Mounir Tarek
2
Documents
Présentation
**Mounir Tarek**
CNRS section 13, DR1
Senior Research Director
Laboratoire de Physique et Chimie Théoriques
UMR 7019 LPCT Université de Lorraine,
Boulevard des Aiguillettes, BP 70239
54506 Vandoeuvre-lès-Nancy, cedex France
tel: +33 (0) 3-72-74-52 74
***RESEARCH INTEREST***Simulation of model membranes and membrane bound species is in biophysics a frontier area of research seething with excitements and challenges. The availability of all the ingredients to investigate membranes, in-silico, opens new perspectives particularly in the biological front. The aim of my research is to take computer simulations to an extra level, where manipulation of molecular nano-objects in-silico, by reproducing realistic mechanisms, sheds light onto challenging multidisciplinary problems. TOPICS • Electroporation of cell membranes (drug and gene delivery, electroshock healing, antibacterial treatment).... • Transport through voltage-gated potassium ion channels (ion conduction and selectivity, regulation, mutations, chanellopathies) • Action of synthetic peptides on membranes (antibacterial action) • Interaction of carbon nanostructures with membranes and membrane proteins. • Membrane Oxidation, Mecanisms. • Development of Coarse grained force fields for biomolecular simulation
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Modulation of the IKS channel by PIP2 requires two binding sites per monomerBBA Advances, 2023, 3, pp.100073. ⟨10.1016/j.bbadva.2023.100073⟩
Article dans une revue
hal-04325911v1
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Two-stage electro-mechanical coupling of a KV channel in voltage-dependent activationNature Communications, 2020, 11, ⟨10.1038/s41467-020-14406-w⟩
Article dans une revue
hal-03089983v1
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