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Characterization of a Toxoplasma effector uncovers an alternative GSK3/β-catenin-regulatory pathway of inflammation

Huan He , Marie-Pierre Brenier-Pinchart , Laurence Braun , Alexandra Kraut , Bastien Touquet , et al.
eLife, 2018, 7, pp.e39887. ⟨10.7554/eLife.39887⟩
Article dans une revue inserm-02440386v1
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Metal-captured inhibition of pre-mRNA processing activity by CPSF3 controls Cryptosporidium infection

Christopher Swale , Alexandre Bougdour , Audrey Gnahoui-David , Julie Tottey , Sonia Georgeault , et al.
Sci Transl Med, 2019, 11 (517), 11 p. ⟨10.1126/scitranslmed.aax7161⟩
Article dans une revue inserm-02440382v1
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A brain cyst load-associated antigen is a Toxoplasma gondii biomarker for serodetection of persistent parasites and chronic infection

Céline Dard , Christopher Swale , Marie-Pierre Brenier-Pinchart , Dayana C Farhat , Valeria Bellini , et al.
BMC Biology, 2021, 19 (1), pp.25. ⟨10.1186/s12915-021-00959-9⟩
Article dans une revue inserm-03312061v1

Toxoplasma GRA 15 limits parasite growth in IFN γ‐activated fibroblasts through TRAF ubiquitin ligases

Debanjan Mukhopadhyay , Lamba Omar Sangaré , Laurence Braun , Mohamed-Ali Hakimi , Jeroen Pj Saeij
EMBO Journal, 2020, 39 (10), ⟨10.15252/embj.2019103758⟩
Article dans une revue hal-03094841v1
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A plant-like mechanism coupling m6A reading to polyadenylation safeguards transcriptome integrity and developmental gene partitioning in Toxoplasma

Dayana C Farhat , Matthew W Bowler , Guillaume Communie , Dominique Pontier , Lucid Belmudes , et al.
eLife, 2021, 10, pp.e68312. ⟨10.7554/elife.68312⟩
Article dans une revue hal-03313548v1
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Toxoplasma Parasite Twisting Motion Mechanically Induces Host Cell Membrane Fission to Complete Invasion within a Protective Vacuole

Georgios Pavlou , Mateusz Biesaga , Bastien Touquet , Vanessa Lagal , Martial Balland , et al.
Cell Host and Microbe, 2018, 24 (1), pp.81-96.e5. ⟨10.1016/j.chom.2018.06.003⟩
Article dans une revue inserm-02440390v1

Metal-captured inhibition of pre-mRNA processing activity by CPSF3 controls very efficiently Cryptosporidium infection

Christopher Swale , Alexandre Bougdour , Audrey Gnahoui-David , Julie Tottey , Sonia Georgeault , et al.
ApiCOWplexa 2019. 5. International Meeting on Apicomplexan Parasites in Farm Animals, Oct 2019, Berlin, Germany
Communication dans un congrès hal-03307486v1
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Altiratinib blocks Toxoplasma gondii and Plasmodium falciparum development by selectively targeting a spliceosome kinase

Christopher Swale , Valeria Bellini , Matthew Bowler , Nardella Flore , Marie-Pierre Brenier-Pinchart , et al.
Science Translational Medicine, 2022, 14 (656), 17 p. ⟨10.1126/scitranslmed.abn3231⟩
Article dans une revue hal-03752215v1

A drug repurposing screen identifies altiratinib as a selective inhibitor of a key regulatory splicing kinase and a potential therapeutic for toxoplasmosis and malaria

Christopher Swale , Valeria Bellini , Matthew Bowler , Flore Nardella , Marie-Pierre Brenier-Pinchart , et al.
2021
Pré-publication, Document de travail hal-03414875v1
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Multi-omics analysis delineates the distinct functions of sub-cellular acetyl-CoA pools in Toxoplasma gondii

Joachim Kloehn , Rebecca D Oppenheim , Ghizal Siddiqui , Pieter-Jan de Bock , Sunil Kumar Dogga , et al.
BMC Biology, 2020, 18 (1), pp.67. ⟨10.1186/s12915-020-00791-7⟩
Article dans une revue inserm-02971633v1
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Target Identification of an Antimalarial Oxaborole Identifies AN13762 as an Alternative Chemotype for Targeting CPSF3 in Apicomplexan Parasites

Valeria Bellini , Christopher Swale , Marie-Pierre Brenier-Pinchart , Tiffany Pezier , Sonia Georgeault , et al.
iScience, 2020, 23 (12), 14 p. ⟨10.1016/j.isci.2020.101871⟩
Article dans une revue hal-03106392v1
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The Toxoplasma effector TEEGR promotes parasite persistence by modulating NF-κB signalling via EZH2

Laurence Braun , Marie-Pierre Brenier-Pinchart , Pierre-Mehdi Hammoudi , Dominique Cannella , Sylvie Kieffer-Jaquinod , et al.
Nature Microbiology, 2019, 4 (7), pp.1208-1220. ⟨10.1038/s41564-019-0431-8⟩
Article dans une revue inserm-02440385v1