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Evaluation of drug-induced neurotoxicity based on metabolomics, proteomics and electrical activity measurements in complementary CNS in vitro models
Luise Schultz
,
Marie-Gabrielle Zurich
,
Maxime Culot
,
Anaelle da Costa
,
Christophe Landry
,
et al.
Article dans une revue
hal-02513335v1
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Topical Intestinal Aminoimidazole Agonists of G-Protein-Coupled Bile Acid Receptor 1 Promote Glucagon Like Peptide-1 Secretion and Improve Glucose Tolerance
Manuel Lasalle
,
Vanessa Hoguet
,
Nathalie Hennuyer
,
Florence Leroux
,
Catherine Piveteau
,
et al.
Article dans une revue
inserm-02115415v1
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Blood–Brain Barrier In Vitro Models and Their Applications in Toxicology
Anaelle Fabulas-da Costa
,
Christophe Landry
,
Lucie Dehouck
,
Emmanuel Sevin
,
Marie-Pierre Dehouck
,
et al.
In Vitro Toxicology Systems. Methods in Pharmacology and Toxicology, Humana Press, pp.147-166, 2014, 978-1-4939-0520-1. ⟨10.1007/978-1-4939-0521-8_7⟩
Chapitre d'ouvrage
hal-02504329v1
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Endothelial calcium dynamics, connexin channels and blood–brain barrier function
Marijke de Bock
,
Nan Wang
,
Elke Decrock
,
Mélissa Bol
,
Ashish Gadicherla
,
et al.
Article dans une revue
hal-02515498v1
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Cyclosporine A kinetics in brain cell cultures and its potential of crossing the blood–brain barrier
P. Bellwon
,
M. Culot
,
A. Wilmes
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T. Schmidt
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M.G. Zurich
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et al.
Article dans une revue
hal-02513358v1
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An in vitro strategy using multiple human induced pluripotent stem cell-derived models to assess the toxicity of chemicals: A case study on paraquat
Carolina Nunes
,
Pranika Singh
,
Zahra Mazidi
,
Cormac Murphy
,
Aurore Bourguignon
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et al.
Article dans une revue
hal-03706955v1
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Evaluation of the impact of iPSC differentiation protocols on transcriptomic signatures
Vidya Chandrasekaran
,
Sara Wellens
,
Aurore Bourguignon
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Ivo Djidrovski
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Leonie Fransen
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et al.
Article dans une revue
hal-04546651v1
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An in vitro blood-brain barrier model for high throughput (HTS) toxicological screening
Maxime Culot
,
Stefan Lundquist
,
Dorothée Vanuxeem
,
Stéphane Nion
,
Christophe Landry
,
et al.
Toxicology in Vitro, 2008, 22, p. 799-811
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hal-00527560v1
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New strategy for alerting central nervous system toxicity: Integration of blood-brain barrier toxicity and permeability in neurotoxicity assessment
Dorothée Hallier-Vanuxeem
,
Pilar Prieto
,
Maxime Culot
,
Heidi Diallo
,
Christophe Landry
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et al.
Toxicology in Vitro, 2009, 23, p. 447-453
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Beyond the Rule of 5: Impact of PEGylation with Various Polymer Sizes on Pharmacokinetic Properties, Structure–Properties Relationships of mPEGylated Small Agonists of TGR5 Receptor
Vanessa Hoguet
,
Manuel Lasalle
,
Mathieu Maingot
,
Geoffroy Dequirez
,
Rajaa Boulahjar
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et al.
Article dans une revue
hal-03185533v1
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Cerebrovascular protection as a possible mechanism for the protective effects of NXY-059 in preclinical models: An in vitro study
Maxime Culot
,
Caroline Mysiorek
,
Mila Renftel
,
Benoit D. Roussel
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Yannick Hommet
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et al.
Brain Research, 2009, 1294, p. 144-152
Article dans une revue
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Central nervous system delivery of molecules across the blood-brain barrier
Fabien Gosselet
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Rodrigo Azevedo Loiola
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Anna Roig
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Anna Rosell
,
Maxime Culot
Article dans une revue
hal-03282235v1
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In vitro blood–brain barrier permeability predictions for GABAA receptor modulating piperine analogs
Daniela Elisabeth Eigenmann
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Carmen Dürig
,
Evelyn Andrea Jähne
,
Martin Smieško
,
Maxime Culot
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et al.
Article dans une revue
hal-02510088v1
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Contribution of brain pericytes in blood–brain barrier formation and maintenance: a transcriptomic study of cocultured human endothelial cells derived from hematopoietic stem cells
Marjolein Heymans
,
Ricardo Figueiredo
,
Lucie Dehouck
,
David Francisco
,
Yasuteru Sano
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et al.
Article dans une revue
hal-03127036v1
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A new angle on blood-CNS interfaces: A role for connexins?
Marijke de Bock
,
Roosmarijn Vandenbroucke
,
Elke Decrock
,
Maxime Culot
,
Roméo Cecchelli
,
et al.
Article dans une revue
hal-02515256v1
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Transport study of interleukin-1 inhibitors using a human in vitro model of the blood-brain barrier
Elisabet Sjöström
,
Maxime Culot
,
Lisa Leickt
,
Mikael Åstrand
,
Erik Nordling
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et al.
Article dans une revue
hal-03472272v1
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A Miniaturized Pump Out Method for Characterizing Molecule Interaction with ABC Transporters
Emmanuel Sevin
,
Lucie Dehouck
,
Romain Versele
,
Maxime Culot
,
Fabien Gosselet
Article dans une revue
hal-03282234v1
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Mimicking brain tissue binding in an in vitro model of the blood-brain barrier illustrates differences between in vitro and in vivo methods for assessing the rate of brain penetration
Marjolein Heymans
,
Emmanuel Sevin
,
Fabien Gosselet
,
Stefan Lundquist
,
Maxime Culot
Article dans une revue
hal-02506299v1
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Development and validation of a LC–MS/MS method for assessment of an anti-inflammatory indolinone derivative by in vitro blood–brain barrier models
Evelyn Jähne
,
Daniela Eigenmann
,
Maxime Culot
,
Roméo Cecchelli
,
Fruzsina Walter
,
et al.
Article dans une revue
hal-02515229v1
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Homology Modeling of the Human P-glycoprotein (ABCB1) and Insights into Ligand Binding through Molecular Docking Studies
Liadys Mora Lagares
,
Nikola Minovski
,
Ana Yisel Caballero Alfonso
,
Emilio Benfenati
,
Sara Wellens
,
et al.
Article dans une revue
hal-03127238v1
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Ca2+ regulation of connexin 43 hemichannels in C6 glioma and glial cells
Elke de Vuyst
,
Nan Wang
,
Elke Decrock
,
Marijke de Bock
,
Mathieu Vinken
,
et al.
Cell Calcium, 2009, 46, p. 176-187
Article dans une revue
hal-00544068v1
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Accelerated Caco-2 cell permeability model for drug discovery
Emmanuel Sevin
,
L. Dehouck
,
A. Fabulas-da Costa
,
R. Cecchelli
,
M.P. Dehouck
,
et al.
Article dans une revue
hal-02515314v1
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Flow induces barrier and glycocalyx-related genes and negative surface charge in a lab-on-a-chip human blood-brain barrier model
Ana R Santa-Maria
,
Fruzsina R Walter
,
Ricardo Figueiredo
,
András Kincses
,
Judith Vigh
,
et al.
Article dans une revue
hal-03185580v1
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A Stable and Reproducible Human Blood-Brain Barrier Model Derived from Hematopoietic Stem Cells
Roméo Cecchelli
,
Sezin Aday
,
Emmanuel Sevin
,
Catarina Almeida
,
Maxime Culot
,
et al.
Article dans une revue
hal-02515233v1
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Challenges and opportunities in the use of transcriptomics characterization for human iPSC-derived BBB models
Sara Wellens
,
Fabien Gosselet
,
Maxime Culot
Article dans une revue
hal-03708257v2
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A Simple Method for Assessing Free Brain/Free Plasma Ratios Using an In Vitro Model of the Blood Brain Barrier
Maxime Culot
,
Anaëlle Fabulas - da Costa
,
Emmanuel Sevin
,
Erica Szorath
,
Stefan Martinsson
,
et al.
Article dans une revue
hal-02515332v1
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Catalytic site inhibition of insulin-degrading enzyme by a small molecule induces glucose intolerance in mice
Rebecca Déprez-Poulain
,
Nathalie Hennuyer
,
Damien Bosc
,
Wenguang Liang
,
Emmanuelle Enée
,
et al.
Article dans une revue
hal-02511111v1
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Brain pericytes from stress-susceptible pigs increase blood-brain barrier permeability in vitro.
Elodie Vandenhaute
,
Maxime Culot
,
Fabien Gosselet
,
Lucie Dehouck
,
Catherine Godfraind
,
et al.
Article dans une revue
inserm-00714318v1
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Pharmacokinetics and In Vitro Blood-Brain Barrier Screening of the Plant-Derived Alkaloid Tryptanthrin
Evelyn Jähne
,
Daniela Eigenmann
,
Chethan Sampath
,
Veronika Butterweck
,
Maxime Culot
,
et al.
Article dans une revue
hal-02506889v1
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Evaluation of a human iPSC-derived BBB model for repeated dose toxicity testing with cyclosporine A as model compound
Sara Wellens
,
Lucie Dehouck
,
Vidya Chandrasekaran
,
Pranika Singh
,
Rodrigo Azevedo Loiola
,
et al.
Article dans une revue
hal-03185595v1
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