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Structural and Functional Insights into the Ligand-binding Domain of a Nonduplicated Retinoid X Nuclear Receptor from the Invertebrate Chordate Amphioxus.

Giuseppe D. Tocchini-Valentini , Natacha Rochel , Hector Escriva , Pierre Germain , Carole Peluso-Iltis , et al.
Journal of Biological Chemistry, 2009, 284 (3), pp.1938-1948. ⟨10.1074/jbc.M805692200⟩
Article dans une revue inserm-00357461v1

Communication between the ERRalpha homodimer interface and the PGC-1alpha binding surface via the helix 8-9 loop.

Holger Greschik , Magnus Althage , Ralf Flaig , Yoshiteru Sato , Virginie Chavant , et al.
Journal of Biological Chemistry, 2008, 283 (29), pp.20220-30. ⟨10.1074/jbc.M801920200⟩
Article dans une revue inserm-00311104v1

Superagonistic fluorinated vitamin D3 analogs stabilize helix 12 of the vitamin D receptor.

Guy Eelen , Noelia Valle , Yoshiteru Sato , Natacha Rochel , Lieve Verlinden , et al.
Chemistry & Biology / Chemistry and Biology; CHEMISTRY & BIOLOGY, 2008, 15 (10), pp.1029-34. ⟨10.1016/j.chembiol.2008.08.008⟩
Article dans une revue inserm-00350744v1

Expression of functional full-length hSRC-1 in eukaryotic cells using modified vaccinia virus Ankara and baculovirus

Judit Osz , Karine Pradeau-Aubreton , Robert Drillien , Nathalie Troffer-Charlier , Isabelle Kolb-Cheynel , et al.
Analytical Biochemistry, 2012, 426 (2), pp.106-108. ⟨10.1016/j.ab.2012.04.006⟩
Article dans une revue istex hal-03611644v1
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Structural Analysis of VDR Complex with ZK168281 Antagonist

Anna y Belorusova , Sandra Chalhoub , Daniela Rovito , Natacha Rochel
Journal of Medicinal Chemistry, 2020, 63 (17), pp.9457 - 9463. ⟨10.1021/acs.jmedchem.0c00656⟩
Article dans une revue hal-03032831v1
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Vitamin D Analogs Bearing C-20 Modifications Stabilize the Agonistic Conformation of Non-Responsive Vitamin D Receptor Variants

Anna Belorusova , Daniela Rovito , Yassmine Chebaro , Stefanie Doms , Lieve Verlinden , et al.
International Journal of Molecular Sciences, 2022, 23 (15), pp.8445. ⟨10.3390/ijms23158445⟩
Article dans une revue hal-03766784v1

A Vitamin D Receptor Selectively Activated by Gemini Analogs Reveals Ligand Dependent and Independent Effects

Tiphaine Huet , Gilles Laverny , Fabrice Ciesielski , Ferdinand Molnár , Thanuja gali Ramamoorthy , et al.
Cell Reports, 2015, 10 (4), pp.516-526. ⟨10.1016/j.celrep.2014.12.045⟩
Article dans une revue hal-02981163v1
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The molecular mechanisms underlying the ERalpha-36-mediated signaling in breast cancer

S Omarjee , J Jacquemetton , C Poulard , Natacha Rochel-Guiberteau , Annick Dejaegere-Stote , et al.
Oncogene, 2017, 36 (18), pp.2503-2514. ⟨10.1038/onc.2016.415⟩
Article dans une revue hal-03679162v1

Crystal structure of the ligand-binding domain of the ultraspiracle protein USP, the ortholog of retinoid X receptors in insects

Isabelle M. Billas , Luc Moulinier , Natacha Rochel , Dino Moras
Journal of Biological Chemistry, 2001, 276 (10), pp.7465-7474. ⟨10.1074/jbc.M008926200⟩
Article dans une revue hal-04112680v1

Structural adaptability in the ligand-binding pocket of the ecdysone hormone receptor

Isabelle M. L Billas , Thomas Iwema , Jean-Marie Garnier , André Mitschler , Natacha Rochel , et al.
Nature, 2003, 426 (6962), pp.91-96. ⟨10.1038/nature02112⟩
Article dans une revue istex hal-04133428v1
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Advances in vitamin D receptor function and evolution based on the 3D structure of the lamprey ligand binding domain

Rita Sigüeiro , Laurent Bianchetti , Carole Peluso-Iltis , Sandra Chalhoub , Annick Dejaegere , et al.
Journal of Medicinal Chemistry, 2022, 65 (7), pp.5821-5829. ⟨10.1021/acs.jmedchem.2c00171⟩
Article dans une revue hal-03745351v1

Structural aspects of Vitamin D endocrinology

Natacha Rochel-Guiberteau , Ferdinand Molnár
Molecular and Cellular Endocrinology, 2017, 453, pp.22-35. ⟨10.1016/j.mce.2017.02.046⟩
Article dans une revue hal-03680449v1
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Vitamin D Receptor Antagonist MeTC7 Inhibits PD-L1

Negar Khazan , Emily Quarato , Niloy Singh , Cameron Snyder , Taylor Moore , et al.
Cancers, 2023, 15 (13), pp.3432. ⟨10.3390/cancers15133432⟩
Article dans une revue hal-04274207v1
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Vitamin D and Its Receptor from a Structural Perspective

Natacha Rochel
Nutrients, 2022, 14, pp.2847. ⟨10.3390/nu14142847⟩
Article dans une revue hal-03860880v1
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Molecular determinants of MED1 interaction with the DNA bound VDR–RXR heterodimer

Y Belorusova Anna , Maxime Bourguet , Steve Hessmann , Sandra Chalhoub , Bruno Kieffer , et al.
Nucleic Acids Research, 2020, ⟨10.1093/nar/gkaa775⟩
Article dans une revue hal-02962412v1
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Phosphorylation of the retinoic acid receptor alpha induces a mechanical allosteric regulation and changes in internal dynamics

Yassmine Chebaro , Ismail Amal , Natacha Rochel , Cécile Rochette-Egly , Roland Stote , et al.
PLoS Computational Biology, 2013, 9 (4), pp.e1003012. ⟨10.1371/journal.pcbi.1003012⟩
Article dans une revue hal-04143714v1

Crystal structures of the vitamin D nuclear receptor liganded with the vitamin D side chain analogues calcipotriol and seocalcitol, receptor agonists of clinical importance. Insights into a structural basis for the switching of calcipotriol to a receptor antagonist by further side chain modification

Giuseppe Tocchini-Valentini , Natacha Rochel , Jean-Marie Wurtz , Dino Moras
Journal of Medicinal Chemistry, 2004, 47 (8), pp.1956-1961. ⟨10.1021/jm0310582⟩
Article dans une revue istex hal-04126026v1
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Investigation of 20S-hydroxyvitamin D3 analogs and their 1alpha-OH derivatives as potent vitamin D receptor agonists with anti-inflammatory activities

Zongtao Lin , Srinivasa Marepally , Emily Goh , Chloe Cheng , Zorica Janjetovic , et al.
Scientific Reports, 2018, 8, pp.1478. ⟨10.1038/s41598-018-19183-7⟩
Article dans une revue hal-03671899v1

9-cis-13,14-Dihydroretinoic Acid Is an Endogenous Retinoid Acting as RXR Ligand in Mice

Ralph Rühl , Agnieszka Krzyżosiak , Anna Niewiadomska-Cimicka , Natacha Rochel , Lajos Szeles , et al.
PLoS Genetics, 2015, 11 (6), pp.e1005213. ⟨10.1371/journal.pgen.1005213⟩
Article dans une revue hal-03604050v1
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Structural Basis for α‐Helix Mimicry and Inhibition of Protein–Protein Interactions with Oligourea Foldamers

Léonie Cussol , Laura Mauran‐ambrosino , Jérémie Buratto , Anna Belorusova , Maxime Neuville , et al.
Angewandte Chemie International Edition, 2020, ⟨10.1002/anie.202008992⟩
Article dans une revue hal-03039251v1
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Aromatic-Based Design of Highly Active and Noncalcemic Vitamin D Receptor Agonists

Pranjal Gogoi , Samuel Seoane , Rita Sigüeiro , Thierry Guiberteau , Miguel Maestro , et al.
Journal of Medicinal Chemistry, 2018, 61 (11), pp.4928-4937. ⟨10.1021/acs.jmedchem.8b00337⟩
Article dans une revue hal-02383159v1

Crystal structure of the vitamin D nuclear receptor ligand binding domain in complex with a locked side chain analog of calcitriol.

Natacha Rochel , Shinji Hourai , Xenxo Pérez-García , Antonio Rumbo , Antonio Mourino , et al.
Archives of Biochemistry and Biophysics, 2007, 460 (2), pp.172-6. ⟨10.1016/j.abb.2007.01.031⟩
Article dans une revue istex hal-00189973v1

Structural investigation of the ligand binding domain of the zebrafish VDR in complexes with 1alpha,25(OH)2D3 and Gemini: purification, crystallization and preliminary X-ray diffraction analysis

Fabrice Ciesielski , Natacha Rochel , André Mitschler , Alexander Kouzmenko , Dino Moras
Journal of Steroid Biochemistry and Molecular Biology, 2004, 89-90 (1-5), pp.55-59. ⟨10.1016/j.jsbmb.2004.03.109⟩
Article dans une revue istex hal-04138418v1

Bacterial iron transport: Coordination properties of pyoverdin PaA, a peptidic siderophore of Pseudomonas aeruginosa

A.-M. Albrecht-Gary , Sylvie Blanc , N. Rochel , A.Z. Ocaktan , M.A. Abdallah
Inorganic Chemistry, 1994, 33 (26), pp.6391-6402. ⟨10.1021/ic00104a059⟩
Article dans une revue istex hal-01458140v1

Ligand binding domain of vitamin D receptors.

Natacha Rochel , Dino Moras
Current Topics in Medicinal Chemistry, 2006, 6 (12), pp.1229-41
Article dans une revue hal-00188120v1

Co-expression of protein complexes in prokaryotic and eukaryotic hosts: experimental procedures, database tracking and case studies.

Christophe Romier , Marouane Ben Jelloul , Shira Albeck , Gretel Buchwald , Didier Busso , et al.
Acta crystallographica Section D : Structural biology [1993-..], 2006, 62 (Pt 10), pp.1232-42. ⟨10.1107/S0907444906031003⟩
Article dans une revue hal-00188127v1

Retinoic acid receptors recognise the mouse genome through binding elements with diverse spacing and topology.

Emmanuel Moutier , Tao Ye , Mohamed-Amin Choukrallah , Sylvia Urban , Judit Osz , et al.
Journal of Biological Chemistry, 2012, epub ahead of print. ⟨10.1074/jbc.M112.361790⟩
Article dans une revue hal-00720090v1

Structural analysis and biological activities of BXL0124, a gemini analog of vitamin D

Anna Belorusova , Nanjoo Suh , Hong Lee , Jae So , Hubert Maehr , et al.
Journal of Steroid Biochemistry and Molecular Biology, 2017, 173, pp.69-74. ⟨10.1016/j.jsbmb.2016.09.015⟩
Article dans une revue hal-03680448v1

Solution Behavior of the Intrinsically Disordered N-Terminal Domain of Retinoid X Receptor alpha in the Context of the Full-Length Protein

Anna Belorusova , Judit Osz , Maxim V. Petoukhov , Carole Peluso-Iltis , Bruno Kieffer , et al.
Biochemistry, 2016, 55 (12), pp.1741-1748. ⟨10.1021/acs.biochem.5b01122⟩
Article dans une revue hal-03686928v1

Structure-function relationships and crystal structures of the vitamin D receptor bound 2 alpha-methyl-(20S,23S)- and 2 alpha-methyl-(20S,23R)-epoxymethano-1 alpha,25-dihydroxyvitamin D3

Pierre Antony , Rita Sigüeiro , Tiphaine Huet , Yoshiteru Sato , Nick Ramalanjaona , et al.
Journal of Medicinal Chemistry, 2010, 53 (3), pp.1159-1171. ⟨10.1021/jm9014636⟩
Article dans une revue hal-04089573v1