CNRS Research Director
National Scientific Research Center (CNRS) - France.
Born 01/10/1970
•Team Leader of the team Vector for Molecular Imaging and targeted therapy in the Chemical and Biological Technologies for Health (Université Paris Descartes – Chimie ParisTech - UMR 8258 - CNRS – UMR-S 1022 Inserm)
Main scientific field and domain of competence:
Nanomedicine, non viral vectors for gene delivery, liposomes - Biomaterials - Drug delivery - Cancer therapy – Nanovectors characterisation – Bioimaging, optical imaging techniques.
Main work patents and discoveries concern gene delivery vectors, including chemical vectors delivery methods, new characterisation methods, pharmacokinetic and bioimaging.
Scientific Publications:
h index: 18 (1997-)
1283 quotations without self-citations
91 articles in reviewed journals or book chapters.
26 reviews or books chapters
10 independent patent applications
25 invited speaker lectures in International Meetings
Editor for Elsevier of 3 special issues in International Journal of Pharmaceutics
Diplomas
2008: Habilitation to lead research
1996: PhD in bio-organic chemistry, montpellier, France
Scientific Responsibilities (present time):
2004 – ongoing: Team Leader Vectors for Molecular Imaging and Targeted Therapies
2017-2018: Committee member for the National Council Research of Norway
2015-ongoing: Committee Member for the National Ligue against Cancer (La Ligue)
2013-2016: Committee member for the national Research Agency.
2017: Working Group member on Nanomedicine for the Alliance Aviesan
2016 Working group member for the Pharmaceutical center prospective
10 Major publications:
V. Baldim, F. Bedioui, N. Mignet, I. Margaill, J.-F. Berret Ce3+-surface density superposition principle observed for CeO2-x superoxide dismutase and catalase-like catalytic activities Nanoscale 2018, 10(15):6971-6980.
2. Zeng N., Seguin J., Dumortier G., Maury M., Bessodes M., Scherman D., Mignet N., Boudy V. Cyanine derivative as a suitable marker for thermosensitive in situ gelling delivery systems: in vitro and in vivo validation of a sustained buccal drug delivery Int J Pharm 2017, 534(1-2):128-135.
3. Ramírez-García G, Gutiérrez-Granados S, Gallegos-Corona MA, Palma-Tirado L, d'Orlyé F, Varenne A, Mignet N, Richard C, Martínez-Alfaro M. Long-term toxicological effects of persistent luminescence nanoparticles after intravenous injection in mice. Int J Pharm. 2017, 532, 686-695.
4 Valero L, Alhareth K, Gil S, Simasotchi C, Roques C, Scherman D, Mignet N, Fournier T, Andrieux K. Assessment of dually labelled PEGylated liposomes transplacental passage and placental penetration using a combination of two ex-vivo models: the dually perfused human placenta and the suspended villous explants. Int J Pharm. 2017, 532(2):729-737
5 Manta S, Renault G, Delalande A, Couture O, Lagoutte I, Seguin J, Lager F, Houzé P, Midoux P, Bessodes M, Scherman D, Bureau MF, Marie C, Pichon C, Mignet, N. Cationic Microbubbles and Antibiotic-Free Plasmid for sustained Ultrasound-mediated Transgene Expression in liver. J. Controlled Rel. 2017, 262:170-181
6 Ramírez-García G, d'Orlyé F, Gutiérrez-Granados S, Martínez-Alfaro M, Mignet N, Richard C, Varenne A. Functionalization and characterization of persistent luminescence nanoparticles by dynamic light scattering, laser Doppler and capillary electrophoresis. Colloids Surf B Biointerfaces. 2015, 136, 272-281
7. Zeng N., Mignet N, Dumortier G, Olivier E, Seguin J, Maury M, Scherman D, Rat P, Boudy V.Poloxamer bioadhesive hydrogel for buccal drug delivery: Cytotoxicity and trans-epithelial permeability evaluations using TR146 human buccal epithelial cell line International Journal of Pharmaceutics, Int J. Pharm. 2015, 495, 1028-37.
8. Seguin J, Dhotel H, Kai-Luen R, Bessodes M, Mignet N. Fine tuning of mixed ionic and hydrogen bond interactions for plasmid delivery using lipoplexes. Eur J Pharm Biopharm. 2015, 90, 63-9.
9. M. Breton, J.F. Berret, C. Bourgaux, T. Kral, M. Hof, C. Pichon, M. Bessodes, D. Scherman, N. Mignet, Protonation of Lipids Impacts the Supramolecular and Biological Properties of Their Self-Assembly. Langmuir, 2011, 27, 12336-45
10. G. Pembouong, N. Morellet, T. Kral, M. Hof, D. Scherman, M-F. Bureau, N. Mignet, Triblock copolymer L64 destabilizes lipidic membranes and does not interact with DNA J. Controlled Release, 2011, 151, 57-64