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Millot Nadine Full Professor Deputy Director of ICB lab

Until 2007: The originality of the approach I have undertaken to synthesize and study nanomaterials was to jointly control the morphology, the size distribution, the nature of the interfaces and the stoichiometry of the products. Indeed, many controversies in literature come from the non-control of one of these parameters (evolution of the lattice parameters, phase transition temperatures…). Some of these controversies have thus been excluded thanks to the approach I have developed.

After 2007 (after my habilitation): I refocused my work to initiate, in my laboratory, a new thematic about bioapplications of nanopowders.

Founder of the Research Team (Bio-)hybrid nanoparticles & nanostructures BH2N

The key nanomaterials studied are:


Article dans une revue48 documents

  • Hanen Hajji, Sophie Le Gallet, Lucien Saviot, Ezzedine Ben Salem, Nadine Millot. Mechanosynthesis of carbonate and lithium co-substituted hydroxyfluorapatite. Materials Research Bulletin, Elsevier, 2022, 150, pp.111750. ⟨10.1016/j.materresbull.2022.111750⟩. ⟨hal-03548824⟩
  • Caroline Guigou, Nadine Millot, Karim Belharet, Alexis Bozorg Grayeli, Kibrom Berihu Girum, et al.. Use of Super Paramagnetic Iron Oxide Nanoparticles as Drug Carriers in Brain and Ear: State of the Art and Challenges. IEEE Transactions on Medical Imaging, Institute of Electrical and Electronics Engineers, 2021, 40 (6), pp.1542-1554. ⟨10.3390/brainsci11030358⟩. ⟨hal-03270803⟩
  • Amira Mahmoud, Mosaab Echabaane, Karim Omri, Julien Boudon, Lucien Saviot, et al.. Cu-Doped ZnO Nanoparticles for Non-Enzymatic Glucose Sensing. Molecules, MDPI, 2021, 26 (4), pp.929. ⟨10.3390/molecules26040929⟩. ⟨hal-03321414⟩
  • Nimisha Singh, Célia Marets, Julien Boudon, Nadine Millot, Lucien Saviot, et al.. In vivo protein corona on nanoparticles: does the control of all material parameters orient the biological behavior?. Nanoscale Advances, RSC, 2021, ⟨10.1039/D0NA00863J⟩. ⟨hal-03132542⟩
  • Regina Komal Kottana, Lionel Maurizi, Brian Schnoor, Kenise Morris, Jessica Ann Webb, et al.. Anti‐Platelet Effect Induced by Iron Oxide Nanoparticles: Correlation with Conformational Change in Fibrinogen. Small, Wiley-VCH Verlag, 2021, 17 (1), pp.2004945. ⟨10.1002/smll.202004945⟩. ⟨hal-03052354⟩
  • Hanen Hajji, Mohieddine Abdellaoui, Lionel Maurizi, Samia Nasr, Nadine Millot, et al.. Kinematic modelisation and parametric study of mechanosynthesis of hydroxyfluorapatite. Advanced Powder Technology, Elsevier, 2021, 32 (10), pp.3585-3600. ⟨10.1016/j.apt.2021.08.013⟩. ⟨hal-03323626⟩
  • Nimisha Singh, Nadine Millot, Lionel Maurizi, Gérard Lizard, Rajender Kumar. Taurine-Conjugated Mussel-Inspired Iron Oxide Nanoparticles with an Elongated Shape for Effective Delivery of Doxorubicin into the Tumor Cells. ACS Omega, ACS Publications, 2020, 5 (26), pp.16165-16175. ⟨10.1021/acsomega.0c01747⟩. ⟨hal-02902885⟩
  • Guillaume Thomas, Julien Boudon, Lionel Maurizi, Mathieu Moreau, Paul Walker, et al.. Innovative Magnetic Nanoparticles for PET/MRI Bimodal Imaging. ACS Omega, ACS Publications, 2019, 4 (2), pp.2637-2648. ⟨10.1021/acsomega.8b03283⟩. ⟨hal-02068644⟩
  • Lionel Maurizi, Fadoua Sallem, Julien Boudon, Olivier Heintz, Harender Bisht, et al.. Efficient Quantification by X-ray Photoelectron Spectroscopy and Thermogravimetric Analyses of the One-Pot Grafting of Two Molecules on the Surface of Iron Oxide Nanoparticles. Journal of Nanoscience and Nanotechnology, American Scientific Publishers, 2019, 19 (8), pp.4920-4929. ⟨10.1166/jnn.2019.16796⟩. ⟨hal-02163532⟩
  • Gaëlle Leterme, Caroline Guigou, Alexandra Oudot, Bertrand Collin, Julien Boudon, et al.. Superparamagnetic Nanoparticle Delivery to the Cochlea Through Round Window by External Magnetic Field: Feasibility and Toxicity. Surgical Innovation, SAGE Publications (UK and US), 2019, pp.155335061986721. ⟨10.1177/1553350619867217⟩. ⟨hal-02342085⟩
  • Fadoua Sallem, Rihab Haji, Dominique Vervandier-Fasseur, Thomas Nury, Lionel Maurizi, et al.. Elaboration of Trans-Resveratrol Derivative-Loaded Superparamagnetic Iron Oxide Nanoparticles for Glioma Treatment. Nanomaterials, MDPI, 2019, 9 (2), pp.287. ⟨10.3390/nano9020287⟩. ⟨hal-02163534⟩
  • Alexis Loiseau, Julien Boudon, Alexandra Oudot, Mathieu Moreau, Romain Boidot, et al.. Titanate Nanotubes Engineered with Gold Nanoparticles and Docetaxel to Enhance Radiotherapy on Xenografted Prostate Tumors. Cancers, MDPI, 2019, 11 (12), pp.1962. ⟨10.3390/cancers11121962⟩. ⟨hal-02735286⟩
  • S. Sruthi, Lionel Maurizi, T. Nury, F. Sallem, J. Boudon, et al.. Cellular interactions of functionalized superparamagnetic iron oxide nanoparticles on oligodendrocytes without detrimental side effects: Cell death induction, oxidative stress and inflammation. Colloids and Surfaces B: Biointerfaces, Elsevier, 2018, 170, pp.454-462. ⟨10.1016/j.colsurfb.2018.06.041⟩. ⟨hal-02163524⟩
  • S. Sruthi, A. Loiseau, J. Boudon, F. Sallem, Lionel Maurizi, et al.. In vitro interaction and biocompatibility of titanate nanotubes with microglial cells. Toxicology and Applied Pharmacology, Elsevier, 2018, 353, pp.74-86. ⟨10.1016/j.taap.2018.06.013⟩. ⟨hal-02163529⟩
  • Alexis Loiseau, Julien Boudon, Céline Mirjolet, Gilles Créhange, Nadine Millot. Taxane-Grafted Metal-Oxide Nanoparticles as a New Theranostic Tool against Cancer: The Promising Example of Docetaxel-Functionalized Titanate Nanotubes on Prostate Tumors. Advanced Healthcare Materials, Wiley, 2017, ⟨10.1002/adhm.201700245⟩. ⟨hal-01553114⟩
  • Céline Mirjolet, Julien Boudon, Alexis Loiseau, Sandy Chevrier, Romain Boidot, et al.. Docetaxel-titanate nanotubes enhance radiosensitivity in an androgen-independent prostate cancer model. International Journal of Nanomedicine, Dove Medical Press, 2017, 12, pp.6357 - 6364. ⟨10.2147/IJN.S139167⟩. ⟨hal-01614449⟩
  • Fadoua Sallem, Julien Boudon, Olivier Heintz, Isabelle Séverin, Adel Megriche, et al.. Synthesis and characterization of chitosan-coated titanate nanotubes: towards a new safe nanocarrier. Dalton Transactions, Royal Society of Chemistry, 2017, 46, pp.15386-15398. ⟨10.1039/c7dt03029k⟩. ⟨hal-01625668⟩
  • Guillaume Thomas, Frédéric Demoisson, Julien Boudon, Nadine Millot. Efficient functionalization of magnetite nanoparticles with phosphonate using a one-step continuous hydrothermal process. Dalton Transactions, Royal Society of Chemistry, 2016, 45 (26), pp.10821 - 10829. ⟨10.1039/C6DT01050D⟩. ⟨hal-01698664⟩
  • Lionel Maurizi, Anne-Laure Papa, Laure Dumont, Frédéric Bouyer, Paul Walker, et al.. Influence of Surface Charge and Polymer Coating on Internalization and Biodistribution of Polyethylene Glycol-Modified Iron Oxide Nanoparticles. Journal of Biomedical Nanotechnology, American Scientific Publishers, 2015, 11 (1), pp.126-136. ⟨10.1166/jbn.2015.1996⟩. ⟨hal-02163365⟩
  • J. Paris, yann Bernhard, J. Boudon, O. Heintz, N. Millot, et al.. Phthalocyanine–titanate nanotubes: a promising nanocarrier detectable by optical imaging in the so-called imaging window. RSC Advances, Royal Society of Chemistry, 2014, 5 (9), pp.6315 - 6322. ⟨10.1039/c4ra13988g⟩. ⟨hal-03263264⟩
  • E. Nehlig, B. Waggeh, N. Millot, y. Lalatonne, L. Motte, et al.. Immobilized Pd on magnetic nanoparticles bearing proline as a highly efficient and retrievable Suzuki–Miyaura catalyst in aqueous media. Dalton Transactions, Royal Society of Chemistry, 2014, 44 (2), pp.2015 Jan 14;44(2):501-5. ⟨10.1039/c4dt02899f⟩. ⟨hal-01113619⟩
  • Lionel Maurizi, F. Bouyer, M. Ariane, R. Chassagnon, N. Millot. Fast and continuous synthesis of nanostructured iron spinel in supercritical water: influence of cations and citrates. RSC Advances, Royal Society of Chemistry, 2014, 4 (86), pp.45673-45678. ⟨10.1039/C4RA08562K⟩. ⟨hal-02163438⟩
  • Julien Boudon, Jérémy Paris, yann Bernhard, Elena Popova, Richard Decréau, et al.. Magneto-optical nanomaterials: a SPIO–phthalocyanine scaffold built step-by-step towards bimodal imaging. Chemical Communications, Royal Society of Chemistry, 2013, 49 (67), pp.7394. ⟨10.1039/c3cc41898g⟩. ⟨hal-03262936⟩
  • Lionel Maurizi, Frédéric Bouyer, Jérémy Paris, Frédéric Demoisson, Lucien Saviot, et al.. One step continuous hydrothermal synthesis of very fine stabilized superparamagnetic nanoparticles of magnetite. Chemical Communications, Royal Society of Chemistry, 2011, 47, pp.11706. ⟨10.1039/C1CC15470B⟩. ⟨hal-00638205⟩
  • S. Tria, O. Elkedim, R. Hamzaoui, X. Guo, F. F. Bernard, et al.. Deposition and characterization of cold sprayed nanocrystalline NiTi. Powder Technology, Elsevier, 2011, 210 (2), pp.181 - 188. ⟨10.1016/j.powtec.2011.02.026⟩. ⟨hal-01620669⟩
  • Anne-Laure Papa, Lionel Maurizi, David Vandroux, Paul Walker, N. Millot. Synthesis of Titanate Nanotubes Directly Coated with USPIO in Hydrothermal Conditions: A New Detectable Nanocarrier. Journal of Physical Chemistry C, American Chemical Society, 2011, 115 (39), pp.19012-19017. ⟨10.1021/jp2056893⟩. ⟨hal-00785179⟩
  • L Maurizi, H Bisht, Frédéric Bouyer, Nadine Millot. Easy Route to Functionalize Iron Oxide Nanoparticles via Long-Term Stable Thiol Groups. Langmuir, American Chemical Society, 2009, 25 (16), pp.8857-8859. ⟨10.1021/la901602w⟩. ⟨hal-00447491⟩
  • G. Rousseau, M. Fattahi, Bernd Grambow, L. Desgranges, Florent Boucher, et al.. Synthesis and characterization of nanometric powders of UO2+x, (Th,U)O2+x and (La,U)O2+x. Journal of Solid State Chemistry, Elsevier, 2009, 182 (10), pp.2591. ⟨10.1016/j.jssc.2009.06.039⟩. ⟨hal-00432849⟩
  • Anne-Laure Papa, Nadine Millot, Lucien Saviot, Rémi Chassagnon, Olivier Heintz. Effect of Reaction Parameters on Composition and Morphology of Titanate Nanomaterials. Journal of Physical Chemistry C, American Chemical Society, 2009, 113 (29), pp.12682-12689. ⟨10.1021/jp903195h⟩. ⟨hal-00404290⟩
  • Ludovic Quémard, Lionel Desgranges, Vincent Bouineau, Michèle Pijolat, G. Baldinozzi, et al.. On the origin of the sigmoid shape in the UO2 oxidation weight gain curves. Journal of the European Ceramic Society, Elsevier, 2009, 29 (13), pp.2791-2798. ⟨10.1016/j.jeurceramsoc.2009.04.010⟩. ⟨hal-00439251v2⟩
  • Lucien Saviot, Caleb H. Netting, Daniel B. Murray, Stéphane Rols, Alain Mermet, et al.. Inelastic neutron scattering due to acoustic vibrations confined in nanoparticles: theory and experiment. Physical Review B: Condensed Matter and Materials Physics (1998-2015), American Physical Society, 2008, 78, pp.245426. ⟨10.1103/PhysRevB.78.245426⟩. ⟨hal-00394360⟩
  • H. Bieber, P. Gilliot, M. Gallart, N. Keller, V. Keller, et al.. Temperature dependent photoluminescence of photocatalytically active titania nanopowders. Catalysis Today, Elsevier, 2007, 122, pp.101-108. ⟨10.1016/j.cattod.2007.01.036⟩. ⟨hal-00212091⟩
  • N. Millot, S. Le Gallet, D. Aymes, F. Bernard, y. Grin. Spark plasma sintering of cobalt ferrite nanopowders prepared by coprecipitation and hydrothermal synthesis.. Journal of the European Ceramic Society, Elsevier, 2007, 27, pp.921-926. ⟨10.1016/j.jeurceramsoc.2006.04.141⟩. ⟨hal-00116595⟩
  • T. Belin, N. Millot, N. Bovet, Marc Gailhanou. In situ and time resolved study of the g/a-Fe2O3 transition in nanometric particles.. Journal of Solid State Chemistry, Elsevier, 2007, 180 (8), pp.2377. ⟨hal-00312812⟩
  • Daniel Aymes, Baowei B. Xin, Anne Aimable, Nadine Millot. Continuous hydrothermal synthesis of nanometric BaZrO3 in supercritical water. Journal of Solid State Chemistry, Elsevier, 2007, 181, pp.183-189. ⟨10.1016/j.jssc.2007.11.015⟩. ⟨hal-00400376⟩
  • Catherine Pighini, Daniel Aymes, Nadine Millot, Lucien Saviot. Low-frequency Raman characterization of size-controlled anatase TiO2 nanopowders prepared by continuous hydrothermal syntheses. Journal of Nanoparticle Research, Springer Verlag, 2007, 9, pp.309. ⟨10.1007/s11051-005-9061-6⟩. ⟨hal-00136053⟩
  • Daniel B. Murray, Caleb H. Netting, Lucien Saviot, Catherine Pighini, Nadine Millot, et al.. Far infrared absorption by acoustic phonons in titanium dioxide nanopowders. Journal of Nanoelectronics and Optoelectronics, American Scientific Publishers, 2006, 1, pp.92. ⟨10.1166/jno.2006.010⟩. ⟨hal-00094084⟩
  • G. Rousseau, L. Desgranges, F. Charlot, N. Millot, Jc Niepce, et al.. A detailed study of UO2 to U3O8 oxidation phases and the associated rate-limiting steps. Journal of Nuclear Materials, Elsevier, 2006, 355 (1-3), pp.10-20. ⟨10.1016/j.jnucmat.2006.03.015⟩. ⟨hal-00115276⟩
  • y. Champion, F. Bernard, Nadine Millot, Pascal Perriat. Surface adsorption effects on the lattice expansion of copper nanocrystals. Applied Physics Letters, American Institute of Physics, 2005, pp.1-3. ⟨hal-00436774⟩
  • y. Champion, F. Bernard, N. Guigue-Millot, Pascal Perriat. Sintering of copper nanopowders under hydrogen: an in situ X-ray diffraction analysis.. Materials Science & Engineering, AStructural Materials: Properties, Microstructure and Processing, 2003, pp.258-263. ⟨hal-00475132⟩
  • N. Guigue-Millot, Sylvie Begin-Colin, y. Champion, Martin Hÿtch, Gérard Le Caër, et al.. Control of grain size and morphologies of nanograined ferrites by adaptation of the synthesis route. Mechanosynthesis and soft chemistry. Journal of Solid State Chemistry, Elsevier, 2003, pp.30-38. ⟨hal-00475138⟩
  • Nadine Millot, D. Aymes, F. Bernard, J.C. Niepce, A. Traverse, et al.. Particle Size Dependency of Ternary Diagrams at the Nanometer Scale: Evidence of TiO2 Clusters in Fe-Based Spinels. Journal of Physical Chemistry B, American Chemical Society, 2003, pp.5740-5750. ⟨hal-00475136⟩
  • N. Guigue-Millot, Olivier Tillement, Pascal Perriat. Apparent magic numbers in embedded Ti-O clusters. Physical Review B: Condensed Matter and Materials Physics (1998-2015), American Physical Society, 2003, pp.1-4. ⟨hal-00475155⟩
  • N. Guigue-Millot, F. Bernard, J.C. Niepce, A. Traverse, Pascal Perriat. Segregation phenomena in nanometric titanium ferrites: Complementarity of different experimental techniques (DRX, XPS, EXAFS...). Journal de Physique IV Proceedings, EDP Sciences, 2002, pp.473-479. ⟨hal-00475483⟩
  • N. Guigue-Millot, y. Champion, Martin Hÿtch, F. Bernard, Sylvie Begin-Colin, et al.. Chemical heterogeneities in nanometric titanomagnetites prepared by soft chemistry and studied ex situ : evidence for fe-segregation and oxidation kinetics. Journal of Physical Chemistry B, American Chemical Society, 2001, pp.7125-7132. ⟨hal-00475337⟩
  • C. Pasquier, N. Millot, R. Njouom, K. Sandres, M. Cazabat, et al.. HIV-1 subtyping using phylogenetic analysis of pol gene sequences.. Journal of Virological Methods, Elsevier, 2001, 94 (1-2), pp.45-54. ⟨10.1016/S0166-0934(01)00272-5⟩. ⟨hal-00542209⟩
  • N. Guigue-Millot, N. Keller, Pascal Perriat. Evidence for the verwey transition in highly nonstoichiometric nanometric fe-based ferrites. Physical Review B: Condensed Matter and Materials Physics (1998-2015), American Physical Society, 2001, pp.24-26. ⟨hal-00475328⟩
  • V. Nivoix, B. Gillot, D. Aymes, P. Perriat, N. Millot, et al.. Correlation Between the Reactivity Towards Oxygen and the Coercitivity in Submicron Vanadium Ferrite Spinels. Journal de Physique IV Proceedings, EDP Sciences, 1997, 07 (C1), pp.C1-237-C1-238. ⟨10.1051/jp4:1997190⟩. ⟨jpa-00255137⟩

Communication dans un congrès1 document

  • Ludovic Quémard, Lionel Desgranges, Vincent Bouineau, Françoise Valdivieso, Michèle Pijolat, et al.. Fragmentation du combustible nucléaire UO2 en environnement oxydant : Etude cinétique et phénoménologique. Matériaux 2006, Nov 2006, Dijon, France. ⟨hal-00600405⟩

Poster1 document

  • Annette Luce, y Saibi, Isabelle Séverin, Julien Boudon, Nadine Millot, et al.. In vitro hazard assessment of nanoparticles developed for biomedical applications. European Society of Toxicology In Vitro (ESTIV) 2016 meeting, Oct 2016, Juan-les-Pins, France. 2016. ⟨hal-01986190⟩

Chapitre d'ouvrage2 documents

  • Julien Boudon, Fadoua Sallem, Alexis Loiseau, Lionel Maurizi, Anne-Laure Papa, et al.. Development of Novel Versatile Theranostic Platforms Based on Titanate Nanotubes: Towards Safe Nanocarriers for Biomedical Applications. New Trends in Macromolecular and Supramolecular Chemistry for Biological Applications, Springer International Publishing, pp.151-178, 2021, ⟨10.1007/978-3-030-57456-7_8⟩. ⟨hal-03276177⟩
  • Lionel Maurizi, Anne-Laure Papa, Julien Boudon, Sruthi Sudhakaran, Benoist Pruvot, et al.. Toxicological Risk Assessment of Emerging Nanomaterials: Cytotoxicity, Cellular Uptake, Effects on Biogenesis and Cell Organelle Activity, Acute Toxicity and Biodistribution of Oxide Nanoparticles. Unraveling the Safety Profile of Nanoscale Particles and Materials-From Biomedical to Environmental Applications, InTech, 2018, ⟨10.5772/intechopen.71833⟩. ⟨hal-02163546⟩