Mounir Tarek
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Documents
Présentation
**Mounir Tarek**
CNRS section 13, DR1
Senior Research Director
Laboratoire de Physique et Chimie Théoriques
UMR 7019 LPCT Université de Lorraine,
Boulevard des Aiguillettes, BP 70239
54506 Vandoeuvre-lès-Nancy, cedex France
tel: +33 (0) 3-72-74-52 74
***RESEARCH INTEREST***Simulation of model membranes and membrane bound species is in biophysics a frontier area of research seething with excitements and challenges. The availability of all the ingredients to investigate membranes, in-silico, opens new perspectives particularly in the biological front. The aim of my research is to take computer simulations to an extra level, where manipulation of molecular nano-objects in-silico, by reproducing realistic mechanisms, sheds light onto challenging multidisciplinary problems. TOPICS • Electroporation of cell membranes (drug and gene delivery, electroshock healing, antibacterial treatment).... • Transport through voltage-gated potassium ion channels (ion conduction and selectivity, regulation, mutations, chanellopathies) • Action of synthetic peptides on membranes (antibacterial action) • Interaction of carbon nanostructures with membranes and membrane proteins. • Membrane Oxidation, Mecanisms. • Development of Coarse grained force fields for biomolecular simulation
Publications
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The contribution of lipid peroxidation to membrane permeability in electropermeabilization: A molecular dynamics studyBioelectrochemistry, 2019, 125, pp.46-57. ⟨10.1016/j.bioelechem.2018.07.018⟩
Article dans une revue
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