Number of documents

41

Curriculum Vitae of Dr Nathalie MIGNET, PhD

 

CNRS Research Director

 

National Scientific Research Center (CNRS) - France.

 

Born 01/10/1970

 

 

 

•Team Leader  of the team Vector for Molecular Imaging and targeted therapy in the Chemical and Biological Technologies for Health  (Université Paris Descartes – Chimie ParisTech - UMR 8258 - CNRS – UMR-S 1022 Inserm)

 

 

 

 

 

Main scientific field and domain of competence:

 

 

 

Diplomas

 

 

 

  1. V. Baldim, F. Bedioui, N. Mignet, I. Margaill, J.-F. Berret Ce3+-surface density superposition principle observed for CeO2-x superoxide dismutase and catalase-like catalytic activities Nanoscale 2018, 10(15):6971-6980.

     

 

2.         Zeng N., Seguin J., Dumortier G., Maury M., Bessodes M., Scherman D., Mignet N., Boudy V. Cyanine derivative as a suitable marker for thermosensitive in situ gelling delivery systems: in vitro and in vivo validation of a sustained buccal drug delivery Int J Pharm 2017, 534(1-2):128-135.

 

 

 

3.         Ramírez-García G, Gutiérrez-Granados S, Gallegos-Corona MA, Palma-Tirado L, d'Orlyé F, Varenne A, Mignet N, Richard C, Martínez-Alfaro M. Long-term toxicological effects of persistent luminescence nanoparticles after intravenous injection in mice. Int J Pharm. 2017, 532, 686-695.

 

4 Valero L, Alhareth K, Gil S, Simasotchi C, Roques C, Scherman D, Mignet N, Fournier T, Andrieux K. Assessment of dually labelled PEGylated liposomes transplacental passage and placental penetration using a combination of two ex-vivo models: the dually perfused human placenta and the suspended villous explants. Int J Pharm. 2017, 532(2):729-737

 

 

 

5 Manta S, Renault G, Delalande A, Couture O, Lagoutte I, Seguin J, Lager F, Houzé P, Midoux P, Bessodes M, Scherman D, Bureau MF, Marie C, Pichon C, Mignet, N. Cationic Microbubbles and Antibiotic-Free Plasmid for sustained Ultrasound-mediated Transgene Expression in liver. J. Controlled Rel. 2017, 262:170-181

 

 

 

6          Ramírez-García G, d'Orlyé F, Gutiérrez-Granados S, Martínez-Alfaro M, Mignet N, Richard C, Varenne A. Functionalization and characterization of persistent luminescence nanoparticles by dynamic light scattering, laser Doppler and capillary electrophoresis. Colloids Surf B Biointerfaces. 2015, 136, 272-281

 

 

 

7.         Zeng N., Mignet N, Dumortier G, Olivier E, Seguin J, Maury M, Scherman D, Rat P, Boudy V.Poloxamer bioadhesive hydrogel for buccal drug delivery: Cytotoxicity and trans-epithelial permeability evaluations using TR146 human buccal epithelial cell line International Journal of Pharmaceutics, Int J. Pharm. 2015, 495, 1028-37.

 

 

 

8.         Seguin J, Dhotel H, Kai-Luen R, Bessodes M, Mignet N. Fine tuning of mixed ionic and hydrogen bond interactions for plasmid delivery using lipoplexes. Eur J Pharm Biopharm. 2015, 90, 63-9.

 

 

 

9.         M. Breton, J.F. Berret, C. Bourgaux, T. Kral, M. Hof, C. Pichon, M. Bessodes, D. Scherman, N. Mignet, Protonation of Lipids Impacts the Supramolecular and Biological Properties of Their Self-Assembly. Langmuir, 2011, 27, 12336-45

 

 

 

10.       G. Pembouong, N. Morellet, T. Kral, M. Hof, D. Scherman, M-F. Bureau, N. Mignet, Triblock copolymer L64 destabilizes lipidic membranes and does not interact with DNA J. Controlled Release, 2011, 151, 57-64

 

 

 

 

 

Journal articles33 documents

  • Caroline Thébault, Grégory Ramniceanu, Aude Michel, Claire Beauvineau, Christian Girard, et al.. In Vivo Evaluation of Magnetic Targeting in Mice Colon Tumors with Ultra-Magnetic Liposomes Monitored by MRI. Molecular Imaging and Biology, Springer Verlag, 2019, 21 (2), pp.269-278. ⟨10.1007/s11307-018-1238-3⟩. ⟨hal-02123141⟩
  • Hugo Salmon, Rabah Gahoual, Pascal Houzé, Tayssir Ibrahim, Michel Bessodes, et al.. Europium labeled lactosylated albumin as a model workflow for the development of biotherapeutics. Nanomedicine: Nanotechnology, Biology and Medicine, Elsevier, 2019, 18, pp.21-30. ⟨10.1016/j.nano.2019.02.011⟩. ⟨hal-02087248⟩
  • Hugo Salmon, Rabah Gahoual, Pascal Houzé, Tayssir Ibrahim, Michel Bessodes, et al.. Europium labeled lactosylated albumin as a model workflow for the development of biotherapeutics. Nanomedicine: Nanotechnology, Biology and Medicine, Elsevier, 2019, 18, pp.21-30. ⟨10.1016/j.nano.2019.02.011⟩. ⟨hal-02123126⟩
  • Brice Martin Couillaud, Philippe Espeau, Nathalie Mignet, Yohann Corvis. State of the Art of Pharmaceutical Solid Forms: from Crystal Property Issues to Nanocrystals Formulation. ChemMedChem, Wiley-VCH Verlag, 2019, 14 (1), pp.8-23. ⟨10.1002/cmdc.201800612⟩. ⟨hal-02123129⟩
  • Francois Lux, Vu Long Tran, Eloise Thomas, Sandrine Dufort, Fabien Rossetti, et al.. AGuIX® from bench to bedside—Transfer of an ultrasmall theranostic gadolinium-based nanoparticle to clinical medicine. British Journal of Radiology, British Institute of Radiology, 2019, 92 (1093), pp.20180365. ⟨10.1259/bjr.20180365⟩. ⟨hal-01935540⟩
  • Wassef Khaled, Joao Piraquive, Benjamin Leporq, Jing Hong Wan, Simon Lambert, et al.. In vitro distinction between proinflammatory and antiinflammatory macrophages with gadolinium-liposomes and ultrasmall superparamagnetic iron oxide particles at 3.0T. Journal of Magnetic Resonance Imaging, Wiley-Blackwell, 2019, 49 (4), pp.1166-1173. ⟨10.1002/jmri.26331⟩. ⟨hal-02123132⟩
  • Jianhua Liu, Thomas Lécuyer, Johanne Seguin, Nathalie Mignet, Daniel Scherman, et al.. Imaging and therapeutic applications of persistent luminescence nanomaterials. Advanced Drug Delivery Reviews, Elsevier, 2019, 138, pp.193-210. ⟨10.1016/j.addr.2018.10.015⟩. ⟨hal-02123130⟩
  • Jianhua Liu, Thomas Lécuyer, Johanne Seguin, Nathalie Mignet, Daniel Scherman, et al.. Imaging and therapeutic applications of persistent luminescence nanomaterials. Advanced Drug Delivery Reviews, Elsevier, 2019, 138, pp.193-210. ⟨10.1016/j.addr.2018.10.015⟩. ⟨hal-02303348⟩
  • Hai Doan Do, Brice Martin Couillaud, Bich-Thuy Do, Yohann Corvis, Nathalie Mignet. Advances on non-invasive physically triggered nucleic acid delivery from nanocarriers. Advanced Drug Delivery Reviews, Elsevier, 2019, 138, pp.3-17. ⟨10.1016/j.addr.2018.10.006⟩. ⟨hal-02123133⟩
  • Katia Lemdani, Johanne Seguin, Christelle Lesieur, Chantal Al Sabbagh, Bich-Thuy Doan, et al.. Mucoadhesive thermosensitive hydrogel for the intra-tumoral delivery of immunomodulatory agents, in vivo evidence of adhesion by means of non-invasive imaging techniques. International Journal of Pharmaceutics, Elsevier, 2019, 567, pp.118421. ⟨10.1016/j.ijpharm.2019.06.012⟩. ⟨hal-02325457⟩
  • Vu-Long Tran, Vivek Thakare, Fabien Rossetti, Anne Baudouin, Grégory Ramniceanu, et al.. One-pot direct synthesis for multifunctional ultrasmall hybrid silica nanoparticles. Journal of materials chemistry‎ B, Royal Society of Chemistry, 2018, 6 (29), pp.4821 - 4834. ⟨10.1039/c8tb00195b⟩. ⟨hal-01861704⟩
  • Caroline Thébault, Grégory Ramniceanu, Aude Michel, Claire Beauvineau, Christian Girard, et al.. In Vivo Evaluation of Magnetic Targeting in Mice Colon Tumors with Ultra-Magnetic Liposomes Monitored by MRI. Molecular Imaging and Biology, Springer Verlag, 2018, pp 1-10. ⟨10.1007/s11307-018-1238-3⟩. ⟨hal-01873316⟩
  • Lucie Valero, Khair Alhareth, Jenifer Espinoza Romero, Warren Viricel, Jeanne Leblond, et al.. Liposomes as Gene Delivery Vectors for Human Placental Cells. Molecules, MDPI, 2018, 23 (5), pp.1085. ⟨10.3390/molecules23051085⟩. ⟨hal-02123142⟩
  • Lucie Valero, Khair Alhareth, Sophie Gil, Edouard Lecarpentier, Vassilis Tsatsaris, et al.. Nanomedicine as a potential approach to empower the new strategies for the treatment of preeclampsia. Drug Discovery Today Biosilico, Elsevier, 2018, 23 (5), pp.1099-1107. ⟨10.1016/j.drudis.2018.01.048⟩. ⟨hal-02123145⟩
  • Wassef Khaled, Joao Piraquive, Benjamin Leporq, Jing Hong Wan, Simon Lambert, et al.. In vitro distinction between proinflammatory and antiinflammatory macrophages with gadolinium-liposomes and ultrasmall superparamagnetic iron oxide particles at 3.0T. Journal of Magnetic Resonance Imaging, Wiley-Blackwell, 2018, ⟨10.1002/jmri.26331⟩. ⟨hal-01917473⟩
  • Katia Lemdani, Nathalie Mignet, Vincent Boudy, Johanne Seguin, Edward Oujagir, et al.. Local immunomodulation combined to radiofrequency ablation results in a complete cure of local and distant colorectal carcinoma. OncoImmunology, Taylor & Francis, 2018, 8 (3), pp.1550342. ⟨10.1080/2162402X.2018.1550342⟩. ⟨hal-02123122⟩
  • Yohann Corvis, Simona Manta, Caroline Thébault, Olivier Couture, Hélène Dhotel, et al.. Novel Perfluorinated Triblock Amphiphilic Copolymers for Lipid-Shelled Microbubble Stabilization. Langmuir, American Chemical Society, 2018, 34 (33), pp.9744-9753. ⟨10.1021/acs.langmuir.8b01668⟩. ⟨hal-02123140⟩
  • Anthony Delalande, Colette Bastié, Lucie Pigeon, Simona Manta, Matthias Lebertre, et al.. Cationic gas-filled microbubbles for ultrasound-based nucleic acids delivery. Bioscience Reports, Portland Press, 2017, 37 (6), pp.BSR20160619. ⟨10.1042/BSR20160619⟩. ⟨hal-02123147⟩
  • Ni Zeng, Johanne Seguin, Pierre-Louis Destruel, Gilles Dumortier, Marc Maury, et al.. Cyanine derivative as a suitable marker for thermosensitive in situ gelling delivery systems: In vitro and in vivo validation of a sustained buccal drug delivery. International Journal of Pharmaceutics, Elsevier, 2017, 534 (1-2), pp.128-135. ⟨10.1016/j.ijpharm.2017.09.073⟩. ⟨hal-02123148⟩
  • Lucie Valero, Khair Alhareth, Sophie Gil, Christelle Simasotchi, Caroline Roques, et al.. Assessment of dually labelled PEGylated liposomes transplacental passage and placental penetration using a combination of two ex-vivo human models: the dually perfused placenta and the suspended villous explants. International Journal of Pharmaceutics, Elsevier, 2017, 532 (2), pp.729-737. ⟨10.1016/j.ijpharm.2017.07.076⟩. ⟨hal-02319716⟩
  • Simona Manta, Gilles Renault, Anthony Delalande, Olivier Couture, Isabelle Lagoutte, et al.. Cationic microbubbles and antibiotic-free miniplasmid for sustained ultrasound–mediated transgene expression in liver. Journal of Controlled Release, Elsevier, 2017, 262, pp.170 - 181. ⟨10.1016/j.jconrel.2017.07.015⟩. ⟨hal-01656574⟩
  • Simona Manta, Anthony Delalande, Michel Bessodes, Michel Francis Bureau, Daniel Scherman, et al.. Characterization of Positively Charged Lipid Shell Microbubbles with Tunable Resistive Pulse Sensing (TRPS) Method: A Technical Note. Ultrasound in Medicine and Biology, Elsevier, 2016, 42 (2), pp.624 - 630. ⟨10.1016/j.ultrasmedbio.2015.10.010⟩. ⟨hal-01407496⟩
  • Estelle Sigward, Nathalie Mignet, Patrice Rat, Melody Dutot, Saleh Muhamed, et al.. Formulation and cytotoxicity evaluation of new self-emulsifying multiple W/O/W nanoemulsions. International Journal of Nanomedicine, Dove Medical Press, 2013, 8, pp.611 - 625. ⟨10.2147/IJN.S35661⟩. ⟨hal-01583935⟩
  • Anthony Delalande, Michiel Postema, Nathalie Mignet, Patrick Midoux, Chantal Pichon. Ultrasound and microbubble-assisted gene delivery: recent advances and ongoing challenges.. Ther Deliv, 2012, 3 (10), pp.1199-1215. ⟨hal-00817350⟩
  • Johanne Seguin, Céline Nicolazzi, Nathalie Mignet, Daniel Scherman, Guy Chabot. Vascular density and endothelial cell expression of integrin alpha v beta 3 and E-selectin in murine tumours.. Tumor Biology, Springer Verlag, 2012, 33 (5), pp.1709-17. ⟨10.1007/s13277-012-0428-x⟩. ⟨inserm-00709732⟩
  • Michel Bureau, Luc Wasungu, Lauriane Jugé, Daniel Scherman, Marie-Pierre Rols, et al.. Investigating relationship between transfection and permeabilization by the electric field and/or the Pluronic® L64 in vitro and in vivo.. The Journal of Gene Medicine, Wiley, 2012, 14 (3), pp.204-15. ⟨10.1002/jgm.2610⟩. ⟨inserm-00679701⟩
  • Marie Breton, Jean-François Berret, Claudie Bourgaux, Teresa Kral, Martin Hof, et al.. Protonation of lipids impacts the supramolecular and biological properties of their self-assembly.. Langmuir, American Chemical Society, 2011, 27 (20), pp.12336-45. ⟨10.1021/la202439s⟩. ⟨hal-00720543⟩
  • Marie Breton, Jeanne Leblond, Johanne Seguin, Patrick Midoux, Daniel Scherman, et al.. Comparative gene transfer between cationic and thiourea lipoplexes. The Journal of Gene Medicine, Wiley, 2010, 12 (1), pp.45-54. ⟨10.1002/jgm.1417⟩. ⟨hal-00529308⟩
  • Malak Safi, Hiba Sarrouj, Olivier Sandre, Mignet Nathalie, Jean-François Berret. Interactions between sub-10-nm iron and cerium oxide nanoparticles and 3T3 fibroblasts: the role of the coating and aggregation state. Nanotechnology, Institute of Physics, 2010, 21, pp.145103. ⟨10.1088/0957-4484/21/14/145103⟩. ⟨hal-00533474⟩
  • Marie Breton, Michel Bessodes, Serge Bouaziz, Jean Herscovici, Daniel Scherman, et al.. Iminothiol/thiourea tautomeric equilibrium in thiourea lipids impacts DNA compaction by inducing a cationic nucleation for complex assembly. Biophysical Chemistry, Elsevier, 2009, 145 (1), pp.7. ⟨10.1016/j.bpc.2009.08.003⟩. ⟨hal-00579023⟩
  • Marie Breton, Michel Bessodes, Serge Bouaziz, Jean Herscovici, Daniel Scherman, et al.. Iminothiol/thiourea tautomeric equilibrium in thiourea lipids impacts DNA compaction by inducing a cationic nucleation for complex assembly. Biophysical Chemistry, Elsevier, 2009, 145 (1), pp.7-16. ⟨10.1016/j.bpc.2009.08.003⟩. ⟨hal-02122492⟩
  • Mignet Nathalie, Le Masne de Chermont Quentin, Randrianarivelo Tatiana, Seguin Johanne, Richard Cyrille, et al.. Liposome biodistribution by time resolved fluorimetry of lipophilic europium complexes. European Biophysics Journal, Springer Verlag (Germany), 2006, 35 (2), pp.155-161. ⟨inserm-00162498⟩
  • Jeanne Leblond, Nathalie Mignet, Lucie Leseurre, Céline Largeau, Michel Bessodes, et al.. Design, synthesis, and evaluation of enhanced DNA binding new lipopolythioureas.. Bioconjugate Chemistry, American Chemical Society, 2006, 17 (5), pp.1200-8. ⟨10.1021/bc060110g⟩. ⟨inserm-00165275⟩

Conference papers6 documents

  • Wassef Khaled, Benjamin Leporq, J.H Wan, Philippe Garteiser, Simon A. Lambert, et al.. Distinction between pro and anti-inflammatory macrophages using MRI relaxometry and quantitative susceptibility mapping. 23th International Society of Magnetic Resonance in Medicine annual meeting, May 2015, Toronto, Canada. ⟨hal-01918412⟩
  • Gregory Ramniceanu, Bich-Thuy Doan, Camille Vezignol, Alain Graillot, Quentin Crouzet, et al.. Phosphonate PEG Copolymers to control the USPIO stealthiness. Journées RITS 2015, Mar 2015, Dourdan, France. p20-21. ⟨inserm-01145542⟩
  • Caroline Thébault, Grégory Ramniceanu, Johanne Seguin, Aude Michel, Claire Beauvineau, et al.. Multimodal RM and Optic Imaging using ultramagnetic liposomes to monitor a cancer therapy. Journées RITS 2015, Mar 2015, Dourdan, France. p16-17 Section nanomédecine. ⟨inserm-01143980⟩
  • Simona Manta, Anthony Delalande, Gilles Renault, Michel Francis Bureau, Matthias Lebertre, et al.. Positively charged microbubbles to target nucleic acid delivery with ultrasound. Journées RITS 2015, Mar 2015, Dourdan, France. ⟨inserm-01154976⟩
  • Mickaël Garnier, Maya Alsheh Ali, Johanne Seguin, Nathalie Mignet, Thomas Hurtut, et al.. Grading cancer from liver histology images using inter and intra region spatial relations. International Conference on Image Analysis and Recognition, Oct 2014, Portugal. pp.247-254. ⟨hal-01063797⟩
  • Maya Alsheh Ali, Johanne Seguin, Aurélie Fisher, Nathalie Mignet, Laurent Wendling, et al.. Comparison of the Spatial Organization in Colorectal Tumors using Second-Order Statistics and Functional ANOVA. Image and Signal Processing and Analysis (ISPA), 2013 8th International Symposium on, 2013, Italy. pp.257 - 261, ⟨10.1109/ISPA.2013.6703749⟩. ⟨hal-00992369⟩

Book sections2 documents

  • Michel Bessodes, Helene Dhotel, Nathalie Mignet. Lipids for Nucleic Acid Delivery: Cationic or Neutral Lipoplexes, Synthesis, and Particle Formation. Methods Mol. Biol, pp.123-139, 2019. ⟨hal-02123120⟩
  • Nathalie Mignet, Corinne Marie, Anthony Delalande, Simona Manta, Johanne Seguin, et al.. Microbubbles for Nucleic Acid Delivery in Liver Using Mild Sonoporation.. Methods Mol Biol., pp.377-387, 2019, ⟨10.1016/j.nano.2019.02.011⟩. ⟨hal-02123117⟩