Nombre de documents

55

CV Luc Maroteaux


CURRICULUM VITAE

 

 

 

n  Nom, prénom :                   MAROTEAUX, Luc

 

Date et lieu de naissance:    14 Septembre 1955, Versailles, France

 

Grade :                                   Directeur de Recherche 1° Classe CNRS

 

Adresse Professionnelle :    INSERM U839

 

                                               Institut du Fer à Moulin

 

                                               Rue du Fer à Moulin

 

                                               75005 PARIS

 

Email :                                   luc.maroteaux@upmc.fr

 

Tel :                                        33 (0)1.45.87.61.23

 

Fax :                                       33 (0)1.45.87.61.32

 

 

 

 

 

DEROULEMENT DE CARRIERE

 

1976-1980 : Ecole Normale Supérieure St Cloud

 

1979 : DEA de Biologie Moléculaire - Univ.L. Pasteur Strasbourg. Biologie Moléculaire (P. Chambon) Séquence et identification de la première "TATA BOX" eucaryote.

 

1981-1983 : stage pré doctoral (laboratoire du Pr. M. Revel) Institut Weissman - Israël Clonage des interférons humains alpha et beta.

 

1984 : Thèse d'état en Biologie Moléculaire (Pr P. Chambon) - Université L. Pasteur - Strasbourg: Etude de la régulation de la transcription de l'interféron beta1 humain.

 

1984-1985 : Chargé de recherches 2° classe CNRS - Banyuls sur Mer.

 

1985-1987 : Chargé de recherches 2° classe CNRS - Banyuls sur Mer. Clonage des gènes ribosomiques de Dinoflagellés- Evolution moléculaire.

 

1987-1989 : Post-doctorat- en neurobiologie moléculaire (laboratoire R. Scheller) Université de Stanford, USA. Clonage et caractérisation des synucléines.

 

1989-1993 : Chargé de recherches 1° classe CNRS - Laboratoire du Pr P. Chambon - Strasbourg. Clonage de nouveaux GPCRs.

 

1993 : Directeur de recherches 2° classe CNRS - direction d'un groupe de recherche sur le rôle morphogène de la sérotonine à l’IGBMC Strasbourg.

 

2001 : Directeur de recherches 1° classe - CNRS à l’IGBMC Strasbourg.

 

2004: Mutation à Paris, Création de l’U616 Inserm Sérotonine et développement

 

2007: Création de l’U839 Inserm-Institut du Fer à Moulin Responsable de l'équipe 5 " Signalisation de la sérotonine dans la plasticité et la pathologie"

 

 

 


Article dans une revue55 documents

  • Estelle Ayme-Dietrich, Roland Lawson, Francine Côté, Claudia De Tapia, Sylvia Da Silva, et al.. Serotonergic 5-HT 2B receptors in mitral valvulopathy: bone marrow mobilization of endothelial progenitors. British Journal of Pharmacology, Wiley, 2017, 〈10.1111/bph.13981〉. 〈hal-01593837〉
  • Estelle Ayme-Dietrich, Gaëlle Aubertin-Kirch, Luc Maroteaux, Laurent Monassier. Cardiovascular remodeling and the peripheral serotonergic system. Archives of cardiovascular diseases, Elsevier/French Society of Cardiology, 2017, 110 (1), pp.51 - 59. 〈10.1016/j.acvd.2016.08.002〉. 〈hal-01593856〉
  • Stephane Doly, Emily Quentin, Raphaël Eddine, Stefania Tolu, Sebastian Fernandez, et al.. Serotonin 2B receptors in mesoaccumbens dopamine pathway regulate cocaine responses. Journal of Neuroscience, Society for Neuroscience, 2017, 〈10.1523/JNEUROSCI.1354-17.2017〉. 〈hal-01593826〉
  • Stéphane Doly, Emily Quentin, Raphaël Eddine, Stefania Tolu, Sebastian P. Fernandez, et al.. Serotonin 2B receptors in mesoaccumbens dopamine pathway regulate cocaine responses. Journal of Neuroscience, Society for Neuroscience, 2017, 〈10.1523/JNEUROSCI.1354-17.2017〉. 〈hal-01593860〉
  • Coedy Hadden, Tariq Fahmi, Anthonya Cooper, Alena V. Savenka, Vladimir V. Lupashin, et al.. Serotonin transporter protects the placental cells against apoptosis in caspase 3-independent pathway. Journal of Cellular Physiology, Wiley, 2017, 232 (12), pp.3520 - 3529. 〈10.1002/jcp.25812〉. 〈hal-01593857〉
  • Imane Moutkine, Emily Quentin, Bruno P. Guiard, Luc Maroteaux, Stephane Doly. Heterodimers of serotonin receptor subtypes 2 are driven by 5-HT 2C protomers. Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2017, 292 (15), pp.6352 - 6368. 〈10.1074/jbc.M117.779041〉. 〈hal-01593858〉
  • Imane Moutkine, Emily Quentin, Bruno P. Guiard, Luc Maroteaux, Stephane Doly. Heterodimers of serotonin receptor subtypes 2 are driven by 5-HT 2C protomers. Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2017, 292 (15), pp.6352-6368. 〈10.1074/jbc.M117.779041〉. 〈hal-01593841〉
  • Luc Maroteaux, Estelle Ayme-Dietrich, Gaëlle Aubertin-Kirch, Sophie Banas, Emily Quentin, et al.. New therapeutic opportunities for 5-HT2 receptor ligands. Pharmacology and Therapeutics, Elsevier, 2017, 170, pp.14 - 36. 〈10.1016/j.pharmthera.2016.10.008〉. 〈hal-01593853〉
  • Luc Maroteaux, Estelle Ayme-Dietrich, Gaëlle Aubertin-Kirch, Sophie Banas, Emily Quentin, et al.. New therapeutic opportunities for 5-HT2 receptor ligands. Pharmacology and Therapeutics, Elsevier, 2017, 170, pp.14 - 36. 〈10.1016/j.pharmthera.2016.10.008〉. 〈hal-01593842〉
  • Hajer El Oussini, Hanna Bayer, Jelena Scekic-Zahirovic, Pauline Vercruysse, Jérôme Sinniger, et al.. Serotonin 2B receptor slows disease progression and prevents degeneration of spinal cord mononuclear phagocytes in amyotrophic lateral sclerosis.. Acta Neuropathologica, Springer Verlag, 2016, 131 (3), pp.465-480. 〈10.1007/s00401-016-1534-4〉. 〈hal-01253857〉
  • Yicong Li, Anthonya Cooper, Imelda Odibo, Asli Ahmed, Pamela Murphy, et al.. Discrepancy in insulin regulation between GDM-platelets and -placenta. Journal ob Biological Chemistry, 2016, 〈10.1074/jbc.M116.713693〉. 〈hal-01280557〉
  • Luc Maroteaux, Estelle Ayme-Dietrich, Gaëlle Aubertin-Kirch, Sophie Banas, Emily Quentin, et al.. New therapeutic opportunities for 5-HT2 receptor ligands. Pharmacology and Therapeutics, Elsevier, 2016, 170, pp.14 - 36. 〈10.1016/j.pharmthera.2016.10.008〉. 〈hal-01387994〉
  • Estelle Ayme-Dietrich, Sophie M. Banas, Laurent Monassier, Luc Maroteaux. Pulmonary arterial hypertension, bone marrow, endothelial cell precursors and serotonin. Biologie Aujourd'hui, EDP sciences, 2016, 210 (2), pp.79 - 88. 〈hal-01387997〉
  • Estelle Ayme-Dietrich, Sophie M. Banas, Laurent Monassier, Luc Maroteaux. Hypertension artérielle pulmonaire, moelle osseuse, précurseurs endothéliaux et sérotonine. Biologie Aujourd'hui, EDP sciences, 2016, 210 (2), pp.79-88. 〈10.1051/jbio/2016012〉. 〈hal-01593852〉
  • Estelle Ayme-Dietrich, Halim Marzak, Roland Lawson, Walid Mokni, Olivia Wendling, et al.. Contribution of serotonin to cardiac remodeling associated with hypertensive diastolic ventricular dysfunction in rats. Journal of Hypertension, Lippincott, Williams & Wilkins, 2015, 33 (11), pp.2310-21. 〈10.1097/HJH.0000000000000695〉. 〈hal-01224568〉
  • Marta Kolodziejczak, Catherine Béchade, Nicolas Gervasi, Theano Irinopoulou, Sophie M. Banas, et al.. Serotonin Modulates Developmental Microglia via 5-HT 2B Receptors: Potential Implication during Synaptic Refinement of Retinogeniculate Projections. ACS Chemical Neuroscience, American Chemical Society (ACS), 2015, 6 (7), pp.1219 - 1230. 〈10.1021/cn5003489〉. 〈hal-01593865〉
  • Estelle Ayme-Dietrich, Halim Marzak, Roland Lawson, Walid Mokni, Olivia Wendling, et al.. Contribution of serotonin to cardiac remodeling associated with hypertensive diastolic ventricular dysfunction in rats. Journal of Hypertension, Lippincott, Williams & Wilkins, 2015, 33 (11), pp.2310 - 2321. 〈10.1097/HJH.0000000000000695〉. 〈hal-01593863〉
  • Luc Maroteaux, Pothitos Pitychoutis, Arnauld Belmer, Imane Moutkine, Joëlle Adrien. Mice Lacking the Serotonin Htr2B Receptor Gene Present an Antipsychotic-Sensitive Schizophrenic-Like Phenotype. Neuropsychopharmacology, Nature Publishing Group, 2015, 40 (12), pp.2764 - 2773. 〈10.1038/npp.2015.126〉. 〈hal-01593864〉
  • Sophie M. Banas, Silvina L. Diaz, Stéphane Doly, Arnauld Belmer, Luc Maroteaux. Commentary: Chronic SSRI stimulation of astrocytic 5-HT2B receptors change multiple gene expressions/editings and metabolism of glutamate, glucose and glycogen: a potential paradigm shift. Frontiers in Behavioral Neuroscience, Frontiers, 2015, 9, pp.207. 〈10.3389/fnbeh.2015.00207〉. 〈hal-01215402〉
  • Silvina Laura Diaz, Nicolas Narboux-Nême, Katia Boutourlinsky, Stéphane Doly, Luc Maroteaux. Mice lacking the serotonin 5-HT2B receptor as an animal model of resistance to selective serotonin reuptake inhibitors antidepressants.. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2015, 26 (2), pp.265-279. 〈10.1016/j.euroneuro.2015.12.012〉. 〈hal-01253863〉
  • Arnauld Belmer, Stephane Doly, Vincent Setola, Sophie Banas, Imane Moutkine, et al.. Role of the N-terminal region in G protein-coupled receptor functions: negative modulation revealed by 5-HT2B receptor polymorphisms.. Molecular Pharmacology, American Society for Pharmacology and Experimental Therapeutics, 2014, 85 (1), pp.127-38. 〈10.1124/mol.113.089086〉. 〈inserm-00996746〉
  • Yicong Li, Coedy Hadden, Preeti Singh, Charles P Mercado, Pamela Murphy, et al.. GDM-associated insulin deficiency hinders the dissociation of SERT from ERp44 and down-regulates placental 5-HT uptake.. Proceedings of the National Academy of Sciences of the United States of America , National Academy of Sciences, 2014, 111 (52), pp.E5697-705. 〈10.1073/pnas.1416675112〉. 〈hal-01225032〉
  • Sophie M Banas, Silvina L Diaz, Stéphane Doly, Arnauld Belmer, Luc Maroteaux. Commentary: Chronic SSRI stimulation of astrocytic 5-HT2B receptors change multiple gene expressions/editings and metabolism of glutamate, glucose and glycogen: a potential paradigm shift.. Frontiers in Behavioral Neuroscience, Frontiers, 2014, 9, pp.207. 〈hal-01225050〉
  • Charles Mercado, Maritza Quintero, Yicong Li, Preeti Singh, Alicia Byrd, et al.. A serotonin-induced N-glycan switch regulates platelet aggregation.. Sci Rep, 2013, 3, pp.2795. 〈10.1038/srep02795〉. 〈inserm-00996761〉
  • Luc Maroteaux. Overexpression of 5-hydroxytryptamine 2B receptor gene in pulmonary hypertension: still a long way to understand its transcriptional regulation.. Hypertension, American Heart Association, 2013, 61 (4), pp.e28-9. 〈10.1161/HYPERTENSIONAHA.111.00702〉. 〈inserm-00996750〉
  • Silvina Diaz, Nicolas Narboux-Nême, Sara Trowbridge, Sophie Scotto-Lomassese, Felix Kleine Borgmann, et al.. Paradoxical increase in survival of newborn neurons in the dentate gyrus of mice with constitutive depletion of serotonin.. European Journal of Neuroscience, Wiley, 2013, 38 (5), pp.2650-8. 〈10.1111/ejn.12297〉. 〈inserm-00996749〉
  • Silvina Diaz, Nicolas Narboux-Nême, Sara Trowbridge, Sophie Scotto-Lomassese, Felix B. Kleine Borgmann, et al.. Paradoxical increase in survival of newborn neurons in the dentate gyrus of mice with constitutive depletion of serotonin. European Journal of Neuroscience, Wiley, 2013, 38 (5), pp.2650 - 2658. 〈10.1111/ejn.12297〉. 〈hal-01593866〉
  • Jean-Marie Launay, Philippe Hervé, Jacques Callebert, Ziad Mallat, Corinne Collet, et al.. Serotonin 5-HT2B receptors are required for bone-marrow contribution to pulmonary arterial hypertension.. Blood, American Society of Hematology, 2012, 119 (7), pp.1772-80. 〈10.1182/blood-2011-06-358374〉. 〈inserm-00996752〉
  • Silviana Laura Diaz, Stéphane Doly, Nicolas Narboux-Nême, Sébasatien Fernández, Pierre Mazot, et al.. 5-HT(2B) receptors are required for serotonin-selective antidepressant actions.. Molecular Psychiatry, Nature Publishing Group, 2012, 17 (2), pp.154-63. 〈10.1038/mp.2011.159〉. 〈inserm-00652573〉
  • Yasmine Chabbi-Achengli, Jean-Marie Launay, Luc Maroteaux, Marie Christine De Vernejoul, Corinne Collet. Serotonin 2B receptor (5-HT2B R) signals through prostacyclin and PPAR-ß/δ in osteoblasts.. PLoS ONE, Public Library of Science, 2012, 8 (9), pp.e75783. 〈10.1371/journal.pone.0075783〉. 〈hal-01225060〉
  • Nataliya Urtikova, Nadège Berson, Juliette Van Steenwinckel, Stéphane Doly, Jérémy Truchetto, et al.. Anti-nociceptive effect of peripheral serotonin 5-HT2B receptor activation on neuropathic pain.. PAIN, Elsevier, 2012, 153 (6), pp.1320-31. 〈10.1016/j.pain.2012.03.024〉. 〈hal-01225065〉
  • Clara Dees, Alfiya Akhmetshina, Pawel Zerr, Nicole Reich, Katrin Palumbo, et al.. Platelet-derived serotonin links vascular disease and tissue fibrosis.: Serotonin in 5-HT2B fibrotic disease. Journal of Experimental Medicine, Rockefeller University Press, 2011, 208 (5), pp.961-972. 〈10.1084/jem.20101629 〉. 〈inserm-00589662〉
  • Silvina Laura Diaz, Luc Maroteaux. Implication of 5-HT(2B) receptors in the serotonin syndrome.. Neuropharmacology, Elsevier, 2011, 61 (3), pp.495-502. 〈10.1016/j.neuropharm.2011.01.025〉. 〈inserm-00561473〉
  • Sophie Banas, Stéphane Doly, Katia Boutourlinsky, Silvina Diaz, Arnauld Belmer, et al.. Deconstructing Antiobesity Compound Action: Requirement of Serotonin 5-HT(2B) Receptors for Dexfenfluramine Anorectic Effects.: Anorectic compounds and 5-HTreceptors. Neuropsychopharmacology, Nature Publishing Group, 2011, 36 (2), pp.423-33. 〈10.1038/npp.2010.173〉. 〈inserm-00549170〉
  • Mohammad Ebrahimkhani, Fiona Oakley, Lindsay Murphy, Jelena Mann, Anna Moles, et al.. Stimulating healthy tissue regeneration by targeting the 5-HT₂B receptor in chronic liver disease.. Nature Medicine, Nature Publishing Group, 2011, 17 (12), pp.1668-73. 〈10.1038/nm.2490〉. 〈inserm-00652584〉
  • V. S. Tharayil, M. M. Wouters, J. E. Stanich, J. L. Roeder, S. Lei, et al.. Lack of serotonin 5-HT2B receptor alters proliferation and network volume of interstitial cells of Cajal in vivo.. Neurogastroenterology and Motility, Wiley, 2010, 22 (4), pp.462-9, e109-10. 〈10.1111/j.1365-2982.2009.01435.x〉. 〈inserm-00996753〉
  • Sophie M Banas, Stephane Doly, Katia Boutourlinsky, Silvina L Diaz, Arnauld Belmer, et al.. Deconstructing antiobesity compound action: requirement of serotonin 5-HT2B receptors for dexfenfluramine anorectic effects.. Neuropsychopharmacology, Nature Publishing Group, 2010, 36, pp.423-433. 〈10.1038/npp.2010.173〉. 〈hal-00583533〉
  • Laura Bevilacqua, Stéphane Doly, Jaakko Kaprio, Qiaoping Yuan, Roope Tikkanen, et al.. A population-specific HTR2B stop codon predisposes to severe impulsivity.. Nature, Nature Publishing Group, 2010, 468 (7327), pp.1061-6. 〈10.1038/nature09629〉. 〈inserm-00550376〉
  • Laurent Monassier, Marc André Laplante, Tarak Ayadi, Stéphane Doly, Luc Maroteaux. Contribution of gene-modified mice and rats to our understanding of the cardiovascular pharmacology of serotonin.. Pharmacology & Therapeutics / Pharmacology and Therapeutics, 2010, 128 (3), pp.559-67. 〈10.1016/j.pharmthera.2010.08.004〉. 〈inserm-00549197〉
  • Fabrice Jaffré, Philippe Bonnin, Jacques Callebert, Haythem Debbabi, Vincent Setola, et al.. Serotonin and angiotensin receptors in cardiac fibroblasts coregulate adrenergic-dependent cardiac hypertrophy.. Circulation Research, American Heart Association, 2009, 104 (1), pp.113-23. 〈10.1161/CIRCRESAHA.108.180976〉. 〈inserm-00484528〉
  • Stéphane Doly, Jesus Bertran-Gonzalez, Jacques Callebert, Alexandra Bruneau, Sophie Marie Banas, et al.. Role of serotonin via 5-HT2B receptors in the reinforcing effects of MDMA in mice.. PLoS ONE, Public Library of Science, 2009, 4 (11), pp.e7952. 〈10.1371/journal.pone.0007952〉. 〈inserm-00484504〉
  • Stéphane Doly, Emmanuel Valjent, Vincent Setola, Jacques Callebert, Denis Hervé, et al.. Serotonin 5-HT2B receptors are required for 3,4-methylenedioxymethamphetamine-induced hyperlocomotion and 5-HT release in vivo and in vitro.. Journal of Neuroscience, Society for Neuroscience, 2008, 28 (11), pp.2933-40. 〈10.1523/JNEUROSCI.5723-07.2008〉. 〈inserm-00484533〉
  • Laurent Monassier, Marc-André Laplante, Fabrice Jaffré, Pascal Bousquet, Luc Maroteaux, et al.. Serotonin 5-HT(2B) receptor blockade prevents reactive oxygen species-induced cardiac hypertrophy in mice.. Hypertension, American Heart Association, 2008, 52 (2), pp.301-7. 〈10.1161/HYPERTENSIONAHA.107.105551〉. 〈inserm-00484531〉
  • Corinne Collet, Corinne Schiltz, Valérie Geoffroy, Luc Maroteaux, Jean-Marie Launay, et al.. The serotonin 5-HT2B receptor controls bone mass via osteoblast recruitment and proliferation.. FASEB Journal, Federation of American Society of Experimental Biology, 2008, 22 (2), pp.418-27. 〈10.1096/fj.07-9209com〉. 〈inserm-00996758〉
  • Agnès Janoshazi, Maud Deraet, Jacques Callebert, Vincent Setola, Silke Guenther, et al.. Modified Receptor Internalization upon Co-expression of 5-HT1B Receptor and 5-HT2B Receptors.. Molecular Pharmacology, American Society for Pharmacology and Experimental Therapeutics, 2007, 71 (6), pp.1463-74. 〈10.1124/mol.106.032656〉. 〈hal-00135110〉
  • Agnes Janoshazi, Maud Deraet, Jacques Callebert, Vincent Setola, Silke Guenther, et al.. Modified Receptor Internalization upon Coexpression of 5-HT1B Receptor and 5-HT2B Receptors. Molecular Pharmacology, American Society for Pharmacology and Experimental Therapeutics, 2007, 71 (6), pp.1463 - 1474. 〈10.1124/mol.106.032656〉. 〈hal-01596606〉
  • B Schaerlinger, J M Launay, J L Vonesch, Luc Maroteaux. Gain of affinity point mutation in the serotonin receptor gene 5-HT2Dro accelerates germband extension movements during Drosophila gastrulation.. Developmental Dynamics, Wiley, 2007, 236 (4), pp.991-999. 〈10.1002/dvdy.21110〉. 〈hal-01274920〉
  • J Callebert, J M Esteve, P Hervé, K Peoc'H, C Tournois, et al.. Evidence for a control of plasma serotonin levels by 5-hydroxytryptamine(2B) receptors in mice.. Journal of Pharmacology and Experimental Therapeutics, American Society for Pharmacology and Experimental Therapeutics, 2006, 317 (2), pp.724-731. 〈10.1124/jpet.105.098269 〉. 〈hal-01274937〉
  • Juan M Esteve, Jean-Marie Launay, Odile Kellermann, Luc Maroteaux. Functions of serotonin in hypoxic pulmonary vascular remodeling.. Cell Biochemistry and Biophysics, Humana Press, 2006, 47 (1), pp.33-44. 〈10.1385/CBB:47:1:33〉. 〈hal-01274919〉
  • Silke Günther, Luc Maroteaux, Stephan W. Schwarzacher. Endogenous 5-HT2B receptor activation regulates neonatal respiratory activity in vitro. Journal of Neurobiology, Wiley, 2006, 66 (9), pp.949-961. 〈10.1002/neu.20253〉. 〈hal-01274950〉
  • Maud Deraet, Philippe Manivet, Agnes Janoshazi, Jacques Callebert, Silke Guenther, et al.. The Natural Mutation Encoding a C Terminus-Truncated 5-Hydroxytryptamine2B Receptor Is a Gain of Proliferative Functions. Molecular Pharmacology, American Society for Pharmacology and Experimental Therapeutics, 2005, 67 (4), pp.983 - 991. 〈10.1124/mol.104.008268〉. 〈hal-01596608〉
  • Maud Deraet, Philippe Manivet, Agnes Janoshazi, Jacques Callebert, Silke Guenther, et al.. The natural mutation encoding a C terminus-truncated 5-hydroxytryptamine 2B receptor is a gain of proliferative functions.. Molecular Pharmacology, American Society for Pharmacology and Experimental Therapeutics, 2005, 67 (4), pp.983-91. 〈10.1124/mol.104.008268〉. 〈hal-00192776〉
  • Fabrice Jaffré, Jacques Callebert, Alexandre Sarre, Nelly Etienne, Canan G Nebigil, et al.. Involvement of the serotonin 5-HT2B receptor in cardiac hypertrophy linked to sympathetic stimulation: control of interleukin-6, interleukin-1beta, and tumor necrosis factor-alpha cytokine production by ventricular fibroblasts.. Circulation, American Heart Association, 2004, 110 (8), pp.969-974. 〈10.1161/01.CIR.0000139856.20505.57〉. 〈hal-01274954〉
  • Nelly Etienne, Bérénice Schaerlinger, Fabrice Jaffré, Luc Maroteaux. Le récepteur 5-HT2B: une cible privilégiée de la sérotonine au niveau cardio-pulmonaire. Journal- Societe de Biologie, Paris : Société de biologie, 2004, 198 (1), pp.22-9. 〈hal-01274957〉
  • Patricia Gaspar, Olivier Cases, Luc Maroteaux. The developmental role of serotonin: news from mouse molecular genetics.. Nature Reviews Neuroscience, Nature Publishing Group, 2003, 4 (12), pp.1002-12. 〈10.1038/nrn1256〉. 〈hal-01274960〉