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37

Marine Gueugneau


 

Ph.D. in Life Sciences

EDUCATION

 2011-2014: Ph.D. in Life sciences

Ecole Doctorale des Sciences de la Vie, Santé, Agronomie, Environnement, Clermont-Ferrand (63), France

 2008-2010: Master in Biology, Genetic and Physiology

Université Blaise Pascal, Clermont-Ferrand (63), France

2005-2008: Bachelor in Animal Physiology

Université Blaise Pascal, Clermont-Ferrand (63), France

RESEARCH EXPERIENCE

September 2017:     Research scientist at INRA in Unit of Human Nutrition (France), Team: Alimentation et Santé Musculo-Squelettique (S. Walrand and Y. Boirie)

-  Heathly and safety nutrition for older adults.

 

August 2014- August 2016:     Postdoctoral position at Catholic University of Louvain (Belgium), Team: Endocrinology, Diabetes and Nutrition (J.P. Thissen)

-  Characterization of changes in muscle secretome associated with muscle atrophy caused by glucocorticoids.

(acquired skills: muscle secretome, culture of primary muscle cells, human clinical trials)

January 2011- February 2014: Ph.D. at INRA in Unit of Human Nutrition (France), Team: Proteolysis (D. Béchet)

- Identification of markers of muscle aging with or without metabolic syndrome.

(acquired skills: proteomics, transcriptomics, immunohistology, Western-Blot, PCR)

January- September 2010: Master student (2nd year), Centre Jean-Perrin (Clermont-Ferrand, France), Team: Cancer Resistance Exploring and Targeting (A. Tchirkov)

- Combinative therapeutics approaches for telomeric targeting in the glioblastoma and bronchial cancer treatment.

(acquired skills: clonogenic cell survival assay, cell culture, PCR, Western-Blot, rodent handling

May - September 2009: Master student (1st year), Unit of Molecular Oncology (Clermont-Ferrand, France), Team: Nutrition and cancer (D. Bernard-Gallon)

- Effects of soy phytoestrogens on methylation of genes implicated in breast cancer. (acquired skills: Methylated DNA immunoprecipitation (MeDIP), PCR, cell culture)

 

TEACHING ACTIVITIES

2011-2013: In charge of practical classes in:

- Immunology (Man facing the disease) (40 h): Bachelor students in biology (1st year)

- Fundamental Immunology (60 h): Bachelor students in biology (3rd year)

- Energy Metabolism and Enzymology (60 h): Bachelor students in biology (2nd and 3rd year)

 

 


Journal articles14 documents

  • Marine Gueugneau, Cécile Coudy-Gandilhon, Christophe Chambon, Julien Verney, Daniel Taillandier, et al.. Muscle Proteomic and Transcriptomic Profiling of Healthy Aging and Metabolic Syndrome in Men. International Journal of Molecular Sciences, MDPI, 2021, 22 (8), pp.4205. ⟨10.3390/ijms22084205⟩. ⟨hal-03238377⟩
  • Insaf Berrazaga, Jérôme Salles, Karima Laleg, Christelle Guillet, Véronique Patrac, et al.. Anabolic Properties of Mixed Wheat-Legume Pasta Products in Old Rats: Impact on Whole-Body Protein Retention and Skeletal Muscle Protein Synthesis. Nutrients, MDPI, 2020, 12 (6), pp.1596. ⟨10.3390/nu12061596⟩. ⟨hal-02916889⟩
  • Insaf Berrazaga, Valerie Micard, Marine Gueugneau, Stephane Walrand. The Role of the Anabolic Properties of Plant- versus Animal-Based Protein Sources in Supporting Muscle Mass Maintenance: A Critical Review. Nutrients, MDPI, 2019, 11 (8), ⟨10.3390/nu11081825⟩. ⟨hal-02266295⟩
  • Cécile Coudy-Gandilhon, Marine Gueugneau, Daniel Taillandier, Lydie Combaret, Cécile Polge, et al.. Magnesium transport and homeostasis-related gene expression in skeletal muscle of young and old adults: analysis of the transcriptomic data from the PROOF cohort Study.. Magnesium Research, John Libbey Eurotext, 2019, 32 (3), pp.72-82. ⟨10.1684/mrh.2019.0458⟩. ⟨hal-02520159⟩
  • Marine Gueugneau, Donatienne d'Hose, Caroline Barbé, Marie de Barsy, Pascale Lause, et al.. Increased Serpina3n release into circulation during glucocorticoid-mediated muscle atrophy. Journal of Cachexia, Sarcopenia and Muscle, Wiley Open Access/Springer Verlag, 2018, 9 (5), ⟨10.1002/jcsm.12315⟩. ⟨hal-01858516⟩
  • Caroline Barbé, Fabrice Bray, Marine Gueugneau, Stéphanie Devassine, Pascale Lause, et al.. Comparative Proteomic and Transcriptomic Analysis of Follistatin-Induced Skeletal Muscle Hypertrophy. Journal of Proteome Research, American Chemical Society, 2017, 16 (10), pp.3477-3490. ⟨10.1021/acs.jproteome.7b00069⟩. ⟨hal-01812831⟩
  • Marine Gueugneau, Cécile Coudy-Gandilhon, Bruno Meunier, Lydie Combaret, Daniel Taillandier, et al.. Lower skeletal muscle capillarization in hypertensive elderly men. Experimental Gerontology, Elsevier, 2016, 76, pp.80-88. ⟨10.1016/j.exger.2016.01.013⟩. ⟨hal-01297805⟩
  • Patrick Merle, Marine Gueugneau, Marie-Paule Teulade-Fichou, Mélanie Müller-Barthélémy, Simon Amiard, et al.. Highly efficient radiosensitization of human glioblastoma and lung cancer cells by a G-quadruplex DNA binding compound. Scientific Reports, Nature Publishing Group, 2015, 5 (1), ⟨10.1038/srep16255⟩. ⟨inserm-01907350⟩
  • Patrick Merle, Marine Gueugneau, Marie-Paule Teulade-Fichou, Mélanie Müller-Barthélémy, Simon Amiard, et al.. Highly efficient radiosensitization of human glioblastoma and lung cancer cells by a G-quadruplex DNA binding compound. Scientific Reports, Nature Publishing Group, 2015, 5 (1), ⟨10.1038/srep16255⟩. ⟨hal-01812829⟩
  • Marine Gueugneau, Cécile Coudy-Gandilhon, Laetitia Théron, Bruno Meunier, Christiane Barboiron, et al.. Skeletal muscle lipid content and oxidative activity in relation to muscle fiber type in aging and metabolic syndrome. Journals of Gerontology, Series A, Oxford University Press (OUP): Policy B - Oxford Open Option D, 2015, 70 (5), pp.566-576. ⟨10.1093/gerona/glu086⟩. ⟨hal-01812812⟩
  • Marine Gueugneau, Cecile Coudy-Gandilhon, Ophelie Gourbeyre, Christophe Chambon, Lydie Combaret, et al.. Proteomics of muscle chronological ageing in post-menopausal women. BMC Genomics, BioMed Central, 2014, 15 (1165), pp.1165. ⟨10.1186/1471-2164-15-1165⟩. ⟨hal-01543975⟩
  • Laetitia Theron, Marine Gueugneau, Cécile Coudy-Gandilhon, Didier Viala, Astrid Bijlsma, et al.. Label-free Quantitative Protein Profiling of vastus lateralis Muscle During Human Aging. Molecular and Cellular Proteomics, American Society for Biochemistry and Molecular Biology, 2014, 13 (1), pp.283-294. ⟨10.1074/mcp.M113.032698⟩. ⟨hal-00986095⟩
  • Huijuan Wang, Anne Listrat, Bruno Meunier, Marine Gueugneau, Cécile Coudy-Gandilhon, et al.. Apoptosis in capillary endothelial cells in ageing skeletal muscle. Aging Cell, Wiley Open Access, 2014, 13 (2), pp.254-262. ⟨10.1111/acel.12169⟩. ⟨hal-02636978⟩
  • Martin A. Baraibar, Marine Gueugneau, Stephanie Duguez, Gillian Butler-Browne, Daniel Bechet, et al.. Expression and modification proteomics during skeletal muscle ageing. Biogerontology, Springer Verlag, 2013, 14 (3, SI), pp.339-352. ⟨10.1007/s10522-013-9426-7⟩. ⟨hal-01543981⟩

Conference papers11 documents

  • Marine Gueugneau. Vieillissement biologique du muscle squelettique chez l’Homme. 3. congrès de la Société de Physiologie et Biologie Intégrative, Société de Physiologie. FRA., Jun 2019, Montpellier, France. ⟨hal-02154664⟩
  • Marine Gueugneau, Christophe Giraudet, Karima Laleg, Insaf Berrazaga, Véronique Patrac, et al.. Alimentation saine et durable adaptée à la population âgée : propriétés nutritionnelles de nouvelles sources alimentaires végétales. Assises du Département AlimH, Jan 2018, Super-Besse, France. ⟨hal-02736825⟩
  • Marine Gueugneau, Christophe Giraudet, Karima Laleg, Insaf Berrazaga, Véronique Patrac, et al.. Protéines végétales et alimentation durable. journée scientifique de l'UNH, May 2018, Clermont-Ferrand, France. ⟨hal-01859278⟩
  • Marine Gueugneau, Karima Laleg, Insaf Berrazaga, Valérie Micard, Stephane Walrand. Intérêt alimentaire de sources protéiques végétales sur la rétention azotée et le métabolisme protéique au cours du vieillissement. 4ème rencontres Nutrition-Alimentation-Métabolisme-Santé, Oct 2018, Rennes, France. ⟨hal-02785102⟩
  • Marine Gueugneau. Place des protéines végétales et animales dans la diète du 21ème siècle. 31ème édition des Entretiens Jacques Cartier EJC 2018, Université Clermont Auvergne (UCA). FRA., Nov 2018, Clermont-Ferrand, France. ⟨hal-01929037⟩
  • Marine Gueugneau, Cécile Coudy-Gandilhon, Frédéic Roche, Jean-Claude Barthélémy, Léonard Féasson, et al.. Cellular and functional mechanisms underlying muscle aging and associated diseases. Nestle Purina Companion Animal Nutrition (CAN) Summit 2018, May 2018, Charleston, South Carolina, United States. ⟨hal-01799543⟩
  • Daniel Bechet, Marine Gueugneau, Cécile Coudy-Gandilhon, Laetitia Theron. Sarcopénie : définitions et contradictions - Approches histologique et moléculaire. Journée Annuelle du Centre Maladies Neuromusculaires Rares Rhone-Alpes, Jul 2014, Saint Etienne, France. ⟨hal-02792234⟩
  • Marine Gueugneau, Cécile Coudy-Gandilhon, Christophe Chambon, Brigitte Picard, A. Bijislma, et al.. Etude protéomique du vieillissement musculaire chez la femme post-ménopausée. 1. Assises de Nutrition et Metabolisme Rhône-Alpes-Auvergne, Oct 2013, Saint Galmier, France. ⟨hal-02749049⟩
  • Marine Gueugneau, Cécile Coudy-Gandilhon, Bruno Meunier, Christiane Barboiron, Anne Listrat, et al.. Effets du syndrome métabolique sur les fibres musculaires chez l'homme âgé. Colloque Myogenèse, Nov 2012, Grenoble, France. ⟨hal-02748572⟩
  • Marine Gueugneau, Cécile Coudy-Gandilhon, Christophe Chambon, A. Bijislma, A. Maier, et al.. Etude protéomique du vieillissement musculaire chez la femme post-ménopausée. 5. Journée Scientifique du CRNH Auvergne, Nov 2012, Clermont-Ferrand, France. ⟨hal-02744948⟩
  • Marine Gueugneau, Cécile Coudy-Gandilhon, Christophe Chambon, Astrid Bijlsma, Andrea Maier, et al.. Proteomics of skeletal muscle aging in women. 2nd MYOAGE symposium: The aging human muscle: An integrated machinery, Aug 2012, Copenhagen, Danemark. ⟨hal-01859273⟩

Poster communications11 documents

  • Marine Gueugneau, Donatienne d'Hose, Caroline Barbé, Marie de Barsy, Pascale Lause, et al.. Increased release of Serpina3n into circulation during glucocorticoid-mediated muscle atrophy. ELMSK: Exercice, Locomotion and Musculoskeletal System, May 2018, Lyon, France. 2018. ⟨hal-01859270⟩
  • Laetitia Theron, Marine Gueugneau, Cécile Coudy-Gandilhon, Didier Viala, Astrid Bijlsma, et al.. Label-free quantitative protein profiling of vastus lateralis muscle during human aging. EuPA 2013 Scientific Meeting, Oct 2013, Saint Malo, France. 2013. ⟨hal-02746900⟩
  • Marine Gueugneau, Cécile Coudy-Gandilhon, Bruno Meunier, Christiane Barboiron, Anne Listrat, et al.. Vieillissement musculaire : effet du syndrome métabolique. 6. Journée scientifique du CNRH Auvergne, Nov 2013, Clermont-Ferrand, France. 2013, 6ème Journée scientifique du CNRH Auvergne. ⟨hal-02750252⟩
  • Huijuan Wang, Anne Listrat, Bruno Meunier, Marine Gueugneau, Cécile Coudy-Gandilhon, et al.. Apoptosis in capillary endothelial cells in ageing skeletal muscle. 7. Cachexia Conference, Dec 2013, Kobe, Japan. Springer Verlag, Journal of Cachexia, Sarcopenia and Muscle, 5 (1), 44 p., 2014, Journal of Cachexia, Sarcopenia and Muscle. ⟨10.1007/s13539-014-0129-y⟩. ⟨hal-01543483⟩
  • Marine Gueugneau, Cécile Coudy-Gandilhon, Christophe Chambon, A. Bijislma, A. Maier, et al.. Proteomics of muscle aging in women. 10. Journées Annuelles de la société Française de Myologie, Nov 2012, Grenoble, France. 2012. ⟨hal-02746372⟩
  • Marine Gueugneau, Cécile Coudy-Gandilhon, Ophélie Gourbeyre, Christophe Chambon, A. Bijislma, et al.. Etude protéomique du vieillissement musculaire chez la femme post-ménopausée. 6. colloque Protéolyse Cellulaire de la Société Française de Biochimie et Biologie Moléculaire (SFBBM), Nov 2012, Clermont-Ferrand, France. 2013. ⟨hal-01812813⟩
  • Marine Gueugneau, Cécile Coudy-Gandilhon, Bruno Meunier, Christiane Barboiron, Anne Listrat, et al.. Syndrome métabolique : effet sur le muscle squelettique lors du vieillissement. Journée Scientifique de l'Ecole Doctorale Sciences de la Vie et de la Santé, Agronomie, Environnement, May 2012, Clermont-Ferrand, France. 2012. ⟨hal-01859275⟩
  • Marine Gueugneau, Cécile Coudy-Gandilhon, Bruno Meunier, Christiane Barboiron, Anne Listrat, et al.. Metabolic syndrome alters the proportion and morphology of skeletal muscle myofibres in elderly men. ICSR 2011 International Conference on Sarcopenia Research, Jun 2011, Toulouse, France. Journal of Nutrition, Health and Aging, 15 (6), 2011, ICSR 2011 International Conference on Sarcopenia Research Wednesday 8th & Thursday 9th June, 2011 Toulouse, France. ⟨hal-02749655⟩
  • Marine Gueugneau, Cécile Coudy-Gandilhon, Bruno Meunier, Christiane Barboiron, Anne Listrat, et al.. Syndrome métabolique et vieillissement : effet sur le muscle squelettique humain. 4ème Journée Scientifique du CRNH Auvergne, Nov 2011, Clermont-Ferrand, France. 2011. ⟨hal-01859271⟩
  • Didier Delalande, Isabelle Piec, Marine Gueugneau, Cécile Coudy-Gandilhon, J. Alliot, et al.. Muscle proteome and transcriptome during aging of LOU/c/jall rats. ICSR 2011 International Conference on Sarcopenia Research, Jun 2011, Toulouse, France. Journal of Nutrition, Health and Aging, 15 (6), pp.499-520, 2011, ICSR 2011 International Conference on Sarcopenia Research Wednesday 8th & Thursday 9th June, 2011 Toulouse, France. ⟨hal-02748707⟩
  • Marine Gueugneau, Cécile Coudy-Gandilhon, Bruno Meunier, Christiane Barboiron, Anne Listrat, et al.. Effet du syndrome métabolique sur le muscle squelettique lors du vieillissement chez l’Homme. 7ème journée de la Recherche IFR, Dec 2011, Clermont-Ferrand, France. 2011. ⟨hal-01859279⟩

Theses1 document

  • Marine Gueugneau. Altérations du muscle squelettique humain lors du vieillissement associé ou non au syndrome métabolique et identification de nouveaux marqueurs. Alimentation et Nutrition. Université d'Auvergne - Clermont-Ferrand I, 2013. Français. ⟨tel-02811232⟩