Recherche - Archive ouverte HAL Accéder directement au contenu

Filtrer vos résultats

32 résultats
Page :
triés par

Comparison of 2 strategies to enhance pyridoclax solubility: Nanoemulsion delivery system versus salt synthesis

 A.-C. Groo , M. de Pascale , A.-S. Voisin-Chiret , S. Corvaisier , M. Since , et al.
European Journal of Pharmaceutical Sciences, 2017, 97, pp.218-226
Article dans une revue hal-02053808v1
Image document

Inhibiting Acetylcholinesterase to Activate Pleiotropic Prodrugs with Therapeutic Interest in Alzheimer’s Disease

 François-Xavier Toublet , Cédric Lecoutey , Julien Lalut , Bérénice Hatat , Audrey Davis , et al.
Molecules, 2019, 24 (15), pp.2786. ⟨10.3390/molecules24152786⟩
Article dans une revue hal-02399906v1
Image document

New 8-Nitroquinolinone Derivative Displaying Submicromolar in Vitro Activities against Both Trypanosoma brucei and cruzi

 Julien Pedron , Clotilde Boudot , Jean-Yves Brossas , Emilie Pinault , Sandra Bourgeade-Delmas , et al.
ACS Medicinal Chemistry Letters, 2020, 11 (4), pp.464-472. ⟨10.1021/acsmedchemlett.9b00566⟩
Article dans une revue hal-02476867v1

Design, synthesis and biological evaluation of novel indano- and thiaindano-pyrazoles with potential interest for Alzheimer's disease.

 David Genest , Christophe Rochais , Cédric Lecoutey , Jana Sopkova-de Oliveira Santos , Céline Ballandonne , et al.
MedChemComm, 2013, 4, pp.925-931
Article dans une revue hal-00840942v1

Comparison of 2 strategies to enhance pyridoclax solubility: Nanoemulsion delivery system versus salt synthesis

 A.-C. Groo , M. de Pascale , A.-S. Voisin-Chiret , S. Corvaisier , M. Since , et al.
European Journal of Pharmaceutical Sciences, 2017, 97, pp.218-226
Article dans une revue hal-02043745v1
Image document

Pleiotropic prodrugs: Design of a dual butyrylcholinesterase inhibitor and 5-HT6 receptor antagonist with therapeutic interest in Alzheimer’s disease

 François-Xavier Toublet , Julien Lalut , Bérénice Hatat , Cédric Lecoutey , Audrey Davis , et al.
European Journal of Medicinal Chemistry, 2021, 210, pp.113059. ⟨10.1016/j.ejmech.2020.113059⟩
Article dans une revue hal-03082877v1

Development of a nasal drug delivery composite nanosystem for Alzheimer’s desease treatment

 Adnet Thomas , Anne-Claire Groo , Loïc Le Pluart , Celine Picard , A. Davis , et al.
Journée normande de recherche biomédicale, Nov 2017, caen, France
Poster de conférence hal-02295929v1

Evaluation of the versatile character of a nanoemulsion formulation

 Emilie Gué , Marc Since , S. Ropars , R. Herbinet , L. Le Pluart , et al.
International Journal of Pharmaceutics, 2016, 498 (1-2), pp.49-65. ⟨10.1016/j.ijpharm.2015.12.010⟩
Article dans une revue hal-01847973v1
Image document

Pyridoclax-loaded nanoemulsion for enhanced anticancer effect on ovarian cancer

 A.C. Groo , S. Hedir , M. Since , E. Brotin , L.-B. Weiswald , et al.
International Journal of Pharmaceutics, 2020, 587, pp.119655 -. ⟨10.1016/j.ijpharm.2020.119655⟩
Article dans une revue hal-03492393v1
Image document

A functional m 6 A‐RNA methylation pathway in the oyster Crassostrea gigas assumes epitranscriptomic regulation of lophotrochozoan development

 Lorane Le Franc , Benoit Bernay , Bruno Petton , Marc Since , Pascal Favrel , et al.
FEBS Journal, In press, ⟨10.1111/febs.15500⟩
Article dans une revue hal-02952460v1
Image document

A biomimetic multiparametric assay to characterise anti-amyloid drugs

 Willy Smeralda , Marc Since , Sophie Corvaisier , Dimitri Fayoll , Julien Cardin , et al.
International Journal of Molecular Sciences, 2023, 24 (23), pp.16982. ⟨10.3390/ijms242316982⟩
Article dans une revue hal-04315267v1
Image document

Design of donecopride, a dual serotonin subtype 4 receptor agonist/acetylcholinesterase inhibitor with potential interest for Alzheimer's disease treatment

 Cédric Lecoutey , Damien Hedou , Thomas Freret , Patrizia Giannoni , Florence Gaven , et al.
Proceedings of the National Academy of Sciences of the United States of America, 2014, 111 (36), pp.E3825--30. ⟨10.1073/pnas.1410315111⟩
Article dans une revue hal-01800439v2

Evaluation préclinique de nanoémulsions polyvalentes comme vecteurs d’un nouvel inhibiteur de Mcl-1, le Pyridoclax : application au traitement des cancers de l’ovaire (PYRINANO)

 Aurélie Malzert-Fréon , Anne-Claire Groo , Siham Hedir , Marc Since , Martina de Pascale , et al.
10émes journées scientifiques du cancéropole nord-ouest, May 2017, Deauville, France
Communication dans un congrès hal-02295794v1

Benzylphenylpyrrolizinones with Anti-amyloid and Radical Scavenging Effects, Potentially Useful in Alzheimer's Disease Treatment

 Jean-Pierre Jourdan , Marc Since , Laïla El kihel , Cédric Lecoutey , Sophie Corvaisier , et al.
ChemMedChem, 2017, 12 (12), pp.913-916. ⟨10.1002/cmdc.201700102⟩
Article dans une revue hal-02043731v1

Synthesis of antiplasmodial 2-aminothieno[3,2-d]pyrimidin-4(3H)-one analogues using the scaffold hopping strategy

 Romain Mustière , Prisca Lagardère , Sébastien Hutter , Viviana Dell’orco , Nadia Amanzougaghene , et al.
European Journal of Medicinal Chemistry, 2022, 241, pp.114619. ⟨10.1016/j.ejmech.2022.114619⟩
Article dans une revue hal-03737417v1
Image document

Introduction to the versatility of biomimetic membranes to characterize modulators of Aβ1-42 fibrillization with potential interest in Alzheimer's disease treatment

 Willy Smeralda , Marc Since , Michael Boisserie , Sophie Corvaisier , Julien Cardin , et al.
32ème Journées Franco-Belges de Chimie Thérapeutique et 26ème Rencontres Internationales des Pharmacochimistes de l'Arc Atlantique, , Jun 2018, Asnelles sur Mer, France. 2018
Poster de conférence hal-01844495v1
Image document

Star-like poly(peptoid)s with selective antibacterial activity

 Pedro Salas-Ambrosio , Antoine Tronnet , Mostafa Badreldin , Luzangel Reyes , Marc Since , et al.
Polymer Chemistry, 2022, 13 (5), pp.600-612. ⟨10.1039/D1PY01529J⟩
Article dans une revue hal-03559890v1

Comparison of 2 strategies to enhance pyridoclax solubility: Nanoemulsion delivery system versus salt synthesis

 Anne-Claire Groo , Martina de Pascale , Anne-Sophie Voisin-Chiret , Sophie Corvaisier , Marc Since , et al.
European Journal of Pharmaceutical Sciences, 2017, 97, pp.218-226. ⟨10.1016/j.ejps.2016.11.025⟩
Article dans une revue hal-02160866v1
Image document

Pharmacotechnical Development of a Nasal Drug Delivery Composite Nanosystem Intended for Alzheimer’s Disease Treatment

 Thomas Adnet , Anne-Claire Groo , Céline Picard , Audrey Davis , Sophie Corvaisier , et al.
Pharmaceutics, 2020, 12 (3), pp.251. ⟨10.3390/pharmaceutics12030251⟩
Article dans une revue hal-03969997v1

New orally effective 3-(2-nitro)phenylpropanamide analgesic derivatives: Synthesis and antinociceptive evaluation

 Marc Since , Thomas Freret , Gerald Nee , Thierry Terme , Patrice Vanelle , et al.
European Journal of Medicinal Chemistry, 2013, 69, pp.728--734. ⟨10.1016/j.ejmech.2013.08.041⟩
Article dans une revue istex hal-01460473v1

Novel benzylidenephenylpyrrolizinones with pleiotropic activities potentially useful in Alzheimer's disease treatment

 Jean-Pierre Jourdan , Marc Since , Laïla El Kihel , Cédric Lecoutey , Sophie Corvaisier , et al.
European Journal of Medicinal Chemistry, 2016, 114, pp.365-379. ⟨10.1016/j.ejmech.2016.03.023⟩
Article dans une revue hal-02043765v1
Image document

8-Alkynyl-3-nitroimidazopyridines display potent antitrypanosomal activity against both T. b. brucei and cruzi

 Cyril Fersing , Clotilde Boudot , Caroline Castera-Ducros , Émilie Pinault , Sébastien Hutter , et al.
European Journal of Medicinal Chemistry, 2020, 202, pp.112558. ⟨10.1016/j.ejmech.2020.112558⟩
Article dans une revue hal-02899751v1
Image document

Synthesis of Pyridoclax Analogues: Insight into Their Druggability by Investigating Their Physicochemical Properties and Interactions with Membranes

 Martina de Pascale , Domenico Iacopetta , Marc Since , Sophie Corvaisier , V. Vié , et al.
ChemMedChem, 2020, 15 (1), pp.136-154. ⟨10.1002/cmdc.201900542⟩
Article dans une revue hal-02434628v1
Image document

β-Amyloid peptide interactions with biomimetic membranes: A multiparametric characterization

 Willy Smeralda , Marc Since , Julien Cardin , Sophie Corvaisier , Sophie Lecomte , et al.
International Journal of Biological Macromolecules, 2021, 181, pp.769-777. ⟨10.1016/j.ijbiomac.2021.03.107⟩
Article dans une revue hal-03187852v1

First SNAr reaction using TDAE-initiated carbanions in quinazoline series

 Marc Since , Omar Khoumeri , Pierre Verhaeghe , Martine Maillard-Boyer , Thierry Terme , et al.
Tetrahedron Letters, 2011, 52 (29), pp.3810--3813. ⟨10.1016/j.tetlet.2011.05.060⟩
Article dans une revue istex hal-01460328v1
Image document

Cyclic Poly(α-peptoid)s by Lithium bis(trimethylsilyl)amide (LiHMDS)-Mediated Ring-Expansion Polymerization

 Pedro Salas-Ambrosio , Antoine Tronnet , Marc Since , Sandra Bourgeade-Delmas , Jean-Luc Stigliani , et al.
Journal of the American Chemical Society, 2021, 143 (10), pp.3697-3702. ⟨10.1021/jacs.0c13231⟩
Article dans une revue hal-03173586v1
Image document

Improving Aqueous Solubility and In Vitro Pharmacokinetic Properties of the 3-Nitroimidazo[1,2-a]pyridine Antileishmanial Pharmacophore

 Romain Paoli-Lombardo , Nicolas Primas , Sandra Bourgeade-Delmas , Sébastien Hutter , Alix Sournia-Saquet , et al.
Pharmaceuticals, 2022, 15 (8), pp.998. ⟨10.3390/ph15080998⟩
Article dans une revue hal-03755519v1
Image document

Nongenotoxic 3-Nitroimidazo[1,2- a ]pyridines Are NTR1 Substrates That Display Potent in Vitro Antileishmanial Activity

 Cyril Fersing , Louise Basmaciyan , Clotilde Boudot , Julien Pedron , Sébastien Hutter , et al.
ACS Medicinal Chemistry Letters, 2019, 10 (1), pp.34-39. ⟨10.1021/acsmedchemlett.8b00347⟩
Article dans une revue hal-02478935v1
Image document

Microplate assay for lipophilicity determination using intrinsic fluorescence of drugs: Application to a promising anticancer lead, pyridoclax

 Willy Smeralda , Marc Since , Sophie Corvaisier , Rémi Legay , Anne-Sophie Voisin-Chiret , et al.
European Journal of Pharmaceutical Sciences, 2019, 131, pp.75-83. ⟨10.1016/j.ejps.2019.02.010⟩
Article dans une revue hal-02168030v1
Image document

Antikinetoplastid SAR study in 3-nitroimidazopyridine series

 Cyril Fersing , Clotilde Boudot , Romain Paoli-Lombardo , Nicolas Primas , Emilie Pinault , et al.
European Journal of Medicinal Chemistry, 2020, 206, pp.112668. ⟨10.1016/j.ejmech.2020.112668⟩
Article dans une revue hal-02920293v1
Page :