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Nutrition Retard de croissance intra-utérin Ageing Growth trajectory Metabolic programming Breast milk Gene expression Amino acids Free amino acid RAT Milk composition Milk Human milk Fenugreek Insulin Croissance précoce Chylomicron Rat Liver Metabolomics
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Marie-Cécile Alexandre-Gouabau

Academic and Degrees:

·         Acreditation to Supervise Research – Nantes University –Nutrition and  Metabolic Pathologies -  2020

·         Research Engineer from 1993 to 2002 in the Vitamin team of the Metabolic Diseases and Micronutrients Unit (UMMM) - Inra Clermont-Ferrand-Theix Centre

·         Research Engineer until 2002 in the Digestive Functions and Human Food Unit (UFDNH), which became, since 2006, the unit of Physiology of Nutritional Adaptations (PhAN-UMR 1280) - INRA Centre Nantes-Angers.

·         Degree of PhD in Life Sciences, in Nantes University in 1993.

·         Degree of Engineer of AgroSup Dijon Institute (ex-Higher National School of Biology for Nutrition and Food or ENSBANA, Dijon, France), in 1989.

 

Expertise and Awards:

·  Research on vitamins metabolism in Metabolic Diseases and Micronutrients Unit (1993-2002)

· Research on perinatal nutrition and metabolic imprinting in “Physiopathologie des Adaptations Nutritionnelles” Unit (since 2002) with an expertise in holistic approaches, using high-throughput proteomics and metabolomics profilings, to decipher mecanisms involved in human (preterm infants) and animal (undernutrition or over-nutrition) models of perinatal nutrition and their impact on offspring metabolic outcome and in milk research area.   

2012: Prize of the «Merit of Research» Foundation SanTDige – Institute of Diseases of the Gastrointestinal System (IMAD) of the University of Nantes. 

 

Research Grants :

-Management of the project LactOMICS « Nutri-metabolomic and chemical profilings of human breast milk and benefits-risk evaluation for infant health ». Grant INRA-AlimH Department (Metaprogram SYALSA), 2021-2023.

 - Management of the project “Can maternal milk composition in lipids and miRNAs be modified by post-partum life style following gestational diabetes history ? ». Grant Insitute of Instestinal Disesases (IMAD), 2019.

 - Management of the project “Impact of antenatal maternal supplementation in glutathione precursor on oxidative balance and metabolome/lipidome signature of materno-fœtal unit in pregnant women at risk of premature birth ». Grant Insitute of Instestinal Disesases (IMAD), 2017.

 - Management of the project “Influence of breast milk composition on the metabolic trajectory of preterm newborns in their first days of life ». Grant : INRA-AlimH Department ("Omic for physiologists"), 2016.

 - Management of the project “Influence of breast milk composition on the early metabolic trajectory of the newborn in a context of prematurity ». Grant INRA-AlimH Department (ANSSD), 2015.

 -WP leader « Analyses of the nutritional quality of milk and link to the diet » of the Prospective randomized open Clinical Trial Breastfeeding:«Does an oral diet that covers the needs for omega3-type polyunsaturated fatty acids increase their content in breast milk?. Grant PME-CHU Rennes (35RC17-8820)-Industrial partner: Association Bleu-Blanc-Cœur – Société Valorex, 2017-2021.

-WP leader “Biological and chemistry analyses » of the project “Can antenatal maternal supplementation with N-acetylcysteine , the acetylated precursor of  glutahione in a context of preterm delivery threat correct the new-born glutathione deficiency ? » (Clinical Trial #NCT03596125). Grant AOI-CHU-Nantes (RC_15_0476), 2015-2018.

 - WP leader “Metabolomics » of the project CITRUPE-Clinical Trial #NCT02801695- Grant AOI-CHU-Nantes, 2017-2020.

-WP leader “Metabolomics » of the project PROTNEONAT Hyperprotein neonatal nutrition: effects on intestinal, renal and hypothalamic maturation in newborns, and long-term consequences.” Grant ANR-05-PNRA-009, 2006-2009.   

-WP-leader “Perinatal nutrition and metabolomic fingerprinting by nuclear magnetic resonance and mass spectrometry” of the regional project «NUPEM-Nutrition and metabolic fingerprinting ». Grant : Collective Regional Project of Emergence, 2008-2010. 

-WP leader “Metabolomics » of the project « Impact of breast milk on neurodevelopment of preterm infant ». Grant European Regional Development Fund Pays de la Loire (ERDF), 2007-2013.

 -WP leader “Metabolomics » of the project « Can citrulline supplementation enhance fetal and neonatal growth in intrauterine growth restriction (IUGR)? ». Grant Ajinomoto Amino Acid Research Program (3ARP), Tokyo, Japan, 2009-2012.

·         Management of collaborative projects/service provisions with industry 

- Co-director of 1 PhD student  (4 publications) with the industry FRANCE Bébé Nutrition, Laval, France, 2018-2020.

Journal articles55 documents

  • Véronique Cariou, Marie Cécile Alexandre-Gouabau, Tom Wilderjans. Three‐way clustering around latent variables approach with constraints on the configurations to facilitate interpretation. Journal of Chemometrics, Wiley, 2021, 35 (2), ⟨10.1002/cem.3269⟩. ⟨hal-03191052⟩
  • Marie Cécile Alexandre-Gouabau, Agnès David-Sochard, Anne-Lise Royer, Patricia Parnet, Vincent Paillé. Moderate High Caloric Maternal Diet Impacts Dam Breast Milk Metabotype and Offspring Lipidome in a Sex-Specific Manner. International Journal of Molecular Sciences, MDPI, 2020, 21 (15), pp.1-29. ⟨10.3390/ijms21155428⟩. ⟨hal-03235887⟩
  • German Cano Sancho, Marie Cécile Alexandre-Gouabau, Thomas Moyon, Anne-Lise Royer, yann Guitton, et al.. Simultaneous exploration of nutrients and pollutants in human milk and their impact on preterm infant growth: An integrative cross-platform approach. Environmental Research, Elsevier, 2020, 182, pp.109018. ⟨10.1016/j.envres.2019.109018⟩. ⟨hal-02620289⟩
  • Thomas Sevrin, Clair-yves Boquien, Alexis Gandon, Isabelle Grit, Pierre de Coppet, et al.. Fenugreek Stimulates the Expression of Genes Involved in Milk Synthesis and Milk Flow through Modulation of Insulin/GH/IGF-1 Axis and Oxytocin Secretion. Genes, MDPI, 2020, 11 (10), ⟨10.3390/genes11101208⟩. ⟨hal-03209164⟩
  • Marie Cécile Alexandre-Gouabau, Thomas Moyon, Agnes Sochard, François Fenaille, Sophie Cholet, et al.. Correction: Alexandre-Gouabau et al. “Comprehensive Preterm Breast Milk Metabotype Associated with Optimal Infant Early Growth Pattern”, Nutrients, 2019, 11, 528. Nutrients, MDPI, 2020, 12 (1), pp.162. ⟨10.3390/nu12010162⟩. ⟨hal-02620488⟩
  • Thomas Sevrin, Marie Cécile Alexandre-Gouabau, Blandine Castellano, Audrey Aguesse, Khadija Ouguerram, et al.. Impact of Fenugreek on Milk Production in Rodent Models of Lactation Challenge. Nutrients, MDPI, 2019, 11 (11), pp.2571. ⟨10.3390/nu11112571⟩. ⟨hal-02463454⟩
  • Marie Cécile Alexandre-Gouabau, Thomas Moyon, Agnes Sochard, François Fenaille, Sophie Cholet, et al.. Comprehensive preterm breast milk metabotype associated with optimal infant early growth pattern. Nutrients, MDPI, 2019, 11 (3), pp.1-26. ⟨10.3390/nu11030528⟩. ⟨hal-02620327⟩
  • Aurore Martin Agnoux, Angelina El Ghaziri, Thomas Moyon, Anthony Pagniez, Agnès David, et al.. Maternal protein restriction during lactation induces early and lasting plasma metabolomic and hepatic lipidomic signatures of the offspring in a rodent programming model. The Journal of Nutritional Biochemistry, 2018, 55, pp.124-141. ⟨10.1016/j.jnutbio.2017.11.009⟩. ⟨hal-02521240⟩
  • Marie Cécile Alexandre-Gouabau, Thomas Moyon, Véronique Cariou, Jean-Philippe Antignac, El Mostafa Qannari, et al.. Breast Milk Lipidome Is Associated with Early Growth Trajectory in Preterm Infants. Nutrients, MDPI, 2018, 10 (2), pp.164. ⟨10.3390/nu10020164⟩. ⟨hal-02429557⟩
  • Thomas Sevrin, Marie Cécile Alexandre-Gouabau, Dominique Darmaun, Antoine Palvadeau, Agnès André, et al.. Use of water turnover method to measure mother's milk flow in a rat model: Application to dams receiving a low protein diet during gestation and lactation.. PLoS ONE, Public Library of Science, 2017, 12 (7), pp.e0180550. ⟨10.1371/journal.pone.0180550⟩. ⟨hal-01607230⟩
  • Nhat Thang Tran, Marie Cécile Alexandre-Gouabau, Anthony Pagniez, Khadija Ouguerram, Clair-yves Boquien, et al.. Neonatal Citrulline Supplementation and Later Exposure to a High Fructose Diet in Rats Born with a Low Birth Weight: A Preliminary Report. Nutrients, MDPI, 2017, 9 (4), pp.1-15. ⟨10.3390/nu9040375⟩. ⟨hal-01607137⟩
  • Arnaud de Luca, Regis Hankard, Marie Cécile Alexandre-Gouabau, Veronique Ferchaud Roucher, Dominique Darmaun, et al.. Higher concentrations of branched-chain amino acids in breast milk of obese mothers. Nutrition, Elsevier, 2016, 32 (11-12), pp.1295-1298. ⟨10.1016/j.nut.2016.05.013⟩. ⟨hal-01605046⟩
  • Hélène Billard, Laure Simon, Emmanuelle Desnots, Agnes Sochard, C. Boscher, et al.. Calibration Adjustment of the Mid-infrared Analyzer for an Accurate Determination of the Macronutrient Composition of Human Milk. Journal of Human Lactation, SAGE Publications, 2016, 32 (3), pp.19-27. ⟨10.1177/0890334415588513⟩. ⟨hal-01487353⟩
  • Neele Dellschaft, Marie Cécile Alexandre-Gouabau, David S. Gardner, Jean-Philippe Antignac, Duane H. Keisler, et al.. Effect of pre- and postnatal growth and post-weaning activity on glucose metabolism in the offspring. Journal of Endocrinology, BioScientifica, 2015, 224 (2), pp.171 - 182. ⟨10.1530/JOE-14-0600⟩. ⟨hal-02636958⟩
  • Aurore Martin-Agnoux, Jean-Philippe Antignac, Clair-yves Boquien, Agnès David, Emmanuelle Desnots, et al.. Perinatal protein restriction affects milk free amino acid and fatty acid profile in lactating rats: potential role on pup growth and metabolic status. Journal of Nutritional Biochemistry, Elsevier, 2015, 26 (7), pp.784-795. ⟨10.1016/j.jnutbio.2015.02.012⟩. ⟨hal-02634633⟩
  • Angelina El Ghaziri, El Mostafa Qannari, Thomas Moyon, Marie Cécile Alexandre-Gouabau. AoV-PLS: a new method for the analysis of multivariate data depending on several factors. Electrophoresis, Wiley-VCH Verlag, 2015, 8 (2), pp.214 - 235. ⟨10.1285/i20705948v8n2p214⟩. ⟨hal-02635984⟩
  • A. Martin Agnoux, Marie Cécile Alexandre-Gouabau, Gwenola Le Drean, Jean-Philippe Antignac, Patricia Parnet. Relative contribution of foetal and post-natal nutritional periods on feeding regulation in adult rats. Acta Physiologica, Wiley, 2014, 210 (1), pp.188-201. ⟨10.1111/apha.12163⟩. ⟨hal-02632499⟩
  • A. Agnoux, J.-P. Antignac, Gilles Simard, G. Poupeau, D. Darmaun, et al.. Time window-dependent effect of perinatal maternal protein restriction on insulin sensitivity and energy substrate oxidation in adult male offspring. AJP - Regulatory, Integrative and Comparative Physiology, American Physiological Society, 2014, 307 (2), ajpregu.00015.2014. ⟨10.1152/ajpregu.00015.2014⟩. ⟨hal-01389210⟩
  • Véronique Ferchaud Roucher, Emmanuelle Desnots, Charlotte Nael, Aurore Martin Agnoux, Marie Cécile Alexandre-Gouabau, et al.. Use of UPLC-ESI-MS/MS to quantitate free amino acid concentrations in micro-samples of mammalian milk.. SpringerPlus, SpringerOpen, 2013, 2, pp.622. ⟨10.1186/2193-1801-2-622⟩. ⟨hal-02647300⟩
  • Marie Cécile Alexandre-Gouabau, Frederique Courant, Thomas Moyon, Alice Kuster, Gwénaëlle Le Gall, et al.. Maternal and Cord Blood LC-HRMS Metabolomics Reveal Alterations in Energy and Polyamine Metabolism, and Oxidative Stress in Very-low Birth Weight Infants. Journal of Proteome Research, American Chemical Society, 2013, 12 (6), pp.2764 - 2778. ⟨10.1021/pr400122v⟩. ⟨hal-01928639⟩
  • Illa Tea, Gwenaelle Le Gall, Alice Kuester, Nadia Guignard, Marie Cécile Alexandre-Gouabau, et al.. H-1-NMR-Based Metabolic Profiling of Maternal and Umbilical Cord Blood Indicates Altered Materno-Foetal Nutrient Exchange in Preterm Infants. PLoS ONE, Public Library of Science, 2012, 7 (1), ⟨10.1371/journal.pone.0029947⟩. ⟨hal-02142704⟩
  • Marie Cécile Alexandre-Gouabau, Emilie Bailly, Thomas Moyon, Isabelle I. Grit, Berengere Coupe Coupé, et al.. Postnatal growth velocity modulates alterations of proteins involved in metabolism and neuronal plasticity in neonatal hypothalamus in rats born with intrauterine growth restriction. Journal of Nutritional Biochemistry, Elsevier, 2012, 23 (2), pp.140-52. ⟨10.1016/j.jnutbio.2010.11.008⟩. ⟨hal-02652580⟩
  • El Mostafa Qannari, Evelyne Vigneau, Thomas Moyon, Frederique Courant, Jean-Philippe Antignac, et al.. A Simple Continuum Approach for Canonical Correlation Analysis; Applications to “Omics” Data. Current Analytical Chemistry, Bentham Science Publishers, 2012, 8 (2), pp.310 - 318. ⟨10.2174/157341112800392652⟩. ⟨hal-01928672⟩
  • Thomas Moyon, Fabien Le Marec, El Mostafa Qannari, Evelyne Vigneau, Aurélie Le Plain, et al.. Statistical strategies for relating metabolomics and proteomics data: a real case study in nutrition research area. Metabolomics, Springer Verlag, 2012, 8 (6), pp.1090 - 1101. ⟨10.1007/s11306-012-0415-7⟩. ⟨hal-01928661⟩
  • Marie Cécile Alexandre-Gouabau, Frédérique Courant, Gwénaëlle Le Gall, Thomas Moyon, Dominique Darmaun, et al.. Offspring Metabolomic Response to Maternal Protein Restriction in a Rat Model of Intrauterine Growth Restriction (IUGR). Journal of Proteome Research, American Chemical Society, 2011, 10 (7), pp.3292 - 3302. ⟨10.1021/pr2003193⟩. ⟨hal-01928607⟩
  • Marie Cécile Alexandre-Gouabau, Ousseynou Sarr, Pascale Fancal, Christine C. Hoebler, Bertrand Kaeffer. SFP-36 – Néonatalogie – Dynamique du protéome des cellules intestinales isolées de nouveau-nés de petits poids de naissance. Validation sur ratons RCIU. Archives de Pédiatrie, Elsevier, 2008, 15 (5), pp.934. ⟨10.1016/S0929-693X(08)72103-1⟩. ⟨hal-02654267⟩
  • yves Rayssiguier, Marie Cécile Alexandre-Gouabau, Bernard Lyan, Elyette Gueux, Andrzej Mazur, et al.. Inflammation interferes with the assessment of vitamin A status in magnesium deficiency. Magnesium Research, John Libbey Eurotext, 2008, 21 (4), pp.237-239. ⟨hal-02660827⟩
  • Bertrand Kaeffer, Clotilde Des Robert, Marie Cécile Alexandre-Gouabau, Anthony Pagniez, Arnaud Legrand, et al.. Recovery of exfoliated cells from the gastrointestinal tract of premature infants: a new tool to perform "Noninvasive Biopsies?". Pediatric Research, Nature Publishing Group, 2007, 62 (5), pp.564-569. ⟨10.1203/PDR.0b013e318155a402⟩. ⟨hal-02661436⟩
  • Frédéric Segaud, Bernard Lardeux, Marie Cécile Alexandre-Gouabau, Fanny Bleiberg-Daniel, Samir Nakib, et al.. Pretreatment of starved rats with ornithine α-ketoglutarate: effects on hepatic mRNA levels and plasma concentrations of three liver-secreted proteins. Nutrition, Elsevier, 2005, 21 (6), pp.732-739. ⟨10.1016/j.nut.2004.11.008⟩. ⟨hal-02680809⟩
  • Patrick P. Brachet, Aurélie Chanson, Christian Demigné, Frederique Batifoulier, Marie Cécile Alexandre-Gouabau, et al.. Age-associated B vitamin deficiency as a determinant of chronic diseases. Nutrition Research Reviews, Cambridge University Press (CUP), 2004, 17 (01), pp.55-68. ⟨10.1079/NRR200478⟩. ⟨hal-02683298⟩
  • Patrick Sauvant, Vincent Sapin, Armand Abergel, Carsten Schmidt, Loïc Blanchon, et al.. PAV-1, a new rat hepatic stellate cell line converts retinol into retinoic acid, a process altered by ethanol. International Journal of Biochemistry and Cell Biology, Elsevier, 2002, 34 (8), pp.1017 - 1029. ⟨10.1016/S1357-2725(02)00023-7⟩. ⟨hal-01918628⟩
  • Patrick A Borel, Bérengère Pasquier, Martine Armand, Viviane Tyssandier, Pascal Grolier, et al.. Processing of vitamin A and E in the human gastrointestinal tract. AJP - Gastrointestinal and Liver Physiology, American Physiological Society, 2001, 280 (1), pp.95-103. ⟨hal-02679533⟩
  • Bernard Lyan, Véronique Azaïs-Braesco, Nicolas Cardinault, Viviane Tyssandier, Patrick A Borel, et al.. Simple method for clinical determination of 13 carotenoids in human plasma using an isocratic high-performance liquid chromatographic method. Journal of Chromatography B - Analytical Technologies in the Biomedical and Life Sciences, Elsevier, 2001, 751 (2), pp.297-303. ⟨hal-02677788⟩
  • Patrick A Borel, Berengere Pasquier, Martine Armand, Viviane Tyssandier, Pascal Grolier, et al.. Processing of vitamin A and E in the human gastrointestinal tract. AJP - Gastrointestinal and Liver Physiology, American Physiological Society, 2001, 280 (1), pp.G95-G103. ⟨10.1152/ajpgi.2001.280.1.G95⟩. ⟨hal-02420167⟩
  • P. Sauvant, V. Sapin, Marie Cécile Alexandre-Gouabau, I. Dodeman, S. Delpal, et al.. Retinol mobilization from cultured rat hepatic stellate cells does not require retinol binding protein synthesis and secretion. International Journal of Biochemistry and Cell Biology, Elsevier, 2001, 33 (10), pp.1000-1012. ⟨10.1016/S1357-2725(01)00066-8⟩. ⟨hal-01189671⟩
  • Vincent Sapin, Samira Chaïb, Loïc Blanchon, Marie Cécile Alexandre-Gouabau, Didier Lémery, et al.. Esterification of Vitamin A by the Human Placenta Involves Villous Mesenchymal Fibroblasts. Pediatric Research, Nature Publishing Group, 2000, 48 (4), pp.565 - 572. ⟨10.1203/00006450-200010000-00024⟩. ⟨hal-01918619⟩
  • C. Feillet Coudray, R. Tourtauchaux, M. Niculescu, Edmond Rock, I. Tauveron, et al.. Plasma levels of 8-epiPGF2alpha, an in vivo marker of oxidative stress, are not affected by aging or Alzheimer's disease. Free Radical Biology and Medicine, Elsevier, 1999, 27 (3-4), pp.463-469. ⟨hal-02690679⟩
  • Christine Feillet-Coudray, Rémi Tourtauchaux, Michel Niculescu, Edmond Rock, Igor Tauveron, et al.. Plasma levels of 8-epiPGF2α, an in vivo marker of oxidative stress, are not affected by aging or Alzheimer’s disease. Free Radical Biology and Medicine, Elsevier, 1999, 27 (3-4), pp.463-469. ⟨10.1016/S0891-5849(99)00096-9⟩. ⟨hal-02696906⟩
  • Patrick A Borel, N. Mekki, yves Boirie, Anne Partier, Marie Cécile Alexandre-Gouabau, et al.. Comparison of postprandial plasma vitamin A response in young and older adults. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, The Gerontological Society of America, 1998, 53A (3), pp.133-140. ⟨hal-02691963⟩
  • Pascal Grolier, Patrick A Borel, C. Duszka, Sandrine Lory, Marie Cécile Alexandre-Gouabau, et al.. The bioavailability of alpha- and beta-carotene is affected by gut microflora in the rat. British Journal of Nutrition, Cambridge University Press (CUP), 1998, 80 (2), pp.199-204. ⟨hal-02695374⟩
  • Viviane Tyssandier, Patrick A Borel, Georges Choubert, Pascal Grolier, Marie Cécile Alexandre-Gouabau, et al.. The bioavailability of carotenoids is positively related to their polarity. Sciences des Aliments, Lavoisier Abonnements, 1998, 18 (3), pp.324. ⟨hal-02696358⟩
  • Patrick A Borel, Pascal Grolier, Nadia Mekki, yves Boirie, yvanne Rochette, et al.. Low and high responders to pharmacological doses of beta-carotene: proportion in the population, mechanisms involved and consequences on beta-carotene metabolism.. Journal of Lipid Research, American Society for Biochemistry and Molecular Biology, 1998, 39 (11), pp.2250-2260. ⟨hal-02698736⟩
  • Patrick A Borel, Viviane Tyssandier, N. Mekki, Pascal Grolier, yvanne Rochette, et al.. Chylomicron Beta-Carotene and retinyl palmitate responses are dramatically diminished when men ingest Beta-Carotene with medium-chain rather than long-chain triglycerides. Journal of Nutrition, American Society for Nutrition, 1998, 128 (8), pp.1361-1367. ⟨10.1093/jn/128.8.1361⟩. ⟨hal-02696749⟩
  • Patrick A Borel, Pascal Grolier, yves Boirie, Léo Simonet, Elisabeth Verdier, et al.. Oxidative stress status and antioxidant status are apparently not related to carotenoid status in healthy subjects. Journal of Laboratory and Clinical Medicine, Elsevier, 1998, 132 (1), pp.61-66. ⟨hal-02698343⟩
  • Pascal Grolier, Patrick A Borel, C. Duszka, Sandrine Lory, Marie Cécile Alexandre-Gouabau, et al.. The bioavailabilty of alpha- and beta-carotene is affected by gut microflora in the rat. British Journal of Nutrition, Cambridge University Press (CUP), 1998, 80 (2), pp.199-204. ⟨hal-02690516⟩
  • Patrick A Borel, N. Mekki, yves Boirie, Anne Partier, Marie Cécile Alexandre-Gouabau, et al.. Comparison of the postprandial plasma vitamin a response in young and older adults. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, The Gerontological Society of America, 1998, 53A (2), pp.B133-B140. ⟨10.1093/gerona/53A.2.B133⟩. ⟨hal-02699033⟩
  • Pascal Grolier, Christelle Duszka, Patrick A Borel, Marie Cécile Alexandre-Gouabau, Véronique Azaïs-Braesco. In Vitroandin vivoInhibition of β-carotene dioxygenase activity by canthaxanthin in rat intestine. Archives of Biochemistry and Biophysics, Elsevier, 1997, 348 (2), pp.233-238. ⟨10.1006/abbi.1997.0388⟩. ⟨hal-02698208⟩
  • Patrick A Borel, N. Mekki, yves Boirie, Anne Partier, Pascal Grolier, et al.. Postprandial chylomicron and plasma vitamin E responses in healthy order subjects compared with younger ones. European Journal of Clinical Investigation, Wiley, 1997, 27, pp.812-821. ⟨hal-02695015⟩
  • Pascal Grolier, C. Duszka, Patrick A Borel, Marie Cécile Alexandre-Gouabau, Véronique Azaïs-Braesco. In vivo and in vitro inhibition of beta-carotene dioxygenase activity by canthaxanthin in rat intestine. Archives of Biochemistry and Biophysics, Elsevier, 1997, 348 (2), pp.233-238. ⟨hal-02689488⟩
  • Patrick A Borel, C Dubois, N Mekki, Pascal Grolier, Anne Partier, et al.. Dietary triglycerides, up to 40 g/meal, do not affect preformed vitamin A bioavailability in humans. European Journal of Clinical Nutrition, Nature Publishing Group, 1997, 51 (11), pp.717-722. ⟨10.1038/sj.ejcn.1600466⟩. ⟨hal-02694144⟩
  • Patrick A Borel, N. Mekky, yves Boirie, Anne Partier, Pascal Grolier, et al.. Postprandial chylomicron and plasma vitamin E responses in healthy older subjects compared with younger ones. European Journal of Clinical Investigation, Wiley, 1997, 27 (10), pp.812-821. ⟨10.1046/j.1365-2362.1997.1960744.x⟩. ⟨hal-02699032⟩
  • Patrick A Borel, C. Dubois, N. Mekki, Pascal Grolier, Anne Partier, et al.. Dietary triglycerides, up to 40g/meal, do not affect preformed vitamin A bioavailability in humans. European Journal of Clinical Nutrition, Nature Publishing Group, 1997, 51, pp.717-722. ⟨hal-02683815⟩
  • Viviane Tyssandier, Patrick A Borel, Georges Choubert, Pascal Grolier, Marie Cécile Alexandre-Gouabau, et al.. La biodisponibilite des carotenoides est d'autant plus forte qu'ils sont plus polaires. Etude chez la truite. Nutrition Clinique et Métabolisme, Elsevier Masson, 1997, 11 (suppl.), pp.15. ⟨hal-02684321⟩
  • Véronique Azaïs-Braesco, Isabelle Dodeman, Serge S. Delpal, Marie Cécile Alexandre-Gouabau, Anne Partier, et al.. Vitamin A contained in the lipid droplets of rat liver stellate cells is substrate for acid retinyl ester hydrolase.. BBA - Biochimica et Biophysica Acta, Elsevier, 1995, 1259 (3), pp.271-276. ⟨10.1016/0005-2760(95)00173-5⟩. ⟨hal-02713862⟩
  • Véronique Azaïs-Braesco, I. Dodeman, Serge Delpal, Marie Cécile Alexandre-Gouabau, Anne Partier, et al.. Vitamin A cotained in the lipid droplets of rat liver stellate cells is substrate for acid retinyl ester hydrolase. Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, Elsevier, 1995, 1259, pp.271-276. ⟨hal-02713593⟩

Conference papers16 documents

  • Marie Cécile Alexandre-Gouabau. La métabolomique et ses perspectives en médecine. 6ème Congrès Association des Pédiatres du Sud de Paris, Sep 2019, Serris-Val d’Europe, France. ⟨hal-02787628⟩
  • German Cano Sancho, Marie Cécile Alexandre-Gouabau, yann Guitton, Philippe Marchand, Clair-yves Boquien, et al.. Metabolomic-exposomic approach based in high resolution mass spectrometry to explore complex environmental-health associations: a proof-of-concept study with preterm infants. 31st annual conference of the International Society for Environmental Epidemiology (ISEE), Aug 2019, Utrecht, Netherlands. ⟨hal-02735998⟩
  • Valentine Moulle, Blandine Castellano, Agnes Sochard, Marie Cécile Alexandre-Gouabau, Patricia Parnet. Impact of the increase of omega 3 intake during gestation and lactation on offspring in a maternal protein restriction model. 23 rd Annual Meeting LARC-Neurosciences Network, Oct 2019, Nantes, France. ⟨hal-02735631⟩
  • Marie Cécile Alexandre-Gouabau. Métabotype du lait maternel en lien avec la croissance précoce pondérale des enfants nés prématurés. XVIII Journée de l’animation transversale "Glande mammaire, lait, Nov 2019, Paris, France. ⟨hal-02736896⟩
  • Thomas Sevrin, Marie Cécile Alexandre-Gouabau, Blandine Castellano, Khadija Ouguerram, Dominique D. Darmaun, et al.. Mesure de la production de lait par enrichissement isotopique à l'eau deutérée dans un modèle rongeur : application à une supplémentation en fenugrec pendant la lactation. journée « Transversalité Glande Mammaire et Lait 2019», UMR 1280 PhAN. FRA., Nov 2019, Paris, France. ⟨hal-02735622⟩
  • Thomas Sevrin, Marie Cécile Alexandre-Gouabau, Blandine Castellano, Dominique D. Darmaun, Clair-yves Boquien. Une supplémentation maternelle postnatale en fenugrec augmente la production de lait dans un modèle de rate allaitant 12 ratons.. Journées francophones de nutrition, Nov 2019, Rennes, France. ⟨hal-02735559⟩
  • Marie Cécile Alexandre-Gouabau, Thomas Moyon, Véronique Cariou, Jean-Philippe Antignac, El Mostafa Qannari, et al.. Breast Milk Lipidome Is Associated with Early Growth Trajectory in Preterm Infants.. 4ème congrès de la Société francophone pour la recherche et l'éducation sur les Origines Développementales Environnementales et Epigénétiques de la Santé et des Maladies (SF DOHAD), Nov 2018, Grenoble, France. ⟨hal-02736108⟩
  • Marie Cécile Alexandre-Gouabau, Thomas Moyon, Véronique Cariou, El Mostafa Qannari, Mickael Croyal, et al.. Breast milk lipidome as a predictive component of postnatal growth trajectory in preterm infants. Société Française d’Electrophorèse et d’Analyse Protéomique (SFEAP)- Réseau Francophone de Métabolomique et Fluxomique (RFMF), Oct 2017, Disneyland Paris, France. ⟨hal-02736107⟩
  • Dominique D. Darmaun, Marie Cécile Alexandre-Gouabau, Jean-Philippe Antignac. Maternal/fetal metabolomics in intrauterine growth restriction and preterm birth. Fetal Physiology Satellite Meeting, 63rd Annual Scientific Meeting, Society for Reproductive Investigation (SRI)., Mar 2016, Montréal, Canada. ⟨hal-02742315⟩
  • Angelina El Ghaziri, El Mostafa Qannari, Thomas Moyon, Marie Cécile Alexandre-Gouabau. Analysis of multivariate data depending on several factors: ANOVA-PLS. XVI Chimiométrie, Jan 2015, Genève, Switzerland. ⟨hal-02742116⟩
  • Thomas Moyon, El Mostafa Qannari, Angelina El Ghaziri, Marie Cécile Alexandre-Gouabau. Analysis of multivariate data depending on several factors: ANOVA-PLS. XVIème Congrès Chimiométrie, Université de Genève (Unige). CHE. Groupe Français de Chimiométrie (GFC), FRA., Jan 2015, Genève, Switzerland. ⟨hal-02799238⟩
  • Marie Cécile Alexandre-Gouabau, Jean-Philippe Antignac, M Molamine, El Mostafa Qannari, V. Cariou, et al.. Le lipidome du lait maternel prédictif de la trajectoire pondérale postnatale du prématuré.. Journées Francophones de Nutrition, 2015, Marseille, France. pp.37, ⟨10.1016/j.nupar.2016.10.020⟩. ⟨hal-02620358⟩
  • Alexandre Verdu, Bernard Lyan, Carole Migné, Catherine Defoort, Cécile Canlet, et al.. Can we trust untargeted metabolomics: results of the metabo-ring study. 2. African-European Conference on Chemometrics - Afrodata 2012, Nov 2012, Stellenbosch, South Africa. ⟨hal-01595486⟩
  • Eloise E. Delamaire, Christine C. Hoebler, Catherine Michel, Bertrand Kaeffer, Marie Cécile Alexandre-Gouabau, et al.. SFRP-02 – Recherche expérimentale – Effet mémoire d’une alimentation hyperprotéique chez le raton. Congrès des Sociétés Françaises Médico-chirurgicales Pédiatriques, Jun 2008, Nantes, France. pp.1031, ⟨10.1016/S0929-693X(08)72420-5⟩. ⟨hal-02663339⟩
  • Viviane Tyssandier, Patrick A Borel, Georges Choubert, Pascal Grolier, Marie Cécile Alexandre-Gouabau, et al.. The bioavailability of carotenoids is positively related to their polarity. Symposium on Animal and Human Nutrition of the Association Française de Nutrition, Nov 1998, La Villette, France. ⟨hal-02837132⟩
  • Viviane Tyssandier, Patrick A Borel, Georges Choubert, Pascal Grolier, Marie Cécile Alexandre-Gouabau, et al.. La biodisponibilite des carotenoides est d'autant plus forte qu'ils sont plus polaires. Etude chez la truite. 1. Journées Francophones de Nutrition (JFN), Nov 1997, Paris, France. ⟨hal-02836584⟩

Poster communications8 documents

  • Thomas Sevrin, Clair-yves Boquien, Blandine Castellano, Alexis Gandon, Pierre de Coppet, et al.. Dietary fenugreek supplementation impacts mammary gland gene expression in a lactating rat model.. Virtual workshop of the International Society for Research in Human Milk and Lactation, Aug 2020, Stocholm, Sweden. ⟨hal-03533117⟩
  • Valentine Moulle, Blandine Castellano, Agnes Sochard, Marie Cécile Alexandre-Gouabau, Patricia Parnet. Impact d’un enrichissement maternel en oméga 3 pendant la gestation et la lactation sur la descendance dans un modèle de dénutrition protéique maternelle chez le rat. Journées Francophones de Nutrition (JFN), Nov 2019, Rennes, France. 2019. ⟨hal-02736322⟩
  • Thomas Sevrin, Marie Cécile Alexandre-Gouabau, Dominique D. Darmaun, A. Andre, P. Nguyen, et al.. Impact d’une restriction protéique périnatale dans un modèle rongeur (rate) sur la production de lait maternel à l’aide de la méthode d’enrichissement isotopique à l’eau deutérée. 4ème congrès SF-DOHAD, Nov 2018, Grenoble, France. 2018. ⟨hal-02735619⟩
  • A. de Luca, Régis Hankard, Marie Cécile Alexandre-Gouabau, Véronique Ferchaud-Roucher, Dominique D. Darmaun, et al.. Higher concentrations of Branched-Chain Amino Acids (BCAA) in breast milk of obese mothers. Journées Francophones de Nutrition (JFN), Nov 2016, Montpellier, France. 2016. ⟨hal-02743026⟩
  • Thomas Sevrin, Marie Cécile Alexandre-Gouabau, Dominique D. Darmaun, Agnès André, Patrick Nguyen, et al.. Effets d’une supplémentation en citrulline sur la production de lait dans un modèle de rate en restriction protéique périnatale. Journées francophones de nutrition, Nov 2016, Montpellier, France. 2016. ⟨hal-02741742⟩
  • Véronique Cariou, El Mostafa Qannari, Mohamed Soumah, Marie Cécile Alexandre-Gouabau, Thomas Moyon. New formulation for multi-block-partial least squares discriminant analysis. AgroStat 2016 Congress - 14. Symposium on Statistical Methods for the Food Industry, Mar 2016, Lausanne, Switzerland. 2016. ⟨hal-02801394⟩
  • Arnaud de Luca, Régis Hankard, Marie Cécile Alexandre-Gouabau, Véronique Ferchaud-Roucher, Dominique D. Darmaun, et al.. Higher concentrations of branched-chain amino acids in breast milk of obese mothers. 2nd congrès SF-DOHAD, Dec 2016, Paris, France. 2016. ⟨hal-02743837⟩
  • Gwenola Le Drean, Aurore Martin-Agnoux, Jean-Vianney Haure-Mirande, Berengere Coupe, Patricia Parnet, et al.. Gastro-intestinal peptides and first meal pattern following energy restriction in a rat model of intra-uterine growth restriction. 4. International Conference on Nutrition & Growth Conference, Mar 2012, Paris, France. 2012. ⟨hal-01604132⟩

Other publications1 document

  • Stéphanie Jolly, Marie Le, Gaëlle Boudry, Clair-yves Boquien, Jean-Marc Goujon, et al.. Allaitement. 2018, https://www.pole-valorial.fr/success_stories/allaitement. ⟨hal-02420645⟩