Natalia de Isla

Documents

Publications

	Relationship between bone marrow mesenchymal stromal cells (MSCs) senescence and clinical evolution of AML and MDS patients after hematopoietic stem cells (HSC) transplantation Meriem El Ouafy , Naceur Charif , Laura Boulanger , Romain Perouf , Allan Bertrand International Cell Senescence Association 2020 Conference (ICSA2020), Dec 2021, Osaka, Japan Communication dans un congrès hal-03626470v1
	The Mechanoadaptation Concept of Cells Jean François Stoltz , Yves Rémond , Daniel George , Jacques Magdalou , Yinping Li 9th International Europe-China Symposium on Stem Cells and Regenerative Medicine, Université de Strasbourg; Association Bioingénierie, Oct 2019, Strasbourg, France. pp.47-59, ⟨10.3233/BHR210010⟩ Communication dans un congrès hal-03245667v1
	Impact of in vitro expansion on immunomodulation properties of mesenchymal stromal cells Naceur Charif , Meriem El Ouafy , Dima Ghannoum , Anne-Béatrice Notarantonio , Yinping Li 9th International Symposium Europe China on Stem Cells and Regenerative Medicine, Oct 2019, Strasbourg, France Communication dans un congrès hal-02973617v1
	Senescence of mesenchymal stem cells and its impact on clinical applications Natalia De Isla , Laurie Targa , Naceur Charif , Émilie Roeder , Ghislaine Cauchois 8th InternationalSymposium China-Europe Stem cells and regenerative medicine, Jun 2018, Wuhan, China Communication dans un congrès hal-02973662v1
	Senescence of mesenchymal stroma cells and clinical applications Dima Ghannoum , Laurie Targa , Naceur Charif , Meriem El Ouafy , Ghislaine Cauchois 9th International Symposium Europe China on Stem Cells and Regenerative Medicine, Jun 2018, Strasbourg, France Communication dans un congrès hal-03629665v1
	Mesenchymal stem cells heterogeneity considering surface markers and senescence Laurie Targa , Naceur Charif , Xing Liu , Audrey Fortunat Zeh Eto'O , Mayssa Kacem 8th InternationalSymposium China-Europe Stem cells and regenerative medicine, Jun 2018, Wuhan, China Communication dans un congrès hal-02973642v1
	Impact of culture conditions on the behavior of mesenchymal stem cells: choosing critical parameters related to cell quality Naceur Charif , Meriem El Ouafy , Laurie Targa , Xing Liu , Audrey Fortunat Zeh Eto'O 8th InternationalSymposium China-Europe Stem cells and regenerative medicine, Jun 2018, Wuhan, China Communication dans un congrès hal-02973631v1
	New advanced therapy medicinal product for cartilage defect treatment with extemporaneous association of a scaffold and Wharton's jelly mesenchymal stromal cells Loïc Reppel , Céline Huselstein , Natalia de Isla , Nathalie Rouas-Freiss , Philippe Moreau 7th international symposium Europe-China Stem cells and Médecine Regenerative, Oct 2017, Shangrao, China Communication dans un congrès hal-03612827v1
	Higher Proliferative Potential of Human Mesenchymal Stromal Cells from Wharton's Jelly Compared to Bone Marrow Is Linked to Decreased Senescence Naceur Charif , Yueying Li , Laurie Targa , Lei Zhang , Yinping Li 2nd International Meeting of the GDRI CNRS 851 CeSMeR “Mesenchymal Stem Cells and Regenerative Medicine”, Oct 2017, Shangrao, China. ⟨10.3233/BHR190019⟩ Communication dans un congrès hal-02973117v1
	Comprendre l'hétérogénéité des CSM pour des produits de thérapie cellulaire personnalisés Laurie Targa , Yueying Li , Naceur Charif , Mainard Didier , Danièle Bensoussan FR CNRS-UL 3209 Bioingénierie Moléculaire Cellulaire & Thérapeutique "La médecine personnalisée", Dec 2016, Nancy, France Communication dans un congrès hal-02974089v1
	RNM as MCS aging biomarkers : pertinence for regenerative medicine Naceur Charif , Li, Yy , T Kaoma, , Vallar, L , Li, Yp 6th International Symposium Europe-China, Jul 2016, Nancy, France Communication dans un congrès hal-03033120v1
	Surface markers expressed differently according to MSC source and aging reflects MCS heterogeneity and define MSC subset Laurie Targa , Li, Y , Ye, J , Naceur Charif , Du, W 6th International Symposium Europe-China, Jul 2016, Nancy, France Communication dans un congrès hal-03033148v1
	Research progress in liver tissue engineering Lei Zhang , Zheng Guan , Jun-Song Ye , Yan-Feng Yin , Jean-François Stoltz 6th China–France International Symposium “Stem Cells and Regenerative Medicine” and the first meeting of the France–China International CNRS Network (GDRI) CeSMeR, Jul 2016, Nancy, France. pp.S113-S119, ⟨10.3233/BME-171632⟩ Communication dans un congrès hal-02973692v1
	Rat BMSC infusion was unable to ameliorate inflammatory injuries in tissues of mice with LPS-induced endotoxemia Xiaolin Xie , Hanhan Liu , Jinhua Wu , Yun Chen , Zhui Yu 6th China–France International Symposium “Stem Cells and Regenerative Medicine” and the first meeting of the France–China International CNRS Network (GDRI) CeSMeR, Oct 2016, Nancy, France. pp.S129-S138, ⟨10.3233/BME-171634⟩ Communication dans un congrès hal-02973711v1
	The importance of mesenchymal stem cell donor’s age for cartilage engineering Yueying Li , Naceur Charif , Didier Mainard , Jean-Francois Stoltz , Natalia De Isla 2014 World Congress on Osteoarthritis, Osteoarthritis Research Society International (OARSI) Apr 2014, Paris, France. pp.S61 Communication dans un congrès hal-01532044v1
	Changes in chondrogenesis differentiation potential of bone marrow mesenchymal stem cells according to donor age Yueying Li , Naceur Charif , Didier Mainard , Natalia De Isla , Jean-Francois Stoltz 2013 Osteoarthritis Research Society International (OARSI) World Congress, Apr 2013, Philadelphie, United States. pp.S283 Communication dans un congrès hal-01511185v1

	Scale-Up of Academic Mesenchymal Stromal Cell Production Caroline Laroye , Mélanie Gauthier , Jessica Morello , Naceur Charif , Véronique Latger-Cannard Journal of Clinical Medicine, 2023, 12 (13), pp.4414. ⟨10.3390/jcm12134414⟩ Article dans une revue hal-04503576v1
	Impact of microcarrier concentration on mesenchymal stem cell growth and death: Experiments and modeling Charlotte Maillot , Natalia De Isla , Celine Loubiere , Dominique Toye , Eric Olmos Biotechnology and Bioengineering, 2022, 119 (12), pp.3537 - 3548. ⟨10.1002/bit.28228⟩ Article dans une revue hal-04504478v1
	Secretome of Mesenchymal Stem Cells from Consecutive Hypoxic Cultures Promotes Resolution of Lung Inflammation by Reprogramming Anti-Inflammatory Macrophages Zhihong Xu , Lulu Lin , Yuxuan Fan , Céline Huselstein , Natalia de Isla International Journal of Molecular Sciences, 2022, 23 (8), pp.4333. ⟨10.3390/ijms23084333⟩ Article dans une revue hal-04504687v1
	Quality by design to define critical process parameters for mesenchymal stem cell expansion Charlotte Maillot , Caroline Sion , Natalia de Isla , Dominique Toye , Eric Olmos Biotechnology Advances, 2021, 50, pp.107765. ⟨10.1016/j.biotechadv.2021.107765⟩ Article dans une revue hal-03505285v1
	Characterization of Bone Marrow and Wharton’s Jelly Mesenchymal Stromal Cells Response on Multilayer Braided Silk and Silk/PLCL Scaffolds for Ligament Tissue Engineering Xing Liu , Adrien Baldit , Emilie de Brosses , Frédéric Velard , Ghislaine Cauchois Polymers, 2020, 12 (9), pp.2163. ⟨10.3390/polym12092163⟩ Article dans une revue hal-02973729v1
	Impact of the type of microcarrier and agitation modes on the expansion performances of mesenchymal stem cells derived from umbilical cord Céline Loubière , Caroline Sion , Natalia de Isla , Loïc Reppel , Emmanuel Guedon Biotechnology Progress, 2019, 35 (6), pp.e2887. ⟨10.1002/btpr.2887⟩ Article dans une revue hal-02968491v1
	Mesenchymal stem cell interacted with PLCL braided scaffold coated with poly- l -lysine/hyaluronic acid for ligament tissue engineering Xing Liu , Cédric Laurent , Qiaoyue Du , Laurie Targa , Ghislaine Cauchois Journal of Biomedical Materials Research Part A, 2018, 106 (12), pp.3042-3052. ⟨10.1002/jbm.a.36494⟩ Article dans une revue hal-02070806v1
	Laser photobiomodulation in pressure ulcer healing of human diabetic patients: gene expression analysis of inflammatory biochemical markers Anelice Calixto Ruh , Lucio Frigo , Marcos Fernando Xisto Braga Cavalcanti , Paulo Svidnicki , Viviane Nogaroto Vicari Lasers in Medical Science, 2018, 33 (1), pp.165 - 171. ⟨10.1007/s10103-017-2384-6⟩ Article dans une revue hal-01831939v1
	Defining a scaffold for ligament tissue engineering: What has been done, and what still needs to be done Cédric P. Laurent , Xing Liu , Natalia de Isla , Xiong Wang , Rachid Rahouadj Journal of Cellular Immunotherapy, 2018, 4 (1), pp.4-9. ⟨10.1016/j.jocit.2018.09.002⟩ Article dans une revue hal-02070833v1
	Stem cells and vascular regenerative medicine: A mini review Jean-François Stoltz , Danièle Bensoussan , Natalia de Isla , L. Zhang , Z. Han Clinical Hemorheology and Microcirculation, 2017, 64 (4), pp.613 - 633. ⟨10.3233/CH-168036⟩ Article dans une revue hal-01715476v1
	Mechanical stimulations on human bone marrow mesenchymal stem cells enhance cells differentiation in a three-dimensional layered scaffold Jessica Schiavi , Loïc Reppel , Naceur Charif , Natalia de Isla , Didier Mainard Journal of Tissue Engineering and Regenerative Medicine, 2017, 12 (2), pp.360-369. ⟨10.1002/term.2461⟩ Article dans une revue hal-01715211v1
	Revisiting MSC expansion from critical quality attributes to critical culture process parameters Céline Martin , Eric Olmos , Marie-Laure Collignon , Natalia de Isla , Fabrice Blanchard Process Biochemistry, 2017, 59, pp.231 - 243. ⟨10.1016/j.procbio.2016.04.017⟩ Article dans une revue hal-01921144v1
	MyD88/ERK/NFkB pathways and pro-inflammatory cytokines release in periodontal ligament stem cells stimulated by Porphyromonas gingivalis Francesca Diomede , Maria Zingariello , Marcos F.X.B. Cavalcanti , Ilaria Merciaro , Jacopo Pizzicannella European Journal of Histochemistry, 2017, 61 (2), ⟨10.4081/ejh.2017.2791⟩ Article dans une revue hal-01831940v1
	Comparative Study of the Physiotherapeutic and Drug Protocol and Low-Level Laser Irradiation in the Treatment of Pain Associated with Temporomandibular Dysfunction Marcos Fernando Xisto Braga Cavalcanti , Uoston Holder Silva , Ernesto Cesar Pinto Leal-Junior , Rodrigo A.B. Lopes-Martins , Rodrigo Labat Marcos Photomedicine and Laser Surgery, 2016, 34 (12), pp.652-656. ⟨10.1089/pho.2016.4195⟩ Article dans une revue hal-02973719v1
	Signalling pathways involved in the process of mesenchymal stem cells differentiating into hepatocytes Jun-Song Ye , Xiao-San Su , Jean-François Stoltz , Natalia de Isla , Lei Zhang Cell Proliferation, 2015, 48 (2), pp.157-165. ⟨10.1111/cpr.12165⟩ Article dans une revue hal-01451903v1
	Stem cells and applications: A survey Jean-François Stoltz , D. Bensoussan , L. Zhang , V. Decot , Natalia de Isla Bio-Medical Materials and Engineering, 2015, 25 (1), pp.S3-S26. ⟨10.3233/BME-141225⟩ Article dans une revue hal-01452233v1
	Stem Cells and Regenerative Medicine Jean-François Stoltz , Natalia de Isla , Y. P. Li, , Danièle Bensoussan , L. Zhang, Stem Cells International, 2015, 2015, pp.734731. ⟨10.1155/2015/734731⟩ Article dans une revue hal-01465786v1
	Active implant combining human stem cell microtissues and growth factors for bone-regenerative nanomedicine. Jessica Schiavi , Laetitia Keller , David-Nicolas Morand , Natalia De Isla , Olivier Huck Nanomedicine, 2015, 10 (5), pp.753-63. ⟨10.2217/nnm.14.228⟩ Article dans une revue hal-01451383v1
	Donor's age dependent proliferation decrease of human bone marrow mesenchymal stem cells is linked to diminished clonogenicity Natalia de Isla , Yueying Li , Naceur Charif , Didier Mainard , Danisle Bensoussan Bio-Medical Materials and Engineering, 2014, 24 (1), pp.S47-S52. ⟨10.3233/BME-140973⟩ Article dans une revue hal-01453218v1
	Towards a Tissue-Engineered Ligament: Design and Preliminary Evaluation of a Dedicated Multi-Chamber Tension-Torsion Bioreactor Cédric Laurent , Cédryck Vaquette , Céline Martin , Emmanuel Guedon , Xiude Wu Processes, 2014, 2 (1), pp.167. ⟨10.3390/pr2010167⟩ Article dans une revue hal-01424974v1
	Research on stem cells as candidates to be differentiated into hepatocytes Lei Zhang , Jun-Song Ye , Veronique Decot , Jean-François Stoltz , Natalia de Isla Bio-Medical Materials and Engineering, 2012, 22 (1-3), pp.105-111. ⟨10.3233/BME-2012-0695⟩ Article dans une revue hal-02973708v1
	Mechanical properties evolution of a PLGA-PLCL composite scaffold for ligament tissue engineering under static and cyclic traction-torsion in vitro culture conditions Cyril Kahn , Kahina Ziani , Ye Min Zang , Jian Liu , Nguyen Tran Journal of Biomaterials Science, Polymer Edition, 2012, 24 (8), pp.899-911. ⟨10.1080/09205063.2012.727265⟩ Article dans une revue hal-00867834v1
	Human Stem Cells and Articular Cartilage Tissue Engineering J-F. Stoltz , Céline Huselstein , Jessica Schiavi , Y.Y. Li , Danièle Bensoussan Current Pharmaceutical Biotechnology, 2012, 13 (15), pp.2682-2691. ⟨10.2174/138920112804724846⟩ Article dans une revue hal-03782970v1
	Does Making Method of Alginate Hydrogel Influence the Chondrogenic Differentiation of Human Mesenchymal Stem Cells? Jessica Schiavi , Naceur Charif , Natalia De Isla , Danièle Bensoussan , Jean-François Stoltz Engineering, 2012, 04 (10), pp.110-113. ⟨10.4236/eng.2012.410B028⟩ Article dans une revue hal-03782979v1
	Long term culture of mesenchymal stem cells in hypoxia promotes a genetic program maintaining their undifferentiated and multipotent status Leticia Basciano , Christophe Nemos , Bernard Foliguet , Natalia de Isla , Marcelo de Carvalho BMC Cell Biology, 2011, 12 (1), pp.12. ⟨10.1186/1471-2121-12-12⟩ Article dans une revue hal-02973723v1
	Designing a three-dimensional alginate hydrogel by spraying method for cartilage tissue engineering Jessica Tritz , Rachid Rahouadj , Natalia de Isla , Naceur Charif , Astrid Pinzano Soft Matter, 2010, 6 (20), pp.5165-5174. ⟨10.1039/c000790k⟩ Article dans une revue hal-03697373v1
	Original approach for cartilage tissue engineering with mesenchymal stem cells Jessica Tritz-Schiavi , Naceur Charif , Christel Henrionnet , Natalia de Isla , Danièle Bensoussan Bio-Medical Materials and Engineering, 2010, 20 (3-4), pp.167-174. ⟨10.3233/BME-2010-0628⟩ Article dans une revue hal-03782996v1
	Collagenous extracellular matrix of cartilage submitted to mechanical forces studied by second harmonic generation microscopy. Elisabeth Werkmeister , Natalia de Isla , Patrick Netter , Jean-François Stoltz , Dominique Dumas Photochemistry and Photobiology, 2010, 86 (2), pp.302-10. ⟨10.1111/j.1751-1097.2009.00648.x⟩ Article dans une revue hal-00558986v1
	Interest of multimodal imaging in tissue engineering. Elisabeth Werkmeister , Dominique Dumas , Natalia de Isla , Luc Marchal , Jean-François Stoltz Bio-Medical Materials and Engineering, 2008, 18 (4-5), pp.329-33. ⟨10.3233/BME-2008-0548⟩ Article dans une revue hal-00559018v1
	Evaluation of human MSCs cell cycle, viability and differentiation in micromass culture. Jing-Wei Yang , Natalia De Isla , Céline Huselstein , Marie-Nathalie Sarda-Kolopp , Na Li Biorheology, 2006, 43 (3,4), pp.489-96 Article dans une revue hal-01981088v1

	Replicative senescent bone marrow mesenchymal stem cells spotting by surface protein expression Laurie Targa , Naceur Charif , G. Cauchois , Jean‐françois Stoltz , Jean-Baptiste Vincourt ICSA Conference "The ins and outs of cellular senescence, May 2017, Paris, France Poster de conférence hal-02974106v1
	Differences in the expression of cell surface proteins between young and replicative senescent bone marrow mesenchymal stromal / stem cells Laurie Targa , Naceur Charif , Ghislaine Cauchois , Jean François Stoltz , Jean-Baptiste Vincourt 6th International Symposium Europe-China Mesenchymal Stem Cells and Regenerative Medicine "Molecular, cellular and tissue engineering, and clinical applications”, Jul 2016, Vandoeuvre-Lès-Nancy, France Poster de conférence hal-02974097v1

	Etude des interactions antigènes-anticorps par des techniques optiques : application aux protéines de surface erythrocytaires Natalia De Isla Autre. Université Henri Poincaré - Nancy 1, 2003. Français. ⟨NNT : 2003NAN11308⟩ Thèse tel-01746925v1

	Multimodality of Microscopy Imaging Applied to Cartilage Tissue Engineering. Dominique Dd Dumas , Bibiana Riquelme , Elisabeth Werkmeister , Natalia de Isla , Jean François Stoltz J. Buckwalter, M. Lotz and J.-.Stoltz. Osteoarthritis, Inflammation and Degradation : A Continuum., IOS Press, pp.254-266, 2011, Biomedical and Health Research Chapitre d'ouvrage hal-00559042v1

Natalia de Isla

Publications

Relationship between bone marrow mesenchymal stromal cells (MSCs) senescence and clinical evolution of AML and MDS patients after hematopoietic stem cells (HSC) transplantation

The Mechanoadaptation Concept of Cells

Impact of in vitro expansion on immunomodulation properties of mesenchymal stromal cells

Senescence of mesenchymal stem cells and its impact on clinical applications

Senescence of mesenchymal stroma cells and clinical applications

Mesenchymal stem cells heterogeneity considering surface markers and senescence

Impact of culture conditions on the behavior of mesenchymal stem cells: choosing critical parameters related to cell quality

New advanced therapy medicinal product for cartilage defect treatment with extemporaneous association of a scaffold and Wharton's jelly mesenchymal stromal cells

Higher Proliferative Potential of Human Mesenchymal Stromal Cells from Wharton's Jelly Compared to Bone Marrow Is Linked to Decreased Senescence

Comprendre l'hétérogénéité des CSM pour des produits de thérapie cellulaire personnalisés

RNM as MCS aging biomarkers : pertinence for regenerative medicine

Surface markers expressed differently according to MSC source and aging reflects MCS heterogeneity and define MSC subset

Research progress in liver tissue engineering

Rat BMSC infusion was unable to ameliorate inflammatory injuries in tissues of mice with LPS-induced endotoxemia

The importance of mesenchymal stem cell donor’s age for cartilage engineering

Changes in chondrogenesis differentiation potential of bone marrow mesenchymal stem cells according to donor age

Scale-Up of Academic Mesenchymal Stromal Cell Production

Impact of microcarrier concentration on mesenchymal stem cell growth and death: Experiments and modeling

Secretome of Mesenchymal Stem Cells from Consecutive Hypoxic Cultures Promotes Resolution of Lung Inflammation by Reprogramming Anti-Inflammatory Macrophages

Quality by design to define critical process parameters for mesenchymal stem cell expansion

Characterization of Bone Marrow and Wharton’s Jelly Mesenchymal Stromal Cells Response on Multilayer Braided Silk and Silk/PLCL Scaffolds for Ligament Tissue Engineering

Impact of the type of microcarrier and agitation modes on the expansion performances of mesenchymal stem cells derived from umbilical cord

Mesenchymal stem cell interacted with PLCL braided scaffold coated with poly- l -lysine/hyaluronic acid for ligament tissue engineering

Laser photobiomodulation in pressure ulcer healing of human diabetic patients: gene expression analysis of inflammatory biochemical markers

Defining a scaffold for ligament tissue engineering: What has been done, and what still needs to be done

Stem cells and vascular regenerative medicine: A mini review

Mechanical stimulations on human bone marrow mesenchymal stem cells enhance cells differentiation in a three-dimensional layered scaffold

Revisiting MSC expansion from critical quality attributes to critical culture process parameters

MyD88/ERK/NFkB pathways and pro-inflammatory cytokines release in periodontal ligament stem cells stimulated by Porphyromonas gingivalis

Comparative Study of the Physiotherapeutic and Drug Protocol and Low-Level Laser Irradiation in the Treatment of Pain Associated with Temporomandibular Dysfunction

Signalling pathways involved in the process of mesenchymal stem cells differentiating into hepatocytes

Stem cells and applications: A survey

Stem Cells and Regenerative Medicine

Active implant combining human stem cell microtissues and growth factors for bone-regenerative nanomedicine.

Donor's age dependent proliferation decrease of human bone marrow mesenchymal stem cells is linked to diminished clonogenicity

Towards a Tissue-Engineered Ligament: Design and Preliminary Evaluation of a Dedicated Multi-Chamber Tension-Torsion Bioreactor

Research on stem cells as candidates to be differentiated into hepatocytes

Mechanical properties evolution of a PLGA-PLCL composite scaffold for ligament tissue engineering under static and cyclic traction-torsion in vitro culture conditions

Human Stem Cells and Articular Cartilage Tissue Engineering

Does Making Method of Alginate Hydrogel Influence the Chondrogenic Differentiation of Human Mesenchymal Stem Cells?

Long term culture of mesenchymal stem cells in hypoxia promotes a genetic program maintaining their undifferentiated and multipotent status

Designing a three-dimensional alginate hydrogel by spraying method for cartilage tissue engineering

Original approach for cartilage tissue engineering with mesenchymal stem cells

Collagenous extracellular matrix of cartilage submitted to mechanical forces studied by second harmonic generation microscopy.

Interest of multimodal imaging in tissue engineering.

Evaluation of human MSCs cell cycle, viability and differentiation in micromass culture.

Replicative senescent bone marrow mesenchymal stem cells spotting by surface protein expression

Differences in the expression of cell surface proteins between young and replicative senescent bone marrow mesenchymal stromal / stem cells

Etude des interactions antigènes-anticorps par des techniques optiques : application aux protéines de surface erythrocytaires

Multimodality of Microscopy Imaging Applied to Cartilage Tissue Engineering.