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    Marie-Christine Chagnon


    Parmi les nombreuses sources de contaminants potentiels des aliments, les substances emballages sont souvent incriminés. En effet, des substances chimiques présentes dans les matériaux au contact des denrées alimentaires (MCDA) peuvent migrer vers les aliments. Ces composés, retrouvés en très faibles quantités, peuvent cependant induire des modifications organoleptiques inacceptables, être toxiques par eux-mêmes ou par les produits générés. L’étude du danger que représente l'ensemble des substances capables de migrer de l'emballage vers l'aliment permet une meilleure évaluation de l'emballage fini. 

    Les effets toxiques potentiels des extraits des emballages finis peuvent donc être testés d’un point de vue toxicologique en utilisant des tests de screening in vitro, précoces, sensibles et spécifiques,  dénommés « biotests ». Certains sont déjà utilisés pour les dossiers d’autorisation pour les substances intentionnelles. Les résultats des biotests peuvent être corrélés aux données analytiques afin d’identifier le ou les substances responsables. Si les données analytiques n’expliquent pas l’effet toxique observé, il peut être dû soit à une substance non identifiée dans le mélange, soit à un effet « cocktail ».


    Article dans une revue73 documents

    • Ludovic Le Corre, Axelle Brulport, Daniel Vaiman, Marie-Christine Chagnon. Epoxiconazole alters the histology and transcriptome of mouse liver in a transgenerational pattern. Chemico-Biological Interactions, Elsevier, 2022, 360, pp.109952. ⟨10.1016/j.cbi.2022.109952⟩. ⟨hal-03690009⟩
    • Laurence Dahbi, Amaury Farce, Nicolas Kambia, Isabelle Séverin, Thierry Dine, et al.. In vitro and in silico approach to study the hormonal activities of the alternative plasticizer tri-(2-ethylhexyl) trimellitate TEHTM and its metabolites. Archives of Toxicology, Springer Verlag, 2022, pp.899-918. ⟨10.1007/s00204-022-03230-4⟩. ⟨hal-03546832⟩
    • yann Pellequer, Gilbert Zanetta, Jean-Michel Rebibou, Isabelle Séverin, Marie-Christine Chagnon, et al.. Development of a new methodology to determine size differences of nanoparticles with nanoparticle tracking analysis. Applied Nanoscience, Open Mind Journals Ltd., 2021, 11, pp.2129-2141. ⟨10.1007/s13204-021-01932-2⟩. ⟨hal-03281325⟩
    • Nicolas Kambia, Isabelle Séverin, Amaury Farce, Laurence Dahbi, Thierry Dine, et al.. Comparative Effects of Di-(2-ethylhexyl)phthalate and Di-(2-ethylhexyl)terephthalate Metabolites on Thyroid Receptors: In Vitro and In Silico Studies. Metabolites, MDPI, 2021, 11 (2), pp.94. ⟨10.3390/metabo11020094⟩. ⟨hal-03141182⟩
    • Axelle Brulport, Corinne Lencina, Marie-Christine Chagnon, Ludovic Le Corre, Laurence Guzylack-Piriou. Transgenerational effects on intestinal inflammation status in mice perinatally exposed to bisphenol S. Chemosphere, Elsevier, 2021, 262, ⟨10.1016/j.chemosphere.2020.128009⟩. ⟨hal-02964984⟩
    • Axelle Brulport, Ludovic Le Corre, Guillaume Maquart, Virginie Barbet, Aurélie Dastugue, et al.. Multigenerational study of the obesogen effects of bisphenol S after a perinatal exposure in C57BL6/J mice fed a high fat diet. Environmental Pollution (Elsevier), 2021, 270, pp.116243. ⟨10.1016/j.envpol.2020.116243⟩. ⟨hal-03148322⟩
    • Axelle Brulport, Daniel Vaiman, Marie-Christine Chagnon, Ludovic Le Corre. Obesogen effect of bisphenol S alters mRNA expression and DNA methylation profiling in male mouse liver. Chemosphere, Elsevier, 2020, 241, pp.125092. ⟨10.1016/j.chemosphere.2019.125092⟩. ⟨hal-02325508⟩
    • Axelle Brulport, Daniel Vaiman, Elias Bou-Maroun, Marie-Christine Chagnon, Ludovic Le Corre. Hepatic transcriptome and DNA methylation patterns following perinatal and chronic BPS exposure in male mice. BMC Genomics, BioMed Central, 2020, 21 (1), pp.881. ⟨10.1186/s12864-020-07294-3⟩. ⟨hal-03114886⟩
    • Nour Doumani, Isabelle Séverin, Laurence Dahbi, Elias Bou-Maroun, Maya Tueni, et al.. Lemon Juice, Sesame Paste, and Autoclaving Influence Iron Bioavailability of Hummus: Assessment by an In Vitro Digestion/Caco-2 Cell Model. Foods, MDPI, 2020, 9 (4), pp.474-494. ⟨10.3390/foods9040474⟩. ⟨hal-02551705⟩
    • Antoine Kieffer, Catherine Loriot, Patrick P. Sauvegrain, Jean Mario Julien, Mai Nguyen, et al.. FITNESS, première plateforme européenne sur l’emballage et le conditionnement des aliments. IAA La revue des industries agroalimentaires, PPI, 2019, pp.24-26. ⟨hal-02511722⟩
    • Nada Lebbos, Claude Daou, Rosette R. Ouaini, Hanna H. Chebib, Michel Afram, et al.. Lebanese Population Exposure to Trace Elements via White Bread Consumption. Foods, MDPI, 2019, 8 (11), pp.574. ⟨10.3390/foods8110574⟩. ⟨hal-02380322⟩
    • Nicolas Kambia, Isabelle Séverin, Amaury Farce, Emmanuel Moreau, Laurence Dahbi, et al.. In vitro and in silico hormonal activity studies of di-(2-ethylhexyl)terephthalate, a di-(2-ethylhexyl)phthalate substitute used in medical devices, and its metabolites. Journal of Applied Toxicology, Wiley, 2019, 39, pp.1043-1056. ⟨10.1002/jat.3792⟩. ⟨hal-02068658⟩
    • Emilie Souton, Isabelle Séverin, Ludovic Le Hegarat, Kevin Hogeveen, Abdulhadi Aljawish, et al.. Genotoxic effects of food contact recycled paperboard extracts on two human hepatic cell lines.. Food additives & contaminants. Part A. Chemistry, analysis, control, exposure & risk assessment, Taylor & Francis, 2018, 35 (1), pp.159-170. ⟨10.1080/19440049.2017.1397774⟩. ⟨hal-01625970⟩
    • N. Lebbos, Elias Bou-Maroun, C. Daou, R. Ouaini, H. Chebib, et al.. Chemical analysis of metallic trace elements of toxicological concern in Lebanese pita and risk characterization for the consumers. Toxicology Letters, Elsevier, 2018, 295, pp.S165-S166. ⟨10.1016/j.toxlet.2018.06.791⟩. ⟨hal-01976398⟩
    • Axelle Brulport, Ludovic Le Corre, Daniel Vaiman, Marie-Christine Chagnon. Are epigenetic modifications linked to BPS obesogen effect after perinatal exposure? Differential DNA methylation study in mouse livers. Toxicology Letters, Elsevier, 2018, 295 (Supplement 1), pp.S132. ⟨10.1016/j.toxlet.2018.06.698⟩. ⟨hal-01959924⟩
    • Isabelle Séverin, Emilie Souton, Laurence Dahbi, Marie-Christine Chagnon. Use of bioassays to assess hazard of food contact material extracts: State of the art. Food and Chemical Toxicology, Elsevier, 2017, 105, pp.429-447. ⟨10.1016/j.fct.2017.04.046⟩. ⟨hal-01560265⟩
    • Teuta Eljezi, Pierre Pinta, Damien Richard Richard, Jérémy Pinguet, Jean-Michel Chezal, et al.. In vitro cytotoxic effects of DEHP-alternative plasticizers and their primary metabolites on a L929 cell line. Chemosphere, Elsevier, 2017, 173, pp.452 - 459. ⟨10.1016/j.chemosphere.2017.01.026⟩. ⟨inserm-01856278⟩
    • Axelle Brulport, Ludovic Le Corre, Marie-Christine Chagnon. Chronic exposure of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induces an obesogenic effect in C57BL/6J mice fed a high fat diet. Toxicology, Elsevier, 2017, 390, pp.43-52. ⟨10.1016/j.tox.2017.07.017⟩. ⟨hal-01577444⟩
    • Elias Bou-Maroun, Laurence Dahbi, Marie-Pierre Pierre, Philippine Pierre, Sandrine Rakotomalala, et al.. Chemical analysis and potential endocrine activities of aluminium coatings intended to be in contact with cosmetic water. Journal of Pharmaceutical and Biomedical Analysis, Elsevier, 2017, 145, pp.641 - 650. ⟨10.1016/j.jpba.2017.07.061⟩. ⟨hal-01616383⟩
    • L. Ivry del Moral, Ludovic Le Corre, Hélène Poirier, Isabelle Niot, T. Truntzer, et al.. Obesogen effects after perinatal exposure of 4,4′-sulfonyldiphenol (Bisphenol S) in C57BL/6 mice. Toxicology, Elsevier, 2016, 357-358, pp.11 - 20. ⟨10.1016/j.tox.2016.05.023⟩. ⟨hal-01431231⟩
    • Isabelle Séverin, Krystelle Lionti, Laurence Dahbi, Catherine Loriot, Bérangère Toury, et al.. In vitro toxicity assessment of extracts derived from sol–gel coatings on polycarbonate intended to be used in food contact applications. Food and Chemical Toxicology, Elsevier, 2016, 93, pp.51 - 57. ⟨10.1016/j.fct.2016.04.025⟩. ⟨hal-01434899⟩
    • Anne-Marie Riquet-Motchidlover, Colette Breysse, Laurence Dahbi, Catherine Loriot, Isabelle Séverin, et al.. The consequences of physical post-treatments (microwave and electron-beam) on food/packaging interactions: A physicochemical and toxicological approach. Food Chemistry, Elsevier, 2016, pp.59-69. ⟨10.1016/j.foodchem.2015.09.034⟩. ⟨hal-01243319⟩
    • Emilie Souton, Isabelle Séverin, Marie-Christine Chagnon. Use of reliable bioassays to detect potential hazard of food contact materials extracts to ensure quality, safety and innovation of paperboards. Toxicology Letters, Elsevier, 2015, Toxicology Letters, 238 (2, supplément), pp.S1-420. ⟨hal-03611999⟩
    • Lise Bernard, R. Cueff, Marie-Christine Chagnon, F. Abdoulouhab, Bertrand Décaudin, et al.. Migration of plasticizers from PVC medical devices: Development of an infusion model.. International Journal of Pharmaceutics, Elsevier, 2015, 494 (1), pp.136-145. ⟨10.1016/j.ijpharm.2015.08.033⟩. ⟨hal-03611985⟩
    • Marie-Christine Chagnon, L. Ivry de Moral, Ludovic Le Corre, Roger Rahmani. Bisphenol S is obesogen in male mice after perinatal exposure. Toxicology Letters, Elsevier, 2015, 238 (2), pp.S370. ⟨10.1016/j.toxlet.2015.08.1058⟩. ⟨hal-01960115⟩
    • Krystelle Lionti, Isabelle Séverin, Laurence Dahbi, Bérangère Toury, Marie-Christine Chagnon. In vitro genotoxicity assessment of MTES, GPTES and TEOS, three precursors intended for use in food contact coatings. Food and Chemical Toxicology, Elsevier, 2014, 65, pp.76-81. ⟨10.1016/j.fct.2013.11.037⟩. ⟨hal-01962377⟩
    • Ludovic Le Corre, Philippe Besnard, Marie-Christine Chagnon. BPA, an Energy Balance Disruptor. Critical Reviews in Food Science and Nutrition, Taylor & Francis, 2014, 55 (6), pp.769-777. ⟨10.1080/10408398.2012.678421⟩. ⟨hal-01960190⟩
    • Ludovic Peyre, Patrick Rouimi, Georges de Sousa, Cécile Héliès-Toussaint, Benjamin Carre, et al.. Comparative study of bisphenol A and its analogue bisphenol S on human hepatic cells: A focus on their potential involvement in nonalcoholic fatty liver disease. Food and Chemical Toxicology, Elsevier, 2014, 70, pp.9 - 18. ⟨10.1016/j.fct.2014.04.011⟩. ⟨hal-02638648⟩
    • Cécile Héliès-Toussaint, Ludovic Peyre, Claudia Costanzo, Marie-Christine Chagnon, Roger Rahmani. Is bisphenol S a safe substitute for bisphenol A in terms of metabolic function? An in vitro study. Toxicology and Applied Pharmacology, Elsevier, 2014, 280 (2), pp.224-235. ⟨10.1016/j.taap.2014.07.025⟩. ⟨hal-02641516⟩
    • L. Ivry-del Moral, Ludovic Le Corre, Kévin Gaire, Cécile Héliès-Toussaint, Hélène Poirier, et al.. P019: Effet obésogène des bisphénols A et S chez la souris C57Bl/6. Nutrition Clinique et Métabolisme, Elsevier Masson, 2014, 28, ⟨10.1016/S0985-0562(14)70662-4⟩. ⟨hal-01915989⟩
    • Cristina Bach, Xavier Dauchy, Isabelle Séverin, Jean-Francois Munoz, Serge Etienne, et al.. Effect of sunlight exposure on the release of intentionally and/or non-intentionally added substances from polyethylene terephthalate (PET) bottles into water: Chemical analysis and in vitro toxicity. Food Chemistry, Elsevier, 2014, 162, pp.63-71. ⟨10.1016/j.foodchem.2014.04.020⟩. ⟨hal-01296979⟩
    • Manuela Göttel, Ludovic Le Corre, Coralie Dumont, Dieter Schrenk, Marie-Christine Chagnon. Estrogen receptor α and aryl hydrocarbon receptor cross-talk in a transfected hepatoma cell line (HepG2) exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicology Reports, Elsevier, 2014, 1, pp.1029-1036. ⟨10.1016/j.toxrep.2014.09.016⟩. ⟨hal-01960137⟩
    • Cristina Bach, Xavier Dauchy, Isabelle Séverin, Jean-François Munoz, Serge Etienne, et al.. Effect of temperature on the release of intentionally and non-intentionally added substances from polyethylene terephthalate (PET) bottles into water: Chemical analysis and potential toxicity. Food Chemistry, Elsevier, 2013, 139 (1-4), pp.672 - 680. ⟨10.1016/j.foodchem.2013.01.046⟩. ⟨anses-01903693⟩
    • Micheline Dsamou, Martine Morzel, Ludovic Le Corre, Isabelle Séverin, Marie-Christine Chagnon. Caffeine increases the expression of cystatin SN in human submandibular acinar-like HSG cells. Archives of Oral Biology, Elsevier, 2013, 58 (10), pp.1511-1516. ⟨10.1016/j.archoralbio.2013.06.005⟩. ⟨hal-01960219⟩
    • Ludovic Le Corre, Lydie Ivry-del Moral, Philippe Besnard, Marie-Christine Chagnon. Effet obésogène du bisphénol A sur des souris C57Bl/6 sous régime hyperlipidique. Cahiers de Nutrition et de Diététique, Elsevier Masson, 2013, 48 (3), pp.129-136. ⟨10.1016/j.cnd.2013.02.003⟩. ⟨hal-01961507⟩
    • Micheline Dsamou, Olivier Palicki, Chantal Septier, Claire Chabanet, Géraldine Lucchi, et al.. Salivary protein profiles and sensitivity to the bitter taste of caffeine.. Chemical Senses, Oxford University Press (OUP), 2012, 37 (1), pp.87-95. ⟨10.1093/chemse/bjr070⟩. ⟨hal-00723339⟩
    • Cristina Bach, Xavier Dauchy, Marie-Christine Chagnon, Serge Etienne. Chemical migration in drinking water stored in polyethylene terephthalate (PET) bottles: a source of controversy reviewed. Water Research, IWA Publishing, 2012, 46 (3), pp. 571-583. ⟨10.1016/j.watres.2011.11.062⟩. ⟨hal-00683918⟩
    • Ludovic Le Corre, Lydie Ivry Del Moral, Philippe Besnard, Marie-Christine Chagnon. Bisphenol A disrupts the intestinal lipid metabolism. Toxicology Letters, Elsevier, 2012, 211, pp.S210. ⟨10.1016/j.toxlet.2012.03.753⟩. ⟨hal-01961543⟩
    • Ludovic Le Corre, Philippe Besnard, Marie-Christine Chagnon. Bisphenol a exposure in C57Bl/6 mice fed with a high fat diet. Toxicology Letters, Elsevier, 2011, 205 (Supplement), pp.S143-S143. ⟨10.1016/j.toxlet.2011.05.508⟩. ⟨hal-00723043⟩
    • Coralie Dumont, Elisabeth Perdu, Georges de Sousa, Laurent Debrauwer, Roger Rahmani, et al.. Bis(hydroxyphenyl)methane-bisphenol F-metabolism by the HepG2 human hepatoma cell line and cryopreserved human hepatocytes. Drug and Chemical Toxicology, Taylor & Francis, 2011, 34 (4), pp.445-453. ⟨10.3109/01480545.2011.585651⟩. ⟨hal-02651168⟩
    • Isabelle Séverin, Anne-Marie Riquet, Marie-Christine Chagnon. Risk assessment and management–Food contact materials. Cahiers de Nutrition et de Diététique, Elsevier Masson, 2011, 46 (2), pp.59-66. ⟨hal-01962438⟩
    • Christian Salles, Marie-Christine Chagnon, Gilles Feron, Elisabeth Guichard, Hélène Labouré, et al.. In-mouth mechanisms leading to flavor release and perception.. Critical Reviews in Food Science and Nutrition, Taylor & Francis, 2011, 51 (1), pp.67-90. ⟨10.1080/10408390903044693⟩. ⟨hal-00823384⟩
    • Manuela Goettel, Ludovic Le Corre, Isabelle Séverin, Dieter Schrenk, Marie-Christine Chagnon. Cross talk between nuclear receptor ERalpha ET AhR in human hepatoma cell line (HepG2) exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicology Letters, Elsevier, 2011, Abstracts of the 47th Congress of the European Societies of Toxicology (EUROTOX), 205, pp.S239-S239. ⟨10.1016/j.toxlet.2011.05.817⟩. ⟨hal-00722931⟩
    • Anne-Marie Saillenfait, Alain-Claude Roudot, Frédéric Gallissot, Jean-Philippe Sabaté, Marie-Christine Chagnon. Developmental toxic potential of di-n-propyl phthalate administered orally to rats.. Journal of Applied Toxicology, Wiley, 2011, 31 (1), pp.36-44. ⟨10.1002/jat.1565⟩. ⟨hal-00723070⟩
    • Isabelle Séverin, Coralie Dumont, Adeline Jondeau-Cabaton, Vanessa Graillot, Marie-Christine Chagnon. Genotoxic activities of the food contaminant 5-hydroxymethylfurfural using different in vitro bioassays. Toxicology Letters, Elsevier, 2010, 192 (2), pp.189-194. ⟨10.1016/j.toxlet.2009.10.022⟩. ⟨hal-00850790⟩
    • Céline Gasnier, Coralie Dumont, Nora Benachour, Emilie Clair, Marie-Christine Chagnon, et al.. Glyphosate-based herbicides are toxic and endocrine disruptors in human cell lines. Toxicology, Elsevier, 2009, 262 (3), pp.184-191. ⟨10.1016/j.tox.2009.06.006⟩. ⟨hal-03426636⟩
    • Anne Endrizzi, Thomas Karbowiak, Frédéric Debeaufort, David Chassagne, Marie-Christine Chagnon, et al.. Transferts de matière au travers des emballages au contact de produits alimentaires : dossier : emballage et conditionnement. Industries Alimentaires et Agricoles, Association des chimistes et ingénieurs de sucrerie, distillerie et industries agricoles de France et des colonies, 2009, 2009-009/010, pp.11-16. ⟨hal-03565946⟩
    • François Chauvigné, Arnaud Menuet, Laurianne Lesné, Marie-Christine Chagnon, Cécile Chevrier, et al.. Time- and dose-related effects of di-(2-ethylhexyl) phthalate and its main metabolites on the function of the rat fetal testis in vitro. Environmental Health Perspectives, National Institute of Environmental Health Sciences, 2009, 117 (4), pp.515-21. ⟨10.1289/ehp.11870⟩. ⟨hal-00669512⟩
    • Nicolas J. Cabaton, Coralie Dumont, Isabelle Séverin, Elisabeth Perdu, Daniel Zalko, et al.. Genotoxic and endocrine activities of bis(hydroxyphenyl)methane (bisphenol F) and its derivatives in the HepG2 cell line. Toxicology, Elsevier, 2009, 255 (1-2), pp.15-24. ⟨10.1016/j.tox.2008.09.024⟩. ⟨hal-01962644⟩
    • Nicolas J. Cabaton, Daniel Zalko, Estelle Rathahao, Cécile Canlet, Georges Delous, et al.. Biotransformation of bisphenol F by human and rat liver subcellular fractions. Toxicology in Vitro, Elsevier, 2008, 22 (7), pp.1697-1704. ⟨10.1016/j.tiv.2008.07.004⟩. ⟨hal-01173776⟩
    • Nathalie Hanet, Allan Lancon, Dominique Delmas, Brigitte Jannin, Marie-Christine Chagnon, et al.. Effects of endocrine disruptors on genes associated with 17 beta-estradiol metabolism and excretion. Steroids, Elsevier, 2008, 73 (12), pp.1242-1251. ⟨10.1016/j.steroids.2008.06.005⟩. ⟨hal-02662141⟩
    • Allan Lançon, Nathalie Hanet, Brigitte Jannin, Dominique Delmas, Jean-Marie Heydel, et al.. Resveratrol in human hepatoma HepG2 cells: metabolism and inducibility of detoxifying enzymes.. Drug Metabolism and Disposition, American Society for Pharmacology and Experimental Therapeutics (ASPET), 2007, 35 (5), pp.699-703. ⟨10.1124/dmd.106.013664⟩. ⟨hal-00259260⟩
    • Thomas Stroheker, Jean-François Regnier, Julie Lassurguère, Marie-Christine Chagnon. Effect of in utero exposure to di-(2-ethylhexyl)phthalate: Distribution in the rat fetus and testosterone production by rat fetal testis in culture. Food and Chemical Toxicology, Elsevier, 2006, 44 (12), pp.2064-2069. ⟨10.1016/j.fct.2006.07.007⟩. ⟨hal-02664478⟩
    • Adeline Jondeau, Laurence Dahbi, Marie-Helene Bani-Estivals, Marie-Christine Chagnon. Evaluation of the sensitivity of three sublethal cytotoxicity assays in human HepG2 cell line using water contaminants. Toxicology, Elsevier, 2006, 226 (2-3), pp.218-228. ⟨10.1016/j.tox.2006.07.007⟩. ⟨hal-00294427⟩
    • Nicolas J. Cabaton, Marie-Christine Chagnon, Jean-Claude Lhuguenot, Jean Pierre J. P. Cravedi, Daniel Zalko. Disposition and metabolic profiling of bisphenol F in pregnant and nonpregnant rats. Journal of Agricultural and Food Chemistry, American Chemical Society, 2006, 54 (26), pp.10307-10314. ⟨10.1021/jf062250q⟩. ⟨hal-02668619⟩
    • Angeline Gradolatto, Jean-Philippe Basly, Raymond Bergès, Caroline C. Teyssier, Marie-Christine Chagnon, et al.. Pharmacokinetic and metabolism of apigenin in female and male rats after a single oral administration. Drug Metabolism and Disposition, American Society for Pharmacology and Experimental Therapeutics (ASPET), 2005, 33 (1), pp.49-54. ⟨10.1124/dmd.104.000893⟩. ⟨hal-02677921⟩
    • Thomas Stroheker, Nicolas Cabatona, Gorian Nourdin, Jean-François Regnier, Jean-Claude Lhuguenota, et al.. Evaluation of anti-androgenic activity of di-(2-ethylhexyl)phthalate. Toxicology, Elsevier, 2005, 208 (1), pp.115-121. ⟨10.1016/j.tox.2004.11.013⟩. ⟨hal-02680300⟩
    • Isabelle Séverin, Adeline Jondeau, Laurence Dahbi, Marie-Christine Chagnon. 2,4-Diaminotoluene (2,4-DAT)-induced DNA damage, DNA repair and micronucleus formation in the human hepatoma cell line HepG2. Toxicology, Elsevier, 2005, 213 (1-2), pp.138-146. ⟨10.1016/j.tox.2005.05.021⟩. ⟨hal-01981435⟩
    • Isabelle Valentin-Severin, V. Thybaud, A.M. Lebon, J.C. Lhuguenot, Marie-Christine Chagnon. The autoradiographic test for unscheduled DNA synthesis : a sensitive assay for the detection of DNA repair in the HepG2 cell line. Mutation Research - Genetic Toxicology and Environmental Mutagenesis, Elsevier, 2004, 559, pp.211-217. ⟨hal-02672058⟩
    • D. Guyonnet, Raymond Bergès, M.H. Siess, M.F. Pinnert, Marie-Christine Chagnon, et al.. Post-initiation modulating effects of allyl sulfides in rat hepatocarcinogenesis. Food and Chemical Toxicology, Elsevier, 2004, 42, pp.1479-1485. ⟨hal-02679472⟩
    • Isabelle Valentin-Severin, Véronique Thybaud, Anne-Marie Le Bon, Jean-Claude Lhuguenot, Marie-Christine Chagnon. The autoradiographic test for unscheduled DNA synthesis: a sensitive assay for the detection of DNA repair in the HepG2 cell line. Mutation Research - Genetic Toxicology and Environmental Mutagenesis, Elsevier, 2004, 559 (1-2), pp.211-217. ⟨10.1016/j.mrgentox.2003.12.007⟩. ⟨hal-01981453⟩
    • D. Guyonnet, Raymond Bergès, M.H. Siess, M.F. Pinnert, Marie-Christine Chagnon, et al.. Post-initiation modulating effects of allyl sulfides in rat hepatocarcinogenesis. Food and Chemical Toxicology, Elsevier, 2004, 42 (9), pp.1479-1485. ⟨hal-02677820⟩
    • T. Stroheker, K. Picard, J.C. Lhuguenot, Marie-Chantal Canivenc Lavier, Marie-Christine Chagnon. Steroid activities comparison of natural and food wrap compounds in human breast cancer cell lines. Food and Chemical Toxicology, Elsevier, 2004, 42, pp.887-897. ⟨hal-02679474⟩
    • Isabelle Valentin-Severin, Ludovic Le Hegarat, Jean-Claude Lhuguenot, Anne-Marie Le Bon, Marie-Christine Chagnon. Use of HepG2 cell line for direct or indirect mutagens screening: comparative investigation between comet and micronucleus assays.. Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, Elsevier, 2003, 536 (1-2), pp.79-90. ⟨10.1016/S1383-5718(03)00031-7⟩. ⟨hal-01981654⟩
    • Isabelle Séverin, Martine Padieu, Jean-Claude Lhuguenot, Marie-Christine Chagnon. Toxic interaction between hydroxyurea and 1-beta-D-arabino-furanosylcytosine on the DNA of a human hepatoma cell line (HEPG2).. Toxicology Letters, Elsevier, 2003, 145 (3), pp.303-11. ⟨10.1016/j.toxlet.2003.08.003⟩. ⟨hal-01981468⟩
    • Thomas Stroheker, Nicolas J. Cabaton, Raymond Berges, Valérie Lamothe, Jean-Claude Lhuguenot, et al.. Influence of dietary soy isoflavones on the accessory sex organs of the Wistar rat. Food and Chemical Toxicology, Elsevier, 2003, 41 (8), pp.1175-83. ⟨10.1016/S0278-6915(03)00108-X⟩. ⟨hal-02681581⟩
    • Thomas Stroheker, Marie-Christine Chagnon, Marie-France Pinnert, Raymond Bergès, Marie-Chantal Canivenc Lavier. Estrogenic effects of food wrap packaging xenoestrogens and flavonoids in female Wistar rats : a comparative study. Reproductive Toxicology, Elsevier, 2003, 17 (4), pp.421-432. ⟨hal-02679922⟩
    • Isabelle Valentin-Severin, L. Le Hagarat, J.C. Lhuguenot, A.M. Lebon, Marie-Christine Chagnon. Use of HepG2 cell line for direct or indirect mutagens screening : comparative investigation between comet and micronucleus assays. Mutation Research - Genetic Toxicology and Environmental Mutagenesis, Elsevier, 2003, 536, pp.79-90. ⟨hal-02680011⟩
    • Isabelle Valentin-Severin, Laurence Laignelet, Jean Claude Lhuguenot, Marie-Christine Chagnon. Uridine uptake inhibition assay: an automated micromethod for the screening of cytotoxicity.. Toxicology, Elsevier, 2002, 171 (2-3), pp.207-13. ⟨10.1016/S0300-483X(01)00587-X⟩. ⟨hal-01981698⟩
    • K. Picard, J.C. Lhuguenot, Marie-Chantal Canivenc Lavier, Marie-Christine Chagnon. Estrogenic activity and metabolism of N-butyl benzyl phtalate in vitro : identification of the active molecule(s). Toxicology and Applied Pharmacology, Elsevier, 2001, 172, pp.108-118. ⟨hal-02675409⟩
    • Isabelle Valentin, Murielle Philippe, Jean-Claude Lhuguenot, Marie-Christine Chagnon. Uridine uptake inhibition as a cytotoxicity test for a human hepatoma cell line (HepG2 cells): comparison with the neutral red assay. Toxicology, Elsevier, 2001, 158, pp.127-139. ⟨hal-01981819⟩
    • C Nativelle, K Picard, Isabelle Valentin, Jean-Claude C Lhuguenot, Marie-Christine Chagnon. Metabolism of N-Butyl Benzyl Phthalate in the Female Wistar Rat. Identification of New Metabolites. Food and Chemical Toxicology, Elsevier, 1999, pp.905-917. ⟨hal-01981781⟩
    • C. Nativelle, K. Picard, Isabelle Valentin, J.C. Lhuguenot, Marie-Christine Chagnon. Metabolism of N-butyl benzyl phtalate in the female wistar rat. Identification of new metabolites. Food and Chemical Toxicology, Elsevier, 1999, 37, pp.905-917. ⟨hal-02694753⟩

    Communication dans un congrès11 documents

    • N. Lebbos, Elias Bou-Maroun, C. Daou, R. Ouaini, H. Chebib, et al.. Chemical analysis of metallic trace elements of toxicological concern in Lebanese pita and risk characterization for the consumers. 54. Congress of the European-Societies-of-Toxicology (EUROTOX) - Toxicology Out of the Box, Sep 2018, Bruxelles, Belgium. ⟨10.1016/j.toxlet.2018.06.791⟩. ⟨hal-02733845⟩
    • Marie-Christine Chagnon, Lydie Ivry-del Moral, Ludovic Le Corre, Roger Rahmani. Bisphenol S is obesogen in male mice after perinatal exposure. 51. Congress of the European-Societies-of-Toxicology (EUROTOX), European Societies of Toxicology (EUROTOX)., Sep 2015, Porto, Portugal. 1 p., ⟨10.1016/j.toxlet.2015.08.1058⟩. ⟨hal-02741257⟩
    • Laurence Dhabi, Isabelle Séverin, Marie-Chantal Canivenc-Lavier, Marie-Christine Chagnon. Effects of genistein, vinclozolin and BPA on the proliferation and differentiation of a human salivary cell line – CIME project. Colloque PNR-PE , Dec 2012, Paris, France. 1 p. ⟨hal-01594399⟩
    • Micheline Dsamou, Martine Morzel, Marie-Christine Chagnon. FP7: The Human Submandibular Gland (HSG) cell line: a tool to study the regulation of salivary markers of bitterness perception. Food Oral Processing: Physics, Physiology, and Psychology of Eating. Session 7: In-mouth biological mechanisms at the origin of sensory perception, Jul 2012, Beaune, France. 1 p. ⟨hal-00723343⟩
    • Marie-Chantal Canivenc-Lavier, Martine Applanat, Thuy-Anh Auxiètre, Sylvie Babajko, Ariane Berdal, et al.. CIME: An integrative and multidisciplinary PNR-PE project on Chronic Impact of ED Mixture Exposure at environmental low doses on Reproduction, Development and Behavior. Colloque PNR-PE, Dec 2012, Paris, France. 1 p. ⟨hal-01595174⟩
    • Isabelle Séverin, Laurence Dahbi, Catherine Bergès, Coralie Dumont, Marie-Christine Chagnon. Food contact materials: Strategy for quality and food safety of packaging systems. 47. Congress of the European-Societies-of-Toxicology, Aug 2011, Paris, France. 2 p., ⟨10.1016/j.toxlet.2011.05.732⟩. ⟨hal-02749456⟩
    • Micheline Dsamou, Olivier Palicki, Chantal Septier, Claire Chabanet, Géraldine Lucchi, et al.. Sensitivity to bitterness: may in-mouth proteolysis be involved?. 9. Pangborn sensory science symposium, Sep 2011, Toronto, Canada. 1 p. ⟨hal-01594410⟩
    • Manuela Göttel, Marie-Christine Chagnon, Dieter Schrenk. Mechanism of TCDD-induced oxidative stress, role of estrogen receptor, and modulation by estradiol in liver cells. 49. Annual Meeting of the German-Society-for-Experimental-and-Clinical-Pharmacology-and-Toxicology, Mar 2008, Mainz, Germany. pp.88. ⟨hal-03426732⟩
    • N J Cabaton, Coralie Dumont, Isabelle Séverin, Daniel Zalko, Marie-Christine Chagnon. Identification of genotoxic and endocrine disruption activities of 4,4’-dihydroxydiphenyl-methane (BPF) and its metabolites using human cell lines. Congrès Annuel de la Société Française de toxicologie, Oct 2007, Montpellier, France. ⟨hal-03593237⟩
    • Isabelle Séverin, Marie-Odile Eichler, Laurence Dahbi, Marie-Christine Chagnon. Use of bcl2 stably transfected HepG2 cell line to improve the specificity of the comet assay. Molecular Research in Environmental Medicine, 2. international conference, Sep 2006, Paris, France. ⟨hal-03592899⟩
    • Thomas Stroheker, Angeline Gradolatto, Marie-France Pinnert, Caroline C. Teyssier, Marie-Christine Chagnon, et al.. Effet perturbateur endocrinien de l’apigénine chez le rat femelle immature. 21e forum de cancérologie, Jun 2001, Paris, France. 1 p. ⟨hal-02833937⟩

    Poster13 documents

    • Isabelle Séverin, Elias Bou-Maroun, Rita Akiki, Ghiwa Zoghbi, Nada Lebbos, et al.. Lebanese pita extracts with presence of trace elements: hazard assessment. 47th Meeting of the European Environmental Mutagenesis and Genomics Society (EEMGS), May 2019, Rennes, France. ⟨10.13140/RG.2.2.30583.88489⟩. ⟨hal-02296298⟩
    • Isabelle Séverin, N. Lebbos, Elias Bou-Maroun, C. Daou, R. Ouaini, et al.. Extraction d'éléments traces métalliques à partir de pains libanais et évaluation du danger de ces mélanges. SFT 2018, 2018, Dijon, France. ⟨hal-01986057⟩
    • N. Lebbos, Elias Bou-Maroun, R. Daou, H. Ouaini, H. Chebib, et al.. Metallic contamination of wheat-cultivated soils in the Bekaa flatland of Lebanon. Proceedings of the 14th International Conference on the Biogeochemistry of Trace Elements (ICOBTE), Jul 2017, Zürich, Switzerland. ⟨hal-03556335⟩
    • Annette Luce, y Saibi, Isabelle Séverin, Julien Boudon, Nadine Millot, et al.. In vitro hazard assessment of nanoparticles developed for biomedical applications. European Society of Toxicology In Vitro (ESTIV) 2016 meeting, Oct 2016, Juan-les-Pins, France. 2016. ⟨hal-01986190⟩
    • Emilie Souton, Laurence Dahbi, Thomas Nury, Abdulhadi Aljawish, Isabelle Séverin, et al.. Reliable bioassays to detect potential hazard of paperboard food contact material extracts. European Society of Toxicology In Vitro (ESTIV) 2016 meeting, Oct 2016, Juan-les-Pins, France. 2016. ⟨hal-01989751⟩
    • Isabelle Séverin, K. Lionti, Laurence Dahbi, C. Loriot, Bérangère Toury, et al.. Genotoxicity assessment of a polycarbonate sol-gel coating and its precursors intended to be used for food contact. 2016 ILSI Annual Meeting, Jan 2016, St. Petersburg, Fl, United States. ⟨hal-01989582⟩
    • Emilie Souton, Isabelle Séverin, Marie-Christine Chagnon. Use of reliable bioassays to detect potential hazard of food contact materials extracts to ensure quality, safety and innovation of paperboards. 51st Congress of the European Societies of Toxicology (EUROTOX), Sep 2015, Porto, Portugal. 51st Congress of the European Societies of Toxicology (EUROTOX), 238 (2, supplément), pp.S348, 2015, Toxicology Letters. ⟨hal-01985967⟩
    • L. Ivry-del Moral, Laurent Le Corre, Roger Rahmani, Cécile Héliès-Toussaint, Marie-Christine Chagnon. Effects of Bisphenol A and its substitutes on the proliferation and differentiation in Caco-2 intestine cell model: MELBA project.. PNRPE National endocrine disruptor research program, International Conference, Dec 2012, Paris, France. 2012. ⟨hal-02809669⟩
    • Claudia Costanzo, Patrick Rouimi, Georges de Sousa, Marie-Christine Chagnon, Roger Rahmani, et al.. Le BPS, une bonne alternative au BPA ? Effets métaboliques du BPA et du BPS dans les hépatocytes et les adipocytes - Projet MELBA -. PNRPE National endocrine disruptor research program, International Conference, Dec 2012, Paris, France. 2012. ⟨hal-02806503⟩
    • Marie-Chantal Canivenc Lavier, M Applanat, Ta Auxiètre, S Babajko, A Berdal, et al.. An integrative and multidisciplinary PNR-PE project for studying Chronic Impact of ED Mixture Exposures at environmental low doses on reproduction, development and behavior.. PNRPE National endocrine disruptor research program, International Conference, Dec 2012, Paris, France. 2012. ⟨hal-02807429⟩
    • Micheline Dsamou, Olivier Palicki, Chantal Septier, Isabelle Séverin, Marie-Christine Chagnon, et al.. Salivary proteome and sensitivity to bitterness. 5. Congrès international goût-nutrition-santé, Mar 2010, Dijon, France. 1 p., 2010. ⟨hal-01137080⟩
    • Manuela Goettel, Isabelle Séverin, Marie-Christine Chagnon, Dieter Schrenk. Effects of estradiol on TCDD-induced oxidative stress in hepatoma cells. 44. Congress of the European Societies of Toxicology, 2007/10/7-10, 2007, Amsterdam, Netherlands. 2007, ⟨10.1016/j.toxlet.2007.05.578⟩. ⟨hal-02821345⟩
    • Nicolas J. Cabaton, Daniel Zalko, Jean-Pierre Cravedi, Marie-Christine Chagnon. Disposition and metabolic profiling of bisphénol F in pregnant and non pregnant rat. Molecular Research in Environmental Medicine, 2. international conference, Sep 2006, Paris, France. ⟨hal-03592921⟩

    Chapitre d'ouvrage3 documents

    • Florence Fricoteaux, Pascal Poupault, Eric Notz, Mark Irle, Marie-Christine Chagnon. Etudes des échanges de molécules entre le bois et son contenu: Chapitre 7. Bois et industries agroalimentaires, 2019, 978-2-7430-2489-5. ⟨hal-03111219⟩
    • Isabelle Séverin, R. Serafimova, G. Kass, Marie-Christine Chagnon. Principes généraux d'évaluation/gestion du risque des matériaux au contact des denrées alimentaires. Pathologie professionnelle et de l'environnement, 1470 p., 2017, 9782842995355. ⟨hal-01984541⟩
    • Isabelle Séverin, Marie-Christine Chagnon. EU régulations and general principles. Bioactivators in food, Kontaminas Mickael, pp.442-455, 2015. ⟨hal-01961954⟩