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Role of reactive oxygen species in atherosclerosis: Lessons from murine genetic models

Anne Nègre-Salvayre , Paul Guerby , Stéphanie Gayral , Muriel Laffargue , Robert Salvayre
Free Radical Biology and Medicine, 2019, ⟨10.1016/j.freeradbiomed.2019.10.011⟩
Article dans une revue hal-02414348v1

Serum IF1 concentration is independently associated to HDL levels and to coronary heart disease: the GENES study.

Annelise Genoux , Jean-Bernard Ruidavets , Jean Ferrières , Guillaume Combes , Laeticia Lichtenstein , et al.
Journal of Lipid Research, 2013, 54 (9), pp.2550-8. ⟨10.1194/jlr.P036335⟩
Article dans une revue inserm-01055265v1
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PKCβ phosphorylates PI3Kγ to activate it and release it from GPCR control.

Romy Walser , John E. Burke , Elena Gogvadze , Thomas Bohnacker , Xuxiao Zhang , et al.
PLoS Biology, 2013, 11 (6), pp.e1001587. ⟨10.1371/journal.pbio.1001587⟩
Article dans une revue inserm-01055308v1

Key role of PI3Kγ in monocyte chemotactic protein-1-mediated amplification of PDGF-induced aortic smooth muscle cell migration.

Anne Fougerat , Natalia F. Smirnova , Stéphanie Gayral , Nicole Malet , Emilio Hirsch , et al.
British Journal of Pharmacology, 2012, 166 (5), pp.1643-53. ⟨10.1111/j.1476-5381.2012.01866.x⟩
Article dans une revue inserm-01054873v1

Targeting PI3Kγ activity decreases vascular trauma-induced intimal hyperplasia through modulation of the Th1 response

Natalia F. Smirnova , Stéphanie Gayral , Christophe Pedros , Gervaise Loirand , Nathalie Vaillant , et al.
Journal of Experimental Medicine, 2014, 211 (9), pp.1779-1792. ⟨10.1084/jem.20131276⟩
Article dans une revue hal-02519407v1

A Function for Phosphoinositide 3-Kinase β Lipid Products in Coupling βγ to Ras Activation in Response to Lysophosphatidic Acid

Armelle Yart , Serge Roche , Reinhard Wetzker , Muriel Laffargue , Nicholas Tonks , et al.
Journal of Biological Chemistry, 2002, 277 (24), pp.21167-21178. ⟨10.1074/jbc.M110411200⟩
Article dans une revue hal-03191860v1
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A non-catalytic function of PI3Kγ drives smooth muscle cell proliferation after arterial damage

Adrien Lupieri , Régis Blaise , Alessandra Ghigo , Natalia Smirnova , Marie-Kerguelen Sarthou , et al.
Journal of Cell Science, 2020, 133 (13), pp.jcs245969. ⟨10.1242/jcs.245969⟩
Article dans une revue hal-02999224v1

Phosphoinositide 3-kinase and integrin signalling are involved in activation of Bruton tyrosine kinase in thrombin-stimulated platelets

Muriel Laffargue , Jeannie M.F. Ragab-Thomas , Ashraf Ragab , Joel Tuech , Karine Missy , et al.
FEBS Letters, 1999, 443 (1), pp.66-70. ⟨10.1016/S0014-5793(98)01680-9⟩
Article dans une revue istex hal-03192171v1

Neuraminidases 1 and 3 Trigger Atherosclerosis by Desialylating Low‐Density Lipoproteins and Increasing Their Uptake by Macrophages

Ekaterina Demina , Victoria Smutova , Xuefang Pan , Anne Fougerat , Tianlin Guo , et al.
Journal of the American Heart Association, 2021, 10 (4), ⟨10.1161/jaha.120.018756⟩
Article dans une revue hal-03445477v1

Genetic and pharmacological targeting of phosphoinositide 3-kinase-gamma reduces atherosclerosis and favors plaque stability by modulating inflammatory processes.

Anne Fougerat , Stéphanie Gayral , Pierre Gourdy , Alexia Schambourg , Thomas Rückle , et al.
Circulation, 2008, 117 (10), pp.1310-7. ⟨10.1161/CIRCULATIONAHA.107.720466⟩
Article dans une revue hal-00324678v1
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Sonic hedgehog mediates a novel pathway of PDGF-BB-dependent vessel maturation

Qinyu Yao , Marie-Ange Renault , Candice Chapouly , Soizic Vandierdonck , Isabelle Belloc , et al.
Blood, 2014, pp.123(15)2429-2437
Article dans une revue inserm-01159066v1

A PI3Kγ mimetic peptide triggers CFTR gating, bronchodilation, and reduced inflammation in obstructive airway diseases

Alessandra Ghigo , Alessandra Murabito , Valentina Sala , Anna Rita Pisano , Serena Bertolini , et al.
Science Translational Medicine, 2022, 14 (638), pp.eabl6328. ⟨10.1126/scitranslmed.abl6328⟩
Article dans une revue hal-03717907v1
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Tamoxifen Accelerates Endothelial Healing by Targeting ERα in Smooth Muscle Cells

Rana Zahreddine , Morgane Davezac , Natalia Smirnova , Melissa Buscato , Emeline Lhuillier , et al.
Circulation Research, 2020, 127 (12), pp.1473-1487. ⟨10.1161/CIRCRESAHA.120.317062⟩
Article dans une revue hal-03040722v1

Smooth muscle cells-derived CXCL10 prevents endothelial healing through PI3Kγ-dependent T cells response

Adrien Lupieri , Natalia F. Smirnova , Romain Solinhac , Nicole Malet , Mehdi Benamar , et al.
Cardiovascular Research, 2019, 116 (2), pp.438-449. ⟨10.1093/cvr/cvz122⟩
Article dans une revue hal-02349692v1

Elastin fragmentation and atherosclerosis progression: The elastokine concept

Pascal Maurice , Sébastien Blaise , Stéphanie Gayral , Laurent Debelle , Muriel Laffargue , et al.
Trends in Cardiovascular Medicine, 2013, 23 (6), pp.211-221. ⟨10.1016/j.tcm.2012.12.004⟩
Article dans une revue istex hal-02347636v1

17Beta-estradiol promotes TLR4-triggered proinflammatory mediator production through direct estrogen receptor alpha signaling in macrophages in vivo.

Bertrand Calippe , Victorine Douin-Echinard , Laurent Delpy , Muriel Laffargue , Karine Lélu , et al.
Journal of Immunology, 2010, 185 (2), pp.1169-76. ⟨10.4049/jimmunol.0902383⟩
Article dans une revue inserm-00504327v1

Noncatalytic function of PI3Kγ drives smooth muscle cell proliferation after arterial damage

A. Lupieri , R. Blaise , A. Ghigo , N. Smirnova , M.-K. Sarthou , et al.
Journal of Cell Science, 2020, pp.jcs.245969. ⟨10.1242/jcs.245969⟩
Article dans une revue hal-02817436v1

Elastin-derived peptides potentiate atherosclerosis through the immune Neu1-PI3Kγ pathway.

Stephanie Gayral , Roselyne Garnotel , Audrey Castaing-Berthou , Sébastien Blaise , Anne Fougerat , et al.
Cardiovascular Research, 2014, 102 (1), pp.118-27. ⟨10.1093/cvr/cvt336⟩
Article dans une revue inserm-01055258v1

Chronic estradiol administration in vivo promotes the proinflammatory response of macrophages to TLR4 activation: involvement of the phosphatidylinositol 3-kinase pathway.

Bertrand Calippe , Victorine Douin-Echinard , Muriel Laffargue , Henrik Laurell , Vanessa Rana-Poussine , et al.
Journal of Immunology, 2008, 180 (12), pp.7980-8
Article dans une revue hal-00321739v1
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Lack of P2Y13 in mice fed a high cholesterol diet results in decreased hepatic cholesterol content, biliary lipid secretion and reverse cholesterol transport.

Laeticia Lichtenstein , Nizar Serhan , Wijtske Annema , Guillaume Combes , Bernard Robaye , et al.
Nutr Metab (Lond), 2013, 10 (1), pp.67. ⟨10.1186/1743-7075-10-67⟩
Article dans une revue inserm-01055313v1

Anti-Inflammatory and Antiatherogenic Effects of the NLRP3 Inflammasome Inhibitor Arglabin in ApoE(2).Ki Mice Fed a High-Fat Diet

Cecile Vindis , Muriel Laffargue , Veronique Mateo , Berthold Buechele , Monica Rubio Ayala , et al.
Circulation, 2015, 131 (12), pp.1061-1070. ⟨10.1161/CIRCULATIONAHA.114.013730⟩
Article dans une revue hal-01543968v1

Role of the ubiquitin-proteasome system in the regulation of P2Y13 receptor expression: impact on hepatic HDL uptake.

Véronique Pons , Nizar Serhan , Stéphanie Gayral , Camille Malaval , Michel Nauze , et al.
Cellular and Molecular Life Sciences, 2014, 71 (9), pp.1775-88. ⟨10.1007/s00018-013-1471-5⟩
Article dans une revue inserm-01054871v1
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The different natural estrogens promote endothelial healing through distinct cell targets

Morgane Davezac , Rana Zahreddine , Melissa Buscato , Natalia F. Smirnova , Chanaëlle Febrissy , et al.
JCI Insight, 2023, 8 (5), ⟨10.1172/jci.insight.161284⟩
Article dans une revue hal-04040711v1

A Critical Role for Phosphoinositide 3-Kinase Upstream of Gab1 and SHP2 in the Activation of Ras and Mitogen-activated Protein Kinases by Epidermal Growth Factor

Armelle Yart , Muriel Laffargue , Patrick Mayeux , Stany Chretien , Christine Pérès , et al.
Journal of Biological Chemistry, 2001, 276 (12), pp.8856-8864. ⟨10.1074/jbc.M006966200⟩
Article dans une revue hal-03191837v1

Integrin-Dependent Tyrosine Phoshorylation and Cytoskeletal Translocation of Tec in Thrombin-Activated Platelets

Muriel Laffargue , Laurent Monnereau , Joël Tuech , Ashraf Ragab , Jeannie Ragab-Thomas , et al.
Biochemical and Biophysical Research Communications, 1997, 238 (1), pp.247-251. ⟨10.1006/bbrc.1997.7269⟩
Article dans une revue istex hal-03192189v1
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Immune and Smooth Muscle Cells Interactions in Atherosclerosis: How to Target a Breaking Bad Dialogue?

Damien Ramel , Stéphanie Gayral , Marie-Kerguelen Sarthou , Nathalie Augé , Anne Nègre-Salvayre , et al.
Frontiers in Pharmacology, 2019, 10, ⟨10.3389/fphar.2019.01276⟩
Article dans une revue hal-02999228v1

The activation function-1 of estrogen receptor alpha prevents arterial neointima development through a direct effect on smooth muscle cells

Natalia F. Smirnova , Coralie Fontaine , Melissa Buscato , Adrien Lupieri , Alexia Vinel , et al.
Circulation Research, 2015, 117 (9), pp.770-778. ⟨10.1161/CIRCRESAHA.115.306416⟩
Article dans une revue hal-02640511v1
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A historical view of estrogen effect on arterial endothelial healing: From animal models to medical implication

Rana Zahreddine , Morgane Davezac , Melissa Buscato , Natalia Smirnova , Muriel Laffargue , et al.
Atherosclerosis, 2021, 338, pp.30-38. ⟨10.1016/j.atherosclerosis.2021.10.013⟩
Article dans une revue hal-03758863v1
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PI3KC2α-dependent and VPS34-independent generation of PI3P controls primary cilium-mediated autophagy in response to shear stress

Asma Boukhalfa , Anna Chiara Nascimbeni , Damien Ramel , Nicolas Dupont , Emilio Hirsch , et al.
Nature Communications, 2020, 11 (1), pp.294. ⟨10.1038/s41467-019-14086-1⟩
Article dans une revue inserm-02493884v1
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Elastic fibers and elastin receptor complex: Neuraminidase-1 takes the center stage

Amar Bennasroune , Beatrice Romier-Crouzet , Sébastien Blaise , Muriel Laffargue , Roman G Efremov , et al.
Article dans une revue hal-02347367v1