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Insights into antitrypanosomal drug mode-of-action from cytology-based profiling

James Thomas , Nicola Baker , Sebastian Hutchinson , Caia Dominicus , Anna Trenaman , et al.
PLoS Neglected Tropical Diseases, 2018, 12 (11), pp.e0006980. ⟨10.1371/journal.pntd.0006980⟩
Article dans une revue pasteur-03107158v1
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Trypanosomal histone γH2A and the DNA damage response

Lucy Glover , David Horn
Molecular and Biochemical Parasitology, 2012, 183 (1), pp.78-83. ⟨10.1016/j.molbiopara.2012.01.008⟩
Article dans une revue pasteur-03107110v1

Genome-scale RNAi screens for high-throughput phenotyping in bloodstream-form African trypanosomes

Lucy Glover , Sam Alsford , Nicola Baker , Daniel Turner , Alejandro Sanchez-Flores , et al.
Nature Protocols, 2015, 10 (1), pp.106-133. ⟨10.1038/nprot.2015.005⟩
Article dans une revue pasteur-03107102v1
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SHERLOCK4HAT: A CRISPR-based tool kit for diagnosis of Human African Trypanosomiasis

Núria Sima , Annick Dujeancourt-Henry , Blanca Liliana Perlaza , Marie-Noelle Ungeheuer , Brice Rotureau , et al.
EBioMedicine, 2022, 85, pp.104308. ⟨10.1016/j.ebiom.2022.104308⟩
Article dans une revue pasteur-04073409v1
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VEX1 Influences mVSG Expression During the Transition to Mammalian Infectivity in Trypanosoma brucei

Eliane Tihon , Karinna Rubio-Peña , Annick Dujeancourt-Henry , Aline Crouzols , Brice Rotureau , et al.
Frontiers in Cell and Developmental Biology, 2022, 10, pp.851475. ⟨10.3389/fcell.2022.851475⟩
Article dans une revue pasteur-03646994v1

Repression of polymerase I‐mediated gene expression at Trypanosoma brucei telomeres

Lucy Glover , David Horn
EMBO Reports, 2006, 7 (1), pp.93-99. ⟨10.1038/sj.embor.7400575⟩
Article dans une revue pasteur-03107108v1
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Transcription Dependent Loss of an Ectopically Expressed Variant Surface Glycoprotein during Antigenic Variation in Trypanosoma brucei

Emilia Jane Mclaughlin , Karinna Rubio-Pena , Annick Dujeancourt-Henry , Lucy Glover
mBio, 2022, 13 (2), pp.e0384721. ⟨10.1128/mbio.03847-21⟩
Article dans une revue pasteur-03647000v1

Aquaglyceroporin 2 controls susceptibility to melarsoprol and pentamidine in African trypanosomes

Nicola Baker , Lucy Glover , Jane Munday , David Aguinaga Andres , Michael P Barrett , et al.
Proceedings of the National Academy of Sciences of the United States of America, 2012, 109 (27), pp.10996-11001. ⟨10.1073/pnas.1202885109⟩
Article dans une revue pasteur-03107134v1
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CRISPR in Parasitology: Not Exactly Cut and Dried!

Jessica Bryant , Sebastian Baumgarten , Lucy Glover , Sebastian Hutchinson , Najma Rachidi
Trends in Parasitology, 2019, 35 (6), pp.409-422. ⟨10.1016/j.pt.2019.03.004⟩
Article dans une revue pasteur-02874588v1
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Site-specific DNA double-strand breaks greatly increase stable transformation efficiency in Trypanosoma brucei

Lucy Glover , David Horn
Molecular and Biochemical Parasitology, 2009, 166 (2), pp.194-197. ⟨10.1016/j.molbiopara.2009.03.010⟩
Article dans une revue pasteur-03107140v1
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A post-transcriptional respiratome regulon in trypanosomes

Anna Trenaman , Lucy Glover , Sebastian Hutchinson , David Horn
Nucleic Acids Research, 2019, 47 (13), pp.7063-7077. ⟨10.1093/nar/gkz455⟩
Article dans une revue pasteur-03107129v1
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Single locus phosphoproteomics reveals phosphorylation of RPA-1 is required for generation of single-strand DNA following a break at a subtelomeric locus

Emilia Mclaughlin , Annick Dujeancourt-Henry , Thibault Chaze , Quentin Giai Gianetto , Mariette Matondo , et al.
2022
Pré-publication, Document de travail pasteur-04093539v1
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The MRN complex promotes DNA repair by homologous recombination and restrains antigenic variation in African trypanosomes

Ann-Kathrin Mehnert , Marco Prorocic , Annick Dujeancourt-Henry , Sebastian Hutchinson , Richard Mcculloch , et al.
Nucleic Acids Research, 2021, ⟨10.1093/nar/gkaa1265⟩
Article dans une revue pasteur-03112362v1

DNA breaks as triggers for antigenic variation in African trypanosomes

Sam Alsford , David Horn , Lucy Glover
Genome Biology, 2009, 10 (6), pp.223. ⟨10.1186/gb-2009-10-6-223⟩
Article dans une revue pasteur-03107131v1

Tagging a T. brucei RRNA locus improves stable transfection efficiency and circumvents inducible expression position effects

Sam Alsford , Taemi Kawahara , Lucy Glover , David Horn
Molecular and Biochemical Parasitology, 2005, 144 (2), pp.142-148. ⟨10.1016/j.molbiopara.2005.08.009⟩
Article dans une revue pasteur-03107132v1

High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome

Sam Alsford , Daniel Turner , Samson Obado , Alejandro Sanchez-Flores , Lucy Glover , et al.
Genome Research, 2011, 21 (6), pp.915-924. ⟨10.1101/gr.115089.110⟩
Article dans une revue pasteur-03107133v1
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Genome-wide RNAi selection identifies a regulator of transmission stage-enriched gene families and cell-type differentiation in Trypanosoma brucei

Eva Rico , Alasdair Ivens , Lucy Glover , David Horn , Keith Matthews
PLoS Pathogens, 2017, 13 (3), pp.e1006279. ⟨10.1371/journal.ppat.1006279⟩
Article dans une revue pasteur-03107156v1
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Persistent DNA Damage Foci and DNA Replication with a Broken Chromosome in the African Trypanosome

Lucy Glover , Catarina Marques , Olga Suska , David Horn
mBio, 2019, 10 (4), pp.e01252-19. ⟨10.1128/mBio.01252-19⟩
Article dans une revue pasteur-03107118v1
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Deletion of a trypanosome telomere leads to loss of silencing and progressive loss of terminal DNA in the absence of cell cycle arrest

Lucy Glover , Sam Alsford , Caroline Beattie , David Horn
Nucleic Acids Research, 2007, 35 (3), pp.872-880. ⟨10.1093/nar/gkl1100⟩
Article dans une revue pasteur-03107105v1
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DNA Break Site at Fragile Subtelomeres Determines Probability and Mechanism of Antigenic Variation in African Trypanosomes

Lucy Glover , Sam Alsford , David Horn
PLoS Pathogens, 2013, 9 (3), pp.e1003260. ⟨10.1371/journal.ppat.1003260⟩
Article dans une revue pasteur-03107107v1
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PPL2 Translesion Polymerase Is Essential for the Completion of Chromosomal DNA Replication in the African Trypanosome

Sean Rudd , Lucy Glover , Stanislaw Jozwiakowski , David Horn , Aidan J Doherty
Molecular Cell, 2013, 52 (4), pp.554-565. ⟨10.1016/j.molcel.2013.10.034⟩
Article dans une revue pasteur-03107124v1
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High-resolution analysis of multi-copy variant surface glycoprotein gene expression sites in African trypanosomes

Sebastian Hutchinson , Lucy Glover , David Horn
BMC Genomics, 2016, 17 (1), pp.806. ⟨10.1186/s12864-016-3154-8⟩
Article dans une revue pasteur-03107120v1

Multiplex analysis of RNA interference defects in Trypanosoma brucei

Sam Alsford , Lucy Glover , David Horn
Molecular and Biochemical Parasitology, 2005, 139 (1), pp.129-132. ⟨10.1016/j.molbiopara.2004.11.001⟩
Article dans une revue pasteur-03107009v1
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Sequence homology and microhomology dominate chromosomal double-strand break repair in African trypanosomes

Lucy Glover , Richard Mcculloch , David Horn
Nucleic Acids Research, 2008, 36 (8), pp.2608-2618. ⟨10.1093/nar/gkn104⟩
Article dans une revue pasteur-03107119v1
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DNA double strand break position leads to distinct gene expression changes and regulates VSG switching pathway choice

Alix Thivolle , Ann-Kathrin Mehnert , Eliane Tihon , Emilia Mclaughlin , Annick Dujeancourt-Henry , et al.
PLoS Pathogens, 2021, 17 (11), pp.e1010038. ⟨10.1371/journal.ppat.1010038⟩
Article dans une revue pasteur-04073401v1

The nuclear envelope and gene organization in parasitic protozoa: Specializations associated with disease

Samson Obado , Lucy Glover , Kirk Deitsch
Molecular and Biochemical Parasitology, 2016, 209 (1-2), pp.104-113. ⟨10.1016/j.molbiopara.2016.07.008⟩
Article dans une revue pasteur-03107121v1

Forward Genetics in African Trypanosomes

Sebastian Hutchinson , Lucy Glover
Trypanosomatids, 2116, pp.339-352, 2020, Methods in Molecular biology, 978-1-0716-0294-2 (online) ; 978-1-0716-0293-5 (print). ⟨10.1007/978-1-0716-0294-2_21⟩
Chapitre d'ouvrage pasteur-03107149v1
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Escaping the immune system by DNA repair and recombination in African trypanosomes

Núria Sima , Emilia Jane Mclaughlin , Sebastian Hutchinson , Lucy Glover
Open Biology, 2019, 9 (11), pp.190182. ⟨10.1098/rsob.190182⟩
Article dans une revue pasteur-03107126v1
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Monoallelic expression and epigenetic inheritance sustained by a Trypanosoma brucei variant surface glycoprotein exclusion complex

Joana Faria , Lucy Glover , Sebastian Hutchinson , Cordula Boehm , Mark Field , et al.
Nature Communications, 2019, 10 (1), pp.3023. ⟨10.1038/s41467-019-10823-8⟩
Article dans une revue pasteur-03107015v1
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Locus-specific control of DNA resection and suppression of subtelomeric VSG recombination by HAT3 in the African trypanosome

Lucy Glover , David Horn
Nucleic Acids Research, 2014, 42 (20), pp.12600-12613. ⟨10.1093/nar/gku900⟩
Article dans une revue pasteur-03107111v1