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77

Marc Le Borgne


Main dates:

2011-       Director of the Research Team EA 4446 B2MC, UCBL.

2009-       Student Exchange Correspondent with Canada and USA, Faculty of Pharmacy, UCBL.

2008        Recruitment as Professor in Medicinal Chemistry, Faculty of Pharmacy - University Lyon 1 (UCBL).

2007        Habilitation in Medicinal Chemistry, national examination - Paris.

2005/08   Vice-Dean in charge of general affairs, logistics and international cooperation, Faculty of Pharmacy - Univ. Nantes.

2003       Accreditation to supervise research (HDR diploma) in Medicinal Chemistry. Title: “Taylor-made molecules as aromatase inhibitors and antifungal agents” - Univ. Nantes.

2000        Research assistant (1997-1999) and Assistant Professor (2000-2008) in the Laboratory of Medicinal Chemistry, Faculty of Pharmacy - Univ. Nantes.

               Lecturer within the framework of continuing education of Pharmacists - Association of Post University Higher Education in Pharmacy - Region Loire-Atlantique.

1998        Thesis award in physico-chemical sciences, awarded by the French Academy of Pharmacy.

1997        Pharmaco-chemistry Ph-D at the Univ. Nantes.

1994        PharmD at the Univ. Nantes.

1992        Practice of Pharmacy (POP) at the Welsh School of Pharmacy.

Research field:

Design, synthesis and structural optimization of functionalized small molecules as anticancer agents, efflux pump inhibitors and anti-infective agents.

Some scaffolds developed: indole, naphthyridine, indeno[1,2-b]indole.

Education experience:

Medicinal Chemistry (design, synthesis, optimization, SAR analysis, ADMET, therapeutic uses).

Drug Lifecycle and Industrial Property Rights at Univ. Lyon 1.


Article dans une revue71 documents

  • Christian Schnaars, Geir Kildahl-Andersen, Anthony Prandina, Roya Popal, Sylvie Large Radix, et al.. Synthesis and preclinical evaluation of TPA-based zinc chelators as metallo-β-lactamase inhibitors. ACS infectious diseases, 2018, 〈10.1021/acsinfecdis.8b00137〉. 〈hal-01844562〉
  • Abdelhamid Nacereddine, Andre Bollacke, Eszter Roka, Christelle Marminon, Zouhair Bouaziz, et al.. Self-Assembled Supramolecular Nanoparticles Improve the Cytotoxic Efficacy of CK2 Inhibitor THN7. Pharmaceuticals, MDPI, Molecular Diversity Preservation International, 2018, 11 ((1)10), 〈10.3390/ph11010010〉. 〈hal-01694352〉
  • Anthony Prandina, Lars Herfindal, Sylvie Radix, Pal Rongved, Stein Døskeland, et al.. Enhancement of iodinin solubility by encapsulation into cyclodextrin nanoparticles. Journal of Enzyme Inhibition and Medicinal Chemistry, Informa Healthcare, 2018, 33 (1), pp.370 - 375. 〈10.1080/14756366.2017.1421638〉. 〈hal-01688994〉
  • Sylwia Bloch, Bożena Nejman-Faleńczyk, Karolina Pierzynowska, Ewa Piotrowska, Alicja Węgrzyn, et al.. Inhibition of Shiga toxin-converting bacteriophage development by novel antioxidant compounds. Journal of Enzyme Inhibition and Medicinal Chemistry, Informa Healthcare, 2018, 33 (1), pp.639 - 650. 〈10.1080/14756366.2018.1444610〉. 〈hal-01736468〉
  • Mehdi Bouchouit, Sofiane Bouacida, Bachir Zouchoune, Hocine Merazig, Silvia Bua, et al.. Synthesis, X-ray structure, in silico calculation, and carbonic anhydrase inhibitory properties of benzylimidazole metal complexes. Journal of Enzyme Inhibition and Medicinal Chemistry, Informa Healthcare, 2018, 33 (1), pp.1150 - 1159. 〈10.1080/14756366.2018.1481404〉. 〈hal-01839213〉
  • Florian Braun, Nicole Bertoletti, Gabriele Möller, Jerzy Adamski, Martin Frotscher, et al.. Structure-based design and profiling of novel 17β-HSD14 inhibitors. European Journal of Medicinal Chemistry, Elsevier, 2018, 155, pp.61-76. 〈https://www-sciencedirect-com.docelec.univ-lyon1.fr/science/article/pii/S0223523418304422?via%3Dihub〉. 〈10.1016/j.ejmech.2018.05.029〉. 〈hal-01801297〉
  • Abdeslem Bouzina, Khaoula Bechlem, Hajira Berredjem, Billel Belhani, Imène Becheker, et al.. Synthesis, Spectroscopic Characterization, and In Vitro Antibacterial Evaluation of Novel Functionalized Sulfamidocarbonyloxyphosphonates. Molecules, MDPI, 2018, 23 (7), 〈10.3390/molecules23071682〉. 〈hal-01839215〉
  • Esma Lamera, Sofiane Bouacida, Hocine Merazig, Aïssa Chibani, Marc Le Borgne, et al.. DMAP as a new efficient catalyst for the one-pot synthesis of condensed phthalazines. Zeitschrift fur Naturforschung B, Verlag der Zeitschrift Fuer Naturforschung, 2017, 72 ((5)b), pp.361-368. 〈10.1515/znb-2016-0262〉. 〈hal-01683401〉
  • Saddam Charaabi, Pata-Eting Tchara, Zouhair Bouaziz, Christelle Marminon, Gérard Holtzinger, et al.. Ebisilc® Organosilicate Particles for Innovative Galenic Formulation. Annals of Pharmacology and Pharmaceutics, Remedy Publications LLC, 2017, 2(20), pp.1103. 〈hal-01806454〉
  • Benoît Bestgen, Zakia Belaid-Choucair, Thierry Lomberget, Marc Le Borgne, Odile Filhol, et al.. In Search of Small Molecule Inhibitors Targeting the Flexible CK2 Subunit Interface. Pharmaceuticals, MDPI, Molecular Diversity Preservation International, 2017, An Updated View on an Emerging Target: Selected Papers from the 8th International Conference on Protein Kinase CK2, 10 ((1)16), 〈10.3390/ph10010016〉. 〈hal-01683243〉
  • Samer Haidar, Zouhair Bouaziz, Christelle Marminon, Tuomo Laitinen, Antti Poso, et al.. Development of Pharmacophore Model for Indeno[1,2-b]indoles as Human Protein Kinase CK2 Inhibitors and Database Mining. Pharmaceuticals, MDPI, Molecular Diversity Preservation International, 2017, An Updated View on an Emerging Target: Selected Papers from the 8th International Conference on Protein Kinase CK2, 10 ((1)8), 〈10.3390/ph10010008〉. 〈hal-01683291〉
  • Joachim Jose, Marc Le-Borgne, Lorenzo Pinna, Mathias Montenarh. Editorial: An Updated View on an Emerging Target: Selected Papers from the 8th International Conference on Protein Kinase CK2. Pharmaceuticals, MDPI, Molecular Diversity Preservation International, 2017, Pharmaceuticals, 10 ((2)33), pp.33 - 33. 〈10.3390/ph10020033〉. 〈hal-01683242〉
  • Jennifer Hochscherf, Dirk Lindenblatt, Benedict Witulski, Robin Birus, Dagmar Aichele, et al.. Unexpected Binding Mode of a Potent Indeno[1,2-b]indole-Type Inhibitor of Protein Kinase CK2 Revealed by Complex Structures with the Catalytic Subunit CK2α and Its Paralog CK2α′. Pharmaceuticals, MDPI, Molecular Diversity Preservation International, 2017, 10 ((4)98), 〈10.3390/ph10040098〉. 〈hal-01683237〉
  • Esma Lamera, Sofiane Bouacida, Marc Le Borgne, Zouhair Bouaziz, Abdelmalek Bouraiou. Sequential MCR/Fisher indolization strategy for the construction of polycyclic carbazole derivatives. Tetrahedron Letters, Elsevier, 2017, 58 (13), pp.1305 - 1307. 〈10.1016/j.tetlet.2017.02.047〉. 〈hal-01683348〉
  • Anaïs Goudard, Laure Lalande, Camille Bertin, Marie Sautereau, Marc Le Borgne, et al.. Sleep Disorders and Therapeutic Management: A Survey in a French Population of Prisoners. Journal of Correctional Health Care, SAGE Publications, 2017, 23 (2), pp.193 - 202. 〈10.1177/1078345817700163〉. 〈hal-01683241〉
  • Caroline Bayart, Sébastien Peronin, Elisa Jean, Joseph Paladino, Philippe Talaga, et al.. The combined use of analytical tools for exploring tetanus toxin and tetanus toxoid structures. Journal of Chromatography B, Elsevier, 2017, 1054, pp.80 - 92. 〈10.1016/j.jchromb.2017.04.009〉. 〈hal-01683240〉
  • Faten Alchab, Estelle Sibille, Laurent Ettouati, Emilie Bana, Zouhair Bouaziz, et al.. Screening of indeno[1,2- b]indoloquinones by MALDI-MS: a new set of potential CDC25 phosphatase inhibitors brought to light. Journal of Enzyme Inhibition and Medicinal Chemistry, Informa Healthcare, 2016, 31 (sup3), pp.25 - 32. 〈10.1080/14756366.2016.1201480〉. 〈hal-01655213〉
  • Nathalie Guragossian, Gustavo Jabor Gozzi, Bruno Fouillet, Marie-Paule Gustin, Raphaël Terreux, et al.. Candidate Molecule Selection Based on In Silico Predicted ADMET Properties of 12 Indenoindole Derivatives. Chemical Informatics, iMedPub Journals, 2016, 2 ((2)6), 〈10.21767/2470-6973.100020〉. 〈hal-01683399〉
  • Andre Bollacke, Christian Nienberg, Marc Le Borgne, Joachim Jose. Toward selective CK2alpha and CK2alpha’ inhibitors: Development of a novel whole-cell kinase assay by Autodisplay of catalytic CK2alpha’. Journal of Pharmaceutical and Biomedical Analysis, Elsevier, 2016, 121, pp.253 - 260. 〈10.1016/j.jpba.2016.01.011〉. 〈hal-01683296〉
  • Elisabeta Baiceanu, Kim-Anh Nguyen, Lucia Gonzalez-Lobato, Rachad Nasr, Hélène Baubichon-Cortay, et al.. 2-Indolylmethylenebenzofuranones as first effective inhibitors of ABCC2. European Journal of Medicinal Chemistry, Elsevier, 2016, 122, pp.408 - 418. 〈10.1016/j.ejmech.2016.06.039〉. 〈hal-01683292〉
  • Gustavo Jabor Gozzi, Zouhair Bouaziz, Evelyn Winter, Nathalia Daflon-Yunes, Dagmar Aichele, et al.. Converting potent indeno[1,2-b]indole inhibitors of protein kinase CK2 into selective inhibitors of the breast cancer resistance protein ABCG2. J Med Chem, 2015, 58 (1), pp.265-77. 〈http://pubs.acs.org/doi/abs/10.1021/jm500943z〉. 〈10.1021/jm500943z〉. 〈hal-01174925〉
  • Christophe Neyra, Joseph Paladino, Marc Le Borgne. Mechanisms of depolymerization and activation of a polysialic acid and its tetramer by hydrogen peroxide. Carbohydrate Polymers, Elsevier, 2015, 115, pp.494 - 501. 〈10.1016/j.carbpol.2014.08.112〉. 〈hal-01683316〉
  • Florine Lecerf-Schmidt, Romain Haudecoeur, Basile Peres, Marc Ferreira Queiroz, Marc Marcourt, et al.. Biomimetic synthesis of Tramadol. Chemical Communications, Royal Society of Chemistry, 2015, 51 (77), pp.14451 - 14453. 〈10.1039/c5cc05948h〉. 〈hal-01683298〉
  • Gustavo Jabor Gozzi, Zouhair Bouaziz, Evelyn Winter, Nathalia Daflon-Yunes, Mylène Honorat, et al.. Phenolic indeno[1,2-b]indoles as ABCG2-selective potent and non-toxic inhibitors stimulating basal ATPase activity.. Drug Design, Development and Therapy, Dove Medical Press, 2015, 9, pp.3481-3495. 〈10.2147/DDDT.S84982〉. 〈hal-01179426〉
  • Faten Alchab, Laurent Ettouati, Zouhair Bouaziz, Andre Bollacke, Jean-Guy Delcros, et al.. Synthesis, Biological Evaluation and Molecular Modeling of Substituted Indeno[1,2-b]indoles as Inhibitors of Human Protein Kinase CK2.. Pharmaceuticals, MDPI, Molecular Diversity Preservation International, 2015, 8 (2), pp.279-302. 〈10.3390/ph8020279〉. 〈hal-01164133〉
  • Christelle Marminon, Abdelhamid Nacereddine, Zouhair Bouaziz, Pascal Nebois, Joachim Jose, et al.. Microwave-assisted oxidation of indan-1-ones into ninhydrins. Tetrahedron Letters, Elsevier, 2015, 56 (14), pp.1840 - 1842. 〈10.1016/j.tetlet.2015.02.086〉. 〈hal-01683347〉
  • Andre Gratz, Andre Bollacke, Sara Stephan, Christian Nienberg, Marc Le Borgne, et al.. Functional display of heterotetrameric human protein kinase CK2 on Escherichia coli: a novel tool for drug discovery. Microbial Cell Factories, BioMed Central, 2015, 14 (74), 〈10.1186/s12934-015-0263-z〉. 〈hal-01683300〉
  • Zouhair Bouaziz, Samar Issa, Jacques Gentili, Andre Gratz, Andre Bollacke, et al.. Biologically active carbazole derivatives: focus on oxazinocarbazoles and related compounds. Journal of Enzyme Inhibition and Medicinal Chemistry, Informa Healthcare, 2015, 30 (2), pp.180 - 188. 〈10.3109/14756366.2014.899594〉. 〈hal-01683306〉
  • Marc De Ravel, Ghina Alameh, Maxime Melikian, Zahia Mahiout, Agnès Emptoz-Bonneton, et al.. Synthesis of New Steroidal Inhibitors of P-Glycoprotein-Mediated Multidrug Resistance and Biological Evaluation on K562/R7 Erythroleukemia Cells. Journal of Medicinal Chemistry, American Chemical Society, 2015, 58 (4), pp.1832 - 1845. 〈10.1021/jm501676v〉. 〈hal-01683301〉
  • Billel Belhani, Malika Berredjem, Marc Le Borgne, Zouhair Bouaziz, Jacques Lebreton, et al.. A one-pot three-component synthesis of novel α-sulfamidophosphonates under ultrasound irradiation and catalyst-free conditions. RSC Advances, Royal Society of Chemistry, 2015, 5 (49), pp.39324 - 39329. 〈10.1039/C5RA03473F〉. 〈hal-01694993〉
  • Esma Lamera, Saida Benzerka, Abdelmalek Bouraiou, Sofiane Bouacida, Hocine Merazig, et al.. Crystal structure of 13-phenyl-2,3,4,13-tetrahydro-1 H -indazolo[1,2- b ]phthalazine-1,6,11-trione. Acta crystallographica. Section E, Crystallographic communications, International Union of Crystallography, 2015, 71 (12), pp.o1036 - o1037. 〈10.1107/S2056989015023452〉. 〈hal-01683294〉
  • Christophe Neyra, Joseph Paladino, Marc Le Borgne. Oxidation of sialic acid using hydrogen peroxide as a new method to tune the reducing activity. Carbohydrate Research, Elsevier, 2014, 386, pp.92 - 98. 〈10.1016/j.carres.2014.01.007〉. 〈hal-01683314〉
  • Julien Defaux, Maud Antoine, Marc Le Borgne, Tilmann Schuster, Irene Seipelt, et al.. Discovery of 7-Aryl-Substituted (1,5-Naphthyridin-4-yl)ureas as Aurora Kinase Inhibitors. ChemMedChem, Wiley-VCH Verlag, 2014, 9 (1), pp.217 - 232. 〈10.1002/cmdc.201300384〉. 〈hal-01683307〉
  • Julien Defaux, Maud Antoine, Cédric Logé, Marc Le Borgne, Tilmann Schuster, et al.. Discovery of (7-aryl-1,5-naphthyridin-2-yl)ureas as dual inhibitors of ERK2 and Aurora B kinases with antiproliferative activity against cancer cells. Bioorganic & Medicinal Chemistry Letters, Elsevier, 2014, 24 (16), pp.3748 - 3752. 〈10.1016/j.bmcl.2014.06.078〉. 〈hal-01683305〉
  • Zouaoui Bourezg, Nathalie Cartiser, Laurent Ettouati, Jean Guillon, Aline Lacoudre, et al.. Structural elucidation of two photolytic degradation products of tetrabenazine. Journal of Pharmaceutical and Biomedical Analysis, Elsevier, 2014, 91, pp.138 - 143. 〈10.1016/j.jpba.2013.12.032〉. 〈hal-01655151〉
  • Ahcène Boumendjel, Germain Sotoing Taïwe, Elisabeth Ngo Bum, Tanguy Chabrol, Chantal Beney, et al.. Occurrence of the Synthetic Analgesic Tramadol in an African Medicinal Plant.. Angewandte Chemie (English Edition), John Wiley & Sons, 2013, 52 (45), pp.11780-4. 〈10.1002/anie.201305697〉. 〈inserm-00874145〉
  • Ahcène Boumendjel, Germain Sotoing Taïwe, Elisabeth Ngo Gum, Tanguy Chabrol, Chantal Beney, et al.. African tree gets to the root of pain. Nature, Nature Publishing Group, 2013, 501 (7467), pp.285 - 285. 〈10.1038/501285b〉. 〈hal-01683403〉
  • Géraldine Agusti, Sandrine Bourgeois, Nathalie Cartiser, Hatem Fessi, Marc Le Borgne, et al.. A safe and practical method for the preparation of 7α-thioether and thioester derivatives of spironolactone. Steroids, Elsevier, 2013, 78 (1), pp.102 - 107. 〈10.1016/j.steroids.2012.09.005〉. 〈hal-01683309〉
  • Florent Perret, Christelle Marminon, Wael Zeinyeh, Pascal Nebois, Andre Bollacke, et al.. Preparation and characterization of CK2 inhibitor-loaded cyclodextrin nanoparticles for drug delivery. International Journal of Pharmaceutics, Elsevier, 2013, 441 (1-2), pp.491 - 498. 〈10.1016/j.ijpharm.2012.11.004〉. 〈hal-01683336〉
  • Pal Rongved, Gilbert Kirsch, Zouhair Bouaziz, Joachim Jose, Marc Le Borgne. Indenoindoles and cyclopentacarbazoles as bioactive compounds: Synthesis and biological applications. European Journal of Medicinal Chemistry, Elsevier, 2013, 69, pp.465 - 479. 〈10.1016/j.ejmech.2013.08.049〉. 〈hal-01524692〉
  • Jean Guillon, Marc Le Borgne, Charlotte Rimbault, Stéphane Moreau, Solène Savrimoutou, et al.. Synthesis and biological evaluation of novel substituted pyrrolo[1,2-a]quinoxaline derivatives as inhibitors of the human protein kinase CK2. European Journal of Medicinal Chemistry, Elsevier, 2013, 65, pp.205 - 222. 〈10.1016/j.ejmech.2013.04.051〉. 〈hal-01683308〉
  • Faten Al Chab, Bernard Fenet, Marc Le Borgne, Joachim Jose, Noël Pinaud, et al.. 1H and 13C NMR assignments of bioactive indeno[1,2-b]indole-10-one derivatives. Magnetic Resonance in Chemistry, Wiley, 2013, 51 (12), pp.837 - 841. 〈10.1002/mrc.4016〉. 〈hal-01655126〉
  • Claas Hundsdörfer, Hans-Jörg Hemmerling, Janina Hamberger, Marc Le Borgne, Patrick Bednarski, et al.. Novel indeno[1,2-b]indoloquinones as inhibitors of the human protein kinase CK2 with antiproliferative activity towards a broad panel of cancer cell lines. Biochemical and Biophysical Research Communications, Elsevier, 2012, 424 (1), pp.71 - 75. 〈10.1016/j.bbrc.2012.06.068〉. 〈hal-01683311〉
  • Claas Hundsdörfer, Hans-Jörg Hemmerling, Claudia Götz, Frank Totzke, Patrick Bednarski, et al.. Indeno[1,2-b]indole derivatives as a novel class of potent human protein kinase CK2 inhibitors. Bioorganic & medicinal chemistry, Elsevier, 2012, 20 (7), pp.2282 - 2289. 〈10.1016/j.bmc.2012.02.017〉. 〈hal-01683312〉
  • Rémi Guillon, Fabrice Pagniez, Francis Giraud, Damien Crépin, Carine Picot, et al.. Design, Synthesis, and in vitro Antifungal Activity of 1-[(4-Substituted-benzyl)methylamino]-2-(2,4-difluorophenyl)-3-(1H-1,2,4-triazol-1-yl)propan-2-ols. ChemMedChem, Wiley-VCH Verlag, 2011, 6 (5), pp.816 - 825. 〈10.1002/cmdc.201000530〉. 〈hal-01689176〉
  • Zouhair Bouaziz, Samar Issa, Marc Le Borgne, Joachim Jose, Andreas Gratz, et al.. 81: Targeting casein kinase 2 in drug discovery: identification of new chemical entities. Bulletin du Cancer, John Libbey Eurotext, 2010, Échappement Tumoral, 97 (1(Supplement)), pp.S68-S69. 〈10.1684/bdc.2010.1058〉. 〈hal-01691315〉
  • Rémi Guillon, Francis Giraud, Cédric Logé, Marc Le Borgne, Carine Picot, et al.. Design of new antifungal agents: synthesis and evaluation of 1-[(1H-indol-5-ylmethyl)amino]-2-phenyl-3-(1H-1,2,4-triazol-1-yl)propan-2-ols. Bioorganic & Medicinal Chemistry Letters, Elsevier, 2009, 19 (20), pp.5833 - 5836. 〈10.1016/j.bmcl.2009.08.089〉. 〈hal-01689189〉
  • Francis Giraud, Rémi Guillon, Cédric Logé, Fabrice Pagniez, Carine Picot, et al.. Synthesis and structure–activity relationships of 2-phenyl-1-[(pyridinyl- and piperidinylmethyl)amino]-3-(1H-1,2,4-triazol-1-yl)propan-2-ols as antifungal agents. Bioorganic & Medicinal Chemistry Letters, Elsevier, 2009, 19 (2), pp.301 - 304. 〈10.1016/j.bmcl.2008.11.101〉. 〈hal-01689192〉
  • Francis Giraud, Cédric Logé, Fabrice Pagniez, Damien Crepin, Sophie Barres, et al.. Design, synthesis and evaluation of 3-(imidazol- 1-ylmethyl)indoles as antileishmanial agents. Part II. Journal of Enzyme Inhibition and Medicinal Chemistry, Informa Healthcare, 2009, 24 (5), pp.1067 - 1075. 〈10.1080/14756360802610795〉. 〈hal-01689191〉
  • Marie-Pierre Lézé, Anja Palusczak, Rolf W Hartmann, Marc Le Borgne. Synthesis of 6- or 4-functionalized indoles via a reductive cyclization approach and evaluation as aromatase inhibitors. Bioorganic & Medicinal Chemistry Letters, Elsevier, 2008, 18 (16), pp.4713 - 4715. 〈10.1016/j.bmcl.2008.06.094〉. 〈hal-01689195〉
  • Francis Giraud, Cédric Logé, Fabrice Pagniez, Damien Crepin, Patrice Le Pape, et al.. Design, synthesis, and evaluation of 1-(N-benzylamino)-2-phenyl-3-(1H-1,2,4-triazol-1-yl)propan-2-ols as antifungal agents. Bioorganic & Medicinal Chemistry Letters, Elsevier, 2008, 18 (6), pp.1820 - 1824. 〈10.1016/j.bmcl.2008.02.027〉. 〈hal-01689196〉
  • Nicolas Lebouvier, Fabrice Pagniez, Muriel Duflos, Patrice Le Pape, Young Min Na, et al.. Synthesis and antifungal activities of new fluconazole analogues with azaheterocycle moiety. Bioorganic & Medicinal Chemistry Letters, Elsevier, 2007, 17 (13), pp.3686 - 3689. 〈10.1016/j.bmcl.2007.04.038〉. 〈hal-01689197〉
  • Marc Le Borgne, Pascal Marchand, Marie-Renée Nourrisson, Denis Loquet, Martina Palzer, et al.. Synthesis and biological evaluation of 3-(azolylmethyl)-1 H -indoles and 3-(α-azolylbenzyl)-1 H -indoles as selective aromatase inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry, Informa Healthcare, 2007, 22 (5), pp.667 - 676. 〈10.1080/14756360701652658〉. 〈hal-01689199〉
  • Nicolas Lebouvier, Francis Giraud, Typhanie Corbin, Young Min Na, Guillaume Le Baut, et al.. Efficient microwave-assisted synthesis of 1-(1H-indol-1-yl)-2-phenyl-3-(1H-1,2,4-triazol-1-yl)propan-2-ols as antifungal agents. Tetrahedron Letters, Elsevier, 2006, 47 (36), pp.6479 - 6483. 〈10.1016/j.tetlet.2006.03.199〉. 〈hal-01689208〉
  • Francis Giraud, Cédric Loge, Marc Le Borgne, Francis Pagniez, Young Min Na, et al.. A 3D-QSAR CoMSIA study on 3-azolylmethylindoles as anti-leishmanial agents. SAR and QSAR in Environmental Research, Taylor & Francis, 2006, 17 (3), pp.299 - 309. 〈10.1080/10659360600787494〉. 〈hal-01689291〉
  • Marie-Pierre Lézé, Marc Le Borgne, Patricia Pinson, Anja Palusczak, Muriel Duflos, et al.. Synthesis and biological evaluation of 5-[(aryl)(1H-imidazol-1-yl)methyl]-1H-indoles: Potent and selective aromatase inhibitors. Bioorganic & Medicinal Chemistry Letters, Elsevier, 2006, 16 (5), pp.1134 - 1137. 〈10.1016/j.bmcl.2005.11.099〉. 〈hal-01689230〉
  • Fabrice Pagniez, Hiam Abdala-Valencia, Pascal Marchand, Marc Le Borgne, Guillaume Le Baut, et al.. Antileishmanial activities and mechanisms of action of indole-based azoles. Journal of Enzyme Inhibition and Medicinal Chemistry, Informa Healthcare, 2006, 21 (3), pp.277 - 283. 〈10.1080/14756360600700517〉. 〈hal-01689215〉
  • Cédric Logé, Marc Le Borgne, Pascal Marchand, Jean-Michel Robert, Guillaume Le Baut, et al.. Three-dimensional model of cytochrome P450 human aromatase. Journal of Enzyme Inhibition and Medicinal Chemistry, Informa Healthcare, 2005, 20 (6), pp.581 - 585. 〈10.1080/14756360500220574〉. 〈hal-01689233〉
  • Marie-Pierre Lézé, Marc Le Borgne, Pascal Marchand, Denis Loquet, Manuela Kogler, et al.. 2- and 3-[(Aryl)(azolyl)methyl]indoles as Potential Non-steroidal Aromatase Inhibitors. Journal of Enzyme Inhibition and Medicinal Chemistry, Informa Healthcare, 2004, 19 (6), pp.549 - 557. 〈10.1080/14756360400004631〉. 〈hal-01689238〉
  • Young Min Na, Nicolas Lebouvier, Marc Le Borgne, Fabrice Pagniez, Nidia Alvarez, et al.. Synthesis and Antileishmanial Activity of 3-Imidazolylalkylindoles. Part I. Journal of Enzyme Inhibition and Medicinal Chemistry, Informa Healthcare, 2004, 19 (6), pp.451 - 457. 〈10.1080/14756360412331280509〉. 〈hal-01689240〉
  • Pascal Marchand, Marc Le Borgne, Martina Palzer, Guillaume Le Baut, Rolf Hartmann. Preparation and pharmacological profile of 7-(α-Azolylbenzyl)-1H-indoles and indolines as new aromatase inhibitors. Bioorganic & Medicinal Chemistry Letters, Elsevier, 2003, 13 (9), pp.1553 - 1555. 〈10.1016/S0960-894X(03)00182-3〉. 〈hal-01689266〉
  • Marc Le Borgne, Pascal Marchand, Guillaume Le Baut, Masoud Ahmadi, H. John Smith, et al.. Retinoic Acid Metabolism Inhibition by 3-Azolylmethyl-1 H -indoles and 2, 3 or 5-(α-Azolylbenzyl)-1 H -indoles. Journal of Enzyme Inhibition and Medicinal Chemistry, Informa Healthcare, 2003, 18 (2), pp.155 - 158. 〈10.1080/1475636032000069819〉. 〈hal-01689267〉
  • Young Na, Marc Le Borgne, Fabrice Pagniez, Guillaume Le Baut, Patrice Le Pape. Synthesis and antifungal activity of new 1-halogenobenzyl-3-imidazolylmethylindole derivatives. European Journal of Medicinal Chemistry, Elsevier, 2003, 38 (1), pp.75 - 87. 〈10.1016/S0223-5234(02)00005-3〉. 〈hal-01689264〉
  • Pascal Marchand, Marc Le Borgne, Young Min Na, Fabrice Pagniez, Hiam Abdala, et al.. Synthesis and Antileishmanial Activity of 3-(α-Azolylbenzyl)indoles. Journal of Enzyme Inhibition and Medicinal Chemistry, Informa Healthcare, 2002, 17 (6), pp.353 - 358. 〈10.1080/1475636021000005613〉. 〈hal-01689261〉
  • Fabrice Pagniez, Marc Le Borgne, Pascal Marchand, Young Min Na, Guillaume Le Baut, et al.. In Vitro Activity of a New Antifungal Azolyl-substituted Indole Against Aspergillus fumigatus. Journal of Enzyme Inhibition and Medicinal Chemistry, Informa Healthcare, 2002, 17 (6), pp.425 - 429. 〈10.1080/1475636021000005686〉. 〈hal-01689259〉
  • Christine Pato, Marc Le Borgne, Guillaume Le Baut, Patrice Le Pape, Didier Marion, et al.. Potential application of plant lipid transfer proteins for drug delivery. Biochemical Pharmacology, Elsevier, 2001, 62 (5), pp.555 - 560. 〈10.1016/S0006-2952(01)00708-0〉. 〈hal-01689248〉
  • Marc Le Borgne, Muriel Duflos, Guillaume Le Baut, Paul Nicholls. Dérivés indoliques à activités anti-inflammatoire ou antitumorale. Annales Pharmaceutiques Francaises, 2000, 58 (5), pp.316 - 320. 〈hal-01689246〉
  • Marc Le Borgne, Pascal Marchand, Bénédicte Delevoye-Seiller, Jean-Michel Robert, Guillaume Le Baut, et al.. New selective nonsteroidal aromatase inhibitors: Synthesis and inhibitory activity of 2,3 or 5-(α-azolylbenzyl)-1H-indoles. Bioorganic & Medicinal Chemistry Letters, Elsevier, 1999, 9 (3), pp.333 - 336. 〈10.1016/S0960-894X(98)00737-9〉. 〈hal-01689251〉
  • Pascal Marchand, Marc Le Borgne, Muriel Duflos, Sylvie Piessard-Robert, Guillaume Le Baut, et al.. 3-(Azolylmethyl)-1H-indoles as Selective P450 Aromatase Inhibitors. Pharmacy and Pharmacology Communications, Royal Pharmaceutical Society of Great Britain, 1998, 4 (4), pp.211 - 218. 〈10.1111/j.2042-7158.1998.tb00337.x〉. 〈hal-01689256〉
  • Marc Le Borgne, Pascal Marchand, Muriel Duflos, Bénédicte Delevoye-Seiller, Sylvie Piessard-Robert, et al.. Synthesis andIn Vitro Evaluation of 3-(1-Azolylmethyl)-1H-indoles and 3-(1-Azolyl-1-phenylmethyl)-1H-indoles as Inhibitors of P450 arom. Archiv der Pharmazie / Chemistry in Life Sciences, Wiley-VCH Verlag, 1997, 330 (5), pp.141 - 145. 〈10.1002/ardp.19973300506〉. 〈hal-01689244〉
  • Marc Le Borgne, Pascal Marchand, Muriel Duflos, Sylvie Piessard-Robert, Guillaume Le Baut, et al.. Comparison of the In-vitro Aromatase Inhibitory Activity of 3-(Azolylmethyl)-1H-indoles. Pharmacy and Pharmacology Communications, Royal Pharmaceutical Society of Great Britain, 1997, 3 (5-6), pp.279 - 281. 〈10.1111/j.2042-7158.1997.tb00264.x〉. 〈hal-01689254〉

Communication dans un congrès3 documents

  • Joachim Jose, Marc Le Borgne, Karsten Niefind. 25th Conference of GP2A: From Selective, Bivalent Inhibitors to Multi-Target Drugs by the Example of Human Protein Kinase CK2, an Emerging Cancer Target. 25th Conference of GP2A, Aug 2017, Liverpool, United Kingdom. Pharmaceuticals, 10 ((4)97), pp.9-10/2.12, 2017, Pharmaceuticals. 〈10.3390/ph10040097〉. 〈hal-01683410〉
  • Dagmar Aichele, Marc Le Borgne, Joachim Jose. Indeno[1,2-b]indole Inhibitors of Human Protein Kinase CK2 and Their Impact on Different Tumor Cell Lines (A021). Second International Electronic Conference on Medicinal Chemistry (ECMC-2), Nov 2016, Bâle, Switzerland. Pharmaceuticals, 10 ((1)20), pp.15/A021, 2017, 〈10.3390/ph10010020〉. 〈hal-01683452〉
  • Laurent Ettouati, Marie-Emmanuelle Million, Ophélie Arnaud, Géraldine Agusti, Waël Zeinyeh, et al.. Advances in peptidomimetics as inhibitors of ABC transporters. 1st International Electronic Conference on Medicinal Chemistry, Nov 2015, sciforum.net, France. MDPI, 2015, 〈Sciforum.net〉. 〈10.3390/ecmc-1-A043〉. 〈hal-01710182〉

Ouvrage (y compris édition critique et traduction)1 document

  • Joachim Jose, Marc Le Borgne, Lorenzo Pinna, Mathias Montenarh. An Updated View on an Emerging Target: Selected Papers from the 8 th International Conference on Protein Kinase CK2. MDPI AG, 2017, 978-3-03842-413-0. 〈hal-01700408〉

Direction d'ouvrage, Proceedings, Dossier2 documents

  • Marc Le Borgne, Samer Haidar, Olivier Duval, Bernhard Wünsch, Joachim Jose. 1st Joint European Conference on Therapeutic Targets and Medicinal Chemistry (TTMC 2015). Aug 2015, Muesnter, France. 9 ((1)1), 2015, Pharmaceuticals, 〈10.3390/ph9010001〉. 〈hal-01683297〉
  • Jean Guillon, Guillaume Le Baut, Marc Le Borgne. Proceedings of the 16th annual conference of the Groupement des Pharmacochimistes de l'Arc Atlantique (GP2A). 16th GP2A, Sep 2007, Bordeaux, France. 23 (5), pp.587 - 587, 2008, 16th GP2A, 〈10.1080/14756360802204656〉. 〈hal-01689205〉