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65

CV HAL Nicolas Bridiau


Journal articles25 documents

  • Justine Bodin, Amandine Adrien, Pierre-Edouard Bodet, Delphine Dufour, Stanislas Baudouin, et al.. Ulva intestinalis Protein Extracts Promote In Vitro Collagen and Hyaluronic Acid Production by Human Dermal Fibroblasts. Molecules, MDPI, 2020, 25 (9), pp.2091. ⟨10.3390/molecules25092091⟩. ⟨hal-02874561⟩
  • Amandine Adrien, Antoine Bonnet, Delphine Dufour, Stanislas Baudouin, Thierry Maugard, et al.. Anticoagulant Activity of Sulfated Ulvan Isolated from the Green Macroalga Ulva rigida. Marine drugs, MDPI, 2019, 17 (5), pp.291. ⟨10.3390/md17050291⟩. ⟨hal-02428656⟩
  • Hugo Groult, Rémi Cousin, Caroline Chot-Plassot, Maheva Maura, Nicolas Bridiau, et al.. λ-Carrageenan Oligosaccharides of Distinct Anti-Heparanase and Anticoagulant Activities Inhibit MDA-MB-231 Breast Cancer Cell Migration. Marine drugs, MDPI, 2019, 17 (3), pp.140. ⟨10.3390/md17030140⟩. ⟨hal-02053593⟩
  • Yesmine Ben Henda, Antoine Bonnet, Ortência Leocádia Nunes Gonzalez da Silva, Rogério Boscolo Wilson, Ingrid Arnaudin, et al.. Identification of ace inhibitory cryptides in Tilapia protein hydrolysate by UPLC–MS/MS coupled to database analysis. Journal of Chromatography B - Analytical Technologies in the Biomedical and Life Sciences, Elsevier, 2017, 1052, pp.43 - 50. ⟨10.1016/j.jchromb.2017.02.015⟩. ⟨hal-01664752⟩
  • Adrien Amandine, Dufour Delphine, Stanislas Baudouin, Thierry Maugard, Bridiau Nicolas. Evaluation of the anticoagulant potential of polysaccharide-rich fractions extracted from macroalgae. Natural Product Research, Taylor & Francis, 2017, ⟨10.1080/14786419.2017.1278595⟩. ⟨hal-01459846⟩
  • Florian Le Joubioux, Nicolas Bridiau, Marianne Graber, Thierry Maugard. Semi-pilot scale-up of a continuous packed-bed bioreactor system developed for the lipase-catalyzed production of pseudo-ceramides. OCL Oilseeds and fats crops and lipids, EDP, 2017, 24 (4), ⟨10.1051/ocl/2017019⟩. ⟨hal-01630116⟩
  • Nicolas Poupard, Hugo Groult, Justine Bodin, Nicolas Bridiau, Stéphanie Bordenave-Juchereau, et al.. Production of heparin and λ-carrageenan anti-heparanase derivatives using a combination of physicochemical depolymerization and glycol splitting. Carbohydrate Polymers, Elsevier, 2017, 166, pp.156 - 165. ⟨10.1016/j.carbpol.2017.02.040⟩. ⟨hal-01664739⟩
  • Nicolas Poupard, Pamela Badarou, Fabienne Fasani, Hugo Groult, Nicolas Bridiau, et al.. Assessment of Heparanase-Mediated Angiogenesis Using Microvascular Endothelial Cells: Identification of λ-Carrageenan Derivative as a Potent Anti Angiogenic Agent. Marine drugs, MDPI, 2017, 15 (5), pp.284 - 298. ⟨10.3390/md15050134⟩. ⟨hal-01628620⟩
  • Amandine Adrien, Antoine Bonnet, Delphine Dufour, Stanislas Baudouin, Thierry Maugard, et al.. Pilot production of ulvans from Ulva sp. and their effects on hyaluronan and collagen production in cultured dermal fibroblasts. Carbohydrate Polymers, Elsevier, 2017, 157, pp.1306 - 1314. ⟨10.1016/j.carbpol.2016.11.014⟩. ⟨hal-01664728⟩
  • Hugo Groult, Nicolas Poupard, Fernando Herranz, Egle Conforto, Nicolas Bridiau, et al.. Family of Bioactive Heparin-Coated Iron Oxide Nanoparticles with Positive Contrast in Magnetic Resonance Imaging for Specific Biomedical Applications. Biomacromolecules, American Chemical Society, 2017, 18 (10), pp.3156 - 3167. ⟨10.1021/acs.biomac.7b00797⟩. ⟨hal-01664798⟩
  • Oussama Achour, Yahya Ashraf, Nicolas Bridiau, Meriem Kacem, Nicolas Poupard, et al.. Alteration of cathepsin D trafficking induced by hypoxia and extracellular acidification in MCF-7 breast cancer cells. Biochimie, Elsevier, 2016, ⟨10.1016/j.biochi.2015.11.007⟩. ⟨hal-01447204⟩
  • Oussama Achour, Nicolas Poupard, Nicolas Bridiau, Stéphanie Bordenave-Juchereau, Frédéric Sannier, et al.. Anti-heparanase activity of ultra-low-molecular-weight heparin produced by physicochemical depolymerization. Carbohydrate Polymers, Elsevier, 2016, ⟨10.1016/j.carbpol.2015.08.041⟩. ⟨hal-01447822⟩
  • Yesmine Ben Henda, Mariem Laamari, Isabelle Lanneluc, Marie-Agnès Travers, Hélène Agogué, et al.. Di and tripeptides from marine sources can target adipogenic process and contribute to decrease adipocyte number and functions. Journal of Functional Foods, Elsevier, 2015, Journal of Functional Foods, 17, pp.1-10. ⟨10.1016/j.jff.2015.04.050⟩. ⟨hal-01356228⟩
  • Fatoumata Tambadou, Thibault Caradec, Anne-Laure Gagez, Antoine Bonnet, Valérie Sopena, et al.. Characterization of the colistin (polymyxin E1 and E2) biosynthetic gene cluster.. Archives of Microbiology, Springer Verlag, 2015, 197 (4), pp.521-532. ⟨10.1007/s00203-015-1084-5⟩. ⟨hal-01247178⟩
  • Florian Le Joubioux, Nicolas Bridiau, Mehdi Sanekli, Marianne Graber, Thierry Maugard. Continuous lipase-catalyzed production of pseudo-ceramides in a packed-bed bioreactor. Journal of Molecular Catalysis B: Enzymatic, Elsevier, 2014, 109, pp.143-153. ⟨10.1016/j.molcatb.2014.08.022⟩. ⟨hal-01070430⟩
  • Emmanuel Bertrand, Guillaume Pierre, Cédric Delattre, Christine Gardarin, Nicolas Bridiau, et al.. Dextranase immobilization on epoxy CIM® disk for the production of isomaltooligosaccharides from dextran. Carbohydrate Polymers, Elsevier, 2014, 111, pp.707 - 713. ⟨10.1016/j.carbpol.2014.04.100⟩. ⟨hal-01852716⟩
  • Yesmine Ben Henda, Anis Labidi, Ingrid Arnaudin, Nicolas Bridiau, Régis Delatouche, et al.. Measuring Angiotensin-I Converting Enzyme Inhibitory Activity by Micro Plate Assays: Comparison Using Marine Cryptides and Tentative Threshold Determinations with Captopril and Losartan. Journal of Agricultural and Food Chemistry, American Chemical Society, 2013, 61 (45), pp.10685-10690. ⟨hal-01967773⟩
  • Florian Le Joubioux, Nicolas Bridiau, Yesmine Ben Henda, Oussama Achour, Marianne Graber, et al.. The control of Novozym® 435 chemoselectivity and specificity by the solvents in acylation reactions of amino-alcohols. Journal of Molecular Catalysis B: Enzymatic, Elsevier, 2013, 95, pp.99-110. ⟨10.1016/j.molcatb.2013.06.002⟩. ⟨hal-01070399⟩
  • Paul-Hubert Baudelet, Anne-Laure Gagez, Jean-Baptiste Bérard, Camille Juin, Nicolas Bridiau, et al.. Antiproliferative Activity of Cyanophora paradoxa Pigments in Melanoma, Breast and Lung Cancer Cells. Marine drugs, MDPI, 2013, 11 (11), pp.4390-4406. ⟨hal-01247728⟩
  • Oussama Achour, Nicolas Bridiau, Azza Godhbani, Florian Le Joubioux, Stephanie Bordenave Juchereau, et al.. Ultrasonic-assisted preparation of a low molecular weight heparin (LMWH) with anticoagulant activity. Carbohydrate Polymers, Elsevier, 2013, 97 (2), pp.684-689. ⟨hal-01967777⟩
  • Oussama Achour, Nicolas Bridiau, Meriem Kacem, Régis Delatouche, Stéphanie Bordenave-Juchereau, et al.. Cathepsin D activity and selectivity in the acidic conditions of a tumor microenvironment: Utilization in the development of a novel Cathepsin D substrate for simultaneous cancer diagnosis and therapy. Biochimie, Elsevier, 2013, 95 (11), pp.2010-2017. ⟨hal-01967774⟩
  • Florian Le Joubioux, Yesmine Ben Henda, Nicolas Bridiau, Oussama Achour, Marianne Graber, et al.. The effect of substrate structure on the chemoselectivity of Candida antarctica lipase B-catalyzed acylation of amino-alcohols. Journal of Molecular Catalysis B: Enzymatic, Elsevier, 2012, 85-86, pp.193-199. ⟨hal-00789681⟩
  • Florian Le Joubioux, A. Oussama, Nicolas Bridiau, Marianne Graber, Thierry Maugard. Kinetic study of 2-butanol O-acylation and sec-butylamine N-acylation catalyzed by Candida antarctica lipase B. Journal of Molecular Catalysis B: Enzymatic, Elsevier, 2011, 70, pp.108-113. ⟨hal-00790682⟩
  • Florian Le Joubioux, Oussama Achour, Nicolas Bridiau, Marianne Graber, Thierry Maugard. Kinetic study of 2-butanol O-acylation and sec-butylamine N-acylation catalyzed by Candida antarctica lipase B. Journal of Molecular Catalysis B: Enzymatic, Elsevier, 2011, 70 (3-4), pp.108-113. ⟨10.1016/j.molcatb.2011.02.012⟩. ⟨hal-01450644⟩
  • Nicolas Bridiau, Selma Taboubi, Marie-Dominique Legoy, Thierry Maugard. β-Galactosidase Catalyzed Selective Galactosylation of Aromatic Compounds. Biotechnology Progress, 2006, 22 (1), pp.326-330. ⟨10.1021/bp050230n⟩. ⟨hal-03519830⟩

Conference papers13 documents

  • Claire Toucheteau, Valentine Deffains, Ian Probert, Guillaume Pierre, Céline Laroche, et al.. Production of collagen and hyaluronic acid by human dermal fibroblasts stimulated by EPS from microalgae: some structural and mechanistic aspects. 7th International Congress of the European Polysaccharide Network of Excellence, Oct 2021, Nantes, France. ⟨hal-03506914⟩
  • Amandine Adrien, Nicolas Bridiau, Delphine Dufour, Stanislas Baudouin, Thierry Maugard. Production d’ulvanes de différents poids moléculaires provenant de l'algue Ulva sp., et leurs effets sur la production d'hyaluronane et de collagène par des fibroblastes cutanés humains. 2ème Colloque du GDR Cosm’actifs (GDR 3711) « Vers une Cosmétique Durable », Sep 2017, Nouan-Le-Fuzelier, France. ⟨hal-02428949⟩
  • Amandine Adrien, Antoine Bonnet, Joaquim Yao, Nicolas Bridiau, Delphine Dufour, et al.. Evaluation of the anticoagulant potential of polysaccharide-rich fractions extracted from macroalgae. 6th International Congress of Aromatic and Medicinal Plants (CIPAM 2016), May 2016, Coimbra, Portugal. ⟨hal-01459864⟩
  • Nicolas Bridiau. Polysaccharides marins pour des applications en santé humaine. Journées scientifiques de l'Université de Nantes - Exopolysaccharides marins et biotechnologies bleues, Jun 2016, Nantes, France. ⟨hal-01459892⟩
  • Florian Le Joubioux, Mehdi Sanekli, Yesmine Ben Henda, Oussama Achour, Nicolas Bridiau, et al.. La lipase B de Candida antarctica : un outil performant pour la production continue de pseudo-céramides. Les lipides du futur : les lipases au coeur des développements scientifiques et industriels, Nov 2015, Romainville, France. ⟨hal-01459912⟩
  • Amandine Adrien, Nicolas Bridiau, Delphine Dufour, Stanislas Baudouin, Thierry Maugard. Activité anticoagulante d'extraits de macroalgues riches en polysaccharides sulfatés. Journées phycologiques de France, Sep 2015, Vannes, France. ⟨hal-01459939⟩
  • Florian Le Joubioux, Nicolas Bridiau, Mehdi Sanekli, Marianne Graber, Thierry Maugard. Production continue de pseudo-céramides catalysée par la lipase B de Candida antarctica (Novozym® 435) dans un bioréacteur à lit fixe. 25ème colloque du Club de Biocatalyse en Synthèse Organique, Jun 2014, Carry-le-Rouet, France. ⟨hal-02428914⟩
  • Guillaume Pierre, Emmanuel Bertrand, Cédric Delattre, Christine Gardarin, Seltanna Chalane, et al.. Epoxy CIM® Disk comme nouveaux supports d’immobilisation de dextranases pour la production continue d’isomaltooligosaccharides . 25eme colloque CBSO, Jun 2014, Carry-le-Rouet, France. ⟨hal-01853261⟩
  • Azza Ghodhbani, Meriem Kacem, Oussama Achour, Florian Le Joubioux, Régis Delatouche, et al.. Aide au ciblage du microenvironnement tumoral par le développement d'un nano-système de détection et de traitement de tumeurs visant l'inhibition spécifique de l'héparanase. Journées de la Section Régionale Centre-Ouest de la Société Chimique de France, Dec 2012, Poitiers, France. ⟨hal-02428967⟩
  • Nicolas Bridiau, Neyssen Issaoui, Thierry Maugard. Effets du co-solvant organique sur l’efficacité et la régio-sélectivité de la synthèse de N-acétyl-lactosamine, catalysée par la β-galactosidase de Bacillus circulans en milieu hydro-organique. 23ème colloque du Club Bioconversion en Synthèse Organique, May 2010, Royat, France. ⟨hal-03520645⟩
  • Nicolas Bridiau, Moulay Benmansour, Marie-Dominique Legoy, Thierry Maugard. Synthèse stéréosélective directe de β-N-aryl-glycosides par N-glycosylation d’amines aromatiques : application à la synthèse d’antigènes tumoraux. 5ème édition du Symposium de Chimie Organique Centre-Auvergne-Limousin Poitou-Charentes, May 2007, La Rochelle, France. ⟨hal-03520628⟩
  • Nicolas Bridiau, Marie-Dominique Legoy, Thierry Maugard. Chemoenzymatic synthesis of β-D-Galp-(1-4)-β-D-GlcpNAc-N-p-amino-phenylalanine and analogues : application to the synthesis of tumor-associated carbohydrate antigens building blocks. 3ème journée thématique organisée par le Groupe Français des Peptides et Protéines : "Du Glycosynthon à la Glycoprotéine : un défi pour chimistes et biologistes", Sep 2007, Orléans, France. ⟨hal-03520638⟩
  • Nicolas Bridiau, Moulay Benmansour, Marie-Dominique Legoy, Thierry Maugard. Synthèse stéréosélective directe de β-N-aryl-glycosides par N-glycosylation d’amines aromatiques : application à la synthèse d’antigènes tumoraux. Journées de la Section Régionale Centre-Ouest de la Société Française de Chimie, Dec 2006, Poitiers, France. ⟨hal-03520621⟩

Poster communications17 documents

  • Justine Bodin, Amandine Adrien, Delphine Dufour, Stanislas Baudouin, Thierry Maugard, et al.. Anti-aging potential of Ulva intestinalis extract on human dermal fibroblasts in vitro. XXVIème Congrès National de la SFBMEc, May 2019, Reims, France. ⟨hal-02428872⟩
  • Justine Bodin, Antoine Bonnet, Pierre-Edouard Bodet, Amandine Adrien, Delphine Dufour, et al.. Structural characterisation of protein/peptide fractions isolated from the green seaweed Ulva intestinalis and in vitro assessment of their anti-aging properties. Advanced Analytical Technologies for Proteins, Oct 2019, Romainville-Grand Paris, France. ⟨hal-02428883⟩
  • Amandine Adrien, Antoine Bonnet, Delphine Dufour, Stanislas Baudouin, Thierry Maugard, et al.. Pilot Production of Ulvans with Different Molecular Weights from the Seaweed Ulva rigida, and their Effects on Hyaluronan and Collagen Production in Cultured Human Dermal Fibroblasts. COS'MING, Jul 2018, Saint-Malo, France. ⟨hal-02428768⟩
  • Claire Toucheteau, Clément Gaignard, Céline Laroche, Ian Probert, Olivier Gonçalves, et al.. POLYSALGUE Project: Production of low molecular weight exopolysaccharides from microalgae for nutraceutical application. BENEFIQ, Oct 2018, Québec, Canada. ⟨hal-02428791⟩
  • Justine Bodin, Amandine Adrien, Nicolas Bridiau, Jean-Marie Piot, Stéphanie Bordenave-Juchereau, et al.. NEURONALG project: development of algal nutritional fraction targeting the inflammation involved in emotional behavior and metabolic disorders. BENEFIQ, Oct 2018, Québec, Canada. ⟨hal-02428860⟩
  • Amandine Adrien, Nicolas Bridiau, Delphine Dufour, Stanislas Baudouin, Thierry Maugard. Pilot production of ulvans with different molecular weights from the seaweed Ulva sp., and their effects on hyaluronan and collagen production in cultured human dermal fibroblasts. 4th International Symposium on Green Chemistry, May 2017, La Rochelle, France. ⟨hal-02428750⟩
  • Hugo Groult, Nicolas Poupard, Nicolas Bridiau, Jean-Marie Piot, Ingrid Fruitier-Arnaudin, et al.. Vectorisation de nanoparticules d'oxyde de fer conjuguées à des héparines modifiées pour le diagnostic et la thérapie du cancer. 10ème Journée du Cancéropole Grand-Ouest, Jun 2016, Les Sables d'Olonne, France. ⟨hal-02428732⟩
  • Amandine Adrien, Nicolas Bridiau, Delphine Dufour, Stanislas Baudouin, Thierry Maugard. Anticoagulant activity of sulfated polysaccharide-rich macroalgae extracts. 11th Carbohydrate Bioengineering Meeting, May 2015, Espoo, Finland. ⟨hal-02428956⟩
  • Guillaume Pierre, Emmanuel Bertrand, Cédric Delattre, Christine Gardarin, Seltanna Chalane, et al.. Epoxy CIM® Disk comme nouveaux supports d’immobilisation de dextranases pour la production continue d’isomaltooligosaccharides . 25eme colloque CBSO, Jun 2014, Carry-le-Rouet, France. ⟨hal-01853262⟩
  • Emmanuel Bertrand, Guillaume Pierre, Cédric Delattre, Christine Gardarin, Seltana Chalane, et al.. Epoxy CIM® Disk comme nouveaux supports d’immobilisation de dextranases pour la production continue d’isomaltooligosaccharides. 25. Colloque du CBSO - Club Biocatalyse en Synthèse Organique, Jun 2014, Carry-le-Rouet, France. 2014. ⟨hal-02740242⟩
  • Nicolas Bridiau, Neyssen Issaoui, Thierry Maugard. The effects of organic co-solvents on the efficiency and regioselectivity of N-acetyl-lactosamine synthesis, using Bacillus circulans β-galactosidase in hydro-organic media. BIOTRANS 2011 - 10th International Symposium on Biocatalysis, Oct 2011, Giardini Naxos, Italy. ⟨hal-02428974⟩
  • Florian Le Joubioux, Yesmine Ben Henda, Nicolas Bridiau, Oussama Achour, Marianne Graber, et al.. The effect of substrate structure and solvent nature on the efficiency and chemoselectivity of the acylation of amino-alcohols catalyzed by Candida antarctica lipase B. BIOTRANS 2011 - 10th International Symposium on Biocatalysis, Oct 2011, Giardini Naxos, Italy. ⟨hal-02428981⟩
  • Nicolas Bridiau, Thierry Maugard. Chemoenzymatic synthesis of LacNAc-amino acid building blocks by transgalactosylation of N-acetylglucosamine. 8th Carbohydrate Bioengineering Meeting (CBM8), May 2009, Naples, Italy. ⟨hal-03520678⟩
  • Nicolas Bridiau, Thierry Maugard. Facile synthesis of pseudo-C-glycosyl p-amino-DL-phenylalanine building-blocks via Amadori rearrangement. 8th Carbohydrate Bioengineering Meeting (CBM8), May 2009, Naples, Italy. ⟨hal-03520680⟩
  • Nicolas Bridiau, Moulay Benmansour, Marie-Dominique Legoy, Thierry Maugard. Direct stereoselective β-N-glycosylation of aromatic compounds. Application to the synthesis of tumor-associated carbohydrate antigens building-blocks. 5ème édition du Symposium de Chimie Organique Centre-Auvergne-Limousin Poitou-Charentes, May 2007, La Rochelle, France. ⟨hal-03520675⟩
  • Nicolas Bridiau, Moulay Benmansour, Marie-Dominique Legoy, Thierry Maugard. Direct stereoselective β-N-glycosylation of aromatic compounds. Application to the synthesis of tumor-associated carbohydrate antigens building-blocks. 7th Carbohydrate Bioengineering Meeting, Apr 2007, Brunswick, Germany. ⟨hal-03520668⟩
  • Nicolas Bridiau, Selma Taboubi, Mohamed Nejib Marzouki, Marie-Dominique Legoy, Thierry Maugard. Chemoenzymatic galactosylation of aromatic compounds. XXIème colloque du club Bioconversion en Synthèse Organique, May 2006, Ax-les-Thermes, France. ⟨hal-03520658⟩

Book sections1 document

Patents8 documents

  • Olivier Gonçalves, Jeremy Pruvost, Anthony Massé, Antoine Decamp, Ian Probert, et al.. UTILISATION D’EXOPOLYSACCHARIDES DE MICRO-ALGUES A TITRE D’AGENTS TEXTURANTS. France, N° de brevet: FR2102024. 2021. ⟨hal-03506907⟩
  • Olivier Goncalves, Jeremy Pruvost, Anthony Massé, Antoine Decamp, Ian Probert, et al.. Nouveaux exopolysaccharides dépolymérisés, issus de micro-algues, leur procédé de préparation et leurs utilisations en cosmétique pour retarder les effets du vieillissement cutané. France, N° de brevet: FR2102020. 2021. ⟨hal-03506901⟩
  • Justine Bodin, Amandine Adrien, Delphine Dufour, Stanislas Baudouin, Nicolas Bridiau, et al.. Extraits protéiques de macroalgues marine, compositions en contenant et utilisation cosmétique anti-âge. France, N° de brevet: FR3084836 (A1). 2020. ⟨hal-02428688⟩
  • Stanislas Baudouin, Delphine Dufour, Amandine Adrien, Thierry Maugard, Nicolas Bridiau. Utilisation d’un extrait d’ulve comme agent cosmétique anti-age.. France, N° de brevet: FR3057770 (A1), 27/04/2018, n° 16/70618. 2018. ⟨hal-01981535⟩
  • Cédric Delattre, Phillipe Michaud, Guillaume Pierre, Nicolas Bridiau, Thierry Maugard, et al.. Nouvel actif immunomodulateur et composition le comprenant. France, N° de brevet: FR3055550 (A1). 2018. ⟨hal-01679024⟩
  • Cédric Delattre, Philippe Michaud, Guillaume Pierre, Nicolas Bridiau, Thierry Maugard, et al.. Polysaccharide sulfaté extrait d’une algue rouge pour son utilisation en tant qu’anticoagulant. France, N° de brevet: FR3055549 (A1). 2018. ⟨hal-01664867⟩
  • Adrien Amandine, Nicolas Bridiau, Stanislas Baudouin, Dufour Delphine, Thierry Maugard. Polysaccharides sulfatés provenant de macro-algues vertes type Ulva sp. et leurs utilisations pour la régulation des troubles de la coagulation . France, N° de brevet: 16/50735. 2016. ⟨hal-01451064⟩
  • Stanislas Baudouin, Delphine Dufour, Amandine Adrien, Thierry Maugard, Nicolas Bridiau. Utilisation d’un extrait d’ulve comme agent cosmétique anti-age.. France, N° de brevet: FR3057770 (A1), 27/04/2018, n° 16/70618. 2016. ⟨hal-01980701⟩

Theses1 document

  • Nicolas Bridiau. Synthèse chimio-enzymatique de pseudo-glyco-aminoacides, analogues de l'antigène Lewis x sialylé. Biochimie, Biologie Moléculaire. Université de La Rochelle, 2009. Français. ⟨tel-03520765⟩