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MEng French Grande Ecole, PhD Bioinformatics


Marc Ferré graduated in 2002 from a French Grande Ecole of Engineering (ESEO) and in December 2009 a PhD in Bioinformatics. Until August 2014, he was employed by the University Hospital of Angers (France) as bioinformatician through the formation of a national network coordinated by the French Department of Health (genetic study of neuromuscular and sensory pathologies and mental retardation).

He is currently Associate Professor in Molecular Biology and Bioinformatics at the Angers Medical School.

He is also a staff-member to the research team Mitolab (mitolab.eu) of the UMR CNRS 6015/INSERM 1083 — CNRS, The Centre National de la Recherche Scientifique (National Center for Scientific Research), is a government-funded research organization, under the administrative authority of France's Ministry of Research; INSERM, the Institut national de la santé et de la recherche médicale (French National Institute of Health and Medical Research), is a public scientific and technological institute which operates under the joint authority of the French Ministry of Health and French Ministry of Research.

Research activity of Dr. Ferré has been conducted in the field of mitochondrial diseases.

He began his career by studying in silico the human mitochondrial proteome and developing a bioinformatics research strategy to identify new mitochondrial proteins on the basis of their prokaryotic origin. In parallel to this overall strategy of screening, he focused on the study of the Opa1 protein, one of the proteins associated with autosomal dominant optic atrophy, which is involved in mitochondrial fusion. Opa1, a dynamin GTPase, is involved in the remodeling of the inner mitochondrial membrane, apoptosis, maintenance of mitochondrial DNA, and energy metabolism. He finally developed an international database listing the variations of Opa1 so as to characterize its mutational spectrum. This tool was used as a complement to a multicentric clinical study involving thousands of patients with optic neuropathy. His work has led to the development of novel bioinformatics tools that should contribute to a better understanding of mitochondrial pathophysiology.

He is currently focused on three axes: (1) designing and the curating clinico-biological databases of genes involved in neuro-ophthalmological diseases (ACO2DNM1LMFN2OPA1RTN4IP1SPG7), as a member of the Human Variome Project since 2012; (2) exceeding the current reading limits of the human mitochondrial genome sequence, via an innovative technique in which the complete double-stranded mitochondrial DNA is read directly without DNA amplification or incorporation of nucleotides; (3) analyzing the big data generated by the two previous axes, by biostatistical methods, bioinformatics and artificial intelligence.


Journal articles17 documents

  • Juan Chao de la Barca, Barnabé Rondet-Courbis, Marc Ferré, Jeanne Muller, Adrien Buisset, et al.. A Plasma Metabolomic Profiling of Exudative Age-Related Macular Degeneration Showing Carnosine and Mitochondrial Deficiencies. Journal of Clinical Medicine, MDPI, 2020, 9 (3), pp.631. ⟨10.3390/jcm9030631⟩. ⟨hal-02543202⟩
  • Bastien Le Roux, Guy Lenaers, Xavier Zanlonghi, Patrizia Amati-Bonneau, Floris Chabrun, et al.. Deciphering exome sequencing data: Bringing mitochondrial DNA variants to light. Human Mutation, Wiley, 2019, 40 (12), pp.2430-2443. ⟨10.1002/humu.23885⟩. ⟨hal-02975361⟩
  • Bastien Le Roux, Guy Lenaers, Xavier Zanlonghi, Patrizia Amati-Bonneau, Floris Chabrun, et al.. OPA1: 516 unique variants and 831 patients registered in an updated centralized Variome database. Orphanet Journal of Rare Diseases, BioMed Central, 2019, 14 (1), ⟨10.1186/s13023-019-1187-1⟩. ⟨hal-02388214⟩
  • Cinzia Bocca, Judith Nzoughet, Stéphanie Leruez, Patrizia Amati-Bonneau, Marc Ferré, et al.. A Plasma Metabolomic Signature Involving Purine Metabolism in Human Optic Atrophy 1 (OPA1)-Related Disorders. Investigative Ophthalmology & Visual Science, Association for Research in Vision and Ophthalmology, 2018, 59, pp.185-195. ⟨10.1167/iovs.17-23027⟩. ⟨hal-01964499⟩
  • J Ebran, Ludovic Martin, Nastassia Navasiolava, Marc Ferré, Dan Milea, et al.. Subretinal fibrosis is associated with fundus pulverulentus in pseudoxanthoma elasticum.. Graefe's Archive for Clinical and Experimental Ophthalmology, Springer Verlag, 2018, 256, pp.699-707. ⟨hal-02104309⟩
  • J Loo, S Singhal, A Rukmini, S Tow, Patrizia Amati-Bonneau, et al.. Multiethnic involvement in autosomal-dominant optic atrophy in Singapore. Eye (Lond), 2017, 31, pp.475-480. ⟨10.1038/eye.2016.255⟩. ⟨hal-02104157⟩
  • Juan Manuel Chao de la Barca, Gilles Simard, Emmanuelle Sarzi, Tanguy Chaumette, Guillaume Rousseau, et al.. Targeted Metabolomics Reveals Early Dominant Optic Atrophy Signature in Optic Nerves of Opa1 delTTAG/+ Mice. Investigative Ophthalmology & Visual Science, Association for Research in Vision and Ophthalmology, 2017, 58 (2), pp.812-820. ⟨10.1167/iovs.16-21116⟩. ⟨hal-01784466⟩
  • Juan Manuel Chao de la Barca, Gilles Simard, Patrizia Amati-Bonneau, Zainab Safiedeen, Delphine Mirebeau-Prunier, et al.. The metabolomic signature of Leber's hereditary optic neuropathy reveals endoplasmic reticulum stress. Brain - A Journal of Neurology , Oxford University Press (OUP), 2016, 139 (11), pp.2864-2876. ⟨10.1093/brain/aww222⟩. ⟨hal-02103390⟩
  • Juan Manuel Chao de la Barca, Delphine Mirebeau-Prunier, Patrizia Amati-Bonneau, Marc Ferré, Emmanuelle Sarzi, et al.. OPA1-related disorders: Diversity of clinical expression, modes of inheritance and pathophysiology. Neurobiology of Disease, Elsevier, 2015, pp.20-26. ⟨10.1016/j.nbd.2015.08.015⟩. ⟨hal-01392230⟩
  • Marc Ferré, Pascal Reynier, Arnaud Chevrollier, Delphine Prunier-Mirebeau, Georges Lefthériotis, et al.. Is ABCC6 a genuine mitochondrial protein?. BMC Research Notes, BioMed Central, 2013, 6 (1), pp.427. ⟨10.1186/1756-0500-6-427⟩. ⟨inserm-00877607⟩
  • Claire Angebault, Naïg Gueguen, Valérie Desquiret-Dumas, Arnaud Chevrollier, Virginie Guillet, et al.. Idebenone increases mitochondrial complex I activity in fibroblasts from LHON patients while producing contradictory effects on respiration.. BMC Research Notes, BioMed Central, 2011, 4 (1), pp.557. ⟨10.1186/1756-0500-4-557⟩. ⟨inserm-00673659⟩
  • Julien Cassereau, Arnaud Chevrollier, Dominique Bonneau, Christophe Verny, Vincent Procaccio, et al.. A locus-specific database for mutations in GDAP1 allows analysis of genotype-phenotype correlations in Charcot-Marie-Tooth diseases type 4A and 2K.. Orphanet Journal of Rare Diseases, BioMed Central, 2011, 6 (1), pp.87. ⟨10.1186/1750-1172-6-87⟩. ⟨inserm-00683147⟩
  • Denis Pierron, Marc Ferré, Christophe Rocher, Arnaud Chevrollier, Pascal Murail, et al.. OPA1-related dominant optic atrophy is not strongly influenced by mitochondrial DNA background.. BMC Medical Genetics, BioMed Central, 2009, 10 (1), pp.70. ⟨10.1186/1471-2350-10-70⟩. ⟨inserm-00663623⟩
  • Denis Pierron, Marc Ferré, Christophe Rocher, Arnaud Chevrollier, Pascal Murail, et al.. OPA1-related dominant optic atrophy is not strongly influenced by mitochondrial DNA background. BMC Medical Genetics, BioMed Central, 2009, 10:70, 1-8 (page number not for citation purposes). ⟨10.1186/1471-2350-10-70⟩. ⟨halshs-00433468⟩
  • Marc Ferré, Dominique Bonneau, Dan Milea, Arnaud Chevrollier, Christophe Verny, et al.. Molecular screening of 980 cases of suspected hereditary optic neuropathy with a report on 77 novel OPA1 mutations.. Human Mutation, Wiley, 2009, 30 (7), pp.E692-705. ⟨10.1002/humu.21025⟩. ⟨inserm-00372261⟩
  • Karen Cornille, Dan Milea, Patrizia Amati-Bonneau, Vincent Procaccio, Lydie Zazoun, et al.. Reversible optic neuropathy with OPA1 exon 5b mutation.. Annals of Neurology, Wiley, 2008, 63 (5), pp.667-71. ⟨10.1002/ana.21376⟩. ⟨inserm-00287509⟩
  • Arnaud Chevrollier, Virginie Guillet, Dominique Loiseau, Naïg Gueguen, Marie-Anne Pou de Crescenzo, et al.. Hereditary optic neuropathies share a common mitochondrial coupling defect.. Annals of Neurology, Wiley, 2008, 63 (6), pp.794-8. ⟨10.1002/ana.21385⟩. ⟨hal-00282865⟩

Theses1 document

  • Marc Ferré. Analyse bio-informatique du protéome mitochondrial et du spectre des mutations de la protéine Opa1. Biologie cellulaire. Université d'Angers, 2009. Français. ⟨tel-00457327⟩