CV Accueil - Archive ouverte HAL

	Generation of a heterozygous SCN5A knockout human induced pluripotent stem cell line by CRISPR/Cas9 edition Marie Gizon , Laëtitia Duboscq-Bidot , Lina El Kassar , Pierre Bobin , Flavie Ader Stem Cell Research, 2022, 60, pp.102680. ⟨10.1016/j.scr.2022.102680⟩ Article dans une revue hal-03549731v1
	Trafficking and Gating Cooperation Between Deficient Nav1.5-mutant Channels to Rescue INa Jérôme Clatot , Alain Coulombe , Isabelle Deschênes , Pascale Guicheney , Nathalie Neyroud Frontiers in Bioscience-Landmark, 2022, 27 (7), pp.209. ⟨10.31083/j.fbl2707209⟩ Article dans une revue hal-03995067v1
	Trafficking and Gating Cooperation Between Deficient Nav1.5-mutant Channels to Rescue INa Jérôme Clatot , Alain Coulombe , Isabelle Deschênes , Pascale Guicheney , Nathalie Neyroud Frontiers in Bioscience-Landmark, 2022, 27, ⟨10.31083/j.fbl2707209⟩ Article dans une revue inserm-04021311v1
	A Type 2 Ryanodine Receptor Variant in the Helical Domain 2 Associated with an Impairment of the Adrenergic Response Malorie Blancard , Zahia Touat-Hamici , Yuriana Aguilar-Sanchez , Liheng Yin , Guy Vaksmann Journal of Personalized Medicine, 2021, 11 (6), pp.579. ⟨10.3390/jpm11060579⟩ Article dans une revue hal-03278104v1
	In vivo Dominant-Negative Effect of an SCN5A Brugada Syndrome Variant Nicolas Doisne , Marta Grauso , Nathalie Mougenot , Michel Clergue , Charlotte Souil Frontiers in Physiology, 2021, 12, ⟨10.3389/fphys.2021.661413⟩ Article dans une revue hal-03261259v1
	In vivo Dominant-Negative Effect of an SCN5A Brugada Syndrome Variant Nicolas Doisne , Marta Grauso , Nathalie Mougenot , Michel Clergue , Charlotte Souil Frontiers in Physiology, 2021, 12, ⟨10.3389/fphys.2021.661413⟩ Article dans une revue hal-03342597v1
	A novel gain‐of‐function mutation in SCN5A responsible for multifocal ectopic Purkinje‐related premature contractions Nicolas Doisne , Victor Waldmann , Alban Redheuil , Xavier Waintraub , Véronique Fressart Human Mutation, 2020, 41 (4), pp.850-859. ⟨10.1002/humu.23981⟩ Article dans une revue hal-02934592v1
	Inter-Regulation of K v 4.3 and Voltage-Gated Sodium Channels Underlies Predisposition to Cardiac and Neuronal Channelopathies Jérôme Clatot , Nathalie Neyroud , Robert Cox , Charlotte Souil , Jing Huang International Journal of Molecular Sciences, 2020, 21 (14), pp.5057. ⟨10.3390/ijms21145057⟩ Article dans une revue hal-02932372v1
	Inter-Regulation of Kv4.3 and Voltage-Gated Sodium Channels Underlies Predisposition to Cardiac and Neuronal Channelopathies Jérôme Clatot , Nathalie Neyroud , Robert Cox , Charlotte Souil , Jing Huang International Journal of Molecular Sciences, 2020, 21, ⟨10.3390/ijms21145057⟩ Article dans une revue inserm-04021335v1
	A truncating SCN5A mutation combined with genetic variability causes sick sinus syndrome and early atrial fibrillation Azza Ziyadeh-Isleem , Jérôme Clatot , Sabine Duchatelet , Estelle Gandjbakhch , Isabelle Denjoy Heart Rhythm, 2014, 11 (6), pp.1015-1023. ⟨10.1016/j.hrthm.2014.02.021⟩ Article dans une revue hal-02330963v1
	Desmosomal Cadherins Are Decreased in Explanted Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy Patient Hearts Alexia Vite , Estelle Gandjbakhch , Catherine Prost , Véronique Fressart , Pierre Fouret PLoS ONE, 2013, 8 (9), pp.e75082. ⟨10.1371/journal.pone.0075082⟩ Article dans une revue hal-02330952v1
	Dominant-negative effect of SCN5A N-terminal mutations through the interaction of Nav1.5 α-subunits Jérôme Clatot , Azza Ziyadeh-Isleem , Svetlana Maugenre , Isabelle Denjoy , Haiyan Liu Cardiovascular Research, 2012, 96 (1), pp.53-63. ⟨10.1093/cvr/cvs211⟩ Article dans une revue hal-02330941v1
	MOG1: a new susceptibility gene for Brugada syndrome. Darouna Kattygnarath , Svetlana Maugenre , Nathalie Neyroud , Elise Balse , Carole Ichai Circulation: Cardiovascular Genetics, 2011, 4 (3), pp.261-268. ⟨10.1161/CIRCGENETICS.110.959130⟩ Article dans une revue hal-02330925v1
	Kv4 Potassium Channels Form a Tripartite Complex With the Anchoring Protein SAP97 and CaMKII in Cardiac Myocytes Saïd El-Haou , Elise Balse , Nathalie Neyroud , Gilles Dilanian , Bruno Gavillet Circulation Research, 2009, 104 (6), pp.758-769. ⟨10.1161/CIRCRESAHA.108.191007⟩ Article dans une revue hal-02330905v1
	Mutations in the Z-band protein myopalladin gene and idiopathic dilated cardiomyopathy Laetitia Duboscq-Bidot , Peng Xu , Philippe Charron , Nathalie Neyroud , Gilles Dilanian Cardiovascular Research, 2008, 77 (1), pp.118-125. ⟨10.1093/cvr/cvm015⟩ Article dans une revue hal-02330870v1
	The anchoring protein SAP97 retains Kv1.5 channels in the plasma membrane of cardiac myocytes Joëlle Abi-Char , Saïd El-Haou , Elise Balse , Nathalie Neyroud , Roger Vranckx AJP - Heart and Circulatory Physiology, 2008, 294 (4), pp.H1851-H1861. ⟨10.1152/ajpheart.01045.2007⟩ Article dans une revue hal-02330886v1
	Heart rate influences on repolarization duration and morphology in symptomatic versus asymptomatic KCNQ1 mutation carriers Fabrice Extramiana , Isabelle Denjoy , Fabio Badilini , Iheb Chabani , Nathalie Neyroud American Journal of Cardiology, 2005, 95 (3), pp.406-409. ⟨10.1016/j.amjcard.2004.09.045⟩ Article dans une revue hal-02330856v1
	MAGUKs: beyond ionic channel anchoring David Godreau , Nathalie Neyroud , Roger Vranckx , Stéphane Hatem Médecine/Sciences, 2004, 20 (1), pp.84-88. ⟨10.1051/medsci/200420184⟩ Article dans une revue hal-04003484v1
	Somatic Gene Transfer of Tagged K+ Channel Fragments to Probe Trafficking and Electrical Function in Epithelial Cells and Cardiac Myocytes Nathalie Neyroud , I. Deschênes , M. Akao , H.B. Nuss , E. Marbán Journal of Membrane Biology, 2002, 190 (2), pp.133-144. ⟨10.1007/s00232-002-1033-5⟩ Article dans une revue hal-02330832v1
	Isoform-Specific Modulation of Voltage-Gated Na + Channels by Calmodulin Isabelle Deschênes , Nathalie Neyroud , Deborah Disilvestre , Eduardo Marban , David Yue Circulation Research, 2002, 90 (4), pp.E49-57. ⟨10.1161/01.res.0000012502.92751.e6⟩ Article dans une revue hal-02330754v1
	Notched T Waves on Holter Recordings Enhance Detection of Patients With LQT2 ( HERG ) Mutations J. Lupoglazoff , I. Denjoy , M. Berthet , Nathalie Neyroud , L. Demay Circulation, 2001, 103 (8), pp.1095-1101. ⟨10.1161/01.cir.103.8.1095⟩ Article dans une revue hal-02330681v1
	[Ventricular repolarization and Holter monitoring. Effect of sympathetic blockage on the QT/RR ratio]. F Extramiana , R Tavernier , P Maison-Blanche , N Neyroud , L Jordaens Archives des Maladies du Coeur et des Vaisseaux, 2000, 93 (11), pp.1277-83 Article dans une revue hal-03999254v1
	Novel mutations in KvLQT1 that affect Iks activation through interactions with Isk C. Chouabe , Nathalie Neyroud , P Richard , I Denjoy , B Hainque Cardiovascular Research, 2000, 45 (4), pp.971-980. ⟨10.1016/s0008-6363(99)00411-3⟩ Article dans une revue hal-02330675v1
	QT interval and arrhythmic risk assessment after myocardial infarction Fabrice Extramiana , Nathalie Neyroud , Heikki V. Huikuri , M.Juhani Koistinen , Philippe Coumel American Journal of Cardiology, 1999, 83 (2), pp.266-269. ⟨10.1016/s0002-9149(98)00835-2⟩ Article dans une revue hal-02330655v1
	Splicing Mutations in KCNQ1: a mutation hot spot at codon 344 that produces in frame transcripts A. Murray , C. Donger , C. Fenske , I. Spillman , P. Richard Circulation, 1999, 100 (10), pp.1077-1084. ⟨10.1161/01.cir.100.10.1077⟩ Article dans une revue hal-02330667v1
	Mutations in a Dominant-Negative Isoform Correlate with Phenotype in Inherited Cardiac Arrhythmias Raha Mohammad-Panah , Sophie Demolombe , Nathalie Neyroud , Pascale Guicheney , Florence Kyndt American Journal of Human Genetics, 1999, 64 (4), pp.1015-1023. ⟨10.1086/302346⟩ Article dans une revue hal-02330661v1
	[Congenital long QT syndrome. The value of genetics in prognostic evaluation]. I Denjoy , J Lupoglazoff , C Donger , M Berthet , P Richard Archives des Maladies du Coeur et des Vaisseaux, 1999, 92 (5), pp.557-63 Article dans une revue hal-03999230v1
	Genomic Organization of the KCNQ1 K + Channel Gene and Identification of C-Terminal Mutations in the Long-QT Syndrome Nathalie Neyroud , Pascale Richard , Nicolas Vignier , Claire Donger , Isabelle Denjoy Circulation Research, 1999, 84 (3), pp.290-297. ⟨10.1161/01.res.84.3.290⟩ Article dans une revue hal-02330607v1
	Heterozygous mutation in the pore of potassium channel gene KvLQT1 causes an apparently normal phenotype in long QT syndrome Nathalie Neyroud , Isabelle Denjoy , Claire Donger , Françoise Gary , Elisabeth Villain European Journal of Human Genetics, 1998, 6 (2), pp.129-133. ⟨10.1038/sj.ejhg.5200165⟩ Article dans une revue hal-02330596v1
	[Congenital long QT syndrome]. J Lupoglazoff , I Denjoy , N Neyroud , P Guicheney , A Casasoprana La Presse Médicale, 1998, 27 (21), pp.1029-34 Article dans une revue hal-03999272v1
	Diagnostic performance of QT interval variables from 24-h electrocardiography in the long QT syndrome Nathalie Neyroud , P. Maison-Blanche , I Denjoy , S. Chevret , C Donger European Heart Journal Supplements, 1998, 19 (1), pp.158-165. ⟨10.1053/euhj.1997.0730⟩ Article dans une revue hal-02330552v1
	Properties of KvLQT1 K+ channel mutations in Romano-Ward and Jervell and Lange-Nielsen inherited cardiac arrhythmias C. Chouabe , Nathalie Neyroud , P Guicheney , M. Lazdunski , G. Romey EMBO Journal, 1997, 16 (17), pp.5472-5479. ⟨10.1093/emboj/16.17.5472⟩ Article dans une revue hal-02330545v1
	KVLQT1 C-Terminal Missense Mutation Causes a Forme Fruste Long-QT Syndrome Claire Donger , Isabelle Denjoy , Myriam Berthet , Nathalie Neyroud , Corinne Cruaud Circulation, 1997, 96 (9), pp.2778-2781. ⟨10.1161/01.cir.96.9.2778⟩ Article dans une revue hal-02330550v1
	A novel mutation in the potassium channel gene KVLQT1 causes the Jervell and Lange-Nielsen cardioauditory syndrome Nathalie Neyroud , Frédérique Tesson , Isabelle Denjoy , Michel Leibovici , Claire Donger Nature Genetics, 1997, 15 (2), pp.186-189. ⟨10.1038/ng0297-186⟩ Article dans une revue hal-02330097v1
	[Dynamics of ventricular repolarisation]. A Leenhardt , P Maison-Blanche , I Denjoy , N Neyroud , D Pellerin Archives des Maladies du Coeur et des Vaisseaux, 1995, 88 Spec No 5, pp.27-33 Article dans une revue hal-03999260v1
	Different circadian behavior of the apex and the end of the T wave P. Coumel , P. Maison-Blanche , D. Catuli , Nathalie Neyroud , J. Fayn Journal of Electrocardiology, 1995, 28, pp.138-142. ⟨10.1016/s0022-0736(95)80039-5⟩ Article dans une revue hal-02329255v1
	[Dynamics of ventricular repolarisation]. A Leenhardt , P Maison-Blanche , I Denjoy , N Neyroud , D Pellerin Archives des Maladies du Coeur et des Vaisseaux, 1995, 88 Spec No 5, pp.27-33 Article dans une revue hal-04003492v1

	A novel approach of therapy using AAVs in a murine model of Scn5a haploinsufficiency. M Ferrand , N Mougenot , Pl Laporte , A Leclerc , V Algalarrondo Printemps de la Cardiologie, SFC, May 2023, Marseille (13), France Communication dans un congrès hal-04003652v1
	CRISPR/Cas9-mediated generation of cardiomyocytes derived from human induced pluripotent stem cells to model SCN5A deficiency. M Gizon , V Fontaine , L Duboscq-Bidot , L El Kassar , K Giraud-Triboult ePrintemps de la Cardiologie, SFC, May 2021, En ligne (Paris), France Communication dans un congrès hal-04003594v1
	In vivo dominant-negative effect of an SCN5A Brugada syndrome variant. N Doisne , Marta Grauso , N Mougenot , M Clergue , C Souil Journée de la filière CARDIOGEN, Apr 2021, En ligne (Paris), France Communication dans un congrès hal-04003643v1
	AAV-mediated gene therapy in a mouse model of Brugada syndrome. N Doisne , Marta Grauso , N Mougenot , M Clergue , A Coulombe IHU ICAN - Les avancées de la Recherche 2018, IHU ICAN, Jan 2018, PARIS, France Communication dans un congrès hal-04003567v1
	Recovery of Scn5a-deficient mice cardiac conduction using AAVs. N Doisne , Marta Grauso , N Mougenot , M Clergue , L Fossé Channelopathy meeting, Jun 2018, Chicago, United States Communication dans un congrès hal-04003581v1
	A novel RYR2 missense mutation causing catecholaminergic polymorphic ventricular tachycardia and numerous sudden deaths. M Blancard , L Yin , G Vaksmann , N Roux-Buisson , I Denjoy Printemps de la Cardiologie, SFC, Apr 2017, Nantes (44000), France Communication dans un congrès hal-04003560v1
	Exploration of the dominant-negative effect of a SCN5A mutation in mice using adeno-associated viruses. N Doisne , Marta Grauso , N Mougenot , M Clergue , A Coulombe Frontiers in CardioVascular Biology, Jul 2016, Florence (IT), Italy Communication dans un congrès hal-04003663v1

	[19] Gene delivery to cardiac muscle Nathalie Neyroud , H Bradley Nuss , Michelle Leppo , Eduardo Marban , J Kevin Donahue Gene delivery to cardiac muscle., 346, pp.323-334, 2002, ⟨10.1016/s0076-6879(02)46064-8⟩ Chapitre d'ouvrage hal-02330727v1

Nathalie Neyroud

Domaines de recherche

Publications

Generation of a heterozygous SCN5A knockout human induced pluripotent stem cell line by CRISPR/Cas9 edition

Trafficking and Gating Cooperation Between Deficient Nav1.5-mutant Channels to Rescue INa

Trafficking and Gating Cooperation Between Deficient Nav1.5-mutant Channels to Rescue INa

A Type 2 Ryanodine Receptor Variant in the Helical Domain 2 Associated with an Impairment of the Adrenergic Response

In vivo Dominant-Negative Effect of an SCN5A Brugada Syndrome Variant

In vivo Dominant-Negative Effect of an SCN5A Brugada Syndrome Variant

A novel gain‐of‐function mutation in SCN5A responsible for multifocal ectopic Purkinje‐related premature contractions

Inter-Regulation of K v 4.3 and Voltage-Gated Sodium Channels Underlies Predisposition to Cardiac and Neuronal Channelopathies

Inter-Regulation of Kv4.3 and Voltage-Gated Sodium Channels Underlies Predisposition to Cardiac and Neuronal Channelopathies

A truncating SCN5A mutation combined with genetic variability causes sick sinus syndrome and early atrial fibrillation

Desmosomal Cadherins Are Decreased in Explanted Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy Patient Hearts

Dominant-negative effect of SCN5A N-terminal mutations through the interaction of Nav1.5 α-subunits

MOG1: a new susceptibility gene for Brugada syndrome.

Kv4 Potassium Channels Form a Tripartite Complex With the Anchoring Protein SAP97 and CaMKII in Cardiac Myocytes

Mutations in the Z-band protein myopalladin gene and idiopathic dilated cardiomyopathy

The anchoring protein SAP97 retains Kv1.5 channels in the plasma membrane of cardiac myocytes

Heart rate influences on repolarization duration and morphology in symptomatic versus asymptomatic KCNQ1 mutation carriers

MAGUKs: beyond ionic channel anchoring

Somatic Gene Transfer of Tagged K+ Channel Fragments to Probe Trafficking and Electrical Function in Epithelial Cells and Cardiac Myocytes

Isoform-Specific Modulation of Voltage-Gated Na + Channels by Calmodulin

Notched T Waves on Holter Recordings Enhance Detection of Patients With LQT2 ( HERG ) Mutations

[Ventricular repolarization and Holter monitoring. Effect of sympathetic blockage on the QT/RR ratio].

Novel mutations in KvLQT1 that affect Iks activation through interactions with Isk

QT interval and arrhythmic risk assessment after myocardial infarction

Splicing Mutations in KCNQ1: a mutation hot spot at codon 344 that produces in frame transcripts

Mutations in a Dominant-Negative Isoform Correlate with Phenotype in Inherited Cardiac Arrhythmias

[Congenital long QT syndrome. The value of genetics in prognostic evaluation].

Genomic Organization of the KCNQ1 K + Channel Gene and Identification of C-Terminal Mutations in the Long-QT Syndrome

Heterozygous mutation in the pore of potassium channel gene KvLQT1 causes an apparently normal phenotype in long QT syndrome

[Congenital long QT syndrome].

Diagnostic performance of QT interval variables from 24-h electrocardiography in the long QT syndrome

Properties of KvLQT1 K+ channel mutations in Romano-Ward and Jervell and Lange-Nielsen inherited cardiac arrhythmias

KVLQT1 C-Terminal Missense Mutation Causes a Forme Fruste Long-QT Syndrome

A novel mutation in the potassium channel gene KVLQT1 causes the Jervell and Lange-Nielsen cardioauditory syndrome

[Dynamics of ventricular repolarisation].

Different circadian behavior of the apex and the end of the T wave

[Dynamics of ventricular repolarisation].

A novel approach of therapy using AAVs in a murine model of Scn5a haploinsufficiency.

CRISPR/Cas9-mediated generation of cardiomyocytes derived from human induced pluripotent stem cells to model SCN5A deficiency.

In vivo dominant-negative effect of an SCN5A Brugada syndrome variant.

AAV-mediated gene therapy in a mouse model of Brugada syndrome.

Recovery of Scn5a-deficient mice cardiac conduction using AAVs.

A novel RYR2 missense mutation causing catecholaminergic polymorphic ventricular tachycardia and numerous sudden deaths.

Exploration of the dominant-negative effect of a SCN5A mutation in mice using adeno-associated viruses.

[19] Gene delivery to cardiac muscle