Mathieu GENDROT

Documents

Présentation

**Education and degrees** Ph.D. 2, « Proveblue as an antimalarial drug » Supervisor : PHC Bruno PRADINES. Curent year 2018-2019, Institut de Recherche Biomédicale des Armées. IHU Méditerranée Infection Marseille, Parasitology-entomology unit. Ph.D. 1, « Proveblue as an antimalarial drug » Supervisor : PHC Bruno PRADINES. Year 2017-2018, Institut de Recherche Biomédicale des Armées. IHU Méditerranée Infection Marseille, Parasitology-entomology unit. Master degree 2, Human Pathology « Maladies infectieuses & contagion-prévention » Options : Medical entomology. Year 2016-2017, Marseille university. M aster degree 1, Human Pathology « Du gène à la maladie » Options : Parasitology, bacteriology, virology, molecular biology. Year 2015-2016, Marseille university. University degree 3, « Biochimie, biologie moléculaire cellulaire et physiologique » Options : Microbiology, Microbiology laboratory analysis, Virology. Year 2014-2015, Rouen university. University degree 2, « Biochimie, biologie moléculaire cellulaire et physiologique » Options : Animal and plant parasitology, Biochemistry. Year 2013-2014, Rouen university. University degree 1, « Science de la vie de la Terre et de l'environnement » Year 2012-2013, Rouen university. Bachelor degree, scientific option. Option: Life, Earth and Environment Sciences Year 2011-2012, High school Louis-Modeste Leroy, Evreux. **Professional experience** July 2017-now : Military volunteer (Officer cadet) of the French Service de Santé des Armées Ph.D. student, 2nd year under direction of supervisor PHC Bruno PRADINES November 2018: One month trainee at Pasteur Institute of Cambodia in Phnom Penh Learning of Piperaquine survival assay and Ring survival assay, experiments on Cambodian resistant strains. November 2017 : Initial Military Training Third Promotion at Gendarmerie of Rochefort, Promotion Major. January to june 2017 : Six months trainee at malaria National Reference Center in Marseille « Use of Methylene blue Proveblue as an antimalarial drug in-vitro. » May to june 2016 : Seven weeks trainee at malaria National Reference Center in Marseille « Identification and validation of molecular markers of resistance to antimalarial drugs. » July to august 2015 : Six weeks trainee at malaria National Reference Center in Marseille « Identification and validation of molecular markers of resistance to antimalarial drugs. »

Publications

	Methylene Blue-Based Combination Therapy with Amodiaquine Prevents Severe Malaria in an Experimental Rodent Model Jérôme Dormoi , Rémy Amalvict , Mathieu Gendrot , Bruno Pradines Pharmaceutics, 2022, 14 (10), pp.2031. ⟨10.3390/pharmaceutics14102031⟩ Article dans une revue hal-03949197v1
	Comparative Assessment of the Sensitivity of Ten Commercial Rapid Diagnostic Test Kits for the Detection of Plasmodium Mathieu Gendrot , Marylin Madamet , Isabelle Fonta , Nicolas Benoit , Rémy Amalvict Diagnostics, 2022, 12 (9), pp.2240. ⟨10.3390/diagnostics12092240⟩ Article dans une revue hal-03948586v1
	Antiviral Activity of Repurposing Ivermectin against a Panel of 30 Clinical SARS-CoV-2 Strains Belonging to 14 Variants Océane Delandre , Mathieu Gendrot , Priscilla Jardot , Marion Le Bideau , Manon Boxberger Pharmaceuticals, 2022, 15 (4), pp.445. ⟨10.3390/ph15040445⟩ Article dans une revue hal-03678577v1
	Absence of Association between Methylene Blue Reduced Susceptibility and Polymorphisms in 12 Genes Involved in Antimalarial Drug Resistance in African Plasmodium falciparum Mathieu Gendrot , Océane Delandre , Marie Robert , Francis Foguim , Nicolas Benoit Pharmaceuticals, 2021, 14 (4), pp.351. ⟨10.3390/ph14040351⟩ Article dans une revue hal-03280743v1
	A Novel Hybrid of Chloroquine and Primaquine Linked by Gold(I): Multitarget and Multiphase Antiplasmodial Agent Caroline Souza Pereira , Helenita Costa Quadros , Diogo Rodrigo Magalhaes Moreira , William Castro , Romulo Ivisson Santos de Deus da Silva ChemMedChem, 2021, 16 (4), pp.662-678. ⟨10.1002/cmdc.202000653⟩ Article dans une revue hal-03160988v1
	Heterogeneity in susceptibility to hydroxychloroquine of SARS-CoV-2 isolates Celine Boschi , Marion Le Bideau , Julien Andreani , Sarah Aherfi , Priscilla Jardot Frontiers in Bioscience-Landmark, 2021, 26 (12), pp.1493-1502. ⟨10.52586/5043⟩ Article dans une revue hal-03663682v1
	Synthesis and antiplasmodial evaluation of 1H-1,2,3-triazole grafted 4-aminoquinoline-benzoxaborole hybrids and benzoxaborole analogues Anu Saini , Sumit Kumar , Raghu Raj , Shefali Chowdhary , Mathieu Gendrot Bioorganic Chemistry, 2021, 109, pp.104733. ⟨10.1016/j.bioorg.2021.104733⟩ Article dans une revue hal-03280779v1
	Prevalence of Mutations in the pfcoronin Gene and Association with Ex Vivo Susceptibility to Common Quinoline Drugs against Plasmodium falciparum Océane Delandre , Mathieu Gendrot , Isabelle Fonta , Joel Mosnier , Nicolas Benoit Pharmaceutics, 2021, 13 (8), pp.1273. ⟨10.3390/pharmaceutics13081273⟩ Article dans une revue hal-03429248v1
	Plasmodium ovale wallikeri and P. ovale curtisi Infections and Diagnostic Approaches to Imported Malaria, France, 2013–2018 Valentin Joste , Justine Bailly , Véronique Hubert , Cécile Pauc , Mathieu Gendrot Emerging Infectious Diseases, 2021, 27 (2), ⟨10.3201/eid2702.202143⟩ Article dans une revue hal-03666032v1
	In Vitro Evaluation of the Antiviral Activity of Methylene Blue Alone or in Combination against SARS-CoV-2 Mathieu Gendrot , Priscilla Jardot , Océane Delandre , Manon Boxberger , Julien Andreani Journal of Clinical Medicine, 2021, 10 (14), pp.3007. ⟨10.3390/jcm10143007⟩ Article dans une revue hal-03421132v1
	Baseline and multinormal distribution of ex vivo susceptibilities of Plasmodium falciparum to methylene blue in Africa, 2013–18 Mathieu Gendrot , Bruno Pradines , P Brouqui , Michel Drancourt , Marylin Madamet Journal of Antimicrobial Chemotherapy, 2020, 75 (8), pp.2141-2148. ⟨10.1093/jac/dkaa174⟩ Article dans une revue hal-02996303v1
	Amide Tethered 4-Aminoquinoline-naphthalimide Hybrids: A New Class of Possible Dual Function Antiplasmodials Sumit Kumar , Mathieu Gendrot , Isabelle Fonta , Joel Mosnier , Nosipho Cele ACS Medicinal Chemistry Letters, 2020, 11 (12), pp.2544-2552. ⟨10.1021/acsmedchemlett.0c00536⟩ Article dans une revue hal-03165070v1
	In Vitro Antiviral Activity of Doxycycline against SARS-CoV-2 Mathieu Gendrot , Julien Andreani , Priscilla Jardot , Sebastien Hutter , Oceane Delandre Molecules, 2020, 25 (21), ⟨10.3390/molecules25215064⟩ Article dans une revue hal-03149268v1
	Antimalarial drugs inhibit the replication of SARS-CoV-2: An in vitro evaluation Mathieu Gendrot , Julien Andreani , Manon Boxberger , Priscilla Jardot , Isabelle Fonta Travel Medicine and Infectious Disease, 2020, 37, pp.101873. ⟨10.1016/j.tmaid.2020.101873⟩ Article dans une revue hal-02996300v1
	Cytotoxic and Anti-Plasmodial Activities of Stephania dielsiana Y.C. Wu Extracts and the Isolated Compounds James Knockleby , Bruno Pradines , Mathieu Gendrot , Joel Mosnier , Thanh Tam Nguyen Molecules, 2020, 25 (16), pp.3755. ⟨10.3390/molecules25163755⟩ Article dans une revue hal-02996315v1
	Absence of association between polymorphisms in the pfcoronin and pfk13 genes and the presence of Plasmodium falciparum parasites after treatment with artemisinin derivatives in Senegal Océane Delandre , Sokhna Daffe , Mathieu Gendrot , Maguette Diallo , Marylin Madamet International Journal of Antimicrobial Agents, 2020, pp.106190. ⟨10.1016/j.ijantimicag.2020.106190⟩ Article dans une revue hal-02996284v1
	Antimalarial artemisinin-based combination therapies (ACT) and COVID-19 in Africa: In vitro inhibition of SARS-CoV-2 replication by mefloquine-artesunate Mathieu Gendrot , Isabelle Duflot , Manon Boxberger , Océane Delandre , Priscilla Jardot International Journal of Infectious Diseases, 2020, 99, pp.437-440. ⟨10.1016/j.ijid.2020.08.032⟩ Article dans une revue hal-02996298v1
	Implications des pompes membranaires de Plasmodium falciparum dans le transport et la résistance aux antipaludiques Bruno Pradines , Mathieu Gendrot , Océane Delandre Revue Francophone des Laboratoires, 2020, 2020 (519), pp.59-66. ⟨10.1016/S1773-035X(20)30063-0⟩ Article dans une revue hal-02996313v1
	Prevalence of mutations in the Plasmodium falciparum chloroquine resistance transporter, PfCRT, and association with ex vivo susceptibility to common anti-malarial drugs against African Plasmodium falciparum isolates Francis Tsombeng Foguim , Hervé Bogreau , Mathieu Gendrot , Joel Mosnier , Isabelle Fonta Malaria Journal, 2020, 19 (1), ⟨10.1186/s12936-020-03281-x⟩ Article dans une revue hal-02996272v1
	Chloroquine as a prophylactic agent against COVID-19? Mathieu Gendrot , Emilie Javelle , Axelle Clerc , Hélène Savini , Bruno Pradines International Journal of Antimicrobial Agents, 2020, 55 (6), pp.105980. ⟨10.1016/j.ijantimicag.2020.105980⟩ Article dans une revue hal-02996310v1
	Methylene blue inhibits replication of SARS-CoV-2 in vitro Mathieu Gendrot , Julien Andreani , Isabelle Duflot , Manon Boxberger , Marion Le Bideau International Journal of Antimicrobial Agents, 2020, pp.106202. ⟨10.1016/j.ijantimicag.2020.106202⟩ Article dans une revue hal-02996278v1
	Baseline Ex Vivo and Molecular Responses of Plasmodium fa lciparum Isolates to Piperaquine before Implementation of Dihydroartemisinin-Piperaquine in Senegal Marie Gladys Robert , Francis Foguim Tsombeng , Mathieu Gendrot , Silman Diawara , Marylin Madamet Antimicrobial Agents and Chemotherapy, 2019, 63 (5), ⟨10.1128/AAC.02445-18⟩ Article dans une revue hal-02140956v1
	Are k13 and plasmepsin II genes, involved in Plasmodium falciparum resistance to artemisinin derivatives and piperaquine in Southeast Asia, reliable to monitor resistance surveillance in Africa? Francis Foguim Tsombeng , Mathieu Gendrot , Marie Gladys Robert , Marylin Madamet , Bruno Pradines Malaria Journal, 2019, 18 (1), pp.285. ⟨10.1186/s12936-019-2916-6⟩ Article dans une revue hal-02272228v1
	Nucleoside-lipid-based nanocarriers for methylene blue delivery: potential application as anti-malarial drug Koffi Kowouvi , Bruno Alies , Mathieu Gendrot , Alexandra Gaubert , Gaelle Vacher RSC Advances, 2019, 9 (33), pp.18844-18852. ⟨10.1039/C9RA02576F⟩ Article dans une revue hal-02165879v1
	Modulation of in vitro antimalarial responses by polymorphisms in Plasmodium falciparum ABC transporters (pfmdr1 and pfmdr5) Mathieu Gendrot , Mamadou Wague Gueye , Francis Tsombeng Foguim , Marylin Madamet , Khalifa Ababacar Wade Acta Tropica, 2019, 196, pp.126-134. ⟨10.1016/j.actatropica.2019.05.020⟩ Article dans une revue hal-02140933v1
	Low polymorphisms in pfact, pfugt and pfcarl genes in African Plasmodium falciparum isolates and absence of association with susceptibility to common anti-malarial drugs Francis Tsombeng Foguim , Marie Gladys Robert , Mamadou Wague Gueye , Mathieu Gendrot , Silman Diawara Malaria Journal, 2019, 18 (1), ⟨10.1186/s12936-019-2919-3⟩ Article dans une revue hal-02408550v1
	Absence of a High Level of Duplication of the Plasmepsin Gene in Africa Marie Gladys Robert , Francis Foguim Tsombeng , Mathieu Gendrot , Joel Mosnier , Remy Amalvict Antimicrobial Agents and Chemotherapy, 2018, 62 (11), ⟨10.1128/AAC.00374-18⟩ Article dans une revue hal-01924107v1
	The D113N mutation in the RING E3 ubiquitin protein ligase gene is not associated with ex vivo susceptibility to common anti-malarial drugs in African Plasmodium falciparum isolates Mathieu Gendrot , Francis Tsombeng Foguim , Marie Gladys Robert , Remy Amalvict , Joel Mosnier Malaria Journal, 2018, 17 (1), pp.108. ⟨10.1186/s12936-018-2252-2⟩ Article dans une revue hal-01780668v1
	Association between Polymorphisms in the Pfmdr6 Gene and Ex Vivo Susceptibility to Quinine in Plasmodium falciparum Parasites from Dakar, Senegal Mathieu Gendrot , Silman Diawara , Marylin Madamet , Mame Bou Kounta , Sebastien Briolant Antimicrobial Agents and Chemotherapy, 2017, 61 (3), ⟨10.1128/AAC.01183-16⟩ Article dans une revue hal-01521240v1
	PROVEBLUE, METHYLENE BLUE, AS AN ANTIMALARIAL DRUG Bruno Pradines , Mathieu Gendrot , Remy Amalvict , Joel Mosnier , Nicolas Benoit American Journal of Tropical Medicine and Hygiene, 2017, 97 (5, S), pp.495-496 Article dans une revue hal-01774369v1
	ABSENCE OF ASSOCIATION BETWEEN EX VIVO SUSCEPTIBILITY TO PIPERAQUINE AND POLYMORPHISMS IN EXONUCLEASE GENE AND COPY NUMBERS IN PLASMEPSIN 2 GENE IN AFRICAN PLASMODIUM FALCIPARUM ISOLATES Marylin Madamet , Mathieu Gendrot , Francis Foguim , Gladys Robert , Nicolas Benoit American Journal of Tropical Medicine and Hygiene, 2017, 97 (5, S), pp.297 Article dans une revue hal-01774368v1
	Absence of Association between Polymorphisms in the RING E3 Ubiquitin Protein Ligase Gene and Ex Vivo Susceptibility to Conventional Antimalarial Drugs in Plasmodium falciparum Isolates from Dakar, Senegal Mathieu Gendrot , Bécaye Fall , Marylin Madamet , Mansour Fall , Khalifa Ababacar Wade Antimicrobial Agents and Chemotherapy, 2016, 60 (8), pp.5010-5013. ⟨10.1128/AAC.03105-15⟩ Article dans une revue hal-01455596v1

Mathieu GENDROT

Présentation

Publications

Methylene Blue-Based Combination Therapy with Amodiaquine Prevents Severe Malaria in an Experimental Rodent Model

Comparative Assessment of the Sensitivity of Ten Commercial Rapid Diagnostic Test Kits for the Detection of Plasmodium

Antiviral Activity of Repurposing Ivermectin against a Panel of 30 Clinical SARS-CoV-2 Strains Belonging to 14 Variants

Absence of Association between Methylene Blue Reduced Susceptibility and Polymorphisms in 12 Genes Involved in Antimalarial Drug Resistance in African Plasmodium falciparum

A Novel Hybrid of Chloroquine and Primaquine Linked by Gold(I): Multitarget and Multiphase Antiplasmodial Agent

Heterogeneity in susceptibility to hydroxychloroquine of SARS-CoV-2 isolates

Synthesis and antiplasmodial evaluation of 1H-1,2,3-triazole grafted 4-aminoquinoline-benzoxaborole hybrids and benzoxaborole analogues

Prevalence of Mutations in the pfcoronin Gene and Association with Ex Vivo Susceptibility to Common Quinoline Drugs against Plasmodium falciparum

Plasmodium ovale wallikeri and P. ovale curtisi Infections and Diagnostic Approaches to Imported Malaria, France, 2013–2018

In Vitro Evaluation of the Antiviral Activity of Methylene Blue Alone or in Combination against SARS-CoV-2

Baseline and multinormal distribution of ex vivo susceptibilities of Plasmodium falciparum to methylene blue in Africa, 2013–18

Amide Tethered 4-Aminoquinoline-naphthalimide Hybrids: A New Class of Possible Dual Function Antiplasmodials

In Vitro Antiviral Activity of Doxycycline against SARS-CoV-2

Antimalarial drugs inhibit the replication of SARS-CoV-2: An in vitro evaluation

Cytotoxic and Anti-Plasmodial Activities of Stephania dielsiana Y.C. Wu Extracts and the Isolated Compounds

Absence of association between polymorphisms in the pfcoronin and pfk13 genes and the presence of Plasmodium falciparum parasites after treatment with artemisinin derivatives in Senegal

Antimalarial artemisinin-based combination therapies (ACT) and COVID-19 in Africa: In vitro inhibition of SARS-CoV-2 replication by mefloquine-artesunate

Implications des pompes membranaires de Plasmodium falciparum dans le transport et la résistance aux antipaludiques

Prevalence of mutations in the Plasmodium falciparum chloroquine resistance transporter, PfCRT, and association with ex vivo susceptibility to common anti-malarial drugs against African Plasmodium falciparum isolates

Chloroquine as a prophylactic agent against COVID-19?

Methylene blue inhibits replication of SARS-CoV-2 in vitro

Baseline Ex Vivo and Molecular Responses of Plasmodium fa lciparum Isolates to Piperaquine before Implementation of Dihydroartemisinin-Piperaquine in Senegal

Are k13 and plasmepsin II genes, involved in Plasmodium falciparum resistance to artemisinin derivatives and piperaquine in Southeast Asia, reliable to monitor resistance surveillance in Africa?

Nucleoside-lipid-based nanocarriers for methylene blue delivery: potential application as anti-malarial drug

Modulation of in vitro antimalarial responses by polymorphisms in Plasmodium falciparum ABC transporters (pfmdr1 and pfmdr5)

Low polymorphisms in pfact, pfugt and pfcarl genes in African Plasmodium falciparum isolates and absence of association with susceptibility to common anti-malarial drugs

Absence of a High Level of Duplication of the Plasmepsin Gene in Africa

The D113N mutation in the RING E3 ubiquitin protein ligase gene is not associated with ex vivo susceptibility to common anti-malarial drugs in African Plasmodium falciparum isolates

Association between Polymorphisms in the Pfmdr6 Gene and Ex Vivo Susceptibility to Quinine in Plasmodium falciparum Parasites from Dakar, Senegal

PROVEBLUE, METHYLENE BLUE, AS AN ANTIMALARIAL DRUG

ABSENCE OF ASSOCIATION BETWEEN EX VIVO SUSCEPTIBILITY TO PIPERAQUINE AND POLYMORPHISMS IN EXONUCLEASE GENE AND COPY NUMBERS IN PLASMEPSIN 2 GENE IN AFRICAN PLASMODIUM FALCIPARUM ISOLATES

Absence of Association between Polymorphisms in the RING E3 Ubiquitin Protein Ligase Gene and Ex Vivo Susceptibility to Conventional Antimalarial Drugs in Plasmodium falciparum Isolates from Dakar, Senegal