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Number of documents

24

mathieu gendrot


Education and degrees

Ph.D. 2, « Proveblue as an antimalarial drug » Supervisor : PHC Bruno PRADINES. Curent year 2018-2019, Institut de Recherche Biomédicale des Armées. IHU Méditerranée Infection Marseille, Parasitology-entomology unit.

Ph.D. 1, « Proveblue as an antimalarial drug » Supervisor : PHC Bruno PRADINES. Year 2017-2018, Institut de Recherche Biomédicale des Armées. IHU Méditerranée Infection Marseille, Parasitology-entomology unit.

 

Master degree 2, Human Pathology « Maladies infectieuses & contagion-prévention » Options : Medical entomology. Year 2016-2017, Marseille university. M

aster degree 1, Human Pathology « Du gène à la maladie » Options : Parasitology, bacteriology, virology, molecular biology. Year 2015-2016, Marseille university.

University degree 3, « Biochimie, biologie moléculaire cellulaire et physiologique » Options : Microbiology, Microbiology laboratory analysis, Virology. Year 2014-2015, Rouen university.

University degree 2, « Biochimie, biologie moléculaire cellulaire et physiologique » Options : Animal and plant parasitology, Biochemistry. Year 2013-2014, Rouen university.

University degree 1, « Science de la vie de la Terre et de l'environnement » Year 2012-2013, Rouen university. Bachelor degree, scientific option. Option: Life, Earth and Environment Sciences Year 2011-2012, High school Louis-Modeste Leroy, Evreux.

 

Professional experience 

July 2017-now : Military volunteer (Officer cadet) of the French Service de Santé des Armées Ph.D. student, 2nd year under direction of supervisor PHC Bruno PRADINES

November 2018: One month trainee at Pasteur Institute of Cambodia in Phnom Penh Learning of Piperaquine survival assay and Ring survival assay, experiments on Cambodian resistant strains.

November 2017 : Initial Military Training Third Promotion at Gendarmerie of Rochefort, Promotion Major.

January to june 2017 : Six months trainee at malaria National Reference Center in Marseille « Use of Methylene blue Proveblue as an antimalarial drug in-vitro. »

May to june 2016 : Seven weeks trainee at malaria National Reference Center in Marseille « Identification and validation of molecular markers of resistance to antimalarial drugs. »

July to august 2015 : Six weeks trainee at malaria National Reference Center in Marseille « Identification and validation of molecular markers of resistance to antimalarial drugs. »


Journal articles24 documents

  • Caroline Souza Pereira, Helenita Costa Quadros, Diogo Rodrigo Magalhaes Moreira, William Castro, Romulo Ivisson Santos de Deus da Silva, et al.. A Novel Hybrid of Chloroquine and Primaquine Linked by Gold(I): Multitarget and Multiphase Antiplasmodial Agent. ChemMedChem, Wiley-VCH Verlag, 2021, 16 (4), pp.662-678. ⟨10.1002/cmdc.202000653⟩. ⟨hal-03160988⟩
  • Sumit Kumar, Mathieu Gendrot, Isabelle Fonta, Joel Mosnier, Nosipho Cele, et al.. Amide Tethered 4-Aminoquinoline-naphthalimide Hybrids: A New Class of Possible Dual Function Antiplasmodials. ACS Medicinal Chemistry Letters, American Chemical Society, 2020, 11 (12), pp.2544-2552. ⟨10.1021/acsmedchemlett.0c00536⟩. ⟨hal-03165070⟩
  • Mathieu Gendrot, Bruno Pradines, P Brouqui, Michel Drancourt, Marylin Madamet, et al.. Baseline and multinormal distribution of ex vivo susceptibilities of Plasmodium falciparum to methylene blue in Africa, 2013–18. Journal of Antimicrobial Chemotherapy, Oxford University Press (OUP), 2020, ⟨10.1093/jac/dkaa174⟩. ⟨hal-02996303⟩
  • Mathieu Gendrot, Julien Andreani, Priscilla Jardot, Sebastien Hutter, Oceane Delandre, et al.. In Vitro Antiviral Activity of Doxycycline against SARS-CoV-2. Molecules, MDPI, 2020, 25 (21), ⟨10.3390/molecules25215064⟩. ⟨hal-03149268⟩
  • Francis Tsombeng Foguim, Hervé Bogreau, Mathieu Gendrot, Joel Mosnier, Isabelle Fonta, et al.. Prevalence of mutations in the Plasmodium falciparum chloroquine resistance transporter, PfCRT, and association with ex vivo susceptibility to common anti-malarial drugs against African Plasmodium falciparum isolates. Malaria Journal, BioMed Central, 2020, 19 (1), ⟨10.1186/s12936-020-03281-x⟩. ⟨hal-02996272⟩
  • Mathieu Gendrot, Emilie Javelle, Axelle Clerc, Hélène Savini, Bruno Pradines. Chloroquine as a prophylactic agent against COVID-19?. International Journal of Antimicrobial Agents, Elsevier, 2020, 55 (6), pp.105980. ⟨10.1016/j.ijantimicag.2020.105980⟩. ⟨hal-02996310⟩
  • Mathieu Gendrot, Julien Andreani, Manon Boxberger, Priscilla Jardot, Isabelle Fonta, et al.. Antimalarial drugs inhibit the replication of SARS-CoV-2: An in vitro evaluation. Travel Medicine and Infectious Disease, Elsevier, 2020, 37, pp.101873. ⟨10.1016/j.tmaid.2020.101873⟩. ⟨hal-02996300⟩
  • Mathieu Gendrot, Isabelle Duflot, Manon Boxberger, Océane Delandre, Priscilla Jardot, et al.. Antimalarial artemisinin-based combination therapies (ACT) and COVID-19 in Africa: In vitro inhibition of SARS-CoV-2 replication by mefloquine-artesunate. International Journal of Infectious Diseases, Elsevier, 2020, 99, pp.437-440. ⟨10.1016/j.ijid.2020.08.032⟩. ⟨hal-02996298⟩
  • Mathieu Gendrot, Julien Andreani, Isabelle Duflot, Manon Boxberger, Marion Le Bideau, et al.. Methylene blue inhibits replication of SARS-CoV-2 in vitro. International Journal of Antimicrobial Agents, Elsevier, 2020, pp.106202. ⟨10.1016/j.ijantimicag.2020.106202⟩. ⟨hal-02996278⟩
  • James Knockleby, Bruno Pradines, Mathieu Gendrot, Joel Mosnier, Thanh Tam Nguyen, et al.. Cytotoxic and Anti-Plasmodial Activities of Stephania dielsiana Y.C. Wu Extracts and the Isolated Compounds. Molecules, MDPI, 2020, 25 (16), pp.3755. ⟨10.3390/molecules25163755⟩. ⟨hal-02996315⟩
  • Bruno Pradines, Mathieu Gendrot, Océane Delandre. Implications des pompes membranaires de Plasmodium falciparum dans le transport et la résistance aux antipaludiques. Revue Francophone des Laboratoires, Elsevier, 2020, 2020 (519), pp.59-66. ⟨10.1016/S1773-035X(20)30063-0⟩. ⟨hal-02996313⟩
  • Océane Delandre, Sokhna Daffe, Mathieu Gendrot, Maguette Diallo, Marylin Madamet, et al.. Absence of association between polymorphisms in the pfcoronin and pfk13 genes and the presence of Plasmodium falciparum parasites after treatment with artemisinin derivatives in Senegal. International Journal of Antimicrobial Agents, Elsevier, 2020, pp.106190. ⟨10.1016/j.ijantimicag.2020.106190⟩. ⟨hal-02996284⟩
  • Mathieu Gendrot, Mamadou Wague Gueye, Francis Tsombeng Foguim, Marylin Madamet, Khalifa Ababacar Wade, et al.. Modulation of in vitro antimalarial responses by polymorphisms in Plasmodium falciparum ABC transporters (pfmdr1 and pfmdr5). Acta Tropica, Elsevier, 2019, 196, pp.126-134. ⟨10.1016/j.actatropica.2019.05.020⟩. ⟨hal-02140933⟩
  • Marie Gladys Robert, Francis Foguim Tsombeng, Mathieu Gendrot, Silman Diawara, Marylin Madamet, et al.. Baseline Ex Vivo and Molecular Responses of Plasmodium fa lciparum Isolates to Piperaquine before Implementation of Dihydroartemisinin-Piperaquine in Senegal. Antimicrobial Agents and Chemotherapy, American Society for Microbiology, 2019, 63 (5), ⟨10.1128/AAC.02445-18⟩. ⟨hal-02140956⟩
  • Francis Foguim Tsombeng, Mathieu Gendrot, Marie Gladys Robert, Marylin Madamet, Bruno Pradines. Are k13 and plasmepsin II genes, involved in Plasmodium falciparum resistance to artemisinin derivatives and piperaquine in Southeast Asia, reliable to monitor resistance surveillance in Africa?. Malaria Journal, BioMed Central, 2019, 18 (1), pp.285. ⟨10.1186/s12936-019-2916-6⟩. ⟨hal-02272228⟩
  • Francis Tsombeng Foguim, Marie Gladys Robert, Mamadou Wague Gueye, Mathieu Gendrot, Silman Diawara, et al.. Low polymorphisms in pfact, pfugt and pfcarl genes in African Plasmodium falciparum isolates and absence of association with susceptibility to common anti-malarial drugs. Malaria Journal, BioMed Central, 2019, 18 (1), ⟨10.1186/s12936-019-2919-3⟩. ⟨hal-02408550⟩
  • Koffi Kowouvi, Bruno Alies, Mathieu Gendrot, Alexandra Gaubert, Gaelle Vacher, et al.. Nucleoside-lipid-based nanocarriers for methylene blue delivery: potential application as anti-malarial drug. RSC Advances, Royal Society of Chemistry, 2019, 9 (33), pp.18844-18852. ⟨10.1039/C9RA02576F⟩. ⟨hal-02165879⟩
  • Marie Gladys Robert, Francis Foguim Tsombeng, Mathieu Gendrot, Joel Mosnier, Remy Amalvict, et al.. Absence of a High Level of Duplication of the Plasmepsin Gene in Africa. Antimicrobial Agents and Chemotherapy, American Society for Microbiology, 2018, 62 (11), ⟨10.1128/AAC.00374-18⟩. ⟨hal-01924107⟩
  • Mathieu Gendrot, Francis Tsombeng Foguim, Marie Gladys Robert, Remy Amalvict, Joel Mosnier, et al.. The D113N mutation in the RING E3 ubiquitin protein ligase gene is not associated with ex vivo susceptibility to common anti-malarial drugs in African Plasmodium falciparum isolates. Malaria Journal, BioMed Central, 2018, 17 (1), pp.108. ⟨10.1186/s12936-018-2252-2⟩. ⟨hal-01780668⟩
  • Mathieu Gendrot, Silman Diawara, Marylin Madamet, Mame Bou Kounta, Sebastien Briolant, et al.. Association between Polymorphisms in the Pfmdr6 Gene and Ex Vivo Susceptibility to Quinine in Plasmodium falciparum Parasites from Dakar, Senegal. Antimicrobial Agents and Chemotherapy, American Society for Microbiology, 2017, 61 (3), ⟨10.1128/AAC.01183-16⟩. ⟨hal-01521240⟩
  • Bruno Pradines, Mathieu Gendrot, Remy Amalvict, Joel Mosnier, Nicolas Benoit, et al.. PROVEBLUE, METHYLENE BLUE, AS AN ANTIMALARIAL DRUG. American Journal of Tropical Medicine and Hygiene, American Society of Tropical Medicine and Hygiene, 2017, 97 (5, S), pp.495-496. ⟨hal-01774369⟩
  • Marylin Madamet, Mathieu Gendrot, Francis Foguim, Gladys Robert, Nicolas Benoit, et al.. ABSENCE OF ASSOCIATION BETWEEN EX VIVO SUSCEPTIBILITY TO PIPERAQUINE AND POLYMORPHISMS IN EXONUCLEASE GENE AND COPY NUMBERS IN PLASMEPSIN 2 GENE IN AFRICAN PLASMODIUM FALCIPARUM ISOLATES. American Journal of Tropical Medicine and Hygiene, American Society of Tropical Medicine and Hygiene, 2017, 97 (5, S), pp.297. ⟨hal-01774368⟩
  • Mathieu Gendrot, Bécaye Fall, Marylin Madamet, Mansour Fall, Khalifa Ababacar Wade, et al.. Absence of Association between Polymorphisms in the RING E3 Ubiquitin Protein Ligase Gene and Ex Vivo Susceptibility to Conventional Antimalarial Drugs in Plasmodium falciparum Isolates from Dakar, Senegal. Antimicrobial Agents and Chemotherapy, American Society for Microbiology, 2016, 60 (8), pp.5010-5013. ⟨10.1128/AAC.03105-15⟩. ⟨hal-02140971⟩
  • Mathieu Gendrot, Bécaye Fall, Marylin Madamet, Mansour Fall, Khalifa Ababacar Wade, et al.. Absence of Association between Polymorphisms in the RING E3 Ubiquitin Protein Ligase Gene and Ex Vivo Susceptibility to Conventional Antimalarial Drugs in Plasmodium falciparum Isolates from Dakar, Senegal. Antimicrobial Agents and Chemotherapy, American Society for Microbiology, 2016, 60 (8), pp.5010-5013. ⟨10.1128/AAC.03105-15⟩. ⟨hal-01455596⟩