmanuelle Leteurtre
,
Nicolas Jonckheere
,
Brigitte Hemon
Biochemical Journal, 2004, 377, pp.701 - 708
Article dans une revue
hal-02905712v1
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Transcriptional activation of the murine Muc5ac mucin gene in epithelial cancer cells by TGF-β/Smad4 signalling pathway is potentiated by Sp1
Nicolas Jonckheere
,
Maria van Der Sluis
,
Amélie Velghe
,
Marie-Pierre Buisine
,
Marjolein Sutmuller
Article dans une revue
hal-02905751v1
|
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Human MUC2 Mucin Gene Is Transcriptionally Regulated by Cdx Homeodomain Proteins in Gastrointestinal Carcinoma Cell Lines
Patrícia Mesquita
,
Nicolas Jonckheere
,
Raquel Almeida
,
Marie-Paule Ducourouble
,
Jacinta Serpa
Article dans une revue
hal-02905842v1
|