Nathalie Poupin, PhD

Pablo Rodríguez-Mier, Nathalie Poupin, Carlo de Blasio, Laurent Le Cam, Fabien Jourdan. DEXOM: Diversity-based enumeration of optimal context-specific metabolic networks. PLoS Computational Biology, Public Library of Science, 2021, 17 (2), ⟨10.1371/journal.pcbi.1008730⟩. ⟨hal-03154775⟩

Joran Villaret-Cazadamont, Nathalie Poupin, Anthony Tournadre, Aurélie Batut, Lara Gales, et al.. An Optimized Dual Extraction Method for the Simultaneous and Accurate Analysis of Polar Metabolites and Lipids Carried out on Single Biological Samples. Metabolites, MDPI, 2020, 10 (9), pp.338. ⟨10.3390/metabo10090338⟩. ⟨hal-02927122⟩

Joran Villaret-Cazadamont, Nathalie Poupin, Anthony Tournadre, Aurélie Batut, Lara Gales, et al.. Addendum: An Optimised Dual Extraction Method for the Simultaneous and Accurate Analysis of Polar Metabolites and Lipids Carried out on Single Biological Samples. Metabolites 2020, 10, 338. Metabolites, MDPI, 2020, 10 (12), ⟨10.3390/metabo10120490⟩. ⟨hal-03109907⟩

Nathalie Poupin, Florence Vinson, Arthur Moreau, Aurélie Batut, Maxime Chazalviel, et al.. Improving lipid mapping in Genome Scale Metabolic Networks using ontologies. Metabolomics, Springer Verlag, 2020, 16 (4), ⟨10.1007/s11306-020-01663-5⟩. ⟨hal-02935172⟩

Marie Tremblay-Franco, Nathalie Poupin, Aurélien Amiel, Cécile Canlet, Didier Remond, et al.. Postprandial NMR-Based Metabolic Exchanges Reflect Impaired Phenotypic Flexibility across Splanchnic Organs in the Obese Yucatan Mini-Pig. Nutrients, MDPI, 2020, 12 (8), pp.2442. ⟨10.3390/nu12082442⟩. ⟨hal-02927174⟩

Karla Fabiola Corral-Jara, Laura Cantini, Nathalie Poupin, Tao Ye, Jean-Paul Rigaudière, et al.. An Integrated Analysis of miRNA and Gene Expression Changes in Response to an Obesogenic Diet to Explore the Impact of Transgenerational Supplementation with Omega 3 Fatty Acids. Nutrients, MDPI, 2020, 12 (12), pp.3864. ⟨10.3390/nu12123864⟩. ⟨hal-03100700⟩

Nathalie Poupin, Anne Corlu, Nicolas J. Cabaton, Hélène Dubois-Pot-Schneider, Cecile Canlet, et al.. Large-Scale Modeling Approach Reveals Functional Metabolic Shifts during Hepatic Differentiation. Journal of Proteome Research, American Chemical Society, 2019, 18 (1), pp.204-216. ⟨10.1021/acs.jproteome.8b00524⟩. ⟨hal-01937261⟩

Nathalie Poupin, Marie Tremblay Franco, Aurélien Amiel, Cecile Canlet, Didier Rémond, et al.. Arterio-venous metabolomics exploration reveals major changes across liver and intestine in the obese Yucatan minipig. Scientific Reports, Nature Publishing Group, 2019, 9 (1), ⟨10.1038/s41598-019-48997-2⟩. ⟨hal-02282295⟩

Nicolas J. Cabaton, Nathalie Poupin, Cécile Canlet, Marie Tremblay Franco, Marc Audebert, et al.. An untargeted metabolomics approach to explore the metabolic modulation of HepG2 cells exposed to low doses of bisphenol A and 17β-estradiol 2. Frontiers in Endocrinology, Frontiers, 2018, 9, ⟨10.3389/fendo.2018.00571⟩. ⟨hal-02618654⟩

Robin Mesnage, Martina Biserni, Sucharitha Balu, Clément Frainay, Nathalie Poupin, et al.. Integrated transcriptomics and metabolomics reveal signatures of lipid metabolism dysregulation in HepaRG liver cells exposed to PCB 126. Archives of Toxicology, Springer Verlag, 2018, 92 (8), pp.2533-2547. ⟨10.1007/s00204-018-2235-7⟩. ⟨hal-02621552⟩

Maxime Chazalviel, Clément Frainay, Nathalie Poupin, Florence Vinson, Benjamin Merlet, et al.. MetExploreViz: web component for interactive metabolic network visualization. Bioinformatics, Oxford University Press (OUP), 2018, 34 (2), pp.312-313. ⟨10.1093/bioinformatics/btx588⟩. ⟨hal-02621786⟩

Ludovic Cottret, Clément Frainay, Maxime Chazalviel, Floréal Cabanettes, Yoann Gloaguen, et al.. MetExplore: collaborative edition and exploration of metabolic networks. Nucleic Acids Research, Oxford University Press, 2018, 46 (W1), 8 p. ⟨10.1093/nar/gky301⟩. ⟨hal-01886470⟩

Olivier Mantha, Sergio Polakof, Jean-François Huneau, François Mariotti, Nathalie Poupin, et al.. Early changes in tissue amino acid metabolism and nutrient routing in rats fed a high-fat diet: evidence from natural isotope abundances of nitrogen and carbon in tissue proteins. British Journal of Nutrition, Cambridge University Press (CUP), 2018, 119 (9), pp.981-991. ⟨10.1017/S0007114518000326⟩. ⟨hal-01761202⟩

Benjamin Merlet, Nils Paulhe, Florence Vinson, Clément Frainay, Maxime Chazalviel, et al.. A computational solution to automatically map metabolite libraries in the context of genome scale metabolic networks. Frontiers in Molecular Biosciences, Frontiers Media, 2016, 3, ⟨10.3389/fmolb.2016.00002⟩. ⟨hal-02631089⟩

Nathalie Poupin, François Mariotti, Jean-François Huneau, Dominique Hermier, Helene Fouillet. Natural Isotopic Signatures of Variations in Body Nitrogen Fluxes: A Compartmental Model Analysis. PLoS Computational Biology, Public Library of Science, 2014, 10 (10), ⟨10.1371/journal.pcbi.1003865⟩. ⟨hal-01186909⟩

Sheila G. West, Molly D. Mcintyre, Matthew J. Piotrowski, Nathalie Poupin, Debra L. Miller, et al.. Effects of dark chocolate and cocoa consumption on endothelial function and arterial stiffness in overweight adults. British Journal of Nutrition, Cambridge University Press (CUP), 2014, 111 (4), pp.653-661. ⟨10.1017/S0007114513002912⟩. ⟨hal-02638645⟩

Nathalie Poupin, Jean-François Huneau, François Mariotti, Daniel Tomé, Cecile Bos, et al.. Isotopic and modeling investigation of long-term protein turnover in rat tissues. AJP - Regulatory, Integrative and Comparative Physiology, American Physiological Society, 2013, 304 (3), pp.R218 - R231. ⟨10.1152/ajpregu.00310.2012⟩. ⟨hal-01001592⟩

J Calvez, Nathalie Poupin, C Chesneau, C Lassale, D Tomé. Protein intake, calcium balance and health consequences. European Journal of Clinical Nutrition, Nature Publishing Group, 2012, 66 (3), pp.281 - 295. ⟨10.1038/ejcn.2011.196⟩. ⟨hal-01519022⟩

Nathalie Poupin, Juliane Calvez, Camille Lassale, Caroline Chesneau, Daniel Tomé. Impact of the diet on net endogenous acid production and acid–base balance. Clinical Nutrition, Elsevier, 2012, 31 (3), pp.313 - 321. ⟨10.1016/j.clnu.2012.01.006⟩. ⟨hal-01519016⟩

Nathalie Poupin, Cecile Bos, François Mariotti, Jean-François Huneau, Daniel Tomé, et al.. The nature of the dietary protein impacts the tissue-to-diet N-15 discrimination factors in laboratory rats. PLoS ONE, Public Library of Science, 2011, 6 (11), ⟨10.1371/journal.pone.0028046⟩. ⟨hal-01186796⟩

Nathalie Poupin, Marie Tremblay-Franco, Cécile Canlet, Aurélien Amiel, Didier Rémond, et al.. Modelling intrahepatic metabolic rewiring during the onset of obesity using arterio- venous blood metabolomics profiles. European RFMF Metabomeeting 2020, Jan 2020, Toulouse, France. ⟨hal-02948334⟩

Nathalie Poupin, Marie Tremblay-Franco, Cécile Canlet, Aurélien Amiel, Didier Remond, et al.. Modelling intrahepatic metabolic rewiring during the onset of obesity using arterio- venous blood metabolomics profiles. European RFMF Metabomeeting 2020, Jan 2020, Toulouse, France. ⟨hal-02946074⟩

Sergio Polakof, Marie Tremblay Franco, Nathalie Poupin, Florence Castelli, Jérémie David, et al.. Insights from metabolomic and molecular signatures to detect, in a blood sample, muscle anabolic resistance associated with catabolic situation. Case model of glucocorticoids effect in mini-pigs. Fifth International Congress of Translational Research in Human Nutrition (ICTRHN), Jun 2019, Clermont-Ferrand, France. ⟨hal-02154641⟩

Nathalie Poupin. Analysis of OMICS data in the context of metabolic networks. Workshop "Analyse et interprétation des données en protéomique et métabolomique : points communs et spécificités", Mar 2018, Lyon, France. ⟨hal-02948297⟩

Laurent Fernando, Lucille Stuani, Tony Palama, Tony Kaoma, Jean-Emmanuel Sarry, et al.. Modélisation du réseau métabolique des cellules de Leucémies Aiguës Myéloïdes pour comprendre les différences métaboliques liées à la mutation sur IDH1. Congrès de Spectrométrie de Masse, Métabolomique et Fluxomique (SMMAP), Oct 2017, Marne-la-Vallée, France. ⟨hal-02946080⟩

Nathalie Poupin. Exploring metabolic modulations using genome-scale network modelling and omics data. Workshop "Metabolism in Systems Biology", Nov 2016, Lille, France. ⟨hal-02948304⟩

Nathalie Poupin. Modélisation sous contraintes du métabolisme : une approche globale pour l’étude des modulations métaboliques. 1ères journées du club Métabo-Cancer GSO, Apr 2015, Toulouse, France. ⟨hal-02792590⟩

Nathalie Poupin, Jean-François Huneau, François Mariotti, Dominique Hermier, Tristan Mary-Huard, et al.. Les signatures isotopiques des dérégulations du métabolisme protéino-énergétique lors du développement d'un syndrome métabolique chez le rat. 1er séminaire Abondances Isotopiques Naturelles en Nutrition et Santé, Jan 2014, Paris, France. ⟨hal-01598850⟩

Nathalie Poupin, François Mariotti, Jean-François Huneau, Dominique Hermier, Hélène Fouillet. Les abondances isotopiques de l'azote comme marqueurs des adaptations métaboliques à la qualité de l'apport protéique : analyse et interprétation par modélisation chez le rat. 1er séminaire Abondances Isotopiques Naturelles en Nutrition et Santé, Jan 2014, Paris, France. ⟨hal-01598849⟩

Nathalie Poupin, J.F. Huneau, Tristan Mary-Huard, J.P. Godin, D. Hermier, et al.. d15N and d13C values in body pools are biomarkers of the protein-energy dysregulations of the metabolic syndrome onse. GEOMED 1st workshop on biomedical application of geochemistry, Aug 2013, Gargonza, Italy. ⟨hal-01562202⟩

Nathalie Poupin, François Mariotti, J.-F. Huneau, D. Hermier, H. Fouillet. Les abondances isotopiques naturelles témoignent de modulations nutritionnelles et physiopathologiques du métabolisme azoté : analyse par modélisation compartimentale. Journées francophones de Nutrition, Dec 2013, Bordeaux, France. pp.S29 - S30, ⟨10.1016/S0007-9960(13)70311-0⟩. ⟨hal-01584713⟩

Nathalie Poupin, François Mariotti, Jean-François Huneau, Tristan Mary-Huard, Jean-Philippe Godin, et al.. Les abondances isotopiques naturelles signent l’initiation nutritionnelle du syndrome métabolique.. Journées Francophones de Nutrition, Dec 2012, Lyon, France. ⟨hal-01592265⟩

Nathalie Poupin, Jean-François Huneau, François Mariotti, Cecile Bos, Daniel Tomé, et al.. A new method for the multi-tissue estimation of protein turnover by compartmental analysis of the nitrogen isotope dynamics in rats fed a N-15-enriched diet. Experimental Biology Meeting 2011, Apr 2011, Washington D.C., France. ⟨hal-01186837⟩

Maxime Chazalviel, Adrien Rohan, Nathalie Poupin, Florence Vinson, Clément Frainay, et al.. MetExplore: Omics data analysis in the context of metabolic networks. European RFMF Metabomeeting 2020, Jan 2020, Toulouse, France. ⟨hal-02948391⟩

Pablo Rodríguez-Mier, Nathalie Poupin, Carlo de Blasio, Laurent Le Cam, Fabien Jourdan. Improving prediction of essential genes using context-specific metabolic network ensembles. European RFMF Metabomeeting 2020, Jan 2020, Toulouse, France. ⟨hal-02948371⟩

Joran Villaret-Cazadamont, Noémie Butin, Jean-François Martin, Marie Tremblay-Franco, Christelle Canlet, et al.. Fast-Quenching Standard Comparison of two sampling and extraction protocols to perform metabolomic studies on human adherent cells. European RFMF Metabomeeting 2020, Jan 2020, Toulouse, France. ⟨hal-02948361⟩

Stéphanie Monnerie, Mélanie Pétéra, Cécile Canlet, Florence Castelli, Benoit Colsch, et al.. INPUT OF DEEP PHENOTYPING IN THE METABOLIC SYNDROME STRATIFICATION. European RFMF Metabomeeting 2020, Jan 2020, Toulouse, France. 262 p., 2020, Oral and Poster Abstracts European RMF Metabomeeting 2020. ⟨hal-02505908⟩

Joran Villaret Cazadamont, Noemie Butin, Cecile Canlet, Marie Tremblay Franco, R. Gautier, et al.. Study of the hepatic metabolic effects induced by PFOA exposure using a multiplatform metabolomics approach. 55. Congress of the European-Societies-of-Toxicology (EUROTOX) - Toxicology - Science Providing Solutions, Sep 2019, Helsinki, Finland. ELSEVIER IRELAND LTD, TOXICOLOGY LETTERS, 2019, TOXICOLOGY LETTERS. ⟨hal-02306108⟩

Sergio Polakof, Jean-François Huneau, Dominique Hermier, Didier Rémond, Gaîa Lépine, et al.. Par rapport aux protéines de lait, un mélange de protéines de blé et de pois limite l’insulino-résistance et la lipogenèse de novo induites par un régime riche en lipides et saccharose. Journées Francophones de Nutrition, Nov 2019, Rennes, France. 2019, JFN 2019 Livre des résumés. ⟨hal-02383599⟩

Helene Fouillet, Didier Rémond, François Mariotti, Gaïa Lépine, Véronique Mathé, et al.. Un mélange équilibré de protéines végétales permet une homéostasie protéique tissulaire normale grâce à l’activation de remaniements métaboliques des acides aminés. Journées Francophones de Nutrition, Nov 2019, Rennes, France. ⟨hal-02948410⟩

Sergio Polakof, Marie Tremblay Franco, Cécile Canlet, Jérémie David, Fabien Jourdan, et al.. Hepatic metabolomics and transcriptomics provide valuable insights on inflammatory and metabolic features in rats fed on a high fat diet but showing similar clinical phenotyping alterations. 12. Journées Scientifiques du Réseau Francophone de Métabolomique et Fluxomique RFMF, May 2019, Clermont-Ferrand, France. 168 p., 2019, Livre des résumés. ⟨hal-02162582⟩

Nathalie Poupin, Marie Tremblay Franco, Aurélien Amiel, Cécile Canlet, Didier Rémond, et al.. Modelling hepatic metabolic changes during the onset of obesity using NMR metabolomics arterio-venous blood exploration in minipigs. 12. Journées Scientifiques du Réseau Francophone de Métabolomique et Fluxomique RFMF, May 2019, Clermont-Ferrand, France. 168 p., 2019, Livre des résumés. ⟨hal-02162584⟩

Marie Tremblay Franco, Nathalie Poupin, Florence Castelli, Jérémie David, Marianne Jarzaguet, et al.. Impaired postprandial skeletal muscle metabolism in a minipig model of insulin resistance: insights from arteriovenous and biopsy-based metabolomics analyses. 12. Journées Scientifiques du Réseau Francophone de Métabolomique et Fluxomique RFMF, May 2019, Clermont-Ferrand, France. 168 p., 2019, Livre des résumés. ⟨hal-02285596⟩

Nathalie Poupin, Marie Tremblay Franco, Aurélien Amiel, Cecile Canlet, Didier Remond, et al.. Modeling hepatic metabolic changes during the onset of obesity from metabolomics arterio-venous blood exploration in minipigs. Copenhagen Bioscience Conference 2017: Where big-data gets translated into knowledge, May 2017, Copenhague, Netherlands. 2017, Bioscience Conference 2017. ⟨hal-01606420⟩

Jean-François Huneau, Klaus-Jürgen Petzke, Nathalie Poupin, Tristan Mary-Huard, Olivier Mantha, et al.. Natural abundance of nitrogen isotopes in amino acids are biomarkers of the metabolic syndrome onset. 12th european nutrition conference, Oct 2015, Berlin, Germany. KARGER, Annals of Nutrition and Metabolism, 67, pp.1, 2015, Annals of Nutrition and Metabolism. ⟨hal-01572322⟩

Fabien Jourdan, Nathalie Poupin. Human metabolic networks and metabolomics. Metabolomics as tool in nutrition research, Woodhead publishing Limited, 2014. ⟨hal-01187878⟩

Pablo Rodríguez-Mier, Nathalie Poupin, Carlo de Blasio, Laurent Le Cam, Fabien Jourdan. DEXOM: Diversity-based enumeration of optimal context-specific metabolic networks. 2020. ⟨hal-02935163⟩

Lucille Stuani, Marie Sabatier, Feng Wang, Nathalie Poupin, Claudie Bosc, et al.. Combinatory therapy targeting mitochondrial oxidative phosphorylation improves efficacy of IDH mutant inhibitors in acute myeloid leukemia. 2020. ⟨hal-02935177⟩

Nathalie Poupin. Les abondances naturelles des isotopes stables de l'azote chez le rat : facteurs de variabilité et application pour l'étude des flux azotés et de l'impact métabolique de conditions nutritionnelles et physiopathologiques par modélisation compartimentale.. Alimentation et Nutrition. AgroParisTech, 2013. Français. ⟨NNT : 2013AGPT0003⟩. ⟨pastel-00927219⟩