Recherche - Archive ouverte HAL Accéder directement au contenu

Filtrer vos résultats

96 résultats

Grafts of olfactory stem cells restore breathing and motor functions after a rat spinal cord injury

Jean-Claude Stamegna , Kevin Sadelli , Guy Escoffier , Stéphane D. Girard , Antoine D. Veron , et al.
Journal of Neurotrauma, 2018, ⟨10.1089/neu.2017.5383⟩
Article dans une revue hal-01718177v1

Use of LDL receptor-targeting peptide vectors for in vitro and in vivo cargo transport across the blood-brain barrier.

Yves Molino , Marion David , Karine Varini , Françoise Jabès , Nicolas Gaudin , et al.
FASEB Journal, 2017
Article dans une revue hal-01478978v1
Image document

Neurotensin receptor 2 is induced in astrocytes and brain endothelial cells in relation to neuroinflammation following pilocarpine‐induced seizures in rats

Grigorios Kyriatzis , Anne Bernard , Angélique Bôle , Guillaume Pflieger , Petros Chalas , et al.
Glia, 2021, 69 (11), pp.2618 - 2643. ⟨10.1002/glia.24062⟩
Article dans une revue hal-03452666v1

Utilisation de dérivés peptidiques (peptides et pseudo-peptides), qui présentent une affinité pour des récepteurs/transporteurs cellulaires, des types cellulaires particuliers et/ou qui passent les membranes cellulaires notamment celles des barrières physiologiques du cerveau telle que la barrière hémato-encéphalique (BHE), comme vecteurs de molécules d'intérêt thérapeutique ou d'agents d'imagerie ou de diagnostic ou de toute autre molécule comme une sonde moléculaire

Michel Khrestchatisky , Société Vect-Horus
N° de brevet: En cours. 2009
Brevet hal-00321258v1

Cholecalciferol (vitamin D-3) improves functional recovery when delivered during the acute phase after a spinal cord trauma

Yatma Gueye , Tanguy Marqueste , Fanny Maurel , Michel Khrestchatisky , Patrick Decherchi , et al.
Journal of Steroid Biochemistry and Molecular Biology, 2015, 154, pp.23-31. ⟨10.1016/j.jsbmb.2015.06.007⟩
Article dans une revue hal-01414098v1
Image document

Neurotensin receptor 2 is induced in astrocytes and brain endothelial cells in relation to status epilepticus and neuroinflammation following pilocarpine administration in rats

Kyriatzis Grigorios , Bernard Anne , Bôle Angélique , Pflieger Guillaume , Chalas Petros , et al.
2020
Pré-publication, Document de travail hal-03073954v1

Target engagement and intracellular delivery of mono- and bivalent LDL receptor-binding peptide-cargo conjugates: Implications for the rational design of new targeted drug therapies

K. Varini , P. Lécorché , R. Sonnette , F. Gassiot , B. Broc , et al.
Journal of Controlled Release, 2019, 314, pp.141-161. ⟨10.1016/j.jconrel.2019.10.033⟩
Article dans une revue hal-02348680v1
Image document

Gene expression comparison reveals distinct basal expression of HOX members and differential TNF-induced response between brain- and spinal ă cord-derived microvascular endothelial cells

Yves Molino , Francoise Jabes , Amandine Bonnet , Nicolas Gaudin , Anne Bernard , et al.
Journal of Neuroinflammation, 2016, 13 (1), pp.290. ⟨10.1186/s12974-016-0749-6⟩
Article dans une revue hal-01477828v1

Onset of hippocampus-dependent memory impairments in 5XFAD transgenic mouse model of Alzheimer's disease

Stéphane D. Girard , Marlyse Jacquet , Kévin Baranger , Martine Migliorati , Guy Escoffier , et al.
Hippocampus, 2014, 24 (7), pp.762--772. ⟨10.1002/hipo.22267⟩
Article dans une revue istex hal-01718190v1

A unique method for the isolation of nasal olfactory stem cells in living rats

Jean-Claude Stamegna , Stéphane D. Girard , Antoine Veron , Gilles Sicard , Michel Khrestchatisky , et al.
Stem Cell Research, 2014, 12 (3), pp.673--679. ⟨10.1016/j.scr.2014.02.010⟩
Article dans une revue hal-01718191v1

Specific interaction between the XNP/ATR-X gene product and the SET domain of the human EZH2 protein.

M Cardoso , S Timsit , L Villard , Michel Khrestchatisky , M Fontès , et al.
Human Molecular Genetics, 1998, 7 (4), pp.679-84
Article dans une revue hal-02090196v1
Image document

Pilocarpine-Induced Status Epilepticus in the Rat Hippocampus is Associated with Reactive Glia and Concomitant Increased Expression of CD31, PDGFRβ and Collagen IV in Endothelial Cells and Pericytes of the Blood Brain Barrier

Grigorios Kyriatzis , Anne Bernard , Angélique Bôle , Michel Khrestchatisky , Lotfi Ferhat
2023
Pré-publication, Document de travail hal-04301907v1
Image document

Correction to: Current research into brain barriers and the delivery of therapeutics for neurological diseases: a report on CNS barrier congress London, UK, 2017

John Greenwood , Margareta Hammarlund-Udenaes , Hazel C. Jones , Alan W. Stitt , Roosmarijn E. Vandenbroucke , et al.
Fluids and Barriers of the CNS, 2018, 15 (1), pp.3. ⟨10.1186/s12987-017-0086-x⟩
Article dans une revue hal-01718178v1
Image document

Long-Term Pantethine Treatment Counteracts Pathologic Gene Dysregulation and Decreases Alzheimer’s Disease Pathogenesis in a Transgenic Mouse Model

Kévin Baranger , Manuel van Gijsel-Bonnello , Delphine Stephan , Wassila Carpentier , Santiago Rivera , et al.
Neurotherapeutics, 2019, ⟨10.1007/s13311-019-00754-z⟩
Article dans une revue hal-02339537v1

Enhancement of L-3-hydroxybutyryl-CoA dehydrogenase activity and circulating ketone body levels by pantethine. Relevance to dopaminergic injury.

Emilie Cornille , Mhamad Abou-Hamdan , Michel Khrestchatisky , André Nieoullon , Max de Reggi , et al.
BMC Neuroscience, 2010, 11, pp.51. ⟨10.1186/1471-2202-11-51⟩
Article dans une revue hal-00848881v1
Image document

Current research into brain barriers and the delivery of therapeutics for neurological diseases: a report on CNS barrier congress London, UK, 2017

John Greenwood , Margareta Hammarlund-Udenaes , Hazel C. Jones , Alan W. Stitt , Roosmarijn E. Vandenbroucke , et al.
Fluids and Barriers of the CNS, 2017, 14 (1), pp.31. ⟨10.1186/s12987-017-0079-9⟩
Article dans une revue hal-01718184v1
Image document

MT5-MMP Promotes Alzheimer's Pathogenesis in the Frontal Cortex of 5xFAD Mice and APP Trafficking in vitro

Kévin Baranger , Amandine E Bonnet , Stéphane D Girard , Michel Paumier , Laura García-González , et al.
Frontiers in Molecular Neuroscience, 2017, 9, pp.163. ⟨10.3389/fnmol.2016.00163⟩
Article dans une revue hal-01479008v1
Image document

Differential spatio-temporal regulation of MMPs in the 5xFAD mouse model of Alzheimer's disease: evidence for a pro-amyloidogenic role of MT1-MMP

Nathalie A. Py , Amandine E. Bonnet , Anne Bernard , Yannick Marchalant , Eliane Charrat , et al.
Frontiers in Aging Neuroscience, 2014, 6, pp.247. ⟨10.3389/fnagi.2014.00247⟩
Article dans une revue hal-01718189v1

Proamyloidogenic effects of membrane type 1 matrix metalloproteinase involve MMP-2 and BACE-1 activities, and the modulation of APP trafficking

Jean-Michel Paumier , Nathalie Py , Laura García-González , Anne Bernard , Delphine Stephan , et al.
FASEB Journal, 2019, 33 (2), pp.2910-2927. ⟨10.1096/fj.201801076R⟩
Article dans une revue hal-02387988v1

Medicinal chemistry based approaches and nanotechnology-based systems to improve CNS drug targeting and delivery

Patrick Vlieghe , Michel Khrestchatisky
Medicinal Research Reviews, 2013, 33 (3), pp.457--516. ⟨10.1002/med.21252⟩
Article dans une revue istex hal-01718195v1
Image document

Identification and characterization of highly versatile peptide-vectors that bind non-competitively to the low-density lipoprotein receptor for in vivo targeting and delivery of small molecules and protein cargos

Marion David , Pascaline Lecorché , Maxime Masse , Aude Faucon , Karima Abouzid , et al.
PLoS ONE, 2018, 13 (2), pp.e0191052. ⟨10.1371/journal.pone.0191052⟩
Article dans une revue hal-01765841v1

The FVB/N mice: A well suited strain to study learning and memory ă processes using olfactory cues

Stephane D. Girard , Guy Escoffier , Michel Khrestchatisky , Francois S. Roman
Behavioural Brain Research, 2016, 296, pp.254-259. ⟨10.1016/j.bbr.2015.09.004⟩
Article dans une revue hal-01477821v1
Image document

MT5-MMP, just a new APP processing proteinase in Alzheimer's disease?

Kévin Baranger , Michel Khrestchatisky , Santiago Rivera
Journal of Neuroinflammation, 2016, 13, ⟨10.1186/s12974-016-0633-4⟩
Article dans une revue hal-01477833v1
Image document

In the Rat Hippocampus, Pilocarpine-Induced Status Epilepticus Is Associated with Reactive Glia and Concomitant Increased Expression of CD31, PDGFRβ, and Collagen IV in Endothelial Cells and Pericytes of the Blood–Brain Barrier

Grigorios Kyriatzis , Anne Bernard , Angélique Bôle , Michel Khrestchatisky , Lotfi Ferhat
International Journal of Molecular Sciences, 2024, 25 (3), pp.1693. ⟨10.3390/ijms25031693⟩
Article dans une revue hal-04453136v1

LDL receptor-peptide conjugate as in vivo tool for specific targeting of pancreatic ductal adenocarcinoma

Angélina Acier , Magali Godard , Fanny Gassiot , Pascal Finetti , Marion Rubis , et al.
Communications Biology, 2021, 4 (1), pp.987. ⟨10.1038/s42003-021-02508-0⟩
Article dans une revue hal-04235770v1

Dérivés peptidiques et leur utilistion comme vecteurs de molécules sous forme de conjugués

Michel Khrestchatisky , Marion David , Yves Molino , Anne Fourtoul , Patrick Vlieghe
France, Patent n° : FR 08 57159. 2008
Brevet hal-00342607v1

The Human Nose Harbors a Niche of Olfactory Ectomesenchymal Stem Cells Displaying Neurogenic and Osteogenic Properties

Bruno Delorme , Emmanuel Nivet , Julien Gaillard , Thomas Häupl , Jochen Ringe , et al.
Stem Cells and Development, 2010, 19 (6), pp.853-866. ⟨10.1089/scd.2009.0267⟩
Article dans une revue hal-02373958v1

The human nose harbors a niche of olfactory ectomesenchymal stem cells displaying neurogenic and osteogenic properties

Bruno Delorme , Emmanuel Nivet , Julien Gaillard , Thomas Häupl , Jochen Ringe , et al.
Stem Cells and Development, 2010, 19 (6), pp.853--866. ⟨10.1089/scd.2009.0267⟩
Article dans une revue hal-01736210v1
Image document

Cholecalciferol (vitamin D₃) improves myelination and recovery after nerve injury

Jean-Francois Chabas , Delphine Stephan , Tanguy Marqueste , Stephane Garcia , Marie-Noelle Lavaut , et al.
PLoS ONE, 2013, 8 (5), pp.e65034. ⟨10.1371/journal.pone.0065034⟩
Article dans une revue hal-01718197v1
Image document

Q/R editing of the rat GluR5 and GluR6 kainate receptors in vivo and in vitro: evidence for independent developmental, pathological and cellular regulation.

Anne Bernard , Lotfi Ferhat , Frédéric Dessi , Gérard Charton , Alfonso Represa , et al.
European Journal of Neuroscience, 1999, 11 (2), pp.604-16
Article dans une revue inserm-00487253v1