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Murat Saparbaev

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Individual Contributions of Amido Acid Residues Tyr122, Ile168, and Asp173 to the Activity and Substrate Specificity of Human DNA Dioxygenase ABH2

Anastasiia T Davletgildeeva , Timofey E Tyugashev , Mingxing Zhao , Nikita A Kuznetsov , Alexander A Ishchenko
Cells, 2023, 12 (14), pp.1839. ⟨10.3390/cells12141839⟩
Article dans une revue hal-04289624v1
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Abasic site–peptide cross-links are blocking lesions repaired by AP endonucleases

Anna V Yudkina , Nikita A Bulgakov , Daria V Kim , Svetlana V Baranova , Alexander A Ishchenko
Nucleic Acids Research, 2023, 51 (12), pp.6321-6336. ⟨10.1093/nar/gkad423⟩
Article dans une revue hal-04289451v1
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Chargaff’s second parity rule lies at the origin of additive genetic interactions in quantitative traits to make omnigenic selection possible

Bakhyt T Matkarimov , Murat K Saparbaev
PeerJ, 2023, 11, pp.e16671. ⟨10.7717/peerj.16671⟩
Article dans une revue hal-04425843v1
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NEIL3-mediated proteasomal degradation facilitates the repair of cisplatin-induced DNA damage in human cells

Umit Aliyaskarova , Yeldar Baiken , Flore Renaud , Sophie Couve , Alexei Kisselev
Scientific Reports, 2023, 13 (1), pp.5174. ⟨10.1038/s41598-023-32186-3⟩
Article dans une revue hal-04289483v1

Cloning and characterization of the major AP endonuclease from Staphylococcus aureus

Aigerim Turgimbayeva , Ulan Zein , Dmitry Zharkov , Yerlan Ramankulov , Murat Saparbaev
DNA Repair, 2022, 119, pp.103390. ⟨10.1016/j.dnarep.2022.103390⟩
Article dans une revue hal-03858686v1
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Kinetic Features of 3′–5′–Exonuclease Activity of Apurinic/Apyrimidinic Endonuclease Apn2 from Saccharomyces cerevisiae

Aleksandra A Kuznetsova , Anastasia A Gavrilova , Alexander A Ishchenko , Murat Saparbaev , Olga S Fedorova
International Journal of Molecular Sciences, 2022, 23 (22), pp.14404. ⟨10.3390/ijms232214404⟩
Article dans une revue hal-04289790v1
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Conformational Dynamics of Human ALKBH2 Dioxygenase in the Course of DNA Repair as Revealed by Stopped-Flow Fluorescence Spectroscopy

Lyubov Yu. Kanazhevskaya , Denis Smyshliaev , Nadezhda Timofeyeva , Alexander Ishchenko , Murat Saparbaev
Molecules, 2022, 27 (15), pp.4960. ⟨10.3390/molecules27154960⟩
Article dans une revue hal-03858651v1
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Comparative Analysis of Exo- and Endonuclease Activities of APE1-like Enzymes

Anastasiia Davletgildeeva , Alexandra Kuznetsova , Darya Novopashina , Alexander Ishchenko , Murat Saparbaev
International Journal of Molecular Sciences, 2022, 23 (5), pp.2869. ⟨10.3390/ijms23052869⟩
Article dans une revue hal-03859362v1
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Pre-steady-state kinetic and mutational insights into mechanisms of endo- and exonuclease DNA processing by mutant forms of human AP endonuclease

Artemiy Bakman , Alexander Ishchenko , Murat Saparbaev , Olga Fedorova , Nikita Kuznetsov
Biochimica et Biophysica Acta (BBA) - General Subjects, 2022, 1866 (12), pp.130198. ⟨10.1016/j.bbagen.2022.130198⟩
Article dans une revue hal-03858673v1
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The Kinetic Mechanism of 3′-5′ Exonucleolytic Activity of AP Endonuclease Nfo from E. coli

Svetlana I Senchurova , Aleksandra A Kuznetsova , Alexander A Ishchenko , Murat Saparbaev , Olga S Fedorova
Article dans une revue hal-03858645v1
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Evolutionary origins of DNA repair pathways: Role of oxygen catastrophe in the emergence of DNA glycosylases

Paulina Prorok , Inga R Grin , Bakhyt T Matkarimov , Alexander A Ishchenko , Jacques Laval
Cells, 2021, 10 (7), pp.1591. ⟨10.3390/cells10071591⟩
Article dans une revue hal-04289943v2
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Role of Base Excision Repair Pathway in the Processing of Complex DNA Damage Generated by Oxidative Stress and Anticancer Drugs

Yeldar Baiken , Damira Kanayeva , Sabira Taipakova , Regina Groisman , Alexander A Ishchenko
Frontiers in Cell and Developmental Biology, 2021, 8, pp.617884. ⟨10.3389/fcell.2020.617884⟩
Article dans une revue hal-03432685v1
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Common Kinetic Mechanism of Abasic Site Recognition by Structurally Different Apurinic/Apyrimidinic Endonucleases

Alexandra A Kuznetsova , Svetlana I Senchurova , Alexander Ishchenko , Murat A Saparbaev , Olga S Fedorova
International Journal of Molecular Sciences, 2021, 22 (16), pp.8874. ⟨10.3390/ijms22168874⟩
Article dans une revue hal-03432659v1
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The Arabidopsis thaliana Poly(ADP-Ribose) Polymerases 1 and 2 Modify DNA by ADP-Ribosylating Terminal Phosphate Residues

Sabira Taipakova , Aigerim Kuanbay , Christine Saint-Pierre , Didier Gasparutto , Yeldar Baiken
Frontiers in Cell and Developmental Biology, 2020, 8, pp.606596. ⟨10.3389/fcell.2020.606596⟩
Article dans une revue hal-03432679v1
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Reading targeted DNA damage in the active demethylation pathway: role of accessory domains of eukaryotic AP endonucleases and thymine-DNA glycosylases

Alexander V Popov , Inga R Grin , Antonina P Dvornikova , Bakhyt T Matkarimov , Regina Groisman
Journal of Molecular Biology, 2020, 432 (6), pp.1747-1768. ⟨10.1016/j.jmb.2019.12.020⟩
Article dans une revue hal-03060641v1
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Mechanistic insight into the role of Poly(ADP-ribosyl)ation in DNA topology modulation and response to DNA damage

Bakhyt Matkarimov , Dmitry Zharkov , Murat Saparbaev
Mutagenesis, inPress, 35 (1), pp.107-117. ⟨10.1093/mutage/gez045⟩
Article dans une revue hal-02392725v1
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An Assay for the Activity of Base Excision Repair Enzymes in Cellular Extracts Using Fluorescent DNA Probes

O. A Kladova , D. A Iakovlev , R. Groisman , A. Ishchenko , M. K Saparbaev
Биохимия / Biochemistry, In press, 85 (4), pp.480-489. ⟨10.1134/S0006297920040082⟩
Article dans une revue hal-03068193v1
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Modulation of the Apurinic/Apyrimidinic Endonuclease Activity of Human APE1 and of Its Natural Polymorphic Variants by Base Excision Repair Proteins

Olga A Kladova , Irina V Alekseeva , Murat A Saparbaev , Olga S Fedorova , Nikita A Kuznetsov
International Journal of Molecular Sciences, 2020, 21 (19), pp.7147. ⟨10.3390/ijms21197147⟩
Article dans une revue hal-03066830v1
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DNA-Histone Cross-Links: Formation and Repair

Manideep C Pachva , Alexei F Kisselev , Bakhyt T Matkarimov , Murat A Saparbaev , Regina Groisman
Frontiers in Cell and Developmental Biology, 2020, 8, pp.647045. ⟨10.3389/fcell.2020.607045⟩
Article dans une revue hal-03432690v1
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Wheat Germination Is Dependent on Plant Target of Rapamycin Signaling

Bauyrzhan Smailov , Sanzhar Alybayev , Izat Smekenov , Aibek Mursalimov , Murat A Saparbaev
Frontiers in Cell and Developmental Biology, 2020, 8, pp.606685. ⟨10.3389/fcell.2020.606685⟩
Article dans une revue hal-03432696v2
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Mechanism of stimulation of DNA binding of the transcription factors by human apurinic/apyrimidinic endonuclease 1, APE1

Milena Bazlekowa-Karaban , Paulina Prorok , Sonia Baconnais , Sabira Taipakova , Zhiger Akishev
DNA Repair, 2019, 82, pp.102698. ⟨10.1016/j.dnarep.2019.102698⟩
Article dans une revue hal-02322130v1
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Characterization of biochemical properties of an apurinic/apyrimidinic endonuclease from Helicobacter pylori

Aigerim Turgimbayeva , Sailau Abeldenov , Dmitry Zharkov , Alexander Ishchenko , Yerlan Ramankulov
PLoS ONE, 2018, 13 (8), pp.e0202232. ⟨10.1371/journal.pone.0202232⟩
Article dans une revue hal-02322329v1
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Aberrant repair initiated by the adenine-DNA glycosylase does not play a role in UV-induced mutagenesis in Escherichia coli

Caroline Zutterling , Aibek Mursalimov , Ibtissam Talhaoui , Zhanat Koshenov , Zhiger Akishev
PeerJ, 2018, 6, pp.e6029. ⟨10.7717/peerj.6029⟩
Article dans une revue hal-02322261v1
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The role of the N-terminal domain of human apurinic/apyrimidinic endonuclease 1, APE1, in DNA glycosylase stimulation

Olga Kladova , Milena Bazlekowa-Karaban , Sonia Baconnais , Olivier Pietrement , Alexander Ishchenko
DNA Repair, 2018, 64, pp.10-25. ⟨10.1016/j.dnarep.2018.02.001⟩
Article dans une revue hal-02322373v1

Pre-steady-state kinetic analysis of damage recognition by human single-strand selective monofunctional uracil-DNA glycosylase SMUG1

Alexandra Kuznetsova , Danila Iakovlev , Inna Misovets , Alexander Ishchenko , Murat Saparbaev
Molecular BioSystems, 2017, 13 (12), pp.2638-2649. ⟨10.1039/c7mb00457e⟩
Article dans une revue hal-02393555v1

Aberrant base excision repair pathway of oxidatively damaged DNA: Implications for degenerative diseases

Ibtissam Talhaoui , Bakhyt Matkarimov , Thierry Tchenio , Dmitry Zharkov , Murat Saparbaev
Free Radical Biology and Medicine, 2017, 107, pp.266-277. ⟨10.1016/j.freeradbiomed.2016.11.040⟩
Article dans une revue hal-02393543v1
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The Human DNA glycosylases NEIL1 and NEIL3 Excise Psoralen-Induced DNA-DNA Cross-Links in a Four-Stranded DNA Structure

Peter Martin , Sophie Couvé , Caroline Zutterling , Mustafa Albelazi , Regina Groisman
Scientific Reports, 2017, 7 (1), pp.17438. ⟨10.1038/s41598-017-17693-4⟩
Article dans une revue hal-02393493v1

The major Arabidopsis thaliana apurinic/apyrimidinic endonuclease, ARP is involved in the plant nucleotide incision repair pathway

Zhiger Akishev , Sabira Taipakova , Botagoz Joldybayeva , Caroline Zutterling , Izat Smekenov
DNA Repair, 2016, 48, pp.30-42. ⟨10.1016/j.dnarep.2016.10.009⟩
Article dans une revue hal-02393578v1
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TET2-mediated 5-hydroxymethylcytosine induces genetic instability and mutagenesis

Emna Mahfoudhi , Ibtissam A Talhaoui , Xenia Cabagnols , Véronique Della Valle , Lise Secardin
DNA Repair, 2016, 43, pp.78 - 88. ⟨10.1016/j.dnarep.2016.05.031⟩
Article dans une revue pasteur-01405648v1

Structural comparison of AP endonucleases from the exonuclease III family reveals new amino acid residues in human AP endonuclease 1 that are involved in incision of damaged DNA.

Modesto Redrejo-Rodríguez , Armelle Vigouroux , Aibek Mursalimov , Inga Grin , Doria Alili
Biochimie, 2016
Article dans une revue hal-01356083v1

Oxidatively Generated Guanine(C8)-Thymine(N3) Intrastrand Cross-links in Double-stranded DNA Are Repaired by Base Excision Repair Pathways

Ibtissam Talhaoui , Vladimir Shafirovich , Zhi Liu , Christine Saint-Pierre , Zhiger Akishev
Journal of Biological Chemistry, 2015, 290, pp.14610-14617. ⟨10.1074/jbc.M115.647487⟩
Article dans une revue cea-01745400v1

Characterization of DNA substrate specificities of apurinic/apyrimidinic endonucleases from Mycobacterium tuberculosis

Vladimir Shafirovich , Zhi Liu , Christine Saint-Pierre , Zhiger Akishev , Bakhyt Matkarimov
DNA Repair, 2015, 33 (23), pp.1-16. ⟨10.1016/j.dnarep.2015.05.007⟩
Article dans une revue hal-02393612v1

Lipid peroxidation product 4-hydroxy-2-nonenal modulates base excision repair in human cells

Alicja Winczura , Alicja Czubaty , Kinga Winczura , Katarzyna Masłowska , Matylda Nałęcz
DNA Repair, 2014, 22, pp.1-11. ⟨10.1016/j.dnarep.2014.06.002⟩
Article dans une revue hal-02393629v1

Pre-steady-state fluorescence analysis of damaged DNA transfer from human DNA glycosylases to AP endonuclease APE1

Alexandra Kuznetsova , Nikita Kuznetsov , Alexander Ishchenko , Murat Saparbaev , Olga Fedorova
Biochimica et Biophysica Acta (BBA) - General Subjects, 2014, 1840 (10), pp.3042-3051. ⟨10.1016/j.bbagen.2014.07.016⟩
Article dans une revue hal-02393724v1

Functional variants of human APE1 rescue the DNA repair defects of the yeast AP endonuclease/3′-diesterase-deficient strain

Zhiqiang Wang , Emily Ayoub , Abdelghani Mazouzi , Inga Grin , Alexander Ishchenko
DNA Repair, 2014, 22, pp.53-66. ⟨10.1016/j.dnarep.2014.07.010⟩
Article dans une revue hal-02393647v1
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Aberrant repair initiated by mismatch-specific thymine-DNA glycosylases provides a mechanism for the mutational bias observed in CpG islands

Ibtissam Talhaoui , Sophie Couvé , Laurent Gros , Alexander Ishchenko , Bakhyt Matkarimov
Nucleic Acids Research, 2014, 42 (10), pp.6300-6313. ⟨10.1093/nar/gku246⟩
Article dans une revue hal-02393707v1
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Cloning and Characterization of a Wheat Homologue of Apurinic/Apyrimidinic Endonuclease Ape1L

Botagoz Joldybayeva , Paulina Prorok , Inga Grin , Dmitry Zharkov , Alexander Ishenko
PLoS ONE, 2014, 9 (3), pp.e92963. ⟨10.1371/journal.pone.0092963⟩
Article dans une revue hal-02393740v1

Step-by-step mechanism of DNA damage recognition by human 8-oxoguanine DNA glycosylase

Alexandra Kuznetsova , Nikita Kuznetsov , Alexander Ishchenko , Murat Saparbaev , Olga Fedorova
Biochimica et Biophysica Acta (BBA) - General Subjects, 2014, 1840 (1), pp.387-395. ⟨10.1016/j.bbagen.2013.09.035⟩
Article dans une revue hal-02393729v1

Direct DNA Lesion Reversal and Excision Repair in Escherichia coli

Sophie Couvé , Jacques Laval , Erlan Ramanculov , Olga Fedorova , Alexander Ishchenko
EcoSal Plus, 2013, 5 (2), ⟨10.1128/ecosalplus.7.2.4⟩
Article dans une revue hal-02393792v1

The mechanism of human tyrosyl-DNA phosphodiesterase 1 in the cleavage of AP site and its synthetic analogs

Natalia Lebedeva , Nadejda Rechkunova , Alexander Ishchenko , Murat Saparbaev , Olga Lavrik
DNA Repair, 2013, 12 (12), pp.1037-1042. ⟨10.1016/j.dnarep.2013.09.008⟩
Article dans une revue hal-02393777v1

Excision of 8-oxoguanine from methylated CpG dinucleotides by human 8-oxoguanine DNA glycosylase

Alexandra Kuznetsova , Nikita Kuznetsov , Olga Fedorova , Rustem Kasymov , Inga Grin
FEBS Letters, 2013, 587 (18), pp.3129-3134. ⟨10.1016/j.febslet.2013.08.008⟩
Article dans une revue hal-02393785v1

7,8-dihydro-8-oxoadenine, a highly mutagenic adduct, is repaired by Escherichia coli and human mismatch-specific uracil/thymine-DNA glycosylases

Ibtissam Talhaoui , Sophie Couvé , Alexander Ishchenko , Christophe Kunz , Primo Schär
Nucleic Acids Research, 2013, 41 (2), pp.912-923. ⟨10.1093/nar/gks1149⟩
Article dans une revue hal-02393748v1
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Highly Mutagenic Exocyclic DNA Adducts Are Substrates for the Human Nucleotide Incision Repair Pathway

Paulina Prorok , Christine Saint-Pierre , Didier Gasparutto , Olga Fedorova , Alexander Ishchenko
PLoS ONE, 2012, 7 (12), pp.e51776. ⟨10.1371/journal.pone.0051776⟩
Article dans une revue hal-02368498v1

New Insights in the Removal of the Hydantoins, Oxidation Product of Pyrimidines, via the Base Excision and Nucleotide Incision Repair Pathways

Modesto Redrejo-Rodríguez , Christine Saint-Pierre , Sophie Couvé , Abdelghani Mazouzi , Alexander Ishchenko
PLoS ONE, 2011, 6 (7), pp.e21039. ⟨10.1371/journal.pone.0021039⟩
Article dans une revue cea-02074458v1

Crystallization and preliminary X-ray analysis of human endonuclease 1 (APE1) in complex with an oligonucleotide containing a 5,6-dihydrouracil (DHU) or an alpha-anomeric 2'-deoxyadenosine (alphadA) modified base.

Pascal Retailleau , Alexander A Ishchenko , Nikita A Kuznetsov , Murat Saparbaev , Solange Moréra
Acta crystallographica Section F : Structural biology communications [2014-..], 2010, 66 (Pt 7), pp.798-800. ⟨10.1107/S1744309110017021⟩
Article dans une revue hal-00512071v1

Uncoupling of the base excision and nucleotide incision repair pathways reveals their respective biological roles.

Alexander A Ishchenko , Eric Deprez , Andrei V. Maksimenko , Jean-Claude Brochon , Patrick Tauc
Proceedings of the National Academy of Sciences of the United States of America, 2006, 103 (8), pp.2564-9. ⟨10.1073/pnas.0508582103⟩
Article dans une revue hal-00216010v1

The major human AP endonuclease (Ape1) is involved in the nucleotide incision repair pathway.

Laurent Gros , Alexander A Ishchenko , Hiroshi Ide , Rhoderick H Elder , Murat K Saparbaev
Nucleic Acids Research, 2004, 32 (1), pp.73-81. ⟨10.1093/nar/gkh165⟩
Article dans une revue hal-00277634v1

Apoptotic Topoisomerase I-DNA Complexes Induced by Staurosporine-mediated Oxygen Radicals

Olivier Sordet , Qasim Khan , Isabelle Plo , Philippe Pourquier , Yoshimasa Urasaki
Journal of Biological Chemistry, 2004, 279 (48), pp.50499-50504. ⟨10.1074/jbc.M410277200⟩
Article dans une revue inserm-02438646v1
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DNA repair and mutagenesis in vertebrate mitochondria: evidence for asymmetric DNA strand inheritance

Bakhyt Matkarimov , Murat A Saparbaev
Dmitry O. Zharkov. Mechanisms of genome protection and repair, 1241, Springer, pp.77-100, 2020, Advances in Experimental Medicine and Biology, 978-3-030-41282-1. ⟨10.1007/978-3-030-41283-8_6⟩
Chapitre d'ouvrage hal-03060578v1
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Alternative DNA repair pathways to handle complex DNA damage generated by oxidative stress and anticancer drugs

E. Matta , U. Aliyaskarova , A. A Kuznetsova , B. T Matkarimov , O. S Fedorova
Miral Dizdaroglu; R Stephen Lloyd. DNA Damage, DNA Repair and Disease, 1, Royal Society of Chemistry, pp.249-278, 2020, 978-1-78801-889-0. ⟨10.1039/9781839160769-00249⟩
Chapitre d'ouvrage hal-03301429v1
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Chapter X Alternative DNA repair pathways to handle complex DNA damage generated by oxidative stress and anticancer drugs

E Matta , U Aliyaskarova , A A Kuznetsova , B T Matkarimov , O S Fedorova
DNA Damage, DNA Repair and Disease, 1, Royal Society of Chemistry, 2020, Chemical Biology, 978-1-78801-889-0. ⟨10.1039/9781839160769⟩
Chapitre d'ouvrage hal-03432737v1