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Nicolas Blondeau

Directeur de Recherche CNRS
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Publications

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Enhancing Solubility and Bioefficacy of Stilbenes by Liposomal Encapsulation─The Case of Macasiamenene F

Veronika Brezani , Nicolas Blondeau , Jan Kotouček , Eva Klásková , Karel Šmejkal
Article dans une revue hal-04477610v1
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Unlocking Therapeutic Synergy: Tailoring Drugs for Comorbidities such as Depression and Diabetes through Identical Molecular Targets in Different Cell Types

Thierry Coppola , Guillaume Daziano , Ilona Legroux , Sophie Béraud-Dufour , Nicolas Blondeau
Cells, 2023, 12 (23), pp.2768. ⟨10.3390/cells12232768⟩
Article dans une revue hal-04322771v1
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Linotrins: Omega-3 oxylipins featuring an E,Z,E conjugated triene motif are present in the plant kingdom and alleviate inflammation in LPS-challenged microglial cells

Laurence Balas , Sujit Kumar Dey , Sophie Béraud-Dufour , Dean Edward Riechers , Olivia Augusta Landau
European Journal of Medicinal Chemistry, 2022, 231, pp.114157. ⟨10.1016/j.ejmech.2022.114157⟩
Article dans une revue hal-03560829v1
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Combattre l’accident vasculaire cérébral en inhibant une enzyme liée à la voie de synthèse des polyamines

Nicolas Blondeau
Médecine/Sciences, 2021, 37 (6-7), pp.575-577. ⟨10.1051/medsci/2021068⟩
Article dans une revue hal-03273129v1
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Sortilin-derived peptides promote pancreatic beta-cell survival through CREB signaling pathway

Guillaume Daziano , Nicolas Blondeau , Sophie Béraud-Dufour , Amar Abderrahmani , Carole Rovère
Pharmacological Research, 2021, 167, pp.105539. ⟨10.1016/j.phrs.2021.105539⟩
Article dans une revue hal-03176756v1
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Dietary fat exacerbates postprandial hypothalamic inflammation involving glial fibrillary acidic protein-positive cells and microglia in male mice

Céline Cansell , Katharina Stobbe , Clara Sanchez , Ophélia Le Thuc , Coralie-Anne Mosser
Glia, 2021, 69 (1), pp.42-60. ⟨10.1002/glia.23882⟩
Article dans une revue hal-02899910v1
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Inhibition of eIF5A hypusination reprogrammes metabolism and glucose handling in mouse kidney

Marc Cougnon , Romain Carcy , Nicolas Melis , Isabelle Rubera , Christophe Duranton
Cell Death and Disease, 2021, 12 (4), ⟨10.1038/s41419-021-03577-z⟩
Article dans une revue hal-03176556v1
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Inhibition of eIF5A hypusination pathway as a new pharmacological target for stroke therapy

Miled Bourourou , Elsa Gouix , Nicolas Melis , Jonas Friard , Catherine Heurteaux
Journal of Cerebral Blood Flow and Metabolism, 2020, pp.0271678X2092888. ⟨10.1177/0271678X20928882⟩
Article dans une revue hal-02899981v1
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Therapeutic potential of prenylated stilbenoid macasiamenene F through its anti-inflammatory and cytoprotective effects on LPS-challenged monocytes and microglia

Veronika Leláková , Sophie Béraud-Dufour , Jan Hošek , Karel Šmejkal , Vilailak Prachyawarakorn
Journal of Ethnopharmacology, 2020, pp.113147. ⟨10.1016/j.jep.2020.113147⟩
Article dans une revue hal-02912692v1
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A new pharmacological preconditioning-based target: from drosophila to kidney transplantation

Michel Tauc , Nicolas Melis , Miled Bourourou , Sébastien Giraud , Thierry Hauet
Conditioning Medicine, 2019
Article dans une revue hal-02265197v1
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An acute coronary syndrome in Antarctica

Mathieu Carron , Fanny Hamard , Jacques Levraut , Nicolas Blondeau
International maritime health, 2019, 70 (3), pp.167-170. ⟨10.5603/IMH.2019.0026⟩
Article dans une revue hal-02336412v1
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Sortilin in Glucose Homeostasis: From Accessory Protein to Key Player?

Nicolas Blondeau , Sophie Béraud-Dufour , Patricia Lebrun , Céline Hivelin , Thierry Coppola
Frontiers in Pharmacology, 2019, 9, ⟨10.3389/fphar.2018.01561⟩
Article dans une revue hal-02265199v1
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Bridging the Gap Between Diabetes and Stroke in Search of High Clinical Relevance Therapeutic Targets

Thierry Coppola , Sophie Béraud-Dufour , Patricia Lebrun , Nicolas Blondeau
NeuroMolecular Medicine, 2019, ⟨10.1007/s12017-019-08563-5⟩
Article dans une revue hal-02322686v1
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Requirement for preclinical prioritization of neuroprotective strategies in stroke: Incorporation of preconditioning

Tauskela Joseph S. , Blondeau Nicolas
Conditioning Medicine, 2018
Article dans une revue hal-02057375v1
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Ionic Homeostasis Maintenance in ALS: Focus on New Therapeutic Targets

Rossana Sirabella , Valeria Valsecchi , Serenella Anzilotti , Ornella Cuomo , Antonio Vinciguerra
Frontiers in Neuroscience, 2018, 12, ⟨10.3389/fnins.2018.00510⟩
Article dans une revue hal-02265200v1

Cruise ship pathologies in remote regions

Mathieu Carron , Nicolas Emeyriat , Jacques Levraut , Nicolas Blondeau
International maritime health, 2018, 69 (2), pp.75-83. ⟨10.5603/IMH.2018.0012⟩
Article dans une revue hal-02265201v1

Targeting eIF5A Hypusination Prevents Anoxic Cell Death through Mitochondrial Silencing and Improves Kidney Transplant Outcome

Nicolas Melis , Isabelle Rubera , Marc Cougnon , Sébastien Giraud , Baharia Mograbi
Journal of the American Society of Nephrology, 2017, 28 (3), pp.811-822. ⟨10.1681/ASN.2016010012⟩
Article dans une revue hal-02465982v1
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Hypothalamic Inflammation and Energy Balance Disruptions: Spotlight on Chemokines

Ophélia Le Thuc , Katharina Stobbe , Céline Cansell , Jean-Louis Nahon , Nicolas Blondeau
Frontiers in Endocrinology, 2017, 8, ⟨10.3389/fendo.2017.00197⟩
Article dans une revue hal-02265209v1
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Tackling issues in the path toward clinical translation in brain conditioning: Potential offered by nutraceuticals

Joseph S Tauskela , Miled Bourourou , Nicolas Blondeau
Brain Circulation, 2017, ⟨10.4103/bc.bc_8_17⟩
Article dans une revue hal-02265208v1
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A Potent Protective Role of Lysophospholipids Against Global Cerebral Ischemia and Glutamate Excitotoxicity in Neuronal Cultures

Nicolas Blondeau , Inger Lauritzen , Catherine Widmann , Michel Lazdunski , Catherine Heurteaux
Journal of Cerebral Blood Flow and Metabolism, 2016, 22 (7), pp.821-834. ⟨10.1097/00004647-200207000-00007⟩
Article dans une revue hal-02266278v1
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The nutraceutical potential of omega-3 alpha-linolenic acid in reducing the consequences of stroke

Nicolas Blondeau
Biochimie, 2016, 120, pp.49-55. ⟨10.1016/j.biochi.2015.06.005⟩
Article dans une revue hal-02266089v1

Failure and rescue of preconditioning-induced neuroprotection in severe stroke-like insults

Joseph Tauskela , Amy Aylsworth , Melissa Hewitt , Eric Brunette , Nicolas Blondeau
Neuropharmacology, 2016, 105, pp.533-542. ⟨10.1016/j.neuropharm.2016.02.007⟩
Article dans une revue hal-02265212v1

Central CCL2 signaling onto MCH neurons mediates metabolic and behavioral adaptation to inflammation

Ophélia Le Thuc , Céline Cansell , Miled Bourourou , Raphaël Gp Denis , Katharina Stobbe
EMBO Reports, 2016, 17 (12), pp.1738-1752. ⟨10.15252/embr.201541499⟩
Article dans une revue hal-02266078v1

Alpha-linolenic acid given as enteral or parenteral nutritional intervention against sensorimotor and cognitive deficits in a mouse model of ischemic stroke

Miled Bourourou , Catherine Heurteaux , Nicolas Blondeau
Neuropharmacology, 2016, 108, pp.60-72. ⟨10.1016/j.neuropharm.2016.04.040⟩
Article dans une revue hal-02266080v1
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Alpha-Linolenic Acid: An Omega-3 Fatty Acid with Neuroprotective Properties—Ready for Use in the Stroke Clinic?

Nicolas Blondeau , Robert Lipsky , Miled Bourourou , Mark Duncan , Philip Gorelick
BioMed Research International , 2015, 2015, pp.1-8. ⟨10.1155/2015/519830⟩
Article dans une revue hal-02266097v1

The complex contribution of chemokines to neuroinflammation: switching from beneficial to detrimental effects

Ophélia Le Thuc , Nicolas Blondeau , Jean-Louis Nahon , Carole Rovère
Annals of the New York Academy of Sciences, 2015, 1351 (1), pp.127-140. ⟨10.1111/nyas.12855⟩
Article dans une revue hal-02266096v1

Oxygen glucose deprivation-induced astrocyte dysfunction provokes neuronal death through oxidative stress

E. Gouix , A. Buisson , A. Nieoullon , L. Kerkerian-Legoff , Js Tauskela
Pharmacological Research, 2014, 87, pp.8-17. ⟨10.1016/j.phrs.2014.06.002⟩
Article dans une revue hal-01112536v1

Alpha-linolenic acid: A promising nutraceutical for the prevention of stroke

Carine Nguemeni , Elsa Gouix , Miled Bourourou , Catherine Heurteaux , Nicolas Blondeau
PharmaNutrition, 2013, 1 (1), pp.1-8
Article dans une revue hal-02057392v1
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Alpha-linolenic acid: A promising nutraceutical for the prevention of stroke

Carine Nguemeni , Elsa Gouix , Miled Bourourou , Catherine Heurteaux , Nicolas Blondeau
PharmaNutrition, 2013, 1 (1), pp.1-8. ⟨10.1016/j.phanu.2012.12.002⟩
Article dans une revue hal-02266098v1
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Alpha-linolenic omega-3 fatty acid for stroke protection: from brain preconditioning paradigm to nutrition

Nicolas Blondeau
Oléagineux, Corps Gras, Lipides, 2011, ⟨10.1684/ocl.2011.0389⟩
Article dans une revue hal-02266100v1

Peroxisome proliferator-activated receptor gamma induces apoptosis and inhibits autophagy of human monocyte-derived macrophages via induction of cathepsin L: potential role in atherosclerosis.

Dler Faieeq Darweesh Mahmood , Imene Jguirim-Souissi , El-Hadri Khadija , Nicolas Blondeau , Vimala Diderot
Journal of Biological Chemistry, 2011, 286 (33), pp.28858-66. ⟨10.1074/jbc.M111.273292⟩
Article dans une revue hal-00726335v1

Dietary supplementation of alpha-linolenic acid in an enriched rapeseed oil diet protects from stroke.

C. Nguemeni , B. Delplanque , C. Rovère , N. Simon-Rousseau , C. Gandin
Pharmacological Research, 2010, 61 (3), pp.226-33. ⟨10.1016/j.phrs.2009.12.007⟩
Article dans une revue hal-00497117v1

Association of phenylbutazone usage with horses bought for slaughter: a public health risk.

Nicholas Dodman , Nicolas Blondeau , Ann M Marini
Food and Chemical Toxicology, 2010, 48 (5), pp.1270-4. ⟨10.1016/j.fct.2010.02.021⟩
Article dans une revue hal-00496982v1

The role of monocyte chemoattractant protein MCP1/CCL2 in neuroinflammatory diseases.

Grégory Conductier , Nicolas Blondeau , Alice Guyon , Jean-Louis Nahon , Carole Rovère
Journal of Neuroimmunology, 2010, 224 (1-2), pp.93-100. ⟨10.1016/j.jneuroim.2010.05.010⟩
Article dans une revue hal-00858500v1

Subchronic Alpha-Linolenic Acid Treatment Enhances Brain Plasticity and Exerts an Antidepressant Effect: A Versatile Potential Therapy for Stroke.

Nicolas Blondeau , C. Nguemeni , David N Debruyne , Marie Piens , Xuan Wu
Neuropsychopharmacology, 2009, epub ahead of print. ⟨10.1038/npp.2009.84⟩
Article dans une revue hal-00418411v1

Concomitant transitory up-regulation of X-linked inhibitor of apoptosis protein (XIAP) and the heterogeneous nuclear ribonucleoprotein C1-C2 in surviving cells during neuronal apoptosis.

A. Spahn , N. Blondeau , C. Heurteaux , F. Dehghani , A. Rami
Neurochemical Research, 2008, 33 (9), pp.1859-68. ⟨10.1007/s11064-008-9658-0⟩
Article dans une revue hal-00312699v1

Brain adaptation to stressful stimuli: a new perspective on potential therapeutic approaches based on BDNF and NMDA receptors.

Ann M Marini , Margherita Popolo , Hongna Pan , Nicolas Blondeau , Robert H Lipsky
CNS Neurol Disord Drug Targets, 2008, 7 (4), pp.382-90
Article dans une revue hal-00435991v1
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Altered acetylcholine, bradykinin and cutaneous pressure-induced vasodilation in mice lacking the TREK1 potassium channel: the endothelial link.

Ambroise Garry , Bérengère Fromy , Nicolas Blondeau , Daniel Henrion , Frédéric Brau
EMBO Reports, 2007, 8 (4), pp.354-9. ⟨10.1038/sj.embor.7400916⟩
Article dans une revue hal-00171740v1

A tarantula peptide against pain via ASIC1a channels and opioid mechanisms.

Michel Mazzuca , Catherine Heurteaux , Abdelkrim Alloui , Sylvie Diochot , Anne Baron
Nature Neuroscience, 2007, 10 (8), pp.943-945. ⟨10.1038/nn1940⟩
Article dans une revue hal-00171736v1

Distribution of sphingosine kinase activity and mRNA in rodent brain

Nicolas Blondeau , Yushuan Lai , Sarah Tyndall , Margherita Popolo , Kamil Topalkara
Journal of Neurochemistry, 2007, 103 (2), pp.509-517. ⟨10.1111/j.1471-4159.2007.04755.x⟩
Article dans une revue hal-02266122v1

Preconditioning and neurotrophins: a model for brain adaptation to seizures, ischemia and other stressful stimuli

A. Marini , X. Jiang , X. Wu , H. Pan , Z. Guo
Amino Acids, 2007, 32 (3), pp.299-304. ⟨10.1007/s00726-006-0414-y⟩
Article dans une revue hal-02266112v1

Polyunsaturated fatty acids are cerebral vasodilators via the TREK-1 potassium channel.

Nicolas Blondeau , Olivier Pétrault , Stella Manta , Valérie Giordanengo , Pierre Gounon
Circulation Research, 2007, 101 (2), pp.176-84. ⟨10.1161/CIRCRESAHA.107.154443⟩
Article dans une revue hal-00171737v1

Preconditioning and neurotrophins: a model for brain adaptation to seizures, ischemia and other stressful stimuli.

A. M. Marini , X. Jiang , X. Wu , H. Pan , Z. Guo
Amino Acids, 2007, 32 (3), pp.299-304. ⟨10.1007/s00726-006-0414-y⟩
Article dans une revue hal-00312712v1

Les acides gras essentiels de la famille des oméga-3 et la santé de la mère et de l'enfant

Nicolas Blondeau , Stéphane M. Schneider
Nutrition Clinique et Métabolisme, 2006, 20 (2), pp.68-72. ⟨10.1016/j.nupar.2006.04.008⟩
Article dans une revue hal-02266269v1

Deletion of the background potassium channel TREK-1 results in a depression-resistant phenotype

C. Heurteaux , G. Lucas , N. Guy , Malika El Yacoubi , S. Thümmler
Nature Neuroscience, 2006, 9, pp.1134-1141. ⟨10.1038/nn1749⟩
Article dans une revue hal-00091223v1

TREK-1, a K+ channel involved in polymodal pain perception.

A. Alloui , K. Zimmermann , J. Mamet , Frederic Duprat , J. Noël
EMBO Journal, 2006, 25, pp.2368-2376
Article dans une revue hal-00091208v1

Alpha-Linolenic acid and riluzole treatment confer cerebral protection and improve survival after focal brain ischemia

C. Heurteaux , C. Laigle , N. Blondeau , G. Jarretou , M. Lazdunski
Neuroscience, 2006, 137, pp.241-251
Article dans une revue hal-00091215v1
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Le rôle majeur du canal potassique TREK-1 dans la protection neuronale induite par les oméga-3

Catherine Heurteaux , Nicolas Blondeau
Oléagineux, Corps Gras, Lipides, 2005, 12 (1), pp.68-77. ⟨10.1051/ocl.2005.0068⟩
Article dans une revue hal-02266268v1

Le role majeur du canal potassique TREK-1 dans la protection neuronale induite par les omega-3

C. Heurteaux , N. Blondeau
OCL, 2005, xx, pp.77
Article dans une revue hal-00091446v1
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Cerebral tolerance: a new challenge to identify targets for cerebral protection

Nicolas Blondeau , Catherine Heurteaux
Médecine/Sciences, 2004, 20 (12), pp.1109-1114. ⟨10.1051/medsci/200420121109⟩
Article dans une revue hal-02266270v1

Cerebral Tolerance: a new challenge to identify targets for cerebral protection

N. Blondeau , C. Heurteaux
Médecine/Sciences, 2004, 20, pp.1109-1114
Article dans une revue hal-00091456v1
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TREK-1, a K+ channel involved in neuroprotection and general anesthesia

C. Heurteaux , N. Guy , C. Laigle , N. Blondeau , Frederic Duprat
EMBO Journal, 2004, 23 (13), pp.2684-2695. ⟨10.1038/sj.emboj.7600234⟩
Article dans une revue hal-02266418v1

TREK-1, a K+ channel involved in neuroprotection and general anaesthesia

C. Heurteaux , N. Guy , C. Laigle , N. Blondeau , M. Mazzuca
EMBO Journal, 2004, 23, pp.2684-2695
Article dans une revue hal-00091468v1

Vascular sphingosine-1-phosphate S1P1 and S1P3 receptors

Christian Waeber , Nicolas Blondeau , Salvatore Salomone
Drug News perspect., 2004, 17
Article dans une revue hal-02266274v1

Vascular sphingosine-1-phosphate S1P(1) and S1P(3) receptors

C. Waeber , N. Blondeau , S. Salomone
Drug News perspect., 2004, xx, pp.382
Article dans une revue hal-00091448v1

Linolenic acid prevents neuronal cell death and paraplegia following transient spinal cord ischemia in rats

L. Lang-Lazdunski , N. Blondeau , G. Jarretou , M. Lazdunski , C. Heurteaux
Journal of Vascular Surgery, 2003, 38, pp.564-575
Article dans une revue hal-00090986v1

Linolenic acid prevents neuronal cell death and paraplegia after transient spinal cord ischemia in rats

Loïc Lang-Lazdunski , Nicolas Blondeau , Gisele Jarretou , Michel Lazdunski , Catherine Heurteaux
Journal of Vascular Surgery, 2003, 38 (3), pp.564-575. ⟨10.1016/S0741-5214(03)00473-7⟩
Article dans une revue hal-02266277v1

Polyunsaturated fatty acids induce ischemic and epileptic tolerance

N. Blondeau , C. Widmann , M. Lazdunski , C. Heurteaux
Neuroscience, 2002, 109, pp.231-241
Article dans une revue hal-00090948v1

A potent protective role of lysophospholipids against global cerebral ischemia and glutamate-excitotoxicity in neuronal cultures

N. Blondeau , I. Lauritzen , C. Widmann , M. Lazdunski , C. Heurteaux
Journal of Cerebral Blood Flow and Metabolism, 2002, 22, pp.821-834
Article dans une revue hal-00090913v1

POLYUNSATURATED FATTY ACIDS INDUCE ISCHEMIC AND EPILEPTIC TOLERANCE

N. Blondeau , C Widmann , M. Lazdunski , C. Heurteaux
Neuroscience, 2002, 109 (2), pp.231-241. ⟨10.1016/s0306-4522(01)00473-0⟩
Article dans une revue hal-02266275v1
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Activation of the Nuclear Factor-κB Is a Key Event in Brain Tolerance

Nicolas Blondeau , Catherine Widmann , Michel Lazdunski , Catherine Heurteaux
Journal of Neuroscience, 2001, 21 (13), pp.4668-4677. ⟨10.1523/JNEUROSCI.21-13-04668.2001⟩
Article dans une revue hal-02266280v1

ATP-sensitive potassium channels (K ) in retina: a key role for ATP delayed ischemic tolerance

Mohamed Ettaiche , Catherine Heurteaux , Nicolas Blondeau , Marc Borsotto , Norbert Tinel
Brain Research, 2001, 890 (1), pp.118 - 129. ⟨10.1016/s0006-8993(00)03152-8⟩
Article dans une revue hal-02266411v1

K ATP CHANNEL OPENERS, ADENOSINE AGONISTS AND EPILEPTIC PRECONDITIONING ARE STRESS SIGNALS INDUCING HIPPOCAMPAL NEUROPROTECTION

N. Blondeau , H Plamondon , C Richelme , C. Heurteaux , M Lazdunski²
Neuroscience, 2000, 100 (3), pp.465-474. ⟨10.1016/S0306-4522(00)00304-3⟩
Article dans une revue hal-02266281v1
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Polyunsaturated fatty acids are potent neuroprotectors

Inger Lauritzen , Nicolas Blondeau , Catherine Heurteaux , Catherine Widmann , Georges Romey
EMBO Journal, 2000, 19 (8), pp.1784-1793. ⟨10.1093/emboj/19.8.1784⟩
Article dans une revue hal-02266283v1
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Mutually Protective Actions of Kainic Acid Epileptic Preconditioning and Sublethal Global Ischemia on Hippocampal Neuronal Death: Involvement of Adenosine A 1 Receptors and K ATP Channels

Hélène Plamondon , Nicolas Blondeau , Catherine Heurteaux , Michel Lazdunski
Journal of Cerebral Blood Flow and Metabolism, 1999, 19 (12), pp.1296-1308. ⟨10.1097/00004647-199912000-00002⟩
Article dans une revue hal-02266284v1