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Blood–Brain Barrier In Vitro Models and Their Applications in Toxicology

 Anaelle Fabulas-da Costa , Christophe Landry , Lucie Dehouck , Emmanuel Sevin , Marie-Pierre Dehouck , et al.
In Vitro Toxicology Systems. Methods in Pharmacology and Toxicology, Humana Press, pp.147-166, 2014, 978-1-4939-0520-1. ⟨10.1007/978-1-4939-0521-8_7⟩
Chapitre d'ouvrage hal-02504329v1

Endothelial calcium dynamics, connexin channels and blood–brain barrier function

 Marijke de Bock , Nan Wang , Elke Decrock , Mélissa Bol , Ashish Gadicherla , et al.
Progress in Neurobiology, 2013, 108, pp.1-20. ⟨10.1016/j.pneurobio.2013.06.001⟩
Article dans une revue hal-02515498v1
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Topical Intestinal Aminoimidazole Agonists of G-Protein-Coupled Bile Acid Receptor 1 Promote Glucagon Like Peptide-1 Secretion and Improve Glucose Tolerance

 Manuel Lasalle , Vanessa Hoguet , Nathalie Hennuyer , Florence Leroux , Catherine Piveteau , et al.
Journal of Medicinal Chemistry, 2017, 60 (10), pp.4185-4211. ⟨10.1021/acs.jmedchem.6b01873⟩
Article dans une revue inserm-02115415v1
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Evaluation of drug-induced neurotoxicity based on metabolomics, proteomics and electrical activity measurements in complementary CNS in vitro models

 Luise Schultz , Marie-Gabrielle Zurich , Maxime Culot , Anaelle da Costa , Christophe Landry , et al.
Toxicology in Vitro, 2015, 30 (1), pp.138-165. ⟨10.1016/j.tiv.2015.05.016⟩
Article dans une revue hal-02513335v1

Cyclosporine A kinetics in brain cell cultures and its potential of crossing the blood–brain barrier

 P. Bellwon , M. Culot , A. Wilmes , T. Schmidt , M.G. Zurich , et al.
Toxicology in Vitro, 2015, 30 (1), pp.166-175. ⟨10.1016/j.tiv.2015.01.003⟩
Article dans une revue hal-02513358v1
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An in vitro strategy using multiple human induced pluripotent stem cell-derived models to assess the toxicity of chemicals: A case study on paraquat

 Carolina Nunes , Pranika Singh , Zahra Mazidi , Cormac Murphy , Aurore Bourguignon , et al.
Toxicology in Vitro, 2022, 81, pp.105333. ⟨10.1016/j.tiv.2022.105333⟩
Article dans une revue hal-03706955v1
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Evaluation of the impact of iPSC differentiation protocols on transcriptomic signatures

 Vidya Chandrasekaran , Sara Wellens , Aurore Bourguignon , Ivo Djidrovski , Leonie Fransen , et al.
Toxicology in Vitro, In press, ⟨10.1016/j.tiv.2024.105826⟩
Article dans une revue hal-04546651v1

A Stable and Reproducible Human Blood-Brain Barrier Model Derived from Hematopoietic Stem Cells

 Roméo Cecchelli , Sezin Aday , Emmanuel Sevin , Catarina Almeida , Maxime Culot , et al.
PLoS ONE, 2014, 9 (6), pp.e99733. ⟨10.1371/journal.pone.0099733⟩
Article dans une revue hal-02515233v1

Ca2+ regulation of connexin 43 hemichannels in C6 glioma and glial cells

 Elke de Vuyst , Nan Wang , Elke Decrock , Marijke de Bock , Mathieu Vinken , et al.
Cell Calcium, 2009, 46, p. 176-187
Article dans une revue hal-00544068v1

Accelerated Caco-2 cell permeability model for drug discovery

 Emmanuel Sevin , L. Dehouck , A. Fabulas-da Costa , R. Cecchelli , M.P. Dehouck , et al.
Journal of Pharmacological and Toxicological Methods, 2013, 68 (3), pp.334-339. ⟨10.1016/j.vascn.2013.07.004⟩
Article dans une revue hal-02515314v1
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Flow induces barrier and glycocalyx-related genes and negative surface charge in a lab-on-a-chip human blood-brain barrier model

 Ana R Santa-Maria , Fruzsina R Walter , Ricardo Figueiredo , András Kincses , Judith Vigh , et al.
Journal of Cerebral Blood Flow and Metabolism, 2021, 41 (9), pp.2201-2215. ⟨10.1177/0271678X21992638⟩
Article dans une revue hal-03185580v1
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Challenges and opportunities in the use of transcriptomics characterization for human iPSC-derived BBB models

 Sara Wellens , Fabien Gosselet , Maxime Culot
Toxicology in Vitro, In press, ⟨10.1016/j.tiv.2022.105424⟩
Article dans une revue hal-03708257v2

Beyond the Rule of 5: Impact of PEGylation with Various Polymer Sizes on Pharmacokinetic Properties, Structure–Properties Relationships of mPEGylated Small Agonists of TGR5 Receptor

 Vanessa Hoguet , Manuel Lasalle , Mathieu Maingot , Geoffroy Dequirez , Rajaa Boulahjar , et al.
Journal of Medicinal Chemistry, 2021, 64 (3), pp.1593-1610. ⟨10.1021/acs.jmedchem.0c01774⟩
Article dans une revue hal-03185533v1

Cerebrovascular protection as a possible mechanism for the protective effects of NXY-059 in preclinical models: An in vitro study

 Maxime Culot , Caroline Mysiorek , Mila Renftel , Benoit D. Roussel , Yannick Hommet , et al.
Brain Research, 2009, 1294, p. 144-152
Article dans une revue hal-00544037v1
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Central nervous system delivery of molecules across the blood-brain barrier

 Fabien Gosselet , Rodrigo Azevedo Loiola , Anna Roig , Anna Rosell , Maxime Culot
Neurochemistry International, 2021, 144, ⟨10.1016/j.neuint.2020.104952⟩
Article dans une revue hal-03282235v1
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In vitro blood–brain barrier permeability predictions for GABAA receptor modulating piperine analogs

 Daniela Elisabeth Eigenmann , Carmen Dürig , Evelyn Andrea Jähne , Martin Smieško , Maxime Culot , et al.
European Journal of Pharmaceutics and Biopharmaceutics, 2016, 103, pp.118-126. ⟨10.1016/j.ejpb.2016.03.029⟩
Article dans une revue hal-02510088v1

An in vitro blood-brain barrier model for high throughput (HTS) toxicological screening

 Maxime Culot , Stefan Lundquist , Dorothée Vanuxeem , Stéphane Nion , Christophe Landry , et al.
Toxicology in Vitro, 2008, 22, p. 799-811
Article dans une revue hal-00527560v1

New strategy for alerting central nervous system toxicity: Integration of blood-brain barrier toxicity and permeability in neurotoxicity assessment

 Dorothée Hallier-Vanuxeem , Pilar Prieto , Maxime Culot , Heidi Diallo , Christophe Landry , et al.
Toxicology in Vitro, 2009, 23, p. 447-453
Article dans une revue hal-00527935v1
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Contribution of brain pericytes in blood–brain barrier formation and maintenance: a transcriptomic study of cocultured human endothelial cells derived from hematopoietic stem cells

 Marjolein Heymans , Ricardo Figueiredo , Lucie Dehouck , David Francisco , Yasuteru Sano , et al.
Fluids and Barriers of the CNS, 2020, 17 (1), ⟨10.1186/s12987-020-00208-1⟩
Article dans une revue hal-03127036v1

A new angle on blood-CNS interfaces: A role for connexins?

 Marijke de Bock , Roosmarijn Vandenbroucke , Elke Decrock , Maxime Culot , Roméo Cecchelli , et al.
FEBS Letters, 2014, 588 (8), pp.1259-1270. ⟨10.1016/j.febslet.2014.02.060⟩
Article dans une revue hal-02515256v1
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Transport study of interleukin-1 inhibitors using a human in vitro model of the blood-brain barrier

 Elisabet Sjöström , Maxime Culot , Lisa Leickt , Mikael Åstrand , Erik Nordling , et al.
Brain, Behavior & Immunity - Health, 2021, 16, pp.100307. ⟨10.1016/j.bbih.2021.100307⟩
Article dans une revue hal-03472272v1
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A Miniaturized Pump Out Method for Characterizing Molecule Interaction with ABC Transporters

 Emmanuel Sevin , Lucie Dehouck , Romain Versele , Maxime Culot , Fabien Gosselet
International Journal of Molecular Sciences, 2019, 20, ⟨10.3390/ijms20225529⟩
Article dans une revue hal-03282234v1
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Mimicking brain tissue binding in an in vitro model of the blood-brain barrier illustrates differences between in vitro and in vivo methods for assessing the rate of brain penetration

 Marjolein Heymans , Emmanuel Sevin , Fabien Gosselet , Stefan Lundquist , Maxime Culot
European Journal of Pharmaceutics and Biopharmaceutics, 2018, 127, pp.453-461. ⟨10.1016/j.ejpb.2018.03.007⟩
Article dans une revue hal-02506299v1

Development and validation of a LC–MS/MS method for assessment of an anti-inflammatory indolinone derivative by in vitro blood–brain barrier models

 Evelyn Jähne , Daniela Eigenmann , Maxime Culot , Roméo Cecchelli , Fruzsina Walter , et al.
Journal of Pharmaceutical and Biomedical Analysis, 2014, 98, pp.235-246. ⟨10.1016/j.jpba.2014.05.026⟩
Article dans une revue hal-02515229v1
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Homology Modeling of the Human P-glycoprotein (ABCB1) and Insights into Ligand Binding through Molecular Docking Studies

 Liadys Mora Lagares , Nikola Minovski , Ana Yisel Caballero Alfonso , Emilio Benfenati , Sara Wellens , et al.
International Journal of Molecular Sciences, 2020, 21 (11), pp.4058. ⟨10.3390/ijms21114058⟩
Article dans une revue hal-03127238v1
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Brain pericytes from stress-susceptible pigs increase blood-brain barrier permeability in vitro.

 Elodie Vandenhaute , Maxime Culot , Fabien Gosselet , Lucie Dehouck , Catherine Godfraind , et al.
Fluids and Barriers of the CNS, 2012, 9 (1), pp.11. ⟨10.1186/2045-8118-9-11⟩
Article dans une revue inserm-00714318v1

A Simple Method for Assessing Free Brain/Free Plasma Ratios Using an In Vitro Model of the Blood Brain Barrier

 Maxime Culot , Anaëlle Fabulas - da Costa , Emmanuel Sevin , Erica Szorath , Stefan Martinsson , et al.
PLoS ONE, 2013, 8 (12), pp.e80634. ⟨10.1371/journal.pone.0080634⟩
Article dans une revue hal-02515332v1

Pharmacokinetics and In Vitro Blood-Brain Barrier Screening of the Plant-Derived Alkaloid Tryptanthrin

 Evelyn Jähne , Daniela Eigenmann , Chethan Sampath , Veronika Butterweck , Maxime Culot , et al.
Planta Medica, 2016, 82 (11/12), pp.1021-1029. ⟨10.1055/s-0042-105295⟩
Article dans une revue hal-02506889v1
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Evaluation of a human iPSC-derived BBB model for repeated dose toxicity testing with cyclosporine A as model compound

 Sara Wellens , Lucie Dehouck , Vidya Chandrasekaran , Pranika Singh , Rodrigo Azevedo Loiola , et al.
Toxicology in Vitro, 2021, 73, pp.105112. ⟨10.1016/j.tiv.2021.105112⟩
Article dans une revue hal-03185595v1

In vitro blood–brain barrier model adapted to repeated-dose toxicological screening

 A. Fabulas-da Costa , R. Aijjou , J. Hachani , C. Landry , R. Cecchelli , et al.
Toxicology in Vitro, 2013, 27 (6), pp.1944-1953. ⟨10.1016/j.tiv.2013.06.026⟩
Article dans une revue istex hal-02515342v1
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