Marc Le Borgne

119

Documents

Identifiants chercheurs

marc-le-borgne
ResearcherId : H-1036-2014
0000-0003-1398-075X
Google Scholar : https://scholar.google.com/citations?user=zO1nhO8AAAAJ
IdRef : 095367829
ResearcherId : http://www.researcherid.com/rid/H-1036-2014

Présentation

Publications

	New 2,4-bis[(substituted-aminomethyl)phenyl]phenylquinazoline and 2,4-bis[(substituted-aminomethyl)phenyl]phenylquinoline derivatives: synthesis and biological evaluation as novel anticancer agents by targeting G-quadruplex Jean Guillon , Marc Le Borgne , Vittoria Milano , Aurore Guédin-Beaurepaire , Stéphane Moreau Pharmaceuticals, 2024, 17 (1), pp.30. ⟨10.3390/ph17010030⟩ Article dans une revue hal-04390485v1
	Drug candidates targeting multidrug resistance in cancer and infections Marc Le Borgne , Pierre Falson , Ahcène Boumendjel European Journal of Medicinal Chemistry, 2023, 249, pp.115173. ⟨10.1016/j.ejmech.2023.115173⟩ Article dans une revue hal-03972628v1
	Inhibitors of ABCG2-mediated multidrug resistance: Lead generation through computer-aided drug design Laura Goracci , Alessandra Nurisso , Emile Roussel , Basile Pérès , Vincent Chaptal European Journal of Medicinal Chemistry, 2023, 248, pp.115070. ⟨10.1016/j.ejmech.2022.115070⟩ Article dans une revue hal-03939266v1
	Formulation and Investigation of CK2 Inhibitor-Loaded Alginate Microbeads with Different Excipients Boglárka Papp , Marc Le Borgne , Florent Perret , Christelle Marminon , Liza Józsa Pharmaceutics, 2023, Dosage Form Formulation Technologies for Improving Bioavailability, 15 (12), pp.2701. ⟨10.3390/pharmaceutics15122701⟩ Article dans une revue hal-04314651v1
	Toxicological Risks of the Cobalt–Chromium Alloys in Dentistry: A Systematic Review Brigitte Grosgogeat , Alina Vaicelyte , Rémy Gauthier , Christine Janssen , Marc Le Borgne Materials, 2022, 15 (17), pp.5801. ⟨10.3390/ma15175801⟩ Article dans une revue hal-03815561v1
	Improved biological performance of ketoprofen using novel modified halloysite clay nanotubes Dounia Sid , Milad Baitiche , Lekhmici Arrar , Ferhat Djerboua , Riadh Bourzami Applied Clay Science, 2022, 216, pp.106341. ⟨10.1016/j.clay.2021.106341⟩ Article dans une revue hal-03475833v1
	4,5,7‐trisubstituted indeno[1,2‐ b ]indole inhibits CK2 activity in tumor cells equivalent to CX‐4945 and shows strong anti‐migratory effects Robin Birus , Ehab El‐awaad , Laurens Ballentin , Faten Alchab , Dagmar Aichele FEBS Open Bio, 2022, 12, pp.394-411. ⟨10.1002/2211-5463.13346⟩ Article dans une revue hal-03471998v1
	Tetanus Toxin Fragment C: Structure, Drug Discovery Research and Production Caroline Bayart , Angélique Mularoni , Nada Hemmani , Soumeya Kerachni , Joachim Jose Pharmaceuticals, 2022, 15 (6), pp.756. ⟨10.3390/ph15060756⟩ Article dans une revue hal-03718458v1
	Adsorption studies of benzophenone-3 onto clay minerals and organosilicates: Kinetics and modelling Saddam Charaabi , Rafik Absi , Anne-Marie Pensé-Lhéritier , Marc Le Borgne , Samar Issa Applied Clay Science, 2021, 202, pp.105937. ⟨10.1016/j.clay.2020.105937⟩ Article dans une revue hal-03088439v1
	Brain safety concerns of nanomedicines: The need for a specific regulatory framework Bartlomiej Szabat-Iriaka , Marc Le Borgne Drug Discovery Today, 2021, 26 (11), pp.2502-2507. ⟨10.1016/j.drudis.2021.06.011⟩ Article dans une revue hal-03311532v1
	Broad-Spectrum Anticancer Activity and Pharmacokinetic Properties of a Prenyloxy-Substituted Indeno[1,2-b]indole Derivative, Discovered as CK2 Inhibitor Ehab El-Awaad , Robin Birus , Christelle Marminon , Zouhair Bouaziz , Laurens Ballentin Pharmaceuticals, 2021, 14 (6), pp.542. ⟨10.3390/ph14060542⟩ Article dans une revue hal-03311530v1
	Ninhydrins inhibit carbonic anhydrases directly binding to the metal ion Abdeslem Bouzina , Malika Berredjem , Alessio Nocentini , Silvia Bua , Zouhair Bouaziz European Journal of Medicinal Chemistry, 2021, 209, pp.112875. ⟨10.1016/j.ejmech.2020.112875⟩ Article dans une revue hal-02963341v1
	Solubility enhancement of mefenamic acid by inclusion complex with β-cyclodextrin: in silico modelling, formulation, characterisation, and in vitro studies Dounia Sid , Milad Baitiche , Zineb Elbahri , Ferhat Djerboua , Mokhtar Boutahala Journal of Enzyme Inhibition and Medicinal Chemistry, 2021, 36 (1), pp.605-617. ⟨10.1080/14756366.2020.1869225⟩ Article dans une revue hal-03161350v1
	Uncompetitive nanomolar dimeric indenoindole inhibitors of the human breast cancer resistance pump ABCG2 Nathalie Guragossian , Billel Belhani , Alexis Moreno , Magda Teixeira Nunes , Lucia Gonzalez-Lobato European Journal of Medicinal Chemistry, 2021, 211, pp.113017. ⟨10.1016/j.ejmech.2020.113017⟩ Article dans une revue hal-03032952v1
	Microwave-accelerated multicomponent synthesis and X-ray characterization of novel benzothiadiazinone dioxide derivatives, analogues of Monastrol Abdeslem Bouzina , Malika Berredjem , Billel Belhani , Sofiane Bouacida , Christelle Marminon Research on Chemical Intermediates, 2021, ⟨10.1007/s11164-020-04378-3⟩ Article dans une revue hal-03112770v1
	Mechanistic basis of breast cancer resistance protein inhibition by new indeno[1,2-b]indoles Diogo Henrique Kita , Nathalie Guragossian , Ingrid Fatima Zattoni , Vivian Rotuno Moure , Fabiane Gomes de Moraes Rego Scientific Reports, 2021, 11 (1), pp.1788. ⟨10.1038/s41598-020-79892-w⟩ Article dans une revue hal-03126318v1
	Alliages dentaires cobalt-chrome : compatibilité entre le cadre réglementaire européen et la convention nationale ? Christine Janssen , Alina Vaicelyte , Marc Le Borgne , Brigitte Grosgogeat Biomatériaux Cliniques Dentaires, 2021, 6 (1), pp.104-107 Article dans une revue hal-03475825v1
	Improved Surface Display of Human Hyal1 and Identification of Testosterone Propionate and Chicoric Acid as New Inhibitors Isabelle Lengers , Fabian Herrmann , Marc Le Borgne , Joachim Jose Pharmaceuticals, 2020, 13 (4), pp.54. ⟨10.3390/ph13040054⟩ Article dans une revue hal-02539544v1
	QSAR Model of Indeno[1,2-b]indole Derivatives and Identification of N-isopentyl-2-methyl-4,9-dioxo-4,9-Dihydronaphtho[2,3-b]furan-3-carboxamide as a Potent CK2 Inhibitor Samer Haidar , Christelle Marminon , Dagmar Aichele , Abdelhamid Nacereddine , Wael Zeinyeh Molecules, 2020, 25 (1), pp.97. ⟨10.3390/molecules25010097⟩ Article dans une revue hal-02424862v1
	Biological exploration of a novel 1,2,4-triazole-indole hybrid molecule as antifungal agent Fabrice Pagniez , Nicolas Lebouvier , Young Min Na , Isabelle Ourliac-Garnier , Carine Picot Journal of Enzyme Inhibition and Medicinal Chemistry, 2020, 35 (1), pp.398-403. ⟨10.1080/14756366.2019.1705292⟩ Article dans une revue hal-02455791v1
	Synthesis of new piperazinyl-pyrrolo[1,2- a ]quinoxaline derivatives as inhibitors of Candida albicans multidrug transporters by a Buchwald–Hartwig cross-coupling reaction Jean Guillon , Shweta Nim , Stéphane Moreau , Luisa Ronga , Solène Savrimoutou RSC Advances, 2020, 10 (5), pp.2915-2931. ⟨10.1039/C9RA09348F⟩ Article dans une revue hal-02449065v1
	Synthesis, Optimization, Antifungal Activity, Selectivity, and CYP51 Binding of New 2-Aryl-3-azolyl-1-indolyl-propan-2-ols Nicolas Lebouvier , Fabrice Pagniez , Young M Na , Da Shi , Patricia Pinson Pharmaceuticals, 2020, 13 (8), 186 (32 p.). ⟨10.3390/ph13080186⟩ Article dans une revue hal-02913479v1
	Cobalt–Chromium Dental Alloys: Metal Exposures, Toxicological Risks, CMR Classification, and EU Regulatory Framework Alina Vaicelyte , Christine Janssen , Marc Le Borgne , Brigitte Grosgogeat Crystals, 2020, 10 (12), pp.1151. ⟨10.3390/cryst10121151⟩ Article dans une revue hal-03088443v1
	Fragment Linking Strategies for Structure-Based Drug Design Alexandre Bancet , Claire Raingeval , Thierry Lomberget , Marc Le Borgne , Jean-François Guichou Journal of Medicinal Chemistry, 2020, 63 (20), pp.11420-11435. ⟨10.1021/acs.jmedchem.0c00242⟩ Article dans une revue hal-02909120v1
	1D NMR WaterLOGSY as an efficient method for fragment-based lead discovery Claire Raingeval , Olivier Cala , Béatrice Brion , Marc Le Borgne , Roderick Eliot Hubbard Journal of Enzyme Inhibition and Medicinal Chemistry, 2019, 34 (1), pp.1218-1225. ⟨10.1080/14756366.2019.1636235⟩ Article dans une revue hal-02188259v1
	Comparison of SEC and AF4 analytical tools for size estimation of typhoid Vi polysaccharides Caroline Bayart , Elisa Jean , Marie Paillagot , Alexia Renoud , Alice Raillard Analytical Methods, 2019, ⟨10.1039/C9AY00145J⟩ Article dans une revue hal-02288665v1
	Synthesis and biological evaluation of zinc chelating compounds as metallo-β-lactamase inhibitors Geir Kildahl-Andersen , Christian Schnaars , Anthony Prandina , Sylvie Radix , Marc Le Borgne MedChemComm, inPress, 10 (4), pp.528-537. ⟨10.1039/C8MD00578H⟩ Article dans une revue hal-02077900v1
	Behaviour of Tetrabenazine in Acid Medium: Reassessment and Impact on Formulation Laurent Ettouati , Zoé Senta-Loys , Sandrine Bourgeois , Bernard Fenet , Marc Le Borgne Pharmaceutics, 2019, 11 (1), pp.44. ⟨10.3390/pharmaceutics11010044⟩ Article dans une revue hal-01987081v1
	A comparative adsorption study of benzophenone-3 onto synthesized lipophilic organosilicate, Laponite and montmorillonite Saddam Charaabi , Lucien Tchara , Christelle Marminon , Zouhair Bouaziz , Gérard Holtzinger Applied Clay Science, 2019, 170, pp.114-124. ⟨10.1016/j.clay.2019.01.005⟩ Article dans une revue hal-02004994v1
	Synthesis and biological evaluation of new dipicolylamine zinc chelators as metallo-β-lactamase inhibitors Anthony Prandina , Sylvie Radix , Marc Le Borgne , Lars Petter Jordheim , Zineb Bousfiha Tetrahedron, 2019, 75 (11), pp.1525-1540. ⟨10.1016/j.tet.2019.02.004⟩ Article dans une revue hal-02054167v1
	In vitro modulation of multidrug resistance by pregnane steroids and in vivo inhibition of tumour development by 7α-OBz-11α(R)-OTHP-5β-pregnanedione in K562/R7 and H295R cell xenografts Ghina Alameh , Agnès Emptoz-Bonneton , Marc Rolland de Ravel , Eva Matera , Elisabeth Mappus Journal of Enzyme Inhibition and Medicinal Chemistry, 2019, 34 (1), pp.684-691. ⟨10.1080/14756366.2019.1575825⟩ Article dans une revue hal-02077612v1
	Discovery of holoenzyme-disrupting chemicals as substrate-selective CK2 inhibitors Irina Kufareva , Benoît Bestgen , Paul Brear , Renaud Prudent , Béatrice Laudet Scientific Reports, 2019, 9 (1), pp.15893. ⟨10.1038/s41598-019-52141-5⟩ Article dans une revue hal-02348673v1
	Diacritic Binding of an Indenoindole Inhibitor by CK2α Paralogs Explored by a Reliable Path to Atomic Resolution CK2α′ Structures Dirk Lindenblatt , Anna Nickelsen , Violetta M Applegate , Jennifer Hochscherf , Benedict Witulski ACS Omega, 2019, 4 (3), pp.5471-5478. ⟨10.1021/acsomega.8b03415⟩ Article dans une revue hal-02077897v1
	Carbazole scaffolds in cancer therapy: a review from 2012 to 2018 Samar Issa , Anthony Prandina , Nicolas Bedel , Pal Rongved , Saïd Yous Journal of Enzyme Inhibition and Medicinal Chemistry, 2019, 34 (1), pp.1321-1346. ⟨10.1080/14756366.2019.1640692⟩ Article dans une revue hal-02190476v1
	2-Aminothiazole derivatives as selective allosteric modulators of the protein kinase CK2. Part 1: Identification of an allosteric binding site Benoît Bestgen , Isabelle Krimm , Irina Kufareva , Ahmed Kamal , Wei Guang Seetoh Journal of Medicinal Chemistry, 2019, 62 (4), pp.1803-1816. ⟨10.1021/acs.jmedchem.8b01766⟩ Article dans une revue hal-02004986v1
	2-Aminothiazole Derivatives as Selective Allosteric Modulators of the Protein Kinase CK2. 2. Structure-Based Optimization and Investigation of Effects Specific to the Allosteric Mode of Action Benoît Bestgen , Irina Kufareva , Weiguang Seetoh , Chris Abell , Rolf Hartmann Journal of Medicinal Chemistry, 2019, 62 (4), pp.1817-1836. ⟨10.1021/acs.jmedchem.8b01765⟩ Article dans une revue hal-02465880v1
	2-Aminothiazole derivatives as selective allosteric modulators of the protein kinase CK2. Part 2: Structure–based optimization and investigation of effects specific to the allosteric mode of action Benoît Bestgen , Irina Kufareva , Weiguang Seetoh , Chris Abell , Rolf W Hartmann Journal of Medicinal Chemistry, 2019, 62 (4), pp.1817-1836. ⟨10.1021/acs.jmedchem.8b01765⟩ Article dans une revue hal-02004987v1
	Self-Assembled Supramolecular Nanoparticles Improve the Cytotoxic Efficacy of CK2 Inhibitor THN7 Abdelhamid Nacereddine , Andre Bollacke , Eszter Roka , Christelle Marminon , Zouhair Bouaziz Pharmaceuticals, 2018, 11 ((1)10), ⟨10.3390/ph11010010⟩ Article dans une revue hal-01694352v1
	Enhancement of iodinin solubility by encapsulation into cyclodextrin nanoparticles Anthony Prandina , Lars Herfindal , Sylvie Radix , Pal Rongved , Stein Døskeland Journal of Enzyme Inhibition and Medicinal Chemistry, 2018, 33 (1), pp.370 - 375. ⟨10.1080/14756366.2017.1421638⟩ Article dans une revue hal-01688994v1
	Synthesis and preclinical evaluation of TPA-based zinc chelators as metallo-β-lactamase inhibitors Christian Schnaars , Geir Kildahl-Andersen , Anthony Prandina , Roya Popal , Sylvie Large Radix ACS Infectious Diseases, 2018, ⟨10.1021/acsinfecdis.8b00137⟩ Article dans une revue hal-01844562v1
	Synthesis, Spectroscopic Characterization, and In Vitro Antibacterial Evaluation of Novel Functionalized Sulfamidocarbonyloxyphosphonates Abdeslem Bouzina , Khaoula Bechlem , Hajira Berredjem , Billel Belhani , Imène Becheker Molecules, 2018, 23 (7), ⟨10.3390/molecules23071682⟩ Article dans une revue hal-01839215v1
	Synthesis, X-ray structure, in silico calculation, and carbonic anhydrase inhibitory properties of benzylimidazole metal complexes Mehdi Bouchouit , Sofiane Bouacida , Bachir Zouchoune , Hocine Merazig , Silvia Bua Journal of Enzyme Inhibition and Medicinal Chemistry, 2018, 33 (1), pp.1150 - 1159. ⟨10.1080/14756366.2018.1481404⟩ Article dans une revue hal-01839213v1
	Structure-based design and profiling of novel 17β-HSD14 inhibitors Florian Braun , Nicole Bertoletti , Gabriele Möller , Jerzy Adamski , Martin Frotscher European Journal of Medicinal Chemistry, 2018, 155, pp.61-76. ⟨10.1016/j.ejmech.2018.05.029⟩ Article dans une revue hal-01801297v1
	Inhibition of Shiga toxin-converting bacteriophage development by novel antioxidant compounds Sylwia Bloch , Bożena Nejman-Faleńczyk , Karolina Pierzynowska , Ewa Piotrowska , Alicja Węgrzyn Journal of Enzyme Inhibition and Medicinal Chemistry, 2018, 33 (1), pp.639 - 650. ⟨10.1080/14756366.2018.1444610⟩ Article dans une revue hal-01736468v1
	Sequential MCR/Fisher indolization strategy for the construction of polycyclic carbazole derivatives Esma Lamera , Sofiane Bouacida , Marc Le Borgne , Zouhair Bouaziz , Abdelmalek Bouraiou Tetrahedron Letters, 2017, 58 (13), pp.1305 - 1307. ⟨10.1016/j.tetlet.2017.02.047⟩ Article dans une revue hal-01683348v1
	Unexpected Binding Mode of a Potent Indeno[1,2-b]indole-Type Inhibitor of Protein Kinase CK2 Revealed by Complex Structures with the Catalytic Subunit CK2α and Its Paralog CK2α′ Jennifer Hochscherf , Dirk Lindenblatt , Benedict Witulski , Robin Birus , Dagmar Aichele Pharmaceuticals, 2017, 10 ((4)98), ⟨10.3390/ph10040098⟩ Article dans une revue hal-01683237v1
	Ebisilc® Organosilicate Particles for Innovative Galenic Formulation Saddam Charaabi , Pata-Eting Kougnassoukou Tchara , Zouhair Bouaziz , Christelle Marminon , Gérard Holtzinger Annals of Pharmacology and Pharmaceutics, 2017, 2(10), pp.1103 Article dans une revue hal-01806454v1
	Development of Pharmacophore Model for Indeno[1,2-b]indoles as Human Protein Kinase CK2 Inhibitors and Database Mining Samer Haidar , Zouhair Bouaziz , Christelle Marminon , Tuomo Laitinen , Antti Poso Pharmaceuticals, 2017, An Updated View on an Emerging Target: Selected Papers from the 8th International Conference on Protein Kinase CK2, 10 ((1)8), ⟨10.3390/ph10010008⟩ Article dans une revue hal-01683291v1
	Sleep Disorders and Therapeutic Management: A Survey in a French Population of Prisoners Anaïs Goudard , Laure Lalande , Camille Bertin , Marie Sautereau , Marc Le Borgne Journal of Correctional Health Care, 2017, 23 (2), pp.193 - 202. ⟨10.1177/1078345817700163⟩ Article dans une revue hal-01683241v1
	Editorial: An Updated View on an Emerging Target: Selected Papers from the 8th International Conference on Protein Kinase CK2 Joachim Jose , Marc Le-Borgne , Lorenzo Pinna , Mathias Montenarh Pharmaceuticals, 2017, Pharmaceuticals, 10 ((2)33), pp.33 - 33. ⟨10.3390/ph10020033⟩ Article dans une revue hal-01683242v1
	In Search of Small Molecule Inhibitors Targeting the Flexible CK2 Subunit Interface Benoît Bestgen , Zakia Belaid-Choucair , Thierry Lomberget , Marc Le Borgne , Odile Filhol Pharmaceuticals, 2017, An Updated View on an Emerging Target: Selected Papers from the 8th International Conference on Protein Kinase CK2, 10 ((1)16), ⟨10.3390/ph10010016⟩ Article dans une revue hal-01683243v1
	The combined use of analytical tools for exploring tetanus toxin and tetanus toxoid structures Caroline Bayart , Sébastien Peronin , Elisa Jean , Joseph Paladino , Philippe Talaga Journal of Chromatography B - Analytical Technologies in the Biomedical and Life Sciences, 2017, 1054, pp.80 - 92. ⟨10.1016/j.jchromb.2017.04.009⟩ Article dans une revue hal-01683240v1
	DMAP as a new efficient catalyst for the one-pot synthesis of condensed phthalazines Esma Lamera , Sofiane Bouacida , Hocine Merazig , Aïssa Chibani , Marc Le Borgne Zeitschrift fur Naturforschung B, 2017, 72 ((5)b), pp.361-368. ⟨10.1515/znb-2016-0262⟩ Article dans une revue hal-01683401v1
	2-Indolylmethylenebenzofuranones as first effective inhibitors of ABCC2 Elisabeta Baiceanu , Kim-Anh Nguyen , Lucia Gonzalez-Lobato , Rachad Nasr , Hélène Baubichon-Cortay European Journal of Medicinal Chemistry, 2016, 122, pp.408 - 418. ⟨10.1016/j.ejmech.2016.06.039⟩ Article dans une revue hal-01683292v1
	Screening of indeno[1,2-b]indoloquinones by MALDI-MS: a new set of potential CDC25 phosphatase inhibitors brought to light Faten Alchab , Estelle Sibille , Laurent Ettouati , Emilie Bana , Zouhair Bouaziz Journal of Enzyme Inhibition and Medicinal Chemistry, 2016, 31 (sup3), pp.25-32. ⟨10.1080/14756366.2016.1201480⟩ Article dans une revue hal-01655213v1
	Toward selective CK2alpha and CK2alpha’ inhibitors: Development of a novel whole-cell kinase assay by Autodisplay of catalytic CK2alpha’ Andre Bollacke , Christian Nienberg , Marc Le Borgne , Joachim Jose Journal of Pharmaceutical and Biomedical Analysis, 2016, 121, pp.253 - 260. ⟨10.1016/j.jpba.2016.01.011⟩ Article dans une revue hal-01683296v1
	Candidate Molecule Selection Based on In Silico Predicted ADMET Properties of 12 Indenoindole Derivatives Nathalie Guragossian , Gustavo Jabor Gozzi , Bruno Fouillet , Marie-Paule Gustin , Raphaël Terreux Chemical Informatics, 2016, 2 ((2)6), ⟨10.21767/2470-6973.100020⟩ Article dans une revue hal-01683399v1
	Synthesis of New Steroidal Inhibitors of P-Glycoprotein-Mediated Multidrug Resistance and Biological Evaluation on K562/R7 Erythroleukemia Cells Marc Rolland de Ravel , Ghina Alameh , Maxime Melikian , Zahia Mahiout , Agnès Emptoz-Bonneton Journal of Medicinal Chemistry, 2015, 58 (4), pp.1832 - 1845. ⟨10.1021/jm501676v⟩ Article dans une revue hal-01683301v1
	Microwave-assisted oxidation of indan-1-ones into ninhydrins Christelle Marminon , Abdelhamid Nacereddine , Zouhair Bouaziz , Pascal Nebois , Joachim Jose Tetrahedron Letters, 2015, 56 (14), pp.1840 - 1842. ⟨10.1016/j.tetlet.2015.02.086⟩ Article dans une revue hal-01683347v1
	Phenolic indeno[1,2-b]indoles as ABCG2-selective potent and non-toxic inhibitors stimulating basal ATPase activity. Gustavo Jabor Gozzi , Zouhair Bouaziz , Evelyn Winter , Nathalia Daflon-Yunes , Mylène Honorat Drug Design, Development and Therapy, 2015, 9, pp.3481-3495. ⟨10.2147/DDDT.S84982⟩ Article dans une revue hal-01179426v1
	Functional display of heterotetrameric human protein kinase CK2 on Escherichia coli: a novel tool for drug discovery Andre Gratz , Andre Bollacke , Sara Stephan , Christian Nienberg , Marc Le Borgne Microbial Cell Factories, 2015, 14 (74), ⟨10.1186/s12934-015-0263-z⟩ Article dans une revue hal-01683300v1
	Converting potent indeno[1,2-b]indole inhibitors of protein kinase CK2 into selective inhibitors of the breast cancer resistance protein ABCG2 Gustavo Jabor Gozzi , Zouhair Bouaziz , Evelyn Winter , Nathalia Daflon-Yunes , Dagmar Aichele Journal of Medicinal Chemistry, 2015, 58 (1), pp.265-77. ⟨10.1021/jm500943z⟩ Article dans une revue hal-01174925v1
	Biologically active carbazole derivatives: focus on oxazinocarbazoles and related compounds Zouhair Bouaziz , Samar Issa , Jacques Gentili , Andre Gratz , Andre Bollacke Journal of Enzyme Inhibition and Medicinal Chemistry, 2015, 30 (2), pp.180 - 188. ⟨10.3109/14756366.2014.899594⟩ Article dans une revue hal-01683306v1
	Crystal structure of 13-phenyl-2,3,4,13-tetrahydro-1 H -indazolo[1,2- b ]phthalazine-1,6,11-trione Esma Lamera , Saida Benzerka , Abdelmalek Bouraiou , Sofiane Bouacida , Hocine Merazig Acta crystallographica Section E : Crystallographic communications [2015-..], 2015, 71 (12), pp.o1036 - o1037. ⟨10.1107/S2056989015023452⟩ Article dans une revue hal-01683294v1
	Synthesis, Biological Evaluation and Molecular Modeling of Substituted Indeno[1,2-b]indoles as Inhibitors of Human Protein Kinase CK2. Faten Alchab , Laurent Ettouati , Zouhair Bouaziz , Andre Bollacke , Jean-Guy Delcros Pharmaceuticals, 2015, 8 (2), pp.279-302. ⟨10.3390/ph8020279⟩ Article dans une revue hal-01164133v1
	A one-pot three-component synthesis of novel α-sulfamidophosphonates under ultrasound irradiation and catalyst-free conditions Billel Belhani , Malika Berredjem , Marc Le Borgne , Zouhair Bouaziz , Jacques Lebreton RSC Advances, 2015, 5 (49), pp.39324 - 39329. ⟨10.1039/C5RA03473F⟩ Article dans une revue hal-01694993v1
	Mechanisms of depolymerization and activation of a polysialic acid and its tetramer by hydrogen peroxide Christophe Neyra , Joseph Paladino , Marc Le Borgne Carbohydrate Polymers, 2015, 115, pp.494 - 501. ⟨10.1016/j.carbpol.2014.08.112⟩ Article dans une revue hal-01683316v1
	Biomimetic synthesis of Tramadol Florine Lecerf-Schmidt , Romain Haudecoeur , Basile Peres , Marc Ferreira Queiroz , Marc Marcourt Chemical Communications, 2015, 51 (77), pp.14451 - 14453. ⟨10.1039/c5cc05948h⟩ Article dans une revue hal-01683298v1
	Structural elucidation of two photolytic degradation products of tetrabenazine Zouaoui Bourezg , Nathalie Cartiser , Laurent Ettouati , Jean Guillon , Aline Lacoudre Journal of Pharmaceutical and Biomedical Analysis, 2014, 91, pp.138 - 143. ⟨10.1016/j.jpba.2013.12.032⟩ Article dans une revue hal-01655151v1
	Oxidation of sialic acid using hydrogen peroxide as a new method to tune the reducing activity Christophe Neyra , Joseph Paladino , Marc Le Borgne Carbohydrate Research, 2014, 386, pp.92 - 98. ⟨10.1016/j.carres.2014.01.007⟩ Article dans une revue hal-01683314v1
	Discovery of 7-Aryl-Substituted (1,5-Naphthyridin-4-yl)ureas as Aurora Kinase Inhibitors Julien Defaux , Maud Antoine , Marc Le Borgne , Tilmann Schuster , Irene Seipelt ChemMedChem, 2014, 9 (1), pp.217 - 232. ⟨10.1002/cmdc.201300384⟩ Article dans une revue hal-01683307v1
	Discovery of (7-aryl-1,5-naphthyridin-2-yl)ureas as dual inhibitors of ERK2 and Aurora B kinases with antiproliferative activity against cancer cells Julien Defaux , Maud Antoine , Cédric Logé , Marc Le Borgne , Tilmann Schuster Bioorganic and Medicinal Chemistry Letters, 2014, 24 (16), pp.3748 - 3752. ⟨10.1016/j.bmcl.2014.06.078⟩ Article dans une revue hal-01683305v1
	Indenoindoles and cyclopentacarbazoles as bioactive compounds: Synthesis and biological applications Pal Rongved , Gilbert Kirsch , Zouhair Bouaziz , Joachim Jose , Marc Le Borgne European Journal of Medicinal Chemistry, 2013, 69, pp.465 - 479. ⟨10.1016/j.ejmech.2013.08.049⟩ Article dans une revue hal-01524692v1
	Preparation and characterization of CK2 inhibitor-loaded cyclodextrin nanoparticles for drug delivery Florent Perret , Christelle Marminon , Wael Zeinyeh , Pascal Nebois , Andre Bollacke International Journal of Pharmaceutics, 2013, 441 (1-2), pp.491 - 498. ⟨10.1016/j.ijpharm.2012.11.004⟩ Article dans une revue hal-01683336v1
	Synthesis and biological evaluation of novel substituted pyrrolo[1,2-a]quinoxaline derivatives as inhibitors of the human protein kinase CK2 Jean Guillon , Marc Le Borgne , Charlotte Rimbault , Stéphane Moreau , Solène Savrimoutou European Journal of Medicinal Chemistry, 2013, 65, pp.205 - 222. ⟨10.1016/j.ejmech.2013.04.051⟩ Article dans une revue hal-01683308v1
	A safe and practical method for the preparation of 7α-thioether and thioester derivatives of spironolactone Géraldine Agusti , Sandrine Bourgeois , Nathalie Cartiser , Hatem Fessi , Marc Le Borgne Steroids, 2013, 78 (1), pp.102 - 107. ⟨10.1016/j.steroids.2012.09.005⟩ Article dans une revue hal-01683309v1
	African tree gets to the root of pain Ahcène Boumendjel , Germain Sotoing Taïwe , Elisabeth Ngo Gum , Tanguy Chabrol , Chantal Beney Nature, 2013, 501 (7467), pp.285 - 285. ⟨10.1038/501285b⟩ Article dans une revue hal-01683403v1
	Occurrence of the Synthetic Analgesic Tramadol in an African Medicinal Plant. Ahcène Boumendjel , Germain Sotoing Taïwe , Elisabeth Ngo Bum , Tanguy Chabrol , Chantal Beney Angewandte Chemie International Edition, 2013, 52 (45), pp.11780-4. ⟨10.1002/anie.201305697⟩ Article dans une revue inserm-00874145v1
	1H and 13C NMR assignments of bioactive indeno[1,2-b]indole-10-one derivatives Faten Al Chab , Bernard Fenet , Marc Le Borgne , Joachim Jose , Noël Pinaud Magnetic Resonance in Chemistry, 2013, 51 (12), pp.837 - 841. ⟨10.1002/mrc.4016⟩ Article dans une revue hal-01655126v1
	Novel indeno[1,2-b]indoloquinones as inhibitors of the human protein kinase CK2 with antiproliferative activity towards a broad panel of cancer cell lines Claas Hundsdörfer , Hans-Jörg Hemmerling , Janina Hamberger , Marc Le Borgne , Patrick Bednarski Biochemical and Biophysical Research Communications, 2012, 424 (1), pp.71 - 75. ⟨10.1016/j.bbrc.2012.06.068⟩ Article dans une revue hal-01683311v1
	Indeno[1,2-b]indole derivatives as a novel class of potent human protein kinase CK2 inhibitors Claas Hundsdörfer , Hans-Jörg Hemmerling , Claudia Götz , Frank Totzke , Patrick Bednarski Bioorganic and Medicinal Chemistry, 2012, 20 (7), pp.2282 - 2289. ⟨10.1016/j.bmc.2012.02.017⟩ Article dans une revue hal-01683312v1
	Design, Synthesis, and in vitro Antifungal Activity of 1-[(4-Substituted-benzyl)methylamino]-2-(2,4-difluorophenyl)-3-(1H-1,2,4-triazol-1-yl)propan-2-ols Rémi Guillon , Fabrice Pagniez , Francis Giraud , Damien Crépin , Carine Picot ChemMedChem, 2011, 6 (5), pp.816 - 825. ⟨10.1002/cmdc.201000530⟩ Article dans une revue hal-01689176v1
	Design of new antifungal agents: synthesis and evaluation of 1-[(1H-indol-5-ylmethyl)amino]-2-phenyl-3-(1H-1,2,4-triazol-1-yl)propan-2-ols Rémi Guillon , Francis Giraud , Cédric Logé , Marc Le Borgne , Carine Picot Bioorganic and Medicinal Chemistry Letters, 2009, 19 (20), pp.5833 - 5836. ⟨10.1016/j.bmcl.2009.08.089⟩ Article dans une revue hal-01689189v1
	Design, synthesis and evaluation of 3-(imidazol- 1-ylmethyl)indoles as antileishmanial agents. Part II Francis Giraud , Cédric Logé , Fabrice Pagniez , Damien Crepin , Sophie Barres Journal of Enzyme Inhibition and Medicinal Chemistry, 2009, 24 (5), pp.1067 - 1075. ⟨10.1080/14756360802610795⟩ Article dans une revue hal-01689191v1
	Synthesis and structure–activity relationships of 2-phenyl-1-[(pyridinyl- and piperidinylmethyl)amino]-3-(1H-1,2,4-triazol-1-yl)propan-2-ols as antifungal agents Francis Giraud , Rémi Guillon , Cédric Logé , Fabrice Pagniez , Carine Picot Bioorganic and Medicinal Chemistry Letters, 2009, 19 (2), pp.301 - 304. ⟨10.1016/j.bmcl.2008.11.101⟩ Article dans une revue hal-01689192v1
	Design, synthesis, and evaluation of 1-(N-benzylamino)-2-phenyl-3-(1H-1,2,4-triazol-1-yl)propan-2-ols as antifungal agents Francis Giraud , Cédric Logé , Fabrice Pagniez , Damien Crepin , Patrice Le Pape Bioorganic and Medicinal Chemistry Letters, 2008, 18 (6), pp.1820 - 1824. ⟨10.1016/j.bmcl.2008.02.027⟩ Article dans une revue hal-01689196v1
	Synthesis of 6- or 4-functionalized indoles via a reductive cyclization approach and evaluation as aromatase inhibitors Marie-Pierre Lézé , Anja Palusczak , Rolf W Hartmann , Marc Le Borgne Bioorganic and Medicinal Chemistry Letters, 2008, 18 (16), pp.4713 - 4715. ⟨10.1016/j.bmcl.2008.06.094⟩ Article dans une revue hal-01689195v1
	Synthesis and antifungal activities of new fluconazole analogues with azaheterocycle moiety Nicolas Lebouvier , Fabrice Pagniez , Muriel Duflos , Patrice Le Pape , Young Min Na Bioorganic and Medicinal Chemistry Letters, 2007, 17 (13), pp.3686 - 3689. ⟨10.1016/j.bmcl.2007.04.038⟩ Article dans une revue hal-01689197v1
	Synthesis and biological evaluation of 3-(azolylmethyl)-1 H -indoles and 3-(α-azolylbenzyl)-1 H -indoles as selective aromatase inhibitors Marc Le Borgne , Pascal Marchand , Marie-Renée Nourrisson , Denis Loquet , Martina Palzer Journal of Enzyme Inhibition and Medicinal Chemistry, 2007, 22 (5), pp.667 - 676. ⟨10.1080/14756360701652658⟩ Article dans une revue hal-01689199v1
	A 3D-QSAR CoMSIA study on 3-azolylmethylindoles as anti-leishmanial agents Francis Giraud , Cédric Logé , Marc Le Borgne , Francis Pagniez , Young Min Na SAR and QSAR in Environmental Research, 2006, 17 (3), pp.299 - 309. ⟨10.1080/10659360600787494⟩ Article dans une revue hal-01689291v1
	Antileishmanial activities and mechanisms of action of indole-based azoles Fabrice Pagniez , Hiam Abdala-Valencia , Pascal Marchand , Marc Le Borgne , Guillaume Le Baut Journal of Enzyme Inhibition and Medicinal Chemistry, 2006, 21 (3), pp.277 - 283. ⟨10.1080/14756360600700517⟩ Article dans une revue hal-01689215v1
	Synthesis and biological evaluation of 5-[(aryl)(1H-imidazol-1-yl)methyl]-1H-indoles: Potent and selective aromatase inhibitors Marie-Pierre Lézé , Marc Le Borgne , Patricia Pinson , Anja Palusczak , Muriel Duflos Bioorganic and Medicinal Chemistry Letters, 2006, 16 (5), pp.1134 - 1137. ⟨10.1016/j.bmcl.2005.11.099⟩ Article dans une revue hal-01689230v1
	Efficient microwave-assisted synthesis of 1-(1H-indol-1-yl)-2-phenyl-3-(1H-1,2,4-triazol-1-yl)propan-2-ols as antifungal agents Nicolas Lebouvier , Francis Giraud , Typhanie Corbin , Young Min Na , Guillaume Le Baut Tetrahedron Letters, 2006, 47 (36), pp.6479 - 6483. ⟨10.1016/j.tetlet.2006.03.199⟩ Article dans une revue hal-01689208v1
	Three-dimensional model of cytochrome P450 human aromatase Cédric Logé , Marc Le Borgne , Pascal Marchand , Jean-Michel Robert , Guillaume Le Baut Journal of Enzyme Inhibition and Medicinal Chemistry, 2005, 20 (6), pp.581 - 585. ⟨10.1080/14756360500220574⟩ Article dans une revue hal-01689233v1
	2- and 3-[(Aryl)(azolyl)methyl]indoles as Potential Non-steroidal Aromatase Inhibitors Marie-Pierre Lézé , Marc Le Borgne , Pascal Marchand , Denis Loquet , Manuela Kogler Journal of Enzyme Inhibition and Medicinal Chemistry, 2004, 19 (6), pp.549 - 557. ⟨10.1080/14756360400004631⟩ Article dans une revue hal-01689238v1
	Synthesis and Antileishmanial Activity of 3-Imidazolylalkylindoles. Part I Young Min Na , Nicolas Lebouvier , Marc Le Borgne , Fabrice Pagniez , Nidia Alvarez Journal of Enzyme Inhibition and Medicinal Chemistry, 2004, 19 (6), pp.451 - 457. ⟨10.1080/14756360412331280509⟩ Article dans une revue hal-01689240v1
	Retinoic Acid Metabolism Inhibition by 3-Azolylmethyl-1 H -indoles and 2, 3 or 5-(α-Azolylbenzyl)-1 H -indoles Marc Le Borgne , Pascal Marchand , Guillaume Le Baut , Masoud Ahmadi , H. John Smith Journal of Enzyme Inhibition and Medicinal Chemistry, 2003, 18 (2), pp.155 - 158. ⟨10.1080/1475636032000069819⟩ Article dans une revue hal-01689267v1
	Preparation and pharmacological profile of 7-(α-Azolylbenzyl)-1H-indoles and indolines as new aromatase inhibitors Pascal Marchand , Marc Le Borgne , Martina Palzer , Guillaume Le Baut , Rolf W Hartmann Bioorganic and Medicinal Chemistry Letters, 2003, 13 (9), pp.1553 - 1555. ⟨10.1016/S0960-894X(03)00182-3⟩ Article dans une revue hal-01689266v1
	Synthesis and antifungal activity of new 1-halogenobenzyl-3-imidazolylmethylindole derivatives Young M Na , Marc Le Borgne , Fabrice Pagniez , Guillaume Le Baut , Patrice Le Pape European Journal of Medicinal Chemistry, 2003, 38 (1), pp.75 - 87. ⟨10.1016/S0223-5234(02)00005-3⟩ Article dans une revue hal-01689264v1
	Synthesis and Antileishmanial Activity of 3-(α-Azolylbenzyl)indoles Pascal Marchand , Marc Le Borgne , Young Min Na , Fabrice Pagniez , Hiam Abdala Journal of Enzyme Inhibition and Medicinal Chemistry, 2002, 17 (6), pp.353 - 358. ⟨10.1080/1475636021000005613⟩ Article dans une revue hal-01689261v1
	In Vitro Activity of a New Antifungal Azolyl-substituted Indole Against Aspergillus fumigatus Fabrice Pagniez , Marc Le Borgne , Pascal Marchand , Young Min Na , Guillaume Le Baut Journal of Enzyme Inhibition and Medicinal Chemistry, 2002, 17 (6), pp.425 - 429. ⟨10.1080/1475636021000005686⟩ Article dans une revue hal-01689259v1
	Potential application of plant lipid transfer proteins for drug delivery Christine Pato , Marc Le Borgne , Guillaume Le Baut , Patrice Le Pape , Didier Marion Biochemical Pharmacology, 2001, 62 (5), pp.555 - 560. ⟨10.1016/S0006-2952(01)00708-0⟩ Article dans une revue hal-01689248v1
	Dérivés indoliques à activités anti-inflammatoire ou antitumorale Marc Le Borgne , Muriel Duflos , Guillaume Le Baut , Paul J Nicholls Annales Pharmaceutiques Françaises, 2000, 58 (5), pp.316 - 320 Article dans une revue hal-01689246v1
	New selective nonsteroidal aromatase inhibitors: Synthesis and inhibitory activity of 2,3 or 5-(α-azolylbenzyl)-1H-indoles Marc Le Borgne , Pascal Marchand , Bénédicte Delevoye-Seiller , Jean-Michel Robert , Guillaume Le Baut Bioorganic and Medicinal Chemistry Letters, 1999, 9 (3), pp.333 - 336. ⟨10.1016/S0960-894X(98)00737-9⟩ Article dans une revue hal-01689251v1
	3-(Azolylmethyl)-1H-indoles as Selective P450 Aromatase Inhibitors Pascal Marchand , Marc Le Borgne , Muriel Duflos , Sylvie Piessard-Robert , Guillaume Le Baut Pharmacy and Pharmacology Communications, 1998, 4 (4), pp.211 - 218. ⟨10.1111/j.2042-7158.1998.tb00337.x⟩ Article dans une revue hal-01689256v1
	Comparison of the In-vitro Aromatase Inhibitory Activity of 3-(Azolylmethyl)-1H-indoles Marc Le Borgne , Pascal Marchand , Muriel Duflos , Sylvie Piessard-Robert , Guillaume Le Baut Pharmacy and Pharmacology Communications, 1997, 3 (5-6), pp.279 - 281. ⟨10.1111/j.2042-7158.1997.tb00264.x⟩ Article dans une revue hal-01689254v1
	Synthesis andIn Vitro Evaluation of 3-(1-Azolylmethyl)-1H-indoles and 3-(1-Azolyl-1-phenylmethyl)-1H-indoles as Inhibitors of P450 arom Marc Le Borgne , Pascal Marchand , Muriel Duflos , Bénédicte Delevoye-Seiller , Sylvie Piessard-Robert Archiv der Pharmazie / Chemistry in Life Sciences, 1997, 330 (5), pp.141 - 145. ⟨10.1002/ardp.19973300506⟩ Article dans une revue hal-01689244v1

	The Journey Towards Solubility Assessment of Small Molecules Using HPLC-DAD Nada Hemmani , Anaïs Cacilie Martin , Andy Larivière , Mathis Tresallet , Kensa Tchang 8th International Electronic Conference on Medicinal Chemistry, Nov 2022, Basel (on line), Switzerland. ⟨10.3390/ECMC2022-13143⟩ Communication dans un congrès hal-03840347v1
	Biological evaluation of 4,5,7-trisubstituted Indeno[1,2-b]indoles reveals a potent inhibitor of protein kinase CK2 in tumor cells with diverse anti-cancer effects and preferential cytoplasmic localization Robin Birus , Ehab El-Awaad , Laurens Ballentin , Faten Alchab , Dagmar Aichele 7th International Electronic Conference on Medicinal Chemistry, Nov 2021, Basel, Switzerland. pp.11450, ⟨10.3390/ECMC2021-11450⟩ Communication dans un congrès hal-03552581v1
	Development of water-soluble ternary system for enhancing biological activities of mefenamic acid Dounia Sid , Milad Baitiche , Zineb Elbahri , Ferhat Djerboua , Mokhtar Boutahala 6th International Electronic Conference on Medicinal Chemistry, Nov 2020, Basel, Switzerland. pp.7461, ⟨10.3390/ECMC2020-07461⟩ Communication dans un congrès hal-03566171v1
	Isoform specific inhibition of human protein kinase CK2α and CK2α’ by an indenoindole derivative Anna Nickelsen , Dirk Lindenblatt , Violetta Applegate , Jennifer Hochscherf , Benedict Witulski 6th International Electronic Conference on Medicinal Chemistry, Nov 2020, Basel, Switzerland. pp.7505, ⟨10.3390/ECMC2020-07505⟩ Communication dans un congrès hal-03566145v1
	Indeno[1,2-<em>b</em>]indole scaffold in drug discovery: An effective template in kinase inhibitor medicinal chemistry Robin Birus , Christelle Marminon , Dagmar Aichele , Samer Haidar , Marine Ousset 6th International Electronic Conference on Medicinal Chemistry, Nov 2020, Basel, Switzerland. pp.7433, ⟨10.3390/ECMC2020-07433⟩ Communication dans un congrès hal-03566434v1
	Design, Synthesis, X-ray Structure and Evaluation of Functionalized Hexacyclic Carbazoles as New Inhibitors of ABCG2 Transporter Isadora da Silva Zanzarini , Esma Lamera , Sofiane Bouacida , Ingrid Fatima Zattoni , Diogo Henrique Kita 5th International Electronic Conference on Medicinal Chemistry, Nov 2019, Basel, Switzerland Communication dans un congrès hal-02480387v1
	Investigation of pharmacokinetic properties of CK2 Inhibitors with an Indeno[1,2-b]indole scaffold Robin Birus , Marc Le Borgne , Joachim Jose 5th International Electronic Conference on Medicinal Chemistry, Nov 2019, Basel, Switzerland Communication dans un congrès hal-02480385v1
	Development of Pharmacophore Model for Indeno[1,2-b]indoles as Human Protein Kinase CK2 Inhibitors and Database Mining Samer Haidar , Zouhair Bouaziz , Christelle Marminon , Tiomo Laitinen , Anti Poso 3rd International Electronic Conference on Medicinal Chemistry, Nov 2017, Basel, Switzerland Communication dans un congrès hal-02480388v1
	25th Conference of GP2A Joachim Jose , Marc Le Borgne , Karsten Niefind 25th Conference of GP2A, Aug 2017, Liverpool, United Kingdom. pp.9-10/2.12, ⟨10.3390/ph10040097⟩ Communication dans un congrès hal-01683410v1
	Indeno[1,2-b]indole Inhibitors of Human Protein Kinase CK2 and Their Impact on Different Tumor Cell Lines (A021) Dagmar Aichele , Marc Le Borgne , Joachim Jose Second International Electronic Conference on Medicinal Chemistry (ECMC-2), Nov 2016, Bâle, Switzerland. pp.15/A021, ⟨10.3390/ph10010020⟩ Communication dans un congrès hal-01683452v1
	Advances in peptidomimetics as inhibitors of ABC transporters Laurent Ettouati , Marie-Emmanuelle Million , Ophélie Arnaud , Géraldine Agusti , Waël Zeinyeh 1st International Electronic Conference on Medicinal Chemistry, Nov 2015, sciforum.net, France. ⟨10.3390/ecmc-1-A043⟩ Communication dans un congrès hal-01710182v1

	An Updated View on an Emerging Target: Selected Papers from the 8 th International Conference on Protein Kinase CK2 Joachim Jose , Marc Le Borgne , Lorenzo A Pinna , Mathias Montenarh MDPI AG, 2017, 978-3-03842-413-0 Ouvrages hal-01700408v1

Marc Le Borgne

Présentation

Publications

New 2,4-bis[(substituted-aminomethyl)phenyl]phenylquinazoline and 2,4-bis[(substituted-aminomethyl)phenyl]phenylquinoline derivatives: synthesis and biological evaluation as novel anticancer agents by targeting G-quadruplex

Drug candidates targeting multidrug resistance in cancer and infections

Inhibitors of ABCG2-mediated multidrug resistance: Lead generation through computer-aided drug design

Formulation and Investigation of CK2 Inhibitor-Loaded Alginate Microbeads with Different Excipients

Toxicological Risks of the Cobalt–Chromium Alloys in Dentistry: A Systematic Review

Improved biological performance of ketoprofen using novel modified halloysite clay nanotubes

4,5,7‐trisubstituted indeno[1,2‐ b ]indole inhibits CK2 activity in tumor cells equivalent to CX‐4945 and shows strong anti‐migratory effects

Tetanus Toxin Fragment C: Structure, Drug Discovery Research and Production

Adsorption studies of benzophenone-3 onto clay minerals and organosilicates: Kinetics and modelling

Brain safety concerns of nanomedicines: The need for a specific regulatory framework

Broad-Spectrum Anticancer Activity and Pharmacokinetic Properties of a Prenyloxy-Substituted Indeno[1,2-b]indole Derivative, Discovered as CK2 Inhibitor

Ninhydrins inhibit carbonic anhydrases directly binding to the metal ion

Solubility enhancement of mefenamic acid by inclusion complex with β-cyclodextrin: in silico modelling, formulation, characterisation, and in vitro studies

Uncompetitive nanomolar dimeric indenoindole inhibitors of the human breast cancer resistance pump ABCG2

Microwave-accelerated multicomponent synthesis and X-ray characterization of novel benzothiadiazinone dioxide derivatives, analogues of Monastrol

Mechanistic basis of breast cancer resistance protein inhibition by new indeno[1,2-b]indoles

Alliages dentaires cobalt-chrome : compatibilité entre le cadre réglementaire européen et la convention nationale ?

Improved Surface Display of Human Hyal1 and Identification of Testosterone Propionate and Chicoric Acid as New Inhibitors

QSAR Model of Indeno[1,2-b]indole Derivatives and Identification of N-isopentyl-2-methyl-4,9-dioxo-4,9-Dihydronaphtho[2,3-b]furan-3-carboxamide as a Potent CK2 Inhibitor

Biological exploration of a novel 1,2,4-triazole-indole hybrid molecule as antifungal agent

Synthesis of new piperazinyl-pyrrolo[1,2- a ]quinoxaline derivatives as inhibitors of Candida albicans multidrug transporters by a Buchwald–Hartwig cross-coupling reaction

Synthesis, Optimization, Antifungal Activity, Selectivity, and CYP51 Binding of New 2-Aryl-3-azolyl-1-indolyl-propan-2-ols

Cobalt–Chromium Dental Alloys: Metal Exposures, Toxicological Risks, CMR Classification, and EU Regulatory Framework

Fragment Linking Strategies for Structure-Based Drug Design

1D NMR WaterLOGSY as an efficient method for fragment-based lead discovery

Comparison of SEC and AF4 analytical tools for size estimation of typhoid Vi polysaccharides

Synthesis and biological evaluation of zinc chelating compounds as metallo-β-lactamase inhibitors

Behaviour of Tetrabenazine in Acid Medium: Reassessment and Impact on Formulation

A comparative adsorption study of benzophenone-3 onto synthesized lipophilic organosilicate, Laponite and montmorillonite

Synthesis and biological evaluation of new dipicolylamine zinc chelators as metallo-β-lactamase inhibitors

In vitro modulation of multidrug resistance by pregnane steroids and in vivo inhibition of tumour development by 7α-OBz-11α(R)-OTHP-5β-pregnanedione in K562/R7 and H295R cell xenografts

Discovery of holoenzyme-disrupting chemicals as substrate-selective CK2 inhibitors

Diacritic Binding of an Indenoindole Inhibitor by CK2α Paralogs Explored by a Reliable Path to Atomic Resolution CK2α′ Structures

Carbazole scaffolds in cancer therapy: a review from 2012 to 2018

2-Aminothiazole derivatives as selective allosteric modulators of the protein kinase CK2. Part 1: Identification of an allosteric binding site

2-Aminothiazole Derivatives as Selective Allosteric Modulators of the Protein Kinase CK2. 2. Structure-Based Optimization and Investigation of Effects Specific to the Allosteric Mode of Action

2-Aminothiazole derivatives as selective allosteric modulators of the protein kinase CK2. Part 2: Structure–based optimization and investigation of effects specific to the allosteric mode of action

Self-Assembled Supramolecular Nanoparticles Improve the Cytotoxic Efficacy of CK2 Inhibitor THN7

Enhancement of iodinin solubility by encapsulation into cyclodextrin nanoparticles

Synthesis and preclinical evaluation of TPA-based zinc chelators as metallo-β-lactamase inhibitors

Synthesis, Spectroscopic Characterization, and In Vitro Antibacterial Evaluation of Novel Functionalized Sulfamidocarbonyloxyphosphonates

Synthesis, X-ray structure, in silico calculation, and carbonic anhydrase inhibitory properties of benzylimidazole metal complexes

Structure-based design and profiling of novel 17β-HSD14 inhibitors

Inhibition of Shiga toxin-converting bacteriophage development by novel antioxidant compounds

Sequential MCR/Fisher indolization strategy for the construction of polycyclic carbazole derivatives

Unexpected Binding Mode of a Potent Indeno[1,2-b]indole-Type Inhibitor of Protein Kinase CK2 Revealed by Complex Structures with the Catalytic Subunit CK2α and Its Paralog CK2α′

Ebisilc® Organosilicate Particles for Innovative Galenic Formulation

Development of Pharmacophore Model for Indeno[1,2-b]indoles as Human Protein Kinase CK2 Inhibitors and Database Mining

Sleep Disorders and Therapeutic Management: A Survey in a French Population of Prisoners

Editorial: An Updated View on an Emerging Target: Selected Papers from the 8th International Conference on Protein Kinase CK2

In Search of Small Molecule Inhibitors Targeting the Flexible CK2 Subunit Interface

The combined use of analytical tools for exploring tetanus toxin and tetanus toxoid structures

DMAP as a new efficient catalyst for the one-pot synthesis of condensed phthalazines

2-Indolylmethylenebenzofuranones as first effective inhibitors of ABCC2

Screening of indeno[1,2-b]indoloquinones by MALDI-MS: a new set of potential CDC25 phosphatase inhibitors brought to light

Toward selective CK2alpha and CK2alpha’ inhibitors: Development of a novel whole-cell kinase assay by Autodisplay of catalytic CK2alpha’

Candidate Molecule Selection Based on In Silico Predicted ADMET Properties of 12 Indenoindole Derivatives

Synthesis of New Steroidal Inhibitors of P-Glycoprotein-Mediated Multidrug Resistance and Biological Evaluation on K562/R7 Erythroleukemia Cells

Microwave-assisted oxidation of indan-1-ones into ninhydrins

Phenolic indeno[1,2-b]indoles as ABCG2-selective potent and non-toxic inhibitors stimulating basal ATPase activity.

Functional display of heterotetrameric human protein kinase CK2 on Escherichia coli: a novel tool for drug discovery

Converting potent indeno[1,2-b]indole inhibitors of protein kinase CK2 into selective inhibitors of the breast cancer resistance protein ABCG2

Biologically active carbazole derivatives: focus on oxazinocarbazoles and related compounds

Crystal structure of 13-phenyl-2,3,4,13-tetrahydro-1 H -indazolo[1,2- b ]phthalazine-1,6,11-trione

Synthesis, Biological Evaluation and Molecular Modeling of Substituted Indeno[1,2-b]indoles as Inhibitors of Human Protein Kinase CK2.

A one-pot three-component synthesis of novel α-sulfamidophosphonates under ultrasound irradiation and catalyst-free conditions

Mechanisms of depolymerization and activation of a polysialic acid and its tetramer by hydrogen peroxide

Biomimetic synthesis of Tramadol

Structural elucidation of two photolytic degradation products of tetrabenazine

Oxidation of sialic acid using hydrogen peroxide as a new method to tune the reducing activity

Discovery of 7-Aryl-Substituted (1,5-Naphthyridin-4-yl)ureas as Aurora Kinase Inhibitors

Discovery of (7-aryl-1,5-naphthyridin-2-yl)ureas as dual inhibitors of ERK2 and Aurora B kinases with antiproliferative activity against cancer cells

Indenoindoles and cyclopentacarbazoles as bioactive compounds: Synthesis and biological applications

Preparation and characterization of CK2 inhibitor-loaded cyclodextrin nanoparticles for drug delivery

Synthesis and biological evaluation of novel substituted pyrrolo[1,2-a]quinoxaline derivatives as inhibitors of the human protein kinase CK2

A safe and practical method for the preparation of 7α-thioether and thioester derivatives of spironolactone

African tree gets to the root of pain