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A biphasic and brain-region selective down-regulation of cyclic adenosine monophosphate concentrations supports object recognition in the rat.

Maïte Hotte , François Dauphin , Thomas Freret , Michel Boulouard , Guenaëlle Levallet
PLoS ONE, 2012, 7 (2), pp.e32244. ⟨10.1371/journal.pone.0032244⟩
Article dans une revue hal-00862771v1

Comparison of the effects of erythropoietin and its carbamylated derivative on behaviour and hippocampal neurogenesis in mice.

Claire Leconte , Ebeline Bihel , François-Xavier Lepelletier , Valentine Bouët , Romaric Saulnier , et al.
Neuropharmacology, 2011, 60 (2-3), pp.354-64. ⟨10.1016/j.neuropharm.2010.09.025⟩
Article dans une revue hal-00863054v1

Sensorimotor and cognitive deficits after transient middle cerebral artery occlusion in the mouse.

Valentine Bouët , Thomas Freret , Jérôme Toutain , Didier Divoux , Michel Boulouard , et al.
Experimental Neurology, 2007, 203 (2), pp.555-67. ⟨10.1016/j.expneurol.2006.09.006⟩
Article dans une revue istex hal-00178296v1

4-substituted indazoles as new inhibitors of neuronal nitric oxide synthase.

Michel Boulouard , Pascale Schumann-Bard , Sabrina Butt-Gueulle , Elodie Lohou , Silvia Stiebing , et al.
Bioorganic and Medicinal Chemistry Letters, 2007, 17 (11), pp.3177-80. ⟨10.1016/j.bmcl.2007.03.024⟩
Article dans une revue istex hal-00864259v1

Therapeutic Potential of 5-HT 6 Receptor Agonists

Delphine Karila , Thomas Freret , Valentine Bouet , Michel Boulouard , Patrick Dallemagne , et al.
Journal of Medicinal Chemistry, 2015, 58 (20), pp.7901-7912. ⟨10.1021/acs.jmedchem.5b00179⟩
Article dans une revue hal-02043781v1

5-HT7 receptors are strongly implicated in allocentric navigation strategy in mice

Gregory Beaudet , Christelle Jozet-Alves , Thomas Freret , Pascale Schumann-Bard , Valentine Bouet , et al.
19ème Congrès de la Société Française de Pharmacologie et de Thérapeutique, Apr 2015, Caen, France
Poster de conférence hal-02436415v1

Repeated dexamphetamine treatment alters the dopaminergic system and increases the phMRI response to methylphenidate

Anouk Schrantee , Jordi Tremoleda , Marzena Wylezinska-Arridge , Valentine Bouet , Peter Hesseling , et al.
PLoS ONE, 2017, 12 (2), pp.e0172776. ⟨10.1371/journal.pone.0172776⟩
Article dans une revue hal-02135218v1

Long-term evaluation of sensorimotor and mnesic behaviour following striatal NMDA-induced unilateral excitotoxic lesion in the mouse.

Benoît Haelewyn , Thomas Freret , Emilie Pacary , Pascale Schumann-Bard , Michel Boulouard , et al.
Behavioural Brain Research, 2007, 178 (2), pp.235-43. ⟨10.1016/j.bbr.2006.12.023⟩
Article dans une revue istex hal-00178443v1

Synergistic effect of acetylcholinesterase inhibition (donepezil) and 5-HT(4) receptor activation (RS67333) on object recognition in mice.

Thomas Freret , Valentine Bouet , Anne Quiedeville , Gérald Nee , Patrick Dallemagne , et al.
Behavioural Brain Research, 2012, 230 (1), pp.304-8. ⟨10.1016/j.bbr.2012.02.012⟩
Article dans une revue istex hal-00862757v1

The effects of DHEA, 3beta-hydroxy-5alpha-androstane-6,17-dione, and 7-amino-DHEA analogues on short term and long term memory in the mouse.

Marc-Antoine Bazin , Laïla El Kihel , Michel Boulouard , Valentine Bouët , Sylvain Rault
Steroids, 2009, 74 (12), pp.931-7. ⟨10.1016/j.steroids.2009.06.010⟩
Article dans une revue istex hal-00863107v1

Serotonin 5-HT6 receptor blockade reverses the age-related deficits of recognition memory and working memory in mice.

Virginie da Silva Costa-Aze , François Dauphin , Michel Boulouard
Behavioural Brain Research, 2011, 222 (1), pp.134-40. ⟨10.1016/j.bbr.2011.03.046⟩
Article dans une revue istex hal-00862995v1

Design, synthesis, and pharmacological evaluation of multitarget-directed ligands with both serotonergic subtype 4 receptor (5-HT 4 R) partial agonist and 5-HT 6 R antagonist activities, as potential treatment of Alzheimer’s disease

Samir Yahiaoui , Katia Hamidouche , Céline Ballandonne , Audrey Davis , Jana Sopkova-de Oliveira Santos , et al.
European Journal of Medicinal Chemistry, 2016, 121, pp.283-293. ⟨10.1016/j.ejmech.2016.05.048⟩
Article dans une revue hal-02043759v1

Continuous enriched environment improves learning and memory in adult NMRI mice through theta burst-related-LTP independent mechanisms but is not efficient in advanced aged animals

Valentine Bouet , Thomas Freret , Patrick Dutar , Jean-Marie Billard , Michel Boulouard
Mechanisms of Ageing and Development, 2011, 132 (5), pp.240-248. ⟨10.1016/j.mad.2011.04.006⟩
Article dans une revue istex hal-02325196v1

Selective 5-HT6 receptor blockade improves spatial recognition memory and reverses age-related deficits in spatial recognition memory in the mouse.

Virginie da Silva Costa , Pascal Duchatelle , Michel Boulouard , François Dauphin
Neuropsychopharmacology, 2009, 34 (2), pp.488-500. ⟨10.1038/npp.2008.94⟩
Article dans une revue hal-00863265v1

Dual Histamine H3R/Serotonin 5-HT4R Ligands with Antiamnesic Properties: Pharmacophore-Based Virtual Screening and Polypharmacology.

Alban Lepailleur , Thomas Freret , Stéphane Lemaître , Michel Boulouard , François Dauphin , et al.
Journal of Chemical Information and Modeling, 2014, 54 (6), pp.1773-1784
Article dans une revue hal-01064770v1
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Novel Multitarget-Directed Ligands (MTDLs) with Acetylcholinesterase (AChE) Inhibitory and Serotonergic Subtype 4 Receptor (5-HT 4 R) Agonist Activities As Potential Agents against Alzheimer’s Disease: The Design of Donecopride

Cédric Lecoutey , Cédric Lecoutey , Florence Gaven , Patrizia Giannoni , Katia Hamidouche , et al.
Journal of Medicinal Chemistry, 2015, 58 (7), pp.3172-3187. ⟨10.1021/acs.jmedchem.5b00115⟩
Article dans une revue hal-02043873v1
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Design of donecopride, a dual serotonin subtype 4 receptor agonist/acetylcholinesterase inhibitor with potential interest for Alzheimer's disease treatment

Cédric Lecoutey , Damien Hedou , Thomas Freret , Patrizia Giannoni , Florence Gaven , et al.
Proceedings of the National Academy of Sciences of the United States of America, 2014, 111 (36), pp.E3825--30. ⟨10.1073/pnas.1410315111⟩
Article dans une revue hal-01800439v2

Chronic ethanol consumption induces tolerance to the spatial memory impairing effects of acute ethanol administration in rats.

Michel Boulouard , Véronique Lelong , Martine Daoust , Mickaël Naassila
Behavioural Brain Research, 2002, 136 (1), pp.239-46
Article dans une revue inserm-00746180v1

Long-term functional outcome following transient middle cerebral artery occlusion in the rat: correlation between brain damage and behavioral impairment.

Thomas Freret , Laurent Chazalviel , Simon Roussel , Myriam Bernaudin , Pascale Schumann-Bard , et al.
Behavioral Neuroscience, 2006, 120 (6), pp.1285-98. ⟨10.1037/0735-7044.120.6.1285⟩
Article dans une revue hal-00865366v1
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Pleiotropic prodrugs: Design of a dual butyrylcholinesterase inhibitor and 5-HT6 receptor antagonist with therapeutic interest in Alzheimer’s disease

François-Xavier Toublet , Julien Lalut , Bérénice Hatat , Cédric Lecoutey , Audrey Davis , et al.
European Journal of Medicinal Chemistry, 2021, 210, pp.113059. ⟨10.1016/j.ejmech.2020.113059⟩
Article dans une revue hal-03082877v1
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Mimicking schizophrenia symptoms in mice by combining factors: genetic, early environmental stress and late pharmacological conditioning

Valentine Bouët , Solenn Percelay , Nicole Turnbull , Thomas Freret , Michel Boulouard
NeuroFrance, May 2019, Marseille, France
Poster de conférence hal-02492831v1

Deletion of the serotonin receptor type 7 disrupts the acquisition of allocentric but not egocentric navigation strategies in mice

Gregory Beaudet , Christelle Jozet-Alves , Rachel Asselot , Pascale Schumann-Bard , Thomas Freret , et al.
Behavioural Brain Research, 2017, 320 (1), pp.179 - 185. ⟨10.1016/j.bbr.2016.12.006⟩
Article dans une revue hal-01472663v1

Co-modulation of an allosteric modulator of nicotinic receptor-cholinesterase inhibitor (galantamine) and a 5-HT4 receptor agonist (RS-67333): effect on scopolamine-induced memory deficit in the mouse

Thomas Freret , Véronique Lelong-Boulouard , Pierre Lecouflet , Katia Hamidouche , François Dauphin , et al.
Psychopharmacology, 2017, 234 (15), pp.2365-2374. ⟨10.1007/s00213-017-4664-z⟩
Article dans une revue hal-02135214v1
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Combining adverse factors to build a new 3-hit model of schizophrenia

Solenn Percelay , Valentine Bouët , Thomas Freret , Michel Boulouard
XXIIème journées de l'Ecole Doctorale normande de Biologie Intégrétive, Santé, Environnement, Mar 2019, Caen, France. , 2019
Poster de conférence hal-02135476v1

Novel antagonists of serotonin-4 receptors: synthesis and biological evaluation of pyrrolothienopyrazines.

Stéphane Lemaître , Alban Lepailleur , Ronan Bureau , Sabrina Butt-Gueulle , Véronique Lelong-Boulouard , et al.
Bioorganic and Medicinal Chemistry, 2009, 17 (6), pp.2607-22. ⟨10.1016/j.bmc.2008.11.045⟩
Article dans une revue istex hal-00863300v1

Delayed administration of deferoxamine reduces brain damage and promotes functional recovery after transient focal cerebral ischemia in the rat.

Thomas Freret , Samuel Valable , Laurent Chazalviel , Romaric Saulnier , Eric T Mackenzie , et al.
European Journal of Neuroscience, 2006, 23 (7), pp.1757-65. ⟨10.1111/j.1460-9568.2006.04699.x⟩
Article dans une revue istex hal-00865370v1
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Vezatin is essential for dendritic spine morphogenesis and functional synaptic maturation.

Lydia Danglot , Thomas Freret , Nicolas Le Roux , Nicolas Narboux Nême , Andrea Burgo , et al.
Journal of Neuroscience, 2012, 32 (26), pp.9007-22. ⟨10.1523/JNEUROSCI.3084-11.2012⟩
Article dans une revue hal-00776396v1

Behavioral deficits after distal focal cerebral ischemia in mice: Usefulness of adhesive removal test.

Thomas Freret , Valentine Bouet , Claire Leconte , Simon Roussel , Laurent Chazalviel , et al.
Behavioral Neuroscience, 2009, 123 (1), pp.224-30. ⟨10.1037/a0014157⟩
Article dans une revue hal-00863264v1

Genomic transcriptional profiling in LOU/C/Jall rats identifies genes for successful aging

Véronique Paban , Jean-Marie Billard , Valentine Bouet , Thomas Freret , Michel Boulouard , et al.
Brain Structure and Function, 2013, 218 (6), pp.1501-1512. ⟨10.1007/s00429-012-0472-8⟩
Article dans une revue istex hal-02325134v1

Chronic activation of 5-HT4 receptors or blockade of 5-HT6 receptors improve memory performances

Anne Quiedeville , Michel Boulouard , Katia Hamidouche , Virginie da Silva Costa-Aze , Gerald Nee , et al.
Behavioural Brain Research, 2015, 293, pp.10-17. ⟨10.1016/j.bbr.2015.07.020⟩
Article dans une revue hal-02043824v1