NICOLAS CHARLET BERGUERAND

**Nicolas CHARLET-BERGUERAND.** IGBMC, French, Age 48 (Born 1973), 1 Rue Laurent Fries Assistant Professor (INSERM DR2) 67400 ILLKIRCH, France. ResearcherID: *I-6727-2016* Phone: (+33) 3 88 65 33 09 ORCID ID: *orcid.org/0000-0002-4423-4920* Email: ncharlet@igbmc.fr **MAIN RESEARCH AREA** My researches are mainly focused on “non-coding” genome and human diseases, first in cancer (PhD, University of Paris), then in genetic diseases (post-doctoral training, Baylor college of Medecine). I started my independent group on RNA diseases at the IGBMC (Strasbourg, France) in 2007. Since, we are studying how expanded repeats located in the “non-coding” parts of the genome lead to human genetic diseases. We are notably interested in Myotonic Dystrophy (DM) caused by expanded CTG repeats located in the 3’UTR of the *DMPK* gene, Fragile X-Associated Tremor/Ataxia Syndrome (FXTAS) due to expanded CGG repeats in the 5’UTR of the *FMR1* gene and Amyotrophic Lateral Sclerosis and Frontotemporal Dementia (ALS-FTD) due to GGGGCC expansion in the first intron of the *C9ORF72* gene. These expanded repeats are pathogenic by diverse mechanisms, such as non-canonical translation and/ or sequestration of specific RNA-binding proteins. Our goals are (**i**) to elucidate the molecular causes of these diseases, (**ii**) to establish relevant cellular and rodent (mouse and rat) models of these diseases and (**iii**) to identify drugs able to correct pathogenicity in these models. **EDUCATION & EXPERIENCE:** **Since 2007 TEAM LEADER - IGBMC, STRASBOURG, FRANCE.** « Understanding the molecular causes of RNA diseases. » INSTITUT DE GÉNÉTIQUE ET DE BIOLOGIE MOLÉCULAIRE ET CELLULAIRE, CNRS UMR7104, INSERM U1258, Dept. of Translational Medicine, 67404 Illkirch, France. **2004 - 06 POST-DOCTORAL POSITION - IGBMC, STRASBOURG, FRANCE.** « Regulation of the transcriptionnal bypass of DNA oxidative lesions. » INSTITUT DE GÉNÉTIQUE ET DE BIOLOGIE MOLÉCULAIRE ET CELLULAIRE, CNRS UMR7104, INSERM U1258, Dept. of Functional Genomics, 67404 Illkirch, France. Supervisor: Prof. Jean-Marc EGLY. **1999 - 03 SCIENTIFIC COLLABORATION (MILITARY DUTY) – BCM, HOUSTON, USA.** « Alternative splicing alteration in myotonic dystrophic patients.» Baylor College OF Medicine, Dept. of Pathology, 77030 Houston, Texas, USA. Supervisor: Prof. Thomas COOPER. **1996 - 03 PHD - UNIVERSITY OF PARIS VII, FRANCE.** *Graduation: Excellent, with the felicitation of the Jury.* « Regulation of *RET* and *GFRa1* alternative spling in pheochromocytomas tumors. » Centre de Génétique Moléculaire, CNRS UPR 2167, 91190 Gif-sur-Yvette, France. Supervisor: Dr. Claude THERMES. **1995 - 96 MASTER OF SCIENCE (BIOLOGY OF AGING) - UNIVERSITY OF PARIS VII, FRANCE.** *Graduation: Very Good.* **AWARDS, POSITIONS & FELLOWSHIPS:** **2018 Award of scientific excellence.** INSERM prime d'excellence scientifique. **2012 European Research Council Starting grant.** **2012 INSERM DR2.** Group leader permanent position. **2011 Award of scientific excellence.** INSERM prime d'excellence scientifique. **2006 INSERM CR1.** Scientist permanent position**.** **2006 Award Georges Deflandre.** Foundation de France. **2004 – 06 ARC post-doctoral fellowship.** Foundation against cancer. **1995 – 99** **EMRT** **PhD fellowship**. French Ministry of Research and Education.