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Design, synthesis and biological evaluation of novel tetrahydroacridine pyridine- aldoxime and -amidoxime hybrids as efficient uncharged reactivators of nerve agent-inhibited human acetylcholinesterase
Maria Kliachyna
,
Gianluca Santoni
,
Valentin Nussbaum
,
Julien Renou
,
Benoît Sanson
,
et al.
Article dans une revue
hal-01131268v1
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Design, biological evaluation and X-ray crystallography of multifunctional ligands targeting simultaneously acetylcholinesterase and glycogen synthase kinase-3
Ludovic Jean
Société de Chimie Thérapeutique - Young Research Fellows Meeting (YRFM, 27, 2020), Jan 2020, Caen, France
Communication dans un congrès
hal-02544418v1
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Discovery of a Potent Dual Inhibitor of Acetylcholinesterase and Butyrylcholinesterase with Antioxidant Activity that Alleviates Alzheimer-like Pathology in Old APP/PS1 Mice
Elisabet Viayna
,
Nicolas Coquelle
,
Monika Cieslikiewicz-Bouet
,
Pedro Cisternas
,
Carolina Oliva
,
et al.
Article dans une revue
hal-03094189v1
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Huprine derivatives as sub-nanomolar human acetylcholinesterase inhibitors: from rational design to validation by X-ray crystallography.
Cyril Ronco
,
Eugénie Carletti
,
Jacques-Philippe Colletier
,
Martin Weik
,
Florian Nachon
,
et al.
Article dans une revue
istex
hal-00996475v1
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Synthesis of fluorinated agonist of sphingosine-1-phosphate receptor 1
Lucie Aliouane
,
Sovy Chao
,
Brizuela Leyre
,
Emmanuel Pfund
,
Cuvillier Olivier
,
et al.
Article dans une revue
hal-01063240v1
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Human butyrylcholinesterase produced in insect cells: huprine-based affinity purification and crystal structure.
Xavier Brazzolotto
,
Marielle Wandhammer
,
Cyril Ronco
,
Marie Trovaslet
,
Ludovic Jean
,
et al.
Article dans une revue
hal-00996490v1
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Toward an innovative treatment of Alzheimer's disease: Synthesis and evaluation of multi-target directed ligands (MTDLs) targeting acetylcholinesterase (AChE) and alpha7 nicotinic acetylchloline receptors (alpha7 nAChRs)
Monika Cieslikiewicz-Bouet
,
Sovy Chao
,
Ludovic Jean
,
R. Araoz
,
D. Servent
,
et al.
International Symposium on Cholinergic Mechanisms (ISCM, 15, 2016), Oct 2016, Marseille, France. pp.209-210
Communication dans un congrès
hal-02024978v1
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Novel uncharged reactivators against OP-inhibition of human acetylcholinesterase
Rachid Baati
,
Maria Klyachina
,
Valentin Nussbaum
,
Pierre-Yves Renard
,
Ludovic Jean
,
et al.
France, Patent n° : EP13306584.7. 2013
Brevet
hal-01150304v1
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Labeled huprine derivatives and their use in medical imaging
Cedric Bouteiller
,
Franco Mariani Maurizio
,
Cyril Ronco
,
Pierre-Yves Renard
,
Ludovic Jean
,
et al.
France, Patent n° : WO 2011124713 A1. 2011
Brevet
hal-01150300v1
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Synthesis of new uncharged reactivators for cholinesterases inhibited by organophosphorus nerve agents
Anissa Braïki
,
Julien Renou
,
Catherine Gomez
,
Romain Mougeot
,
Florian Nachon
,
et al.
Tetrahedron Symposium (17, 2016), Jun 2016, Barcelone, Spain
Poster de conférence
hal-02544884v1
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Combination delivery of two oxime-loaded lipid nanoparticles: Time-dependent additive action for prolonged rat brain protection
T.N. Pashirova
,
Anissa Braïki
,
I.V. Zueva
,
K.A. Petrov
,
V.M. Babaev
,
et al.
Article dans une revue
hal-02024524v1
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Straightforward and efficient synthesis of 3-benzyloxy-4-bromopicolinate ester and 3-benzyloxy-5-bromopicolinate ester, common building blocks for pharmaceuticals and agrochemicals
Tristan Verdelet
,
Guillaume Mercey
,
Nobi Correa
,
Ludovic Jean
,
Pierre-Yves Renard
Article dans une revue
istex
hal-01017528v1
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Uncharged Reactivators of cholinesterases Inhibited by organophosphorus nerve agents
Pierre Warnault
,
Julien Renou
,
Catherine Gomez
,
Guillaume Mercey
,
Tristan Verdelet
,
et al.
International Meeting on Cholinesterases - Sixth International Conference on Paraoxonases (12, 2015), Sep 2015, Elche, Spain
Poster de conférence
hal-02544902v1
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Synthesis and in vitro and in vivo evaluations of New Uncharged reactivators for cholinesterases inhibited by organophosphorus nerve agents
Anissa Braïki
,
Julien Renou
,
Romain Mougeot
,
Florian Nachon
,
José Dias
,
et al.
Medical Chemical Defense Conference (MCDC, 17, 2019), Mar 2019, Munich, Germany
Poster de conférence
hal-02543452v1
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A New Class of Bi- and Trifunctional Sugar Oximes as Antidotes against Organophosphorus Poisoning
Ophélie da Silva
,
Nicolas Probst
,
Christophe Landry
,
Anne-Sophie Hanak
,
Pierre Warnault
,
et al.
Article dans une revue
hal-03706969v1
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Crystal structures of human cholinesterases in complex with huprine W and tacrine: elements of specificity for anti-Alzheimer's drugs targeting acetyl- and butyryl-cholinesterase.
Florian Nachon
,
Eugénie Carletti
,
Cyril Ronco
,
Marie Trovaslet
,
Yvain Nicolet
,
et al.
Article dans une revue
hal-00996550v1
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Composition and methods for the purification and production of butyrylcholinesterase.
O. Lockridge,
,
M.A. Larson,
,
S.H. Schopfer,
,
S.H. Hinrichs,
,
Florian Nachon
,
et al.
France, Patent n° : PCT/US14/66373. 2014
Brevet
hal-01150306v1
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Tryptoline-3-hydroxypyridinaldoxime conjugates as efficient reactivators of phosphylated human acetyl and butyrylcholinesterase
Julien Renou
,
Melanie Loiodice
,
Melanie Arboleas
,
Rachid Baati
,
Ludovic Jean
,
et al.
Article dans une revue
hal-01150284v1
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The effects of organophosphorus compounds and novel antidotes on human neuronal cells
T. Zorbaz
,
M. Katalinic
,
I. Pavicic
,
Anissa Braïki
,
J. Renou
,
et al.
International Symposium on Cholinergic Mechanisms (ISCM, 15, 2016), Oct 2016, Marseille, France. pp.224-225
Communication dans un congrès
hal-02024991v1
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Insights on two in situ click chemistry reactions for the synthesis of AChE inhibitors
E. Oueis
,
Ronco C.
,
F. Nachon
,
Cyrille Sabot
,
Ludovic Jean
,
et al.
International Meeting on Cholinesterases - Sixth International Conference on Paraoxonases (12, 2015), Sep 2015, Elche, Spain
Communication dans un congrès
hal-02379142v1
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Multi-target directed ligands: Electrophysiological characterization of an anticholinesterase inhibitor coupled to an agonist of α7 nicotinic acetylcholine receptor
Rómulo Aráoz
,
Monika Bouet
,
Manuela Bartolini
,
Nicolas Coquelle
,
Jacques-Philippe Colletier
,
et al.
Article dans une revue
hal-02329901v1
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Multi Target directed ligands for the treatment of Alzheimer’s disease
Sovy Chao
,
Killian Oukoloff
,
Monika Bouet
,
Diego Muñoz Torrero
,
Jacques-Philippe Colletier
,
et al.
Rencontres internationales de chimie thérapeutique (RICT, 52, 2016), Jul 2016, Caen, France
Poster de conférence
hal-02544849v1
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PET and SPECT radiotracers for Alzheimer's disease
Killian Oukoloff
,
Monika Cieslikiewicz-Bouet
,
Sovy Chao
,
Emilie da Costa Branquinho
,
C. Bouteiller
,
et al.
Article dans une revue
hal-02046165v1
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A selective and sensitive near-infrared fluorescent probe for acetylcholinesterase imaging
Sovy Chao
,
Eric Krejci
,
Véronique Bernard
,
Jacqueline Leroy
,
Ludovic Jean
,
et al.
Article dans une revue
hal-03013508v1
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Structure-Based Optimization of Nonquaternary Reactivators of Acetylcholinesterase Inhibited by Organophosphorus Nerve Agents
Gianluca Santoni
,
J. de Sousa
,
Eugenio de La Mora
,
J. Dias
,
Ludovic Jean
,
et al.
Article dans une revue
hal-02024531v1
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Selective and sensitive near‐infrared fluorescent probe for acetylcholinesterase imaging [abstract]
Pierre-Yves Renard
,
Ludovic Jean
Article dans une revue
hal-02329887v1
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Use of an Air-Stable Cu(I)-NHC Catalyst for the Synthesis of Peptidotriazoles
Pierrick Bruyat
,
Arnaud Gautier
,
Ludovic Jean
,
Pierre-Yves Renard
Article dans une revue
hal-01916360v1
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Improved synthetic pathway for the derivatization of huprine scaffold
Cyril Ronco
,
Ludovic Jean
,
Pierre-Yves Renard
Article dans une revue
istex
hal-01019278v1
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Screening of new huprines--inhibitors of acetylcholinesterases by electrospray ionization ion trap mass spectrometry
Anna Ziemianin
,
Cyril Ronco
,
Romain Dolé
,
Ludovic Jean
,
Pierre-Yves Renard
,
et al.
Article dans une revue
istex
hal-00996397v1
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Syntheses and in vitro evaluations of uncharged reactivators for human acetylcholinesterase inhibited by organophosphorus nerve agents.
Julien Renou
,
Guillaume Mercey
,
Tristan Verdelet
,
Emilia Păunescu
,
Emilie Gillon
,
et al.
Article dans une revue
istex
hal-00996535v1
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